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Skin Barrier Function

Abstract

In this chapter, we will describe first an overview of current concepts of epidermal barrier function emphasizing very recent work on the influence of pigmentation on barrier function. Then, we will assess how these mechanisms go awry in the disease, atopic dermatitis, as the prototype for a barrier-driven, inflammatory dermatosis.

Keywords

  • Atopic Dermatitis
  • Stratum Corneum
  • Lamellar Body
  • Serine Protease Activity
  • Outer Epidermis

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Fig. 4.1
Fig. 4.2
Fig. 4.3
Fig. 4.4

Notes

  1. 1.

    Dr. Elias is a co-inventor of this University of California patented technology. He is a consultant to Promius Pharmaceuticals and to PediaPharm Inc., which markets this technology in the United States and in Canada, respectively.

Abbreviations

AD:

Atopic Dermatitis

AMP:

Antimicrobial Peptides

Cer:

Ceramides

FLG:

Filaggrin

FFA:

Free Fatty Acids

GC:

Glucocorticoids

hBD:

Human Β-Defensins

hCAP:

Human Cathelicidin

IL:

Interleukin

IV:

Ichthyosis Vulgaris

LB:

Lamellar Bodies

LEKTI:

Lymphoepithelial Kazal-Type Trypsin Inhibitor

NS:

Netherton Syndrome

PAR2:

Plasminogen Activator Type 2 Receptor

SP:

Serine Protease

SC:

Stratum Corneum

t-UCA:

Trans-urocanic Acid

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Acknowledgements

This work was supported by NIH grant AR19098 and DOD grant W81XWH-05-2-0094, and by the Medical Research Service, Department of Veterans Affairs.

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Elias, P.M., Wakefield, J.S. (2010). Skin Barrier Function. In: Krutmann, J., Humbert, P. (eds) Nutrition for Healthy Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12264-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-12264-4_4

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