Abstract
The microbiota of the human skin is characterized by a complex and filigrane network of interactions between the microbes and the skin surface cells. Most of the resident microbes on healthy skin can be regarded as being harmless or even beneficial to skin. The topical application of prebiotic and probiotic actives turns out to become a new and promising approach in therapy and cosmetics. In cosmetics, prebiotic actives with the ability to rebalance the skin microflora may be used. Probiotic approaches mainly consist of applying inactivated microbial biomass rather than live bacteria. Stimulating the expression of the skin’s own antimicrobial peptides provides another way of improving the skin microbiota. First examples are given for the treatment of mild to moderate microbial disorders on the skin of face and body, on the scalp, and in the oral cavity.
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References
Akiyama, H., Yamasaki, O., Tada, J., Arata, J.: Adherence characteristics and susceptibility to antimicrobial agents of Staphylococcus aureus strains isolated from skin infections and atopic dermatitis. J. Dermatol. Sci. 23, 155–160 (2000)
Bek-Thomsen, M., Lomholt, H.B., Kilian, M.: Acne is not associated with yet-uncultured bacteria. J. Clin. Microbiol. 46, 3355–3360 (2008)
Bierbaum, G.: The biosynthesis of the lantibiotics epidermin gallidermin, Pep5 and epilancin K7. Antonie Leeuwenhoek 69, 119–127 (1996)
Bockmuehl, D.: Präbiotika für kosmetische Anwendungen. 130, 3–6 (2004)
Bockmuehl, D., Jassoy, C., Nieveler, S., Scholtyssek, R., Wadle, A., Waldmann-Laue, M.: Prebiotic cosmetics: an alternative to antibacterial products. Int. J. Cosmet. Sci. 9, 1–5 (2006)
Bojar, R.A., Holland, K.T.: Review: the human cutaneous microflora and factors controlling colonisation. World J. Microbiol. Biotechnol. 18, 889–903 (2002)
Braat, H., Rottiers, P., Hommes, D.W., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S.J.H., Neirynck, S., Peppelenbosch, M.P., Steidler, L.: A Phase I trial with transgenic bacteria expressing Interleukin-10 in Crohn’s disease. Clin. Gastroenterol. Hepatol. 4, 754–759 (2006)
Braff, M.H., Gallo, R.L.: Antimicrobial peptides: an essential component of the skin defensive barrier. Curr. Top. Microbiol. Immunol. 306, 91–110 (2006)
Braff, M.H., Bardan, A., Nizet, V., Gallo, R.L.: Cutaneous defense mechanisms by antimicrobial peptides. J. Invest. Dermatol. 125, 9–13 (2005)
Burton, J.P., Chilcott, C.N., Moore, C.J., Speiser, G., Tagg, J.R.: A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters. J. Appl. Microbiol. 100, 754–764 (2006)
Çaglar, E., Sandalli, N., Twetman, S., Kavaloglu, S., Ergeneli, S., Selvi, S.: Effect of yogurt with Bifidobacterium DN-173 010 on salivary mutans streptococci and lactobacilli in young adults. Acta Odontol. Scand. 320, 317–320 (2005)
Carolan, H., Watkins, S., Bradshaw, D.: The prebiotic concept-a novel aproach for skin health. Euro Cosmetics 7(8), 22–27 (2008)
Cogen, A.L., Nizet, V., Gallo, R.L.: Skin microbiota: a source of disease or defence? Br. J. Dermatol. 158, 442–455 (2008)
Comelli, E.M., Guggenheim, B., Stingele, F., Neeser, J.R.: Selection of dairy bacterial strains as probiotics for oral health. Eur. J. Oral Sci. 110, 218–224 (2002)
Cosseau, C., Devine, D.A., Dullaghan, E., Gardy, J.L., Chikatamarla, A., Gellatly, S., Yu, L.L., Pistolic, J., Falsafi, R., Tagg, J., Hancock, R.E.W.: The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host–microbe homeostasis. Infect. Immun. 76, 4163–4175 (2008)
Dekio, I., Hayashi, H., Sakamoto, M., Kitahara, M., Nishikawa, T., Suematsu, M., Benno, Y.: Detection of potentially novel bacterial components of the human skin microbiota using culture-independent molecular profiling. J. Med. Microbiol. 54, 1231–1238 (2005)
Donnarumma, G., Paoletti, I., Buommino, E., Orlando, M., Tufano, M.A., Baroni, A.: Malassezia furfur induces the expression of β-defensin-2 in human keratinocytes in a protein kinase C-dependent manner. Arch. Dermatol. Res. 295, 474–481 (2004)
Donnarumma, G., Buommino, E., Baroni, A., Auricchio, L., Filippis, A.D., Cozza, V., Msika, P., Piccardi, N., Tufano, M.A.: Effects of AV119, a natural sugar from avocado, on Malassezia furfur invasiveness and on the expression of HBD-2 and cytokines in human keratinocytes. Exp. Dermatol. 16, 912–919 (2007)
Fierer, N., Hamady, M., Lauber, C.L., Knight, R.: The influence of sex, handedness, and washing on the diversity of hand surface bacteria. Proc. Natl. Acad. Sci. USA 105, 17994–17999 (2008)
Finlay, B.B., Hancock, R.E.W.: Can innate immunity be enhanced to treat microbial infections? Nat. Rev. Microbiol. 2, 497–504 (2004)
Fredricks, D.N.: Microbial ecology of human skin in health and disease. J. Investig. Dermatol. Symp. Proc. 6, 167–169 (2001)
Frohm, M., Agerberth, B., Ahangari, G., Ståhle-Bäckdahl, M., Lidén, S., Wigzell, H., Gudmundsson, G.H.: The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J. Biol. Chem. 272, 15258–15263 (1997)
Gao, Z., Tseng, C.-, Pei, Z., Blaser, M.J.: Molecular analysis of human forearm superficial skin bacterial biota. Proc. Natl. Acad. Sci. USA 104, 2927–2932 (2007)
Garciéa, J.R., Krause, A., Schulz, S., Rodriéguez-Jiménez, F.J., Klüver, E., Adermann, K., Forssmann, U., Frimpong-Boateng, A., Bals, R., Forssmann, W.G.: Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J. 15, 1819–1821 (2001)
Gibson, G.R., Roberfroid, M.B.: Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J. Nutr. 125, 1401–1412 (1995)
Grice, E.A., Kong, H.H., Renaud, G., Young, A.C., Bouffard, G.G., Blakesley, R.W., Wolfsberg, T.G., Turner, M.L., Segre, J.A.: A diversity profile of the human skin microbiota. Genome Res. 18, 1043–1050 (2008)
Gueniche, A., Knaudt, B., Schuck, E., Volz, T., Bastien, P., Martin, R., Röcken, M., Breton, L., Biedermann, T.: Effects of nonpathogenic gram-negative bacterium Vitreoscilla filiformis lysate on atopic dermatitis: A prospective, randomized, double-blind, placebo-controlled clinical study. Br. J. Dermatol. 159, 1357–1363 (2008)
Guéniche, A., Cathelineau, A.-, Bastien, P., Esdaile, J., Martin, R., Queille Roussel, C., Breton, L.: Vitreoscilla filiformis biomass improves seborrheic dermatitis. J. Eur. Acad. Dermatol. Venereol. 22, 1014–1015 (2008)
Guggenheim, M., Shapiro, S., Gmür, R., Guggenheim, B.: Spatial arrangements and associative behavior of species in an in vitro oral biofilm model. Appl. Environ. Microbiol. 67, 1343–1350 (2001)
Haffajee, A.D., Socransky, S.S.: Microbial etiological agents of destructive periodontal diseases. Periodontol. 2000 5, 78–111 (1994)
Haraszthy, V.I., Zambon, J.J., Sreenivasan, P.K., Zambon, M.M., Gerber, D., Rego, R., Parker, C.: Identification of oral bacterial species associated with halitosis. J. Am. Dent. Assoc. 138, 1113–1120 (2007)
Harder, J., Schröder, J.: RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J. Biol. Chem. 277, 46779–46784 (2002)
Harder, J., Bartels, J., Christophers, E., Schroöder, J.: Isolation and characterization of human β-Defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276, 5707–5713 (2001)
Hartley, G., McKenzie, C., Greenman, J., El-Maaytah, M.A., Scully, C., Porter, S.: Tongue microbiota and malodour: effects of metronidazole mouthrinse on tongue microbiota and breath odour. Microb. Ecol. Health Dis. 11, 226–233 (1999)
Haukioja, A., Loimaranta, V., Tenovuo, J.: Probiotic bacteria affect the composition of salivary pellicle and streptococcal adhesion in vitro. Oral Microbiol. Immunol. 23, 336–343 (2008)
Heldermann, M., Van der Hoeven, H.: Probiotic active for the skin – helps your skin stay in balance. Household and Personal Care Today 1, 8–9 (2007)
Hillman, J.D., Brooks, T.A., Michalek, S.M., Harmon, C.C., Snoep, J.L., Van Der Weijden, C.C.: Construction and characterization of an effector strain of Streptococcus mutans for replacement therapy of dental caries. Infect. Immun. 68, 543–549 (2000)
