Skip to main content

Acute Kidney Injury

  • Chapter
  • First Online:
Manual of Pediatric Nephrology

Abstract

The term acute kidney injury (AKI) has largely replaced acute renal failure (ARF), since ARF pessimistically overemphasizes the failure of kidneys and fails to account for the diverse nature of the syndrome of AKI. AKI results from multiple causative factors. The clinical manifestations range from a minimal increase in serum creatinine to anuric renal failure. AKI is potentially preventable in many instances and is, by and large, reversible, although some cases of AKI may progress to chronic kidney disease (CKD). This chapter describes staging systems for AKI, the etiologies, a practical approach to a child with AKI, and management aspects – renal-specific, renal supportive, and renal replacement therapies. Hemodialysis and peritoneal dialysis will be discussed in more detail in Chap. 10; the current chapter focuses on practical aspects of continuous renal replacement therapies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Suggested Reading

  • Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL (2007) Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 71:1028–1035

    Article  CAS  PubMed  Google Scholar 

  • Askenazi DJ, Goldstein SL, Koralkar R, Fortenberry J, Baum M, Hackbarth R, Blowey D, Bunchman TE, Brophy PD, Symons J, Chua A, Flores F, Somers MJ (2013) Continuous renal replacement therapy for children £ 10 kg: a report from the prospective pediatric continuous renal replacement therapy registry. J Pediatr 162:587–592.e3

    Article  PubMed  Google Scholar 

  • Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup (2004) Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8:R204–R212

    Article  PubMed Central  PubMed  Google Scholar 

  • Bunchman TE, Brophy PD, Goldstein SL (2008) Technical considerations for renal replacement therapy in children. Semin Nephrol 28:488–492

    Article  CAS  PubMed  Google Scholar 

  • Cerdá J, Bagga A, Kher V, Chakravarthi RM (2008) The contrasting characteristics of acute kidney injury in developed and developing countries. Nat Clin Pract Nephrol 4:138–153

    Article  PubMed  Google Scholar 

  • CRRT Protocols: http://www.pcrrt.com/Protocols%20PCRRT%20Zurich.pdf

  • de Pont AC (2007) Extracorporeal treatment of intoxications. Curr Opin Crit Care 13:668–673

    Article  PubMed  Google Scholar 

  • Fleming GM, Walters S, Goldstein SL, Alexander SR, Baum MA, Blowey DL, Bunchman TE, Chua AN, Fletcher SA, Flores FX, Fortenberry JD, Hackbarth R, McBryde K, Somers MJ, Symons JM, Brophy PD, Prospective Pediatric Continuous Renal Replacement Therapy Registry Group (2012) Nonrenal indications for continuous renal replacement therapy: a report from the Prospective Pediatric Continuous Renal Replacement Therapy Registry Group. Pediatr Crit Care Med 13:e299–e304

    Article  PubMed  Google Scholar 

  • Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD (2013) KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am J Kidney Dis 61:649–672

    Article  PubMed  Google Scholar 

  • Slater MB, Anand V, Uleryk EM, Parshuram CS (2012) A systematic review of RIFLE criteria in children, and its application and association with measures of mortality and morbidity. Kidney Int 81:791–798

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Indra Gupta .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gupta, I., Bitzan, M. (2014). Acute Kidney Injury. In: Phadke, K., Goodyer, P., Bitzan, M. (eds) Manual of Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12483-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-12483-9_8

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12482-2

  • Online ISBN: 978-3-642-12483-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics