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Selection of Drugs for Intraperitoneal Chemotherapy for Ovarian Cancer

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Abstract

Intraperitoneal therapy improves the survival of women with ovarian cancer that has been extensively removed at primary surgery. This chapter reviews the basic pharmacologic principles that underlie the use of intraperitoneal therapy and highlights the key factors that determine the pharmacologic advantage of this route of administration. Limited penetration of drug from the surface of tumor nodules is a major challenge. Important determinants of penetration include drug concentration gradients, blood flow in the tumor nodule, capillary permeability, and the ability of the drug to bind to extracellular components of the tumor. Pharmacologic strategies for manipulating these factors promise further improvement in the efficacy and safety of intraperitoneal chemotherapy.

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Authors and Affiliations

  1. Department of Medicine and the Moores Cancer Center, University of California, 3855 Health Sciences Drive, La Jolla, CA, 92093-0819, USA

    Stephen B. Howell

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  1. Stephen B. Howell
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Correspondence to Stephen B. Howell .

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Editors and Affiliations

  1. College of Medicine, Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA

    David S. Alberts

  2. Arizona Cancer Center, University of Arizona, N. Campbell Ave. 1515, Tucson, 85724-5024, Arizona, USA

    Mary C. Clouser

  3. School of Medicine, Deps of Pub. Health and Obstetrics and G, Indiana University, N. Senate Ave. EF250 714, Indianapolis, IN, 46202, Arizona, USA

    Lisa M. Hess

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© 2010 Springer Berlin Heidelberg

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Howell, S.B. (2010). Selection of Drugs for Intraperitoneal Chemotherapy for Ovarian Cancer. In: Alberts, D., Clouser, M., Hess, L. (eds) Intraperitoneal Therapy for Ovarian Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12130-2_7

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  • DOI: https://doi.org/10.1007/978-3-642-12130-2_7

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12129-6

  • Online ISBN: 978-3-642-12130-2

  • eBook Packages: MedicineMedicine (R0)

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