Abstract
Researchers began to consistently find associations with adverse health risks of elevated PM2.5 (particulate matter 2.5 µm or less in diameter), measured as mass, in the 1990s. However, monitoring information was then available for few PM2.5 components. Advisory bodies such as the Clean Air Scientific Advisory Committee (1996) and the National Research Council (NRC) of the U.S. National Academies of Sciences (in 1998 and later) suggested the need to better understand which PM2.5 constituents are most or least harmful, to enable targeted control strategies. But how should researchers best distinguish risks of harm from different PM2.5 constituents in complex mixtures of primary and secondary particles?
Methodological issues may play a primary role in this research endeavor. Principles of methodology discussed herein include: (1) need for accurate exposure information in epidemiological studies; (2) using epidemiological studies which compare effects of a wide range of health-relevant pollutants against the same health endpoints in the same study; (3) recognition that a given source can emit several pollutants, and conversely that some common pollutants have multiple sources, but with different co-pollutants, thus creating the possibility that statistical associations with one pollutant could be attributable to co-emitted pollutant(s), perhaps unmeasured; and (4) accounting in some way for atmospheric chemical processes. Further, examining for a relevant pollutant both toxicology studies (in vitro and in vivo) and epidemiological studies (including population based and human panel studies reflecting use of these four principles), might provide the fullest evidentiary pathway to determining differential toxicological properties among PM2.5 components.
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Adar SD, Kaufman JD (2007) Cardiovascular disease and air pollutants: evaluating and improving epidemiological data implicating traffic exposure. Inhal Toxicol 19(Suppl 1):135–149
Bell ML, Ebisu K, Peng RD et al (2009) Hospital admissions and chemical composition of fine particle air pollution. Am J Respir Crit Care Med 179:1115–1120
Brown S, Frankel A, Raffuse SM et al (2007) Source apportionment of PM2.5 in Phoenix, Arizona, using positive matrix factorization. J Air Waste Manage Assoc 57:741–752
Clean Air Scientific Advisory Committee (1996) “Closure” letter to EPA Administrator Carol M Browner, signed June 13, 1996
Chahine T, Baccerelli A, Litonjua A et al (2007) Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort. Environ Health Perspect 115:1617–1622
Creason J, Neas L, Walsh D et al (2001) Particulate matter and heart rate variability among elderly retirees: the Baltimore 1998 PM study. J Environ Expos Anal Environ Epidemiol 11:116–122
Delfino RJ, Staimer N, Tjoa T et al (2008) Circulating biomarkers of inflammation, antioxidant activity, and platelet activation are associated with primary combustion aerosols in subjects with coronary artery disease. Environ Health Perspect 116:898–906
Delfino RJ, Staimer N, Tjoa T et al (2009) Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms. Environ Health Perspect 117:1232–1238
Dockery DW, Pope CA, Xu X et al (1993) An association between air pollution and mortality in six US cities. N Engl J Med 329:1753–1759
Ebelt ST, Wilson WE, Brauer M (2005) Exposure to ambient and nonambient components of particulate matter. Epidemiology 16:396–405
Fann N, Fulcher CM, Hubbell BJ (2009) The influence of location, source, and emission type in estimates of the human health benefits of reducing a ton of air pollution. Air Qual Atmos Health (online June 9, 2009). http://www.springerlink.com/content/1381522137744641/fulltext.html
Finkelstein M, Jerrett M, Sears MR (2004) Traffic air pollution and mortality rate advancement periods. Am J Epidemiol 160:173–177
Franklin M, Koutrakis P, Schwartz J (2008) The role of particle composition on the association between PM2.5 and mortality. Epidemiology 19:680–689
Gold DR, Litonjua AA, Zanobetti A et al (2005) Air pollution and ST-segment depression in elderly subjects. Environ Health Perspect 113:883–887
Grahame TJ (2009) Does improved exposure information for PM2.5 constituents explain differing results among epidemiological studies? Inhal Toxicol 21:381–393
Grahame T, Hidy GM (2007) Pinnacles and pitfalls for source apportionment of potential health effects from airborne particle exposure. Inhal Toxicol 19:727–744
