Skip to main content
Book cover

Nutrition for Healthy Skin pp 71–83Cite as

Systemic and Topical Use of Green Tea Polyphenols for Healthy Skin

Abstract

Tea, a popular beverage with its origins in southeast Asia, generally refers to an infusion derived from processed leaves, leaf buds, and internodes of the plant Camellia sinensis. There are four types of C. sinensis teas commonly available on the market – black, oolong, green, and white – which differ in their modes of processing, and in the case of white tea, maturity. (“Red tea” generally refers to an infusion derived from the South African Rooibos plant.) Green tea is produced from fresh leaves of the plant; unlike the black and oolong varieties, green tea is derived from fresh C. sinensis leaves that are steamed and dried at high temperatures before any oxidation and polymerization of polyphenolic compounds has taken place.

Keywords

  • Nucleotide Excision Repair
  • Cyclobutane Pyrimidine Dimer
  • Seborrheic Keratosis
  • Normal Human Epidermal Keratinocytes
  • Photoprotective Effect

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-12264-4_7
  • Chapter length: 13 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   119.00
Price excludes VAT (USA)
  • ISBN: 978-3-642-12264-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   159.99
Price excludes VAT (USA)
Hardcover Book
USD   219.99
Price excludes VAT (USA)
Learn about institutional subscriptions
Fig. 7.1

References

  1. Sunburn prevalence among adults – United States, 1999, 2003, and 2004. MMWR. Morb. Mortal. Wkly. Rep. 56, 524–528 (2007)

    Google Scholar 

  2. Afaq, F., Adhami, V.M., Ahmad, N., et al.: Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in ­normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate. Oncogene 22, 1035–1044 (2003)

    CAS  PubMed  CrossRef  Google Scholar 

  3. Afaq, F., Ahmad, N., Mukhtar, H.: Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice. Oncogene 22, 9254–9264 (2003)

    CAS  PubMed  CrossRef  Google Scholar 

  4. Agar, N., Young, A.R.: Melanogenesis: a photoprotective response to DNA damage? Mutat. Res. 571, 121–132 (2005)

    CAS  PubMed  Google Scholar 

  5. Agarwal, R., Katiyar, S.K., Khan, S.G., et al.: Protection against ultraviolet B radiation-induced effects in the skin of SKH-1 hairless mice by a polyphenolic fraction isolated from green tea. Photochem. Photobiol. 58, 695–700 (1993)

    CAS  PubMed  CrossRef  Google Scholar 

  6. Ahmad, N., Gupta, S., Mukhtar, H.: Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells. Arch. Biochem. Biophys. 376, 338–346 (2000)

    CAS  PubMed  CrossRef  Google Scholar 

  7. Anderson, R.F., Fisher, L.J., Hara, Y., et al.: Green tea catechins partially protect DNA from (.)OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals. Carcinogenesis 22, 1189–1193 (2001)

    CAS  PubMed  CrossRef  Google Scholar 

  8. Azurdia, R.M., Pagliaro, J.A., Diffey, B.L., et al.: Sunscreen application by photosensitive patients is inadequate for protection. Br. J. Dermatol. 140, 255–258 (1999)

    CAS  PubMed  CrossRef  Google Scholar 

  9. Bae, J.Y., Choi, J.S., Choi, Y.J., et al.: (-)Epigallocatechin gallate hampers collagen destruction and collagenase activation in ultraviolet-B-irradiated human dermal fibroblasts: involvement of mitogen-activated protein kinase. Food Chem. Toxicol. 46, 1298–1307 (2008)

    CAS  PubMed  CrossRef  Google Scholar 

  10. Baeuerle, P.A., Baltimore, D.: NF-kappa B: ten years after. Cell 87, 13–20 (1996)

    CAS  PubMed  CrossRef  Google Scholar 

  11. Balasubramanian, S., Eckert, R.L.: Keratinocyte proliferation, differentiation, and apoptosis–differential mechanisms of regulation by curcumin, EGCG and apigenin. Toxicol. Appl. Pharmacol. 224, 214–219 (2007)

    CAS  PubMed  CrossRef  Google Scholar 

  12. Baldwin Jr., A.S.: The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649–683 (1996)

    CAS  PubMed  CrossRef  Google Scholar 

  13. Baliga, M.S., Katiyar, S.K.: Chemoprevention of photocarcinogenesis by selected dietary botanicals. Photochem. Photobiol. Sci. 5, 243–253 (2006)

