Beauty from Inside: Nutrition-Based Strategies in Cosmetic Dermatology

  • Philippe HumbertEmail author
  • D. Binda
  • S. Robin
  • Jean Krutmann


“Skin is the mirror of the soul”, as well as the first barrier between the whole body and its environment. These essential aesthetic and functional roles depend on skin structure and functionalities and namely on its integrity and ability of renewal. The patients’ lifestyle, and namely nutrition, are of most importance. Indeed skin requires appropriate nutrients, both in terms of quality and quantity. The food has to answer the needs in macronutrients:3


Stratum Corneum Essential Fatty Acid Hair Loss Skin Hydration Skin Barrier Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Alexander, J.: Selenium. Novartis Found. Symp. 282, 143–149 (2007); discussion 149–153CrossRefPubMedGoogle Scholar
  2. 2.
    Ames, B.N.: A role for supplements in optimizing health: the metabolic tune-up. Arch. Biochem. Biophys. 423(1), 227–234 (2004)CrossRefPubMedGoogle Scholar
  3. 3.
    Auboiron, S.: Functional foods and the law. Réalités thérapeutiques en dermo-Vénéréologie 179(2), 18–19 (2008)Google Scholar
  4. 4.
    Bassey, E.J., Littlewood, J.J., Rothwell, M.C., Pye, D.W.: Lack of effect of supplementation with essential fatty acids on bone mineral density in healthy pre- and postmenopausal women: two randomized controlled trials of Efacal v. calcium alone. Brit. J. Nutr. 83(6), 629–635 (2000)CrossRefPubMedGoogle Scholar
  5. 5.
    Beguin, A.: A novel micronutrient supplement in skin aging: a randomized placebo-controlled double-blind study. J. Cosmet. Dermatol. 4, 277–284 (2005)CrossRefPubMedGoogle Scholar
  6. 6.
    Boelsma, E., Hendriks, H.F.J., Roza, L.: Nutritional skin care: health effects of micronutrients and fatty acids. Am. J. Clin. Nutr. 73, 853–864 (2001)PubMedGoogle Scholar
  7. 7.
    Boelsma, E., van de Vijver, L., Goldbohm, A., Klöpping-Ketelaars, I., Hendriks, H., Roza, L.: Human skin condition and its associations with nutrient concentrations in serum and diet. Am. J. Clin. Nutr. 77, 348–355 (2003)PubMedGoogle Scholar
  8. 8.
    Bouhanna, P.: Soigner et entretenir ses cheveux: les nouveaux traitements du cheveu. Alpen Editions (2006) ISBN 291492366X, 9782914923668Google Scholar
  9. 9.
    Brosche, T., et al.: Effect of borage oil consumption on fatty acid metabolism, transepidermal water loss and skin parameters in elderly people. Arch. Gerontol. Geriatr. 30, 139–150 (2000)CrossRefPubMedGoogle Scholar
  10. 10.
    Bouwstra, J.A., Dubbelaar, F.E.R., Gooris, G.S., Ponec, M.: The lipid organisation in the skin barrier. Acta. Derm. Venereol. Supp. 208, 23–30 (2000)Google Scholar
  11. 11.
    Caramia, G., Atzei, A., Fanos, V.: Probiotics and the skin. Clin. Dermatol. 26(1), 4–11 (2008)CrossRefPubMedGoogle Scholar
  12. 12.
    Catani, M.V., Savini, I., Rossi, A., Melino, G., Avigliano, L.: Biological role of vitamin C in keratinocytes. Nutr. Rev. 63(3), 81–90 (2005)CrossRefPubMedGoogle Scholar
  13. 13.
    Cesarini, J.P.: Les compléments alimentaires pour la peau, un intérêt confirmé. Abstr. Dermatol. 512, 8–9 (2006)Google Scholar
  14. 14.
    Chan, S., Gerson, B., Subramaniam, S.: The role of copper, molybdenum, selenium and zinc in nutrition and health. Clin. Lab. Med. 18(4), 673–685 (1998)PubMedGoogle Scholar
  15. 15.
    Chapat, L., et al.: Lactobacillus casei reduces CD8-T cell-mediated skin inflammation. Eur. J. Immunol. 34, 2520–2528 (2004)CrossRefPubMedGoogle Scholar
  16. 16.
    Cohen, J.B., Janniger, C.K., Piela, Z., Szepietowski, J.C., Samady, J.A., Schwartz, R.A.: Dermatologic correlates of selected metabolic events. J. Med. 30(3–4), 149–156 (1999)PubMedGoogle Scholar
  17. 17.
    Cordain, L., et al.: Acne vulgaris: a disease of western civilization. Arch. Dermatol. 138, 1584–1590 (2002)CrossRefPubMedGoogle Scholar
  18. 18.
    Cosgrove, M., Franco, O., Granger, S., Murray, P., Mayes, A.: Dietary nutrient intakes and skin-aging appearance among middle-aged American women. Am. J. Clin. Nutr. 86, 1225–1231 (2007)PubMedGoogle Scholar
  19. 19.
    Dioguardi, F.S.: Nutrition and skin. Collagen integrity: a dominant role for amino acids. Clin. Dermatol. 26, 636–640 (2008)CrossRefPubMedGoogle Scholar
  20. 20.
    Elias, P.M.: Stratum corneum defensive functions: an integrative view. J. Invest. Dermatol. 125, 183–200 (2005)PubMedGoogle Scholar
  21. 21.
    Ernst, E.: The usage of complementary therapies by dermatological patients: a systematic review. Br. J. Dermatol. 142(5), 857–861 (2000)CrossRefPubMedGoogle Scholar
  22. 22.
    Favier, A.: Actualités sur la place du Zinc en nutrition. Rev. Prat. 43(2), 146–151 (1993)PubMedGoogle Scholar
  23. 23.
    Fleckman, P., Scher, R.K.: Fragilité unguéale. In: Onychologie: diagnostic, traitement, chirurgie. Elsevier Masson (2007) ISBN 2842998251, 9782842998257Google Scholar
  24. 24.
    Grether-Beck, S., Mühlberg, K., Brenden, H., Felsner, I., Brynjolfsdottir, A., Einarsson, S., Krutmann, J.: Bioactive molecules from the Blue Lagoon: In-vitro and in-vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin aging. Exp. Dermatol. 17, 771–779 (2008)CrossRefPubMedGoogle Scholar
  25. 25.
    Haneke, E.: Onychocosmeceuticals. J. Cosmet. Dermatol. 5(1), 95–100 (2006)CrossRefPubMedGoogle Scholar
  26. 26.
    Hard, S.: Non-anemic iron deficiency as an etiological factor in diffuse loss of hair of the scalp in women. Acta Derm. Venereol. 43, 562–569 (1963)Google Scholar
  27. 27.
    Hsu, M.M., Huang, Y.R.: Chronic onycholysis dramatically responds to enhanced intake of carotene-rich food. Br. J. Dermatol. 147(2), 389–391 (2002)CrossRefPubMedGoogle Scholar
  28. 28.
    Isolauri, E., Arvola, T., Sutäs, Y., et al.: Probiotics in the management of atopic eczema. Clin. Exp. Allergy 30, 1604–1610 (2000)CrossRefPubMedGoogle Scholar
  29. 29.
    Izumi, T., Saito, M., Obata, A., Arii, M., Yamaguchi, H., Matsuyama, A.: Oral intake of soy isoflavone aglycone improves the aged skin of adult women. J. Nutr. Sci. Vitaminol. (Tokyo) 53(1), 57–62 (2007)CrossRefGoogle Scholar
  30. 30.
    Kantor, J., Jay, K., Brooks, D., Cotsarelis, G.: Decreased serum ferritin is associated with alopecia in women: a case controlled study. J. Invest. Dermatol. 117(2), 435 (2001)Google Scholar
  31. 31.
    Kopcke, Krutmann, J.: Protection from sunburn with beta-carotene: a meta-analysis. Photochem. Photobiol. 84, 284–288 (2008)CrossRefPubMedGoogle Scholar
  32. 32.
    Lassel, T.: De l’approche fonctionnelle à l’approche nutritionnelle pour nourrir la peau. Réalités thérapeutiques en Dermato-Vénéréologie 179(2), 12–17 (2008)Google Scholar
  33. 33.
    Lévêque, J.L., Ribaud, Ch, Garson, J.C.: Caractérisation biophysique du stratum corneum. Relation entre sa structure et ses propriétés. Pathol. Biol. 40(2), 95–108 (1992)PubMedGoogle Scholar
  34. 34.
    Logan, A.C.: Omega-3 fatty acids and acne. Arch. Dermatol. 139, 941–942 (2003)CrossRefPubMedGoogle Scholar
  35. 35.
    Luger, T.A., Stadler, B.M., Katz, S.I., Oppenheim, J.J.: Epidermal cell (keratinocyte) derived thymocyte activating factor (ETAF). J. Immunol. 124, 1489–1493 (1981)Google Scholar
  36. 36.
    Maggini, S., Wintergerst, E.S., Beveridge, S., Hornig, D.H.: Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br. J. Nutr. 98(Suppl 1), S29–S35 (2007)PubMedGoogle Scholar
  37. 37.
    McLaren, D.S., Loveridge, N., Duthie, G., Bolton-Smith, C.: Fat soluble vitamins. In: Garrow, J.S., James, W.P.T. (eds.) Human Nutrition, Dietetics, 9th edn, pp. 208–238. Churchill Livingstone, Edinburgh (1993)Google Scholar
  38. 38.
    Miller, S.: Nutritional deficiency and the skin. J. Am. Acad. Dermatol. 21(1), 1–30 (1989)CrossRefPubMedGoogle Scholar
  39. 39.
    Miquel, J., Ramirez-Bosca, A., Ramirez-Bosca, J.V., Diaz Alperi, J.: Menopause: a review on the role of oxygen stress and favorable effects of dietary antioxidants. Arch. Gerontol. Geriatr. 42, 289–306 (2006)CrossRefPubMedGoogle Scholar
  40. 40.
    Moreau, M.C.: Probiotics and immunity. In: Probiotics and health: summary and perspective. Journée Institut Rosell. Proceedings of the Paris Symposium (2000)Google Scholar
  41. 41.
    Moyad, M.A.: Vitamin D: a rapid review. Urol. Nurs. 28(5), 343–349 (2008)PubMedGoogle Scholar
  42. 42.
    Orfanos, C.E., Zouboulis, C.C., Almond-Roesler, B., Geilen, C.C.: Current use and future potential role of retinoids in dermatology. Drugs 53, 358–388 (1997)CrossRefPubMedGoogle Scholar
  43. 43.
    Packer, L., Valacchi, G.: Antioxidants and the response of skin to oxidative stress: vitamin E as a key indicator. Skin Pharmacol. Appl. Skin Physiol. 15(5), 282–290 (2002)PubMedGoogle Scholar
  44. 44.
    Palombo, P., Fabrizi, G., Ruocco, V., Fluhr, J., Roberts, R., Morganti, P.: Beneficial long-term effects of combined oral / topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol. Physiol. 20, 199–210 (2007)CrossRefPubMedGoogle Scholar
  45. 45.
    Palozza, P.: Prooxidant actions of carotenoids in biological systems. Nutr. Rev. 56, 257–265 (1998)CrossRefPubMedGoogle Scholar
  46. 46.
    Pellae, M.: Existe-t-il une alimentation santé pour la peau? Nouv. Dermatol. 26(Suppl 10), 4–9 (2007)Google Scholar
  47. 47.
    Pessi, T., Sutäs, Y., Hurme, M., et al.: Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG. Clin. Exp. Allergy 30, 1804–1808 (2000)CrossRefPubMedGoogle Scholar
  48. 48.
    Placzek, M., Gaube, S., Kerkmann, U., Gilbertz, K.P., Herzinger, T., Haen, E., Przybilla, B.: Ultraviolet B-induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D-alpha-tocopherol. J. Invest. Dermatol. 124(2), 304–307 (2005)CrossRefPubMedGoogle Scholar
  49. 49.
    Poli, S.: Photoprotection nutritionnelle: avancés et nouvelles perspectives dans le domaine de la photoprotection. Nouv. Dermatol. 27, 45–46 (2008)Google Scholar
  50. 50.
    Pomarède, N.: L’alimentation et la peau: psoriasis, dermatite atopique, sécheresse, photoprotection, acne et vieillissement cutané. Nouv. Dermatol. 26(Suppl 10), 12–16 (2007)Google Scholar
  51. 51.
    Prasad, A.S.: Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp. Gerontol. 43(5), 370–377 (2008)CrossRefPubMedGoogle Scholar
