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Pediatric Uveitis

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Abstract

Uveitis in the pediatric population represents a distinct subset of diagnoses that provide unique diagnostic and therapeutic challenges to the ophthalmologist. About 5–10% of the total cases of uveitis seen in tertiary care centers occur in pediatric patients, with an annual occurrence rate of 6:100,000 [1]. A delay in diagnosis can occur because of the relative rarity of uveitis in children, as well as difficulty for the child to recognize and verbalize symptoms. More so than in the adult population therapeutic options in the pediatric population are limited by side effects. Therapeutic effect can also be limited by family and patient compliance in administering systemic medications and drops. Lastly, children offer the unique risk of amblyopia, a problem not encountered in adults with uveitis.

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References

  1. Cunningham Jr., E.T.: Uveitis in children. Ocul. Immunol. Inflamm. 8(4), 251–261 (2000)

    Article  PubMed  Google Scholar 

  2. Jabs, D.A., Nussenblatt, R.B., Rosenbaum, J.T.: Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am. J. Ophthalmol. 140(3), 509–516 (2005)

    Article  PubMed  Google Scholar 

  3. Tugal-Tutkun, I., Havrlikova, K., Power, W.J., Foster, C.S.: Changing patterns in uveitis of childhood. Ophthalmology 103(3), 375–383 (1996)

    PubMed  CAS  Google Scholar 

  4. Paivonsalo-Hietanen, T., Tuominen, J., Saari, K.M.: Uveitis in children: population-based study in Finland. Acta Ophthalmol. Scand. 78(1), 84–88 (2000)

    Article  PubMed  CAS  Google Scholar 

  5. Miyake, K.: Indomethacin in the treatment of postoperative cystoid macular edema. Surv. Ophthalmol. 28(suppl), 554–568 (1984)

    Google Scholar 

  6. Yannuzzi, L.A.: A perspective on the treatment of aphakic cystoid macular edema. Surv. Ophthalmol. 28(suppl), 540–553 (1984)

    Google Scholar 

  7. Jampol, L.M.: Pharmacologic therapy of aphakic cystoid macular edema. A review. Ophthalmology 89(8), 891–897 (1982)

    PubMed  CAS  Google Scholar 

  8. Tso, M.O.M.: Cystoid macular edema. In: Tso, M.O.M. (ed.) Retinal diseases: biomedical foundations and clinical management. JB Lippincott, Philadelphia, PA (1988)

    Google Scholar 

  9. Henderly, D.E., Genstler, A.J., Rao, N.A., Smith, R.E.: Pars planitis. Trans. Ophthalmol. Soc. U. K. 105(pt 2), 227–232 (1986)

    PubMed  Google Scholar 

  10. Smith, J.R.: Management of uveitis in pediatric patients: special considerations. Paediatr. Drugs 4(3), 183–189 (2002)

    PubMed  Google Scholar 

  11. Vesterdal, E., Sury, B.: Iridocyclitis and