    CAS  PubMed  CrossRef  Google Scholar 

  14. Bernstein, C., Bernstein, H., Payne, C.M., et al.: DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat. Res. 511, 145–178 (2002)

    CAS  PubMed  CrossRef  Google Scholar 

  15. Bickers, D.R., Athar, M.: Novel approaches to chemoprevention of skin cancer. J. Dermatol. 27, 691–695 (2000)

    CAS  PubMed  Google Scholar 

  16. Bode, A.M., Dong, Z.: Signal transduction pathways: targets for chemoprevention of skin cancer. Lancet Oncol. 1, 181–188 (2000)

    CAS  PubMed  CrossRef  Google Scholar 

  17. Brugarolas, J., Chandrasekaran, C., Gordon, J.I., et al.: Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377, 552–557 (1995)

    CAS  PubMed  CrossRef  Google Scholar 

  18. Chatterjee, M.L., Agarwal, R., Mukhtar, H.: Ultraviolet B radiation-induced DNA lesions in mouse epidermis: an assessment using a novel 32P-postlabelling technique. Biochem. Biophys. Res. Commun. 229, 590–595 (1996)

    CAS  PubMed  CrossRef  Google Scholar 

  19. Chen, J.G., Fleischer Jr., A.B., Smith, E.D., et al.: Cost of nonmelanoma skin cancer treatment in the United States. Dermatol. Surg. 27, 1035–1038 (2001)

    CAS  PubMed  CrossRef  Google Scholar 

  20. Chen, W., Bowden, G.T.: Activation of p38 MAP kinase and ERK are required for ultraviolet-B induced c-fos gene expression in human keratinocytes. Oncogene 18, 7469–7476 (1999)

    CAS  PubMed  CrossRef  Google Scholar 

  21. Chen, W., Dong, Z., Valcic, S., et al.: Inhibition of ultraviolet B–induced c-fos gene expression and p38 mitogen-activated protein kinase activation by (−)-epigallocatechin gallate in a human keratinocyte cell line. Mol. Carcinog. 24, 79–84 (1999)

    CAS  PubMed  CrossRef  Google Scholar 

  22. Chiu, A.E., Chan, J.L., Kern, D.G., et al.: Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol. Surg. 31, 855–860 (2005); discussion 860

    CAS  PubMed  CrossRef  Google Scholar 

  23. Choi, C.M., Berson, D.S.: Cosmeceuticals. Semin. Cutan. Med. Surg. 25, 163–168 (2006)

    CAS  PubMed  CrossRef  Google Scholar 

  24. Chow, H.H., Cai, Y., Hakim, I.A., et al.: Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin. Cancer Res. 9, 3312–3319 (2003)

    CAS  PubMed  Google Scholar 

  25. Chung, J.H., Han, J.H., Hwang, E.J., et al.: Dual mechanisms of green tea extract (EGCG)-induced cell survival in human epidermal keratinocytes. FASEB J. 17, 1913–1915 (2003)

    CAS  PubMed  Google Scholar 

  26. Conney, A.H., Lu, Y.P., Lou, Y.R., et al.: Inhibitory effects of tea and caffeine on UV-induced carcinogenesis: relationship to enhanced apoptosis and decreased tissue fat. Eur. J. Cancer Prev. 11(Suppl 2), S28–S36 (2002)

    PubMed  Google Scholar 

  27. Conney, A.H., Wang, Z.Y., Huang, M.T., et al.: Inhibitory effect of green tea on tumorigenesis by chemicals and ultraviolet light. Prev. Med. 21, 361–369 (1992)

    CAS  PubMed  CrossRef  Google Scholar 

  28. Datta, S.R., Brunet, A., Greenberg, M.E.: Cellular survival: a play in three Akts. Genes Dev. 13, 2905–2927 (1999)

    CAS  PubMed  CrossRef  Google Scholar 

  29. Daya-Grosjean, L., Dumaz, N., Sarasin, A.: The specificity of p53 mutation spectra in sunlight induced human cancers. J. Photochem. Photobiol. B 28, 115–124 (1995)

    CAS  PubMed  CrossRef  Google Scholar 

  30. Dvorakova, K., Dorr, R.T., Valcic, S., et al.: Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin. Cancer Chemother. Pharmacol. 43, 331–335 (1999)