  52. 52.
    Prendiville, J.S., Manfredi, L.N.: Skin signs of nutritional disorders. Semin. Dermatol. 11(1), 88–97 (1992)PubMedGoogle Scholar
  53. 53.
    Primavera, G., Berardesca, E.: Clinical and instrumental evaluation of a food supplement in improving skin hydration. Int. J. Cosmetic Sci. 27, 199–204 (2005)CrossRefGoogle Scholar
  54. 54.
    Purba, M., Kouris-Blazos, A., Wattanapenpaibon, N., Lukito, W., Rothenberg, E., Steen, B., Wahlqvist, M.: Skin wrinkling: can food make a difference? J. Am. Coll. Nutr. 20(1), 71–80 (2001)PubMedGoogle Scholar
  55. 55.
    Rushton, D.H.: Nutritional factors and hair loss. Clin. Exp. Dermatol. 27(5), 396–404 (2002)CrossRefPubMedGoogle Scholar
  56. 56.
    Sator, P.G.: Skin treatments and dermatological procedures to promote youthful skin. Clin. Interv. Aging 1(1), 51–56 (2006)CrossRefPubMedGoogle Scholar
  57. 57.
    Scheinfeld, N., Dahdah, M.J., Scher, R.: Vitamins and minerals: their role in nail health and disease. J. Drugs Dermatol. 6(8), 782–787 (2007)PubMedGoogle Scholar
  58. 58.
    Smith, R.N., et al.: The effect of high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet and biochemical parameters associated with acne vulgaris, a randomized, investigator-masked, controlled trial. J. Am. Acad. Dermatol. 57, 247–256 (2007)CrossRefPubMedGoogle Scholar
  59. 59.
    Smith, R.N., Braue, A., Varigos, G.A., Mann, N.J.: The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerides. J. Dermatol. Sci. 50, 41–52 (2008)CrossRefPubMedGoogle Scholar
  60. 60.
    Sporn, M.B., Roberts, A.B.: Role of retinoids in differentiation and carcinogenesis. Cancer Res. 43, 3034–3040 (1983)PubMedGoogle Scholar
  61. 61.
    Stahl, W., et al.: Lycopene rich products and dietary protection. Photochem. Photobiol. Sci. 5, 238–242 (2006)CrossRefPubMedGoogle Scholar
  62. 62.
    Sties, S.: Nutritional protection against skin damage from sunlight. Ann. Rev. Nutr. 24, 173–200 (2004)CrossRefGoogle Scholar
  63. 63.
    Sutter, M., Thomas, J., Brown, J., Morgan, B.: Selenium toxicity: a case of selenosis caused by a nutritional supplement. Ann. Intern. Med. 148(12), 970–971 (2008)PubMedGoogle Scholar
  64. 64.
    Thormahlen, S., Thiroux, J.: La nutrition de la peau vue par Danone Research. Nouv. Dermatol. 26(Suppl 10), 17–19 (2007)Google Scholar
  65. 65.
    Trost, L.B., Bergfeld, W.F., Calogeras, E.: The diagnosis and treatment of iron deficiency an dits potential relationship to hair loss. J. Am. Acad. Dermatol. 54(5), 824–844 (2006)CrossRefPubMedGoogle Scholar
  66. 66.
    Wickett, R.R., Kossmann, E., Barel, A., Demeester, N., Clarys, P., Vanden Berghe, D., Calomme, M.: Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair. Arch. Dermatol. Res. 299(10), 499–505 (2007)CrossRefPubMedGoogle Scholar
  67. 67.
    Ziboh, V.A.: The significance of polyunsaturated fatty acids in cutaneous biology. Lipids 31, S249–S253 (1996)CrossRefPubMedGoogle Scholar

Copyright information

© Springer Berlin Heidelberg 2010

Authors and Affiliations

  • Philippe Humbert
    • 1
    Email author
  • D. Binda
    • 1
  • S. Robin
    • 1
  • Jean Krutmann
    • 2
  1. 1.Department of Dermatology, University Hospital Saint-JacquesUniversity of Franche-ComtéBesançon cedexFrance
  2. 2.IUF-Leibniz Research Center for Environmental MedicineDüsseldorfGermany

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