Grahame TJ, Schlesinger RB (2009) Cardiovascular health and particulate vehicular emissions: a critical evaluation of the evidence. Air Qual Atmos Health (online Jun 30, 2009). http://www.springerlink.com/content/67l125671xl33314/fulltext.html
Health Effects Institute (2000) The national morbidity, mortality, and air pollution study. Part II: Morbidity and mortality from air pollution in the United States. Research Report #94, Boston, MA
Hennekens CH, Buring JE (1987) Epidemiology in medicine. Little, Brown and Co, Boston
Hoek G, Brunekreef B, Goldbohm S et al (2002) Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet 360:1203–1209
Huang Y-CT, Ghio AJ, Stonehuerner J et al (2003) The role of soluble components in ambient fine particles induced changes in human lungs and blood. Inhal Toxicol 15:327–342
Jerrett M, Burnett RT, Ma R et al (2005) Spatial analysis of air pollution and mortality in Los Angeles. Epidemiology 16(6):1–10
Jerrett M, Newbold KB, Burnett RT et al (2007) Geographies of uncertainty in the health benefits of air quality improvements. Stoch Environ Res Risk Assess 21:511–522
Kodavanti UP, Schladweiler MC, Ledbetter AD et al (2005) Consistent pulmonary and systemic responses from inhalation of fine concentrated ambient particles: roles of rat strains used and physicochemical properties. Environ Health Perspect 113(11):1561–1568
Kuenzli N, Jerrett M, Mack WJ et al (2005) Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect 113:201–206
Laden F, Schwartz J, Speizer FE et al (2006) Reduction in fine particulate air pollution and mortality. Am J Respir Crit Care Med 173:667–672
Lewis CW, Norris G, Conner T et al (2003) Source apportionment of Phoenix PM2.5 aerosol with the Unmix receptor model. J Air Waste Manage Assoc 53:325–338
Li N, Wang M, Oberley TD et al (2002a) Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Epidemiol 169:4531–4541
Li N, Kim S, Wang M et al (2002b) Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhal Toxicol 14:459–486
Li N, Sioutas C, Cho A et al (2003) Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111(4):455–460
Lipfert FW, Wyzga RE, Baty JD et al (2006a) Traffic density as a surrogate measure of environmental exposures in studies of air pollution health effects: Long-term mortality in a cohort of U.S. veterans. Atmos Environ 40:154–169
Lipfert FW, Baty JD, Wyzga RE et al (2006b) PM2.5 constituents and related air quality variables as predictors of survival in a cohort of U.S. military veterans. Inhal Toxicol 18:645–657
Lippmann M, Gordon T, Chen LC (2005) Effects of Subchronic exposures to concentrated ambient particles in mice: IX. Integral assessment and human health implications of subchronic exposures of mice to CAPs. Inhal Toxicol 17:255–261
Lippmann M, Ito K, Hwang J-S et al (2006) Cardiovascular effects of nickel in ambient air. Environ Health Perspect 114:1662–1669
Liu W, Wang Y, Russell A et al (2005) Atmospheric aerosol over two urban–rural pairs in the southeastern United States: chemical composition and possible sources. Atmos Environ 39:4453–4470
Liu W, Wang Y, Russell A et al (2006) Enhanced source identification of Southeast aerosols using temperature resolved carbon fractions and gas phase components. Atmos Environ 40:S445–S466
Maciejczyk P, Chen LC (2005) Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice: VIII. Source related daily variations in in vitro responses to CAPs. Inhal Toxicol 17:243–253
Mar TF, Norris G, Koenig J et al (2000) Associations between air pollution and mortality in Phoenix, 1995–1997. Environ Health Perspect 108:347–353
Mar TF, Ito K, Koenig JQ et al (2006) PM source apportionment and health effects. 3. Investigation of inter-method variations in associations between estimated source contributions of PM2.5 and daily mortality in Phoenix, AZ. J Expos Anal Environ Epidemiol 16(4):311–320
Martineau RJ, Martineau Jr. PD, Novello DP (2005) The Clean Air Act handbook, 2nd edn. American Bar Association, p 27
Maynard D, Coull BA, Gryparis A et al (2007) Mortality risk associated with short-term exposure to traffic particles and sulfates. Environ Health Perspect 115:751–755
McDonald JD, Harrod KS, Seagrave J et al (2004) Effects of low sulfur fuel and a catalyzed particle trap on the composition and toxicity of diesel emissions. Environ Health Perspect 112:1307–1312
Metzger KB, Tolbert PE, Klein M et al (2004) Ambient air pollution and cardiovascular emergency department visits. Epidemiology 15:46–56
Mills NL, Tornquist H, Robinson SD et al (2005) Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 112:3930–3936
National Research Council (1998) Research priorities for airborne particulate matter. I: Immediate priorities and a long-range research portfolio. National Academy Press, Washington, DC
National Research Council (2004) Research priorities for airborne particulate matter. IV: Continuing research progress. National Academy Press, Washington, DC
Paatero P (1997) Least-squares formulation of robust nonnegative factor analysis. Chemom Intell Lab Syst 37:23–35
Paatero P, Tapper U (1993) Analysis of different modes of factor analysis as least squares fit problem. Chemom Intell Lab Syst 18:183–194
Paatero P, Tapper U (1994) Positive matrix factorization: a non-negative factor model with optimal utilization of error estimates of data values. Environmetrics 5:111–126
Park SK, O’Neill MS, Stunder BJB et al (2007) Source location of air pollution and cardiac autonomic function: trajectory cluster analysis for exposure assessment. J Expos Sci Environ Epidemiol 17:488–497
Peng RD, Bell ML, Geyh AS et al (2009) Emergency admissions for cardiovascular and respiratory diseases and the chemical composition of fine particle air pollution. Environ Health Perspect 117:957–963
Pope CA, Thun MJ, Namboodiri MM et al (1995) Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am J Crit Care Med 151:669–674
Pope CA, Burnett RT, Thun MJ et al (2002) Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. J Am Med Assoc 287(9):1132–1141
Pope CA III, Ezzati M, Dockery DW (2009) Fine-particulate air pollution and life expectancy in the United States. N Engl J Med 360:376–386
Ramadan Z, Song X-H, Hopke P (2000) Identification of sources of Phoenix aerosol by positive matrix factorization. J Air Waste Manage Assoc 50:1308–1320
Reponen T, Grinshpun S, Trakumas S et al (2003) Concentration gradient patterns of aerosol particles near interstate highways in the Greater Cincinnati airshed. J Environ Monit 5:557–562
Rhoden CR, Wellenius GA, Ghelfi E et al (2005) PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulation. Biochim Biophys Acta 1725:305–313
Salvi S, Blomberg A, Rudell B et al (1999) Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 159:702–709
Samet JM (2007) Traffic, air pollution, and health. Inhal Toxicol 19:1021–1027
Sarnat JA, Marmur A, Klein M et al (2008) Fine particle sources and cardiorespiratory morbidity: an application of chemical mass balance and factor analytical source-apportionment methods. Environ Health Perspect 116:459–466
Schauer JJ (2003) Evaluation of elemental carbon as a marker for diesel particulate matter. J Expos Anal Environ Epidemiol 13:443–453
Schlesinger RB, Cassee F (2003) Atmospheric secondary inorganic particulate matter: the toxicological perspective as a basis for health effects risk assessment. Inhal Toxicol 15:197–235
Schwartz J, Litonjua A, Suh H et al (2005) Traffic related pollution and heart rate variability in a panel of elderly subjects. Thorax 60:455–461
Thurston GD, Spengler JD (1985) A quantitative assessment of source contributions to inhalable particulate matter pollution in metropolitan Boston. Atmos Environ 9(1):9–25
Tolbert PE, Klein M, Peel JL et al (2007) Multipollutant modeling issues in a study of ambient air quality and emergency department visits in Atlanta. J Expos Sci Environ Epidemiol 17:S29–S35
Van Roosbroeck S, Li R, Hoek G et al (2008) Traffic-related outdoor air pollution and respiratory symptoms in children. Epidemiology 19(3):409–416
Zeger SL, Thomas D, Dominici F et al (2000) Exposure measurement error in time-series studies of air pollution: concepts and consequences. Environ Health Perspect 108:419–426
Zhu Y, Hind WC, Kim S et al (2002a) Concentration and size distribution of ultrafine particles near a major highway. J Air Waste Manage Assoc 52:1032–1042
Zhu Y, Hinds WC, Kim S et al (2002b) Study of ultrafine particles near a major highway with heavy-duty diesel traffic. Atmos Environ 36:4323–4335
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The analysis provided in this chapter is the work of the author alone and does not necessarily represent views of the U.S. Department of Energy. Thanks to two anonymous reviewers and especially to JoAnn Yuill for their invaluable assistance.
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Grahame, T.J. (2010). Distinguishing Health Effects Among Different PM2.5 Components. In: Zereini, F., Wiseman, C. (eds) Urban Airborne Particulate Matter. Environmental Science and Engineering(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12278-1_29
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