    CAS  PubMed  CrossRef  Google Scholar 

  31. Einspahr, J.G., Bowden, G.T., Alberts, D.S.: Skin cancer chemoprevention: strategies to save our skin. Recent Results Cancer Res. 163, 151–164 (2003); discussion 264–156

    CAS  PubMed  Google Scholar 

  32. el-Deiry, W.S., Tokino, T., Velculescu, V.E., et al.: WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817–825 (1993)

    CAS  PubMed  CrossRef  Google Scholar 

  33. Elmets, C.A., Singh, D., Tubesing, K., et al.: Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. J. Am. Acad. Dermatol. 44, 425–432 (2001)

    CAS  PubMed  CrossRef  Google Scholar 

  34. Gasparro, F.P.: The role of PUVA in the treatment of psoriasis. Photobiology issues related to skin cancer incidence. Am. J. Clin. Dermatol. 1, 337–348 (2000)

    CAS  PubMed  CrossRef  Google Scholar 

  35. Gensler, H.L., Timmermann, B.N., Valcic, S., et al.: Prevention of photocarcinogenesis by topical administration of pure epigallocatechin gallate isolated from green tea. Nutr. Cancer 26, 325–335 (1996)

    CAS  PubMed  CrossRef  Google Scholar 

  36. Ghosh, S., May, M.J., Kopp, E.B.: NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225–260 (1998)

    CAS  PubMed  CrossRef  Google Scholar 

  37. Green, A., Williams, G., Neale, R., et al.: Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet 354, 723–729 (1999)

    CAS  PubMed  CrossRef  Google Scholar 

  38. Hsieh, C.S., Macatonia, S.E., Tripp, C.S., et al.: Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547–549 (1993)

    CAS  PubMed  CrossRef  Google Scholar 

  39. Hsu, S.: Green tea and the skin. J. Am. Acad. Dermatol. 52, 1049–1059 (2005)

    PubMed  CrossRef  Google Scholar 

  40. Hsu, S., Dickinson, D., Borke, J., et al.: Green tea polyphenol induces caspase 14 in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model. Exp. Dermatol. 16, 678–684 (2007)

    CAS  PubMed  CrossRef  Google Scholar 

  41. Huang, M.T., Ho, C.T., Wang, Z.Y., et al.: Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin. Carcinogenesis 13, 947–954 (1992)

    CAS  PubMed  CrossRef  Google Scholar 

  42. Huang, M.T., Xie, J.G., Wang, Z.Y., et al.: Effects of tea, decaffeinated tea, and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: demonstration of caffeine as a biologically important constituent of tea. Cancer Res. 57, 2623–2629 (1997)

    CAS  PubMed  Google Scholar 

  43. Kamijo, T., Weber, J.D., Zambetti, G., et al.: Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc. Natl. Acad. Sci. USA. 95, 8292–8297 (1998)

    CAS  PubMed  CrossRef  Google Scholar 

  44. Katiyar, S., Ahmad, N., Mukhtar, H.: Green tea and skin. Arch. Dermatol. 136, 989–994 (2000)

    CAS  PubMed  CrossRef  Google Scholar 

  45. Katiyar, S., Elmets, C.: Green tea polyphenolic antioxidants and skin protection. Int. J. Oncol. 18, 1307–1313 (2001)

    CAS  PubMed  Google Scholar 

  46. Katiyar, S.K.: Skin photoprotection by green tea: antioxidant and immunomodulatory effects. Curr. Drug. Targets. Immune. Endocr. Metabol. Disord. 3, 234–242 (2003)

    CAS  PubMed  CrossRef  Google Scholar 

  47. Katiyar, S.K., Afaq, F., Azizuddin, K., et al.: Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol (-)-epigallocatechin-3-gallate. Toxicol. Appl. Pharmacol. 176, 110–117 (2001)

    CAS  PubMed  CrossRef  Google Scholar 

  48. Katiyar, S.K., Afaq, F., Perez, A., et al.: Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress. Carcinogenesis 22, 287–294 (2001)

    CAS  PubMed  CrossRef  Google Scholar 

  49. Katiyar, S.K., Agarwal, R., Mukhtar, H.: Inhibition of spontaneous and photo-enhanced lipid peroxidation in mouse epidermal microsomes by epicatechin derivatives from green tea. Cancer Lett. 79, 61–66 (1994)