Holland, K.T., Bojar, R.A.: Cosmetics: what is their influence on the skin microflora? Am. J. Clin. Dermatol. 3, 445–449 (2002)
Iovieno, A., Lambiase, A., Sacchetti, M., Stampachiacchiere, B., Micera, A., Bonini, S.: Preliminary evidence of the efficacy of probiotic eye-drop treatment in patients with vernal keratoconjunctivitis. Graefes Arch. Clin. Exp. Ophthalmol. 246, 435–441 (2008)
Janssen, F., Waldmann-Laue, M.: Efficacy of a prebiotic product combination against skin impurities. IFSCC Congress poster presentation at the IFSCC Congress in (2008)
Jenkinson, H.F., Lamont, R.J.: Oral microbial communities in sickness and in health. Trends Microbiol. 13, 589–595 (2005)
Katsuyama, M., Wachi, Y., Ikezawa, Z., Kitamura, K., Suga, C., Ohnuma, S.: Correlation between the population of Staphylococcus aureus on the skin and severity of a score of dry type atopic dermatitis conditions. Nippon Hifuka Gakkai Zasshi 107, 1103–1111 (1997)
Kõll, P., Mändar, R., Marcotte, H., Leibur, E., Mikelsaar, M., Hammarström, L.: Characterization of oral lactobacilli as potential probiotics for oral health. Oral Microbiol. Immunol. 23, 139–147 (2008)
Kozuka, T.: Patch testing to exclude allergic contact dermatitis caused by povidone-iodine. Dermatology 204, 96–98 (2002)
Kroes, I., Lepp, P.W., Relman, D.A.: Bacterial diversity within the human subgingival crevice. Proc. Natl. Acad. Sci. USA 96, 14547–14552 (1999)
Krutmann, J.: Pre- and probiotics for human skin. J. Dermatol. Sci. 54, 1–5 (2009)
Lang, C., Veen, M., Budde, E., Böttner, M., Reindl, A., Knöll, R.: Microorganisms inhibiting the formation of axillary malodor. US patent WO 2007/031300 (2007)
Lang, C., Heilmann, A., Veen, M., Budde, E., Böttner, M., Reindl, A., Knöll, R.: Methods and means for protecting the skin against pathogenic bacteria. US patent WO 2006/136420 A2 (2006)
Larson, E.L., Gomez-Duarte, C., Lee, L.V., Della-Latta, P., Kain, D.J., Keswick, B.H.: Microbial flora of hands of homemakers. Am. J. Infect. Control 31, 72–79 (2003)
Leyden, J.J., McGinley, K.J., Holzle, E.: The microbiology of the human axilla and its relationship to axillary odor. J. Invest. Dermatol. 77, 413–416 (1981)
Leyden, J.J., McGinley, K.J., Nordstrom, K.M., Webster, G.F.: Skin microflora. J. Invest. Dermatol. 88, 65–72 (1987)
Masako, K., Hideyuki, I., Shigeyuki, O., Zenro, I.: A novel method to control the balance of skin microflora: Part 1. Attack on biofilm of Staphylococcus aureus without antibiotics. J. Dermatol. Sci. 38, 197–205 (2005)
Masako, K., Yusuke, K., Hideyuki, I., Atsuko, M., Yoshiki, M., Kayoko, M., Makoto, K.: A novel method to control the balance of skin microflora: Part 2. A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. J. Dermatol. Sci. 38, 207–213 (2005)
Midorikawa, K., Ouhara, K., Komatsuzawa, H., Kawai, T., Yamada, S., Fujiwara, T., Yamazaki, K., Sayama, K., Taubman, M.A., Kurihara, H., Hashimoto, K., Sugai, M.: Staphylococcus aureus susceptibility to innate antimicrobial peptides, β-defensins and CAP18, expressed by human keratinocytes. Infect. Immun. 71, 3730–3739 (2003)
Nomura, I., Gao, B., Boguniewicz, M., Darst, M.A., Travers, J.B., Leung, D.Y.M.: Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J. Allergy Clin. Immunol. 112, 1195–1202 (2003)
Offenbacher, S., Katz, V., Fertik, G., Collins, J., Boyd, D., Maynor, G., McKaig, R., Beck, J.: Periodontal infection as a possible risk factor for preterm low birth weight. J. Periodontol. 67, 1103–1113 (1996)
Ogawa, T., Katsuoka, K., Kawano, K., Nishiyama, S.: Comparative study of staphylococcal flora on the skin surface of atopic dermatitis patients and healthy subjects. J. Dermatol. 21, 453–460 (1994)
Ong, P.Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R.L., Leung, D.Y.M.: Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 347, 1151–1160 (2002)
Ouwehand, A.C., Båtsman, A., Salminen, S.: Probiotics for the skin: a new area of potential application? Lett. Appl. Microbiol. 36, 327–331 (2003)
