Abstract
The term acute kidney injury (AKI) has largely replaced acute renal failure (ARF), since ARF pessimistically overemphasizes the failure of kidneys and fails to account for the diverse nature of the syndrome of AKI. AKI results from multiple causative factors. The clinical manifestations range from a minimal increase in serum creatinine to anuric renal failure. AKI is potentially preventable in many instances and is, by and large, reversible, although some cases of AKI may progress to chronic kidney disease (CKD). This chapter describes staging systems for AKI, the etiologies, a practical approach to a child with AKI, and management aspects – renal-specific, renal supportive, and renal replacement therapies. Hemodialysis and peritoneal dialysis will be discussed in more detail in Chap. 10; the current chapter focuses on practical aspects of continuous renal replacement therapies.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Suggested Reading
Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL (2007) Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 71:1028–1035
Askenazi DJ, Goldstein SL, Koralkar R, Fortenberry J, Baum M, Hackbarth R, Blowey D, Bunchman TE, Brophy PD, Symons J, Chua A, Flores F, Somers MJ (2013) Continuous renal replacement therapy for children £ 10 kg: a report from the prospective pediatric continuous renal replacement therapy registry. J Pediatr 162:587–592.e3
Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup (2004) Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8:R204–R212
Bunchman TE, Brophy PD, Goldstein SL (2008) Technical considerations for renal replacement therapy in children. Semin Nephrol 28:488–492
Cerdá J, Bagga A, Kher V, Chakravarthi RM (2008) The contrasting characteristics of acute kidney injury in developed and developing countries. Nat Clin Pract Nephrol 4:138–153
CRRT Protocols: http://www.pcrrt.com/Protocols%20PCRRT%20Zurich.pdf
de Pont AC (2007) Extracorporeal treatment of intoxications. Curr Opin Crit Care 13:668–673
Fleming GM, Walters S, Goldstein SL, Alexander SR, Baum MA, Blowey DL, Bunchman TE, Chua AN, Fletcher SA, Flores FX, Fortenberry JD, Hackbarth R, McBryde K, Somers MJ, Symons JM, Brophy PD, Prospective Pediatric Continuous Renal Replacement Therapy Registry Group (2012) Nonrenal indications for continuous renal replacement therapy: a report from the Prospective Pediatric Continuous Renal Replacement Therapy Registry Group. Pediatr Crit Care Med 13:e299–e304
Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD (2013) KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am J Kidney Dis 61:649–672
Slater MB, Anand V, Uleryk EM, Parshuram CS (2012) A systematic review of RIFLE criteria in children, and its application and association with measures of mortality and morbidity. Kidney Int 81:791–798
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Gupta, I., Bitzan, M. (2014). Acute Kidney Injury. In: Phadke, K., Goodyer, P., Bitzan, M. (eds) Manual of Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12483-9_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-12483-9_8
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-12482-2
Online ISBN: 978-3-642-12483-9
eBook Packages: MedicineMedicine (R0)