    CAS  PubMed  CrossRef  Google Scholar 

  50. Katiyar, S.K., Agarwal, R., Wood, G.S., et al.: Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7, 12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea. Cancer Res. 52, 6890–6897 (1992)

    CAS  PubMed  Google Scholar 

  51. Katiyar, S.K., Challa, A., McCormick, T.S., et al.: Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (-)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production. Carcinogenesis 20, 2117–2124 (1999)

    CAS  PubMed  CrossRef  Google Scholar 

  52. Katiyar, S.K., Elmets, C.A., Agarwal, R., et al.: Protection against ultraviolet-B radiation-induced local and systemic suppression of contact hypersensitivity and edema responses in C3H/HeN mice by green tea polyphenols. Photochem. Photobiol. 62, 855–861 (1995)

    CAS  PubMed  CrossRef  Google Scholar 

  53. Katiyar, S.K., Matsui, M.S., Elmets, C.A., et al.: Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. Photochem. Photobiol. 69, 148–153 (1999)

    CAS  PubMed  Google Scholar 

  54. Katiyar, S.K., Mohan, R.R., Agarwal, R., et al.: Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols. Carcinogenesis 18, 497–502 (1997)

    CAS  PubMed  CrossRef  Google Scholar 

  55. Katiyar, S.K., Mukhtar, H.: Tea in chemoprevention of cancer: Epidemiologic and experimental studies. Int. J. Oncol. 8, 221–238 (1996)

    CAS  Google Scholar 

  56. Katiyar, S.K., Mukhtar, H.: Green tea polyphenol (−)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. J. Leukoc. Biol. 69, 719–726 (2001)

    CAS  PubMed  Google Scholar 

  57. Katiyar, S.K., Perez, A., Mukhtar, H.: Green tea polyphenol treatment to human skin prevents formation of ultraviolet light B-induced pyrimidine dimers in DNA. Clin. Cancer Res. 6, 3864–3869 (2000)

    CAS  PubMed  Google Scholar 

  58. Kawai, K.: Comment on inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. J. Agric. Food. Chem. 53, 1306 (2005); author reply 1307–308

    CAS  PubMed  CrossRef  Google Scholar 

  59. Kawazoe, T., Kim, H., Tsuji, Y., et al.: Green tea polyphenols affect skin preservation in rats and improve the rate of skin grafts. Cell Transplant. 17, 203–209 (2008)

    PubMed  CrossRef  Google Scholar 

  60. Kim, S.H., Kim, S.R., Lee, H.J., et al.: Apoptosis in growing hair follicles following gamma-irradiation and application for the evaluation of radioprotective agents. In Vivo 17, 211–214 (2003)

    CAS  PubMed  Google Scholar 

  61. Kostovic, K., Pasic, A.: Phototherapy of psoriasis: review and update. Acta Dermatovenerol. Croat. 12, 42–50 (2004)

    PubMed  Google Scholar 

  62. Kripke, M.L., Cox, P.A., Alas, L.G., et al.: Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice. Proc. Natl. Acad. Sci. USA. 89, 7516–7520 (1992)

    CAS  PubMed  CrossRef  Google Scholar 

  63. Kundu, J.K., Na, H.K., Chun, K.S., et al.: Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells. J. Nutr. 133, 3805S–3810S (2003)

    CAS  PubMed  Google Scholar 

  64. Levine, A.J.: p53, the cellular gatekeeper for growth and division. Cell 88, 323–331 (1997)

    CAS  PubMed  CrossRef  Google Scholar 

  65. Linden, K.G., Carpenter, P.M., McLaren, C.E., et al.: Chemoprevention of nonmelanoma skin cancer: experience with a polyphenol from green tea. Recent Results Cancer Res 163, 165–171 (2003); discussion 264–266

    CAS  PubMed  Google Scholar 

  66. Lippens, S., VandenBroecke, C., Van Damme, E., et al.: Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall’s bodies. Cell Death Differ. 10, 257–259 (2003)

    CAS  PubMed  CrossRef  Google Scholar 

  67. Lou, Y.R., Lu, Y.P., Xie, J.G., et al.: Effects of oral administration of tea, decaffeinated tea, and caffeine on the formation and growth of tumors in high-risk SKH-1 mice previously treated with ultraviolet B light. Nutr. Cancer 33, 146–153 (1999)

    CAS  PubMed  CrossRef  Google Scholar 

  68. Lu, Y.-P., Lou, Y.-R., Xie, J.-G., et al.: Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice. Proc. Natl. Acad. Sci. USA. 99, 12455–12460 (2002)

    CAS  PubMed  CrossRef  Google Scholar 

  69. Lu, Y.-P., Lou, Y.-R., Xie, J.-G., et al.: Inhibitory effect of black tea on the growth of established skin tumors in mice: effects on tumor size, apoptosis, mitosis and bromodeoxyuridine incorporation into DNA. Carcinogenesis 18, 2163–2169 (1997)

    CAS  PubMed  CrossRef  Google Scholar 

  70. Lu, Y.P., Lou, Y.R., Li, X.H., et al.: Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice. Cancer Res. 60, 4785–4791 (2000)

    CAS  PubMed  Google Scholar 

  71. Lu, Y.P., Lou, Y.R., Lin, Y., et al.: Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat. Cancer Res. 61, 5002–5009 (2001)

    CAS  PubMed  Google Scholar 

  72. Madison, K.C.: Barrier function of the skin: “la raison d’etre” of the epidermis. J. Invest. Dermatol. 121, 231–241 (2003)

    CAS  PubMed  CrossRef  Google Scholar 

  73. Manetti, R., Parronchi, P., Giudizi, M.G., et al.: Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177, 1199–1204 (1993)

    CAS  PubMed  CrossRef  Google Scholar 

  74. Mantena, S.K., Meeran, S.M., Elmets, C.A., et al.: Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors. J. Nutr. 135, 2871–2877 (2005)

    CAS  PubMed  Google Scholar 

  75. Mantena, S.K., Roy, A.M., Katiyar, S.K.: Epigallocatechin-3-gallate inhibits photocarcinogenesis through inhibition of angiogenic factors and activation of CD8+ T cells in tumors. Photochem. Photobiol. 81, 1174–1179 (2005)

    CAS  PubMed  CrossRef  Google Scholar 

  76. Marrot, L., Meunier, J.R.: Skin DNA photodamage and its biological consequences. J. Am. Acad. Dermatol. 58, S139–S148 (2008)

    PubMed  CrossRef  Google Scholar 

  77. Matheu, A., Maraver, A., Klatt, P., et al.: Delayed ageing through damage protection by the Arf/p53 pathway. Nature 448, 375–379 (2007)

    CAS  PubMed  CrossRef  Google Scholar 

  78. Meeran, S.M., Akhtar, S., Katiyar, S.K.: Inhibition of UVB-induced skin tumor development by drinking green tea polyphenols is mediated through dna repair and subsequent inhibition of inflammation. J. Invest. Dermatol. 117, 3753–3764 (2008)

    Google Scholar 

  79. Meeran, S.M., Mantena, S.K., Elmets, C.A., et al.: (−)-Epigallocatechin-3-gallate prevents photocarcinogenesis in mice through interleukin-12-dependent DNA repair. Cancer Res. 66, 5512–5520 (2006)

    CAS  PubMed  CrossRef  Google Scholar 

  80. Meeran, S.M., Mantena, S.K., Katiyar, S.K.: Prevention of ultraviolet radiation-induced immunosuppression by (-)-epigallocatechin-3-gallate in mice is mediated through interleukin 12-dependent DNA repair. Clin. Cancer Res. 12, 2272–2280 (2006)

    CAS  PubMed  CrossRef  Google Scholar 

  81. Mittal, A., Elmets, C.A., Katiyar, S.K.: CD11b+ cells are the major source of oxidative stress in UV radiation-irradiated skin: possible role in photoaging and photocarcinogenesis. Photochem. Photobiol. 77, 259–264 (2003)

    CAS  PubMed  CrossRef  Google Scholar 

  82. Mnich, C.D., Hoek, K.S., Virkki, L.V., et al.: Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls. Exp. Dermatol. 18, 69–77 (2009)

    CAS  PubMed  CrossRef  Google Scholar 

  83. Morley, N., Clifford, T., Salter, L., et al.: The green tea polyphenol (-)-epigallocatechin gallate and green tea can protect human cellular DNA from ultraviolet and visible radiation-induced damage. Photodermatol. Photoimmunol. Photomed. 21, 15–22 (2005)

    CAS  PubMed  CrossRef  Google Scholar 

  84. Mukhtar, H.: Pharmacology of the Skin. CRC Press, Boca Raton (1992)

    Google Scholar 

  85. Nam, S., Smith, D.M., Dou, Q.P.: Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J. Biol. Chem. 276, 13322–13330 (2001)

    CAS  PubMed  CrossRef  Google Scholar 

  86. Noh, S.U., Cho, E.A., Kim, H.O., et al.: Epigallocatechin-3-gallate improves Dermatophagoides pteronissinus extract-induced atopic dermatitis-like skin lesions in NC/Nga mice by suppressing macrophage migration inhibitory factor. Int. Immunopharmacol. 8, 1172–1182 (2008)

    CAS  PubMed  CrossRef  Google Scholar 

  87. Nomura, M., Kaji, A., He, Z., et al.: Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem. 276, 46624–46631 (2001)

    CAS  PubMed  CrossRef  Google Scholar 

  88. Park, G., Yoon, B.S., Moon, J.H., et al.: Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway. J. Invest. Dermatol. 128, 2429–2441 (2008)

    CAS  PubMed  CrossRef  Google Scholar 

  89. Schwarz, A., Maeda, A., Gan, D., et al.: Green tea phenol extracts reduce UVB-induced DNA damage in human cells via interleukin-12. Photochem. Photobiol. 84, 350–355 (2008)

    CAS  PubMed  CrossRef  Google Scholar 

  90. Scott, P.: IL-12: initiation cytokine for cell-mediated immunity. Science 260, 496–497 (1993)

    CAS  PubMed  CrossRef  Google Scholar 

  91. Sevin, A., Oztas, P., Senen, D., et al.: Effects of polyphenols on skin damage due to ultraviolet A rays: an experimental study on rats. J. Eur. Acad. Dermatol. Venereol. 21, 650–656 (2007)

    CAS  PubMed  Google Scholar 

  92. Shaulian, E., Karin, M.: AP-1 in cell proliferation and survival. Oncogene 20, 2390–2400 (2001)

    CAS  PubMed  CrossRef  Google Scholar 

  93. Shi, X., Ye, J., Leonard, S.S., et al.: Antioxidant properties of (-)-epicatechin-3-gallate and its inhibition of Cr(VI)-induced DNA damage and Cr(IV)- or TPA-stimulated NF-kappaB activation. Mol. Cell. Biochem. 206, 125–132 (2000)

    CAS  PubMed  CrossRef  Google Scholar 

  94. Shimizu, T.: Role of macrophage migration inhibitory factor (MIF) in the skin. J. Dermatol. Sci. 37, 65–73 (2005)

    CAS  PubMed  CrossRef  Google Scholar 

  95. Stratton, S.P., Bangert, J.L., Alberts, D.S., et al.: Dermal toxicity of topical (-)epigallocatechin-3-gallate in BALB/c and SKH1 mice. Cancer Lett. 158, 47–52 (2000)

    CAS  PubMed  CrossRef  Google Scholar 

  96. Takano, K., Nakaima, K., Nitta, M., et al.: Inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. J. Agric. Food Chem. 52, 4571–4576 (2004)

    CAS  PubMed  CrossRef  Google Scholar 

  97. Tobi, S.E., Gilbert, M., Paul, N., et al.: The green tea polyphenol, epigallocatechin-3-gallate, protects against the oxidative cellular and genotoxic damage of UVA radiation. Int. J. Cancer 102, 439–444 (2002)

    CAS  PubMed  CrossRef  Google Scholar 

  98. Ullrich, S.E.: Mechanisms underlying UV-induced immune suppression. Mutat. Res. 571, 185–205 (2005)

    CAS  PubMed  Google Scholar 

  99. Vayalil, P.K., Elmets, C.A., Katiyar, S.K.: Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin. Carcinogenesis 24, 927–936 (2003)

    CAS  PubMed  CrossRef  Google Scholar 

  100. Vayalil, P.K., Mittal, A., Hara, Y., et al.: Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin. J. Invest. Dermatol. 122, 1480–1487 (2004)

    CAS  PubMed  CrossRef  Google Scholar 

  101. Walsh, D.S., Borke, J.L., Singh, B.B., et al.: Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation. J. Dermatol. Sci. 37, 61–63 (2005)

    CAS  PubMed  CrossRef  Google Scholar 

  102. Wang, Z., Agarwal, R., Bickers, D., et al.: Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols. Carcinogenesis 12, 1527–1530 (1991)

    CAS  PubMed  CrossRef  Google Scholar 

  103. Wang, Z.Y., Huang, M.T., Ferraro, T., et al.: Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice. Cancer Res. 52, 1162–1170 (1992)

    CAS  PubMed  Google Scholar 

  104. Wang, Z.Y., Huang, M.T., Ho, C.T., et al.: Inhibitory effect of green tea on the growth of established skin papillomas in mice. Cancer Res. 52, 6657–6665 (1992)

    CAS  PubMed  Google Scholar 

  105. Wang, Z.Y., Huang, M.T., Lou, Y.R., et al.: Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7, 12-dimethylbenz[a]anthracene-initiated SKH-1 mice. Cancer Res. 54, 3428–3435 (1994)

    CAS  PubMed  Google Scholar 

  106. Xia, J., Song, X., Bi, Z., et al.: UV-induced NF-kappaB activation and expression of IL-6 is attenuated by (-)-epigallocatechin-3-gallate in cultured human keratinocytes in vitro. Int. J. Mol. Med. 16, 943–950 (2005)

    CAS  PubMed  Google Scholar 

  107. Yamamoto, T., Hsu, S., Lewis, J., et al.: Green tea polyphenol causes differential oxidative environments in tumor versus normal epithelial cells. J. Pharmacol. Exp. Ther. 307, 230–236 (2003)

    CAS  PubMed  CrossRef  Google Scholar 

  108. Yamamoto, T., Lewis, J., Wataha, J., et al.: Roles of catalase and hydrogen peroxide in green tea polyphenol-induced chemopreventive effects. J. Pharmacol. Exp. Ther. 308, 317–323 (2004)

    CAS  PubMed  CrossRef  Google Scholar 

  109. Yang, C., Maliakal, P., Meng, X.: Inhibition of carcinogenesis by tea. Annu. Rev. Pharmacol. Toxicol. 42, 25–54 (2002)

    CAS  PubMed  CrossRef  Google Scholar 

  110. Young, A.R., Chadwick, C.A., Harrison, G.I., et al.: The similarity of action spectra for thymine dimers in human epidermis and erythema suggests that DNA is the chromophore for erythema. J. Invest. Dermatol. 111, 982–988 (1998)

    CAS  PubMed  CrossRef  Google Scholar 

  111. Zhao, J.F., Zhang, Y.J., Jin, X.H., et al.: Green tea protects against psoralen plus ultraviolet A-induced photochemical damage to skin. J. Invest. Dermatol. 113, 1070–1075 (1999)

    CAS  PubMed  CrossRef  Google Scholar 

  112. Ziegler, A., Jonason, A.S., Leffell, D.J., et al.: Sunburn and p53 in the onset of skin cancer. Nature 372, 773–776 (1994)

    CAS  PubMed  CrossRef  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    Aton M. Holzer, Nabiha Yusuf, Brandon Tisdale, Santosh K. Katiyar & Craig A. Elmets

  2. Birmingham VA Medical Center, EFH 414, 1530 3rd Ave. S, Birmingham, AL, 35294–0009, USA

    Santosh K. Katiyar & Craig A. Elmets

Authors
  1. Aton M. Holzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nabiha Yusuf
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Brandon Tisdale
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Santosh K. Katiyar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Craig A. Elmets
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Inst. Umweltmedizinische Forschung (IUF), Universität Düsseldorf, Auf'm Hennekamp 50, Düsseldorf, 40225, Germany

    Jean Krutmann

  2. Service Dermatologie et, Medecine Vasculaire, CHU Besancon, place Saint-Jacques 2, Besancon, 25030, France

    Philippe Humbert

Rights and permissions

Reprints and Permissions

Copyright information

© 2010 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Holzer, A.M., Yusuf, N., Tisdale, B., Katiyar, S.K., Elmets, C.A. (2010). Systemic and Topical Use of Green Tea Polyphenols for Healthy Skin. In: Krutmann, J., Humbert, P. (eds) Nutrition for Healthy Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12264-4_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-12264-4_7

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12263-7

  • Online ISBN: 978-3-642-12264-4

  • eBook Packages: MedicineMedicine (R0)