Pancholi, P., Healy, M., Bittner, T., Webb, R., Wu, F., Aiello, A., Larson, E., Della Latta, P.: Molecular characterization of hand flora and environmental isolates in a community setting. J. Clin. Microbiol. 43, 5202–5207 (2005)
Paster, B.J., Boches, S.K., Galvin, J.L., Ericson, R.E., Lau, C.N., Levanos, V.A., Sahasrabudhe, A., Dewhirst, F.E.: Bacterial diversity in human subgingival plaque. J. Bacteriol. 183, 3770–3783 (2001)
Pernet, I., Reymermier, C., Guezennec, A., Viac, J., Guesnet, J., Perrier, E.: An optimized method for intensive screening of molecules that stimulate β-defensin 2 or 3 (hBD2 or hBD3) expression in cultured normal human keratinocytes. Int. J. Cosmet. Sci. 27, 161–170 (2005)
Pham, L.C., van Spanning, R.J.M., Röling, W.F.M., Prosperi, A.C., Terefework, Z., ten Cate, J.M., Crielaard, W., Zaura, E.: Effects of probiotic Lactobacillus salivarius W24 on the compositional stability of oral microbial communities. Arch. Oral. Biol. 54, 132–137 (2009)
Philpott, M.P.: Defensins and acne. Mol. Immunol. 40, 457–462 (2003)
Roberfroid, M.B.: Inulin-type fructans: functional food ingredients. J. Nutr. 137, 2493S–2502S (2007)
Rogers, K.L., Rupp, M.E., Fey, P.D.: The presence of icaABCDis detrimental to the colonization of human skin by Staphylococcus epidermidis. Appl. Environ. Microbiol. 74, 6155–6157 (2008)
Roth, R.R., James, W.D.: Microbiology of the skin: resident flora, ecology, infection. J. Am. Acad. Dermatol. 20, 367–390 (1989)
Schauber, J., Gallo, R.L.: Antimicrobial peptides and the skin immune defense system. J. Allergy Clin. Immunol. 122, 261–266 (2008)
Schröder, J., Harder, J.: Human beta-defensin-2. Int. J. Biochem. Cell Biol. 31, 645–651 (1999)
Shelley, W.B., Hurley, H.J., Nichols, A.C.: Axillary odor. Arch. Dermatol. Syphilol. 68, 430–446 (1953)
Smiricky-Tjardes, M.R., Flickinger, E.A., Grieshop, C.M., Bauer, L.L., Murphy, M.R., Fahey Jr., G.C.: In vitro fermentation characteristics of selected oligosaccharides by swine fecal microflora. J. Anim. Sci. 81, 2505–2514 (2003)
Steidler, L., Vandenbroucke, K.: Genetically modified Lactococcus lactis: Novel tools for drug delivery. Int. J. Dairy Technol. 59, 140–146 (2006)
Tagg, J.R.: Prevention of streptococcal pharyngitis by anti-Streptococcus pyogenes bacteriocin-like inhibitory substances (BLIS) produced by Streptococcus salivarius. Indian J. Med. Res. 119, 13–16 (2004)
Teughels, W., Van Essche, M., Sliepen, I., Quirynen, M.: Probiotics and oral healthcare. Periodontol. 2000 48, 111–147 (2008)
Trebesius, K., Banowski, B., Beimfohr, C., Bergmaier, I., Jassoy, C., Sättler, A., Scholtyssek, R., Simmering, R., Bockmuehl, D.: Gender-specific composition of the human axillary microbiota. Biospektrum Sonderausgabe VAAM-Jahrestagung 2006, 75 (2006)
Van Winkelhoff, A.J., Loos, B.G., Van Der Reijden, W.A., Van Der Velden, U.: Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction. J. Clin. Periodontol. 29, 1023–1028 (2002)
Washio, J., Sato, T., Koseki, T., Takahashi, N.: Hydrogen sulfide-producing bacteria in tongue biofilm and their relationship with oral malodour. J. Med. Microbiol. 54, 889–895 (2005)
Williams, R.E.A., Gibson, A.G., Aitchison, T.C., Lever, R., Mackie, R.M.: Assessment of a contact-plate sampling technique and subsequent quantitative bacterial studies in atopic dermatitis. Br. J. Dermatol. 123, 493–501 (1990)
Zambon, J.J.: Periodontal diseases: microbial factors. Ann. Periodontol. 1, 879–925 (1996)
Ziebuhr, W., Hennig, S., Eckart, M., Kränzler, H., Batzilla, C., Kozitskaya, S.: Nosocomial infections by Staphylococcus epidermidis: how a commensal bacterium turns into a pathogen. Int. J. Antimicrob. Agents 28, 14–20 (2006)
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Simmering, R., Breves, R. (2010). Prebiotic Cosmetics. In: Krutmann, J., Humbert, P. (eds) Nutrition for Healthy Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12264-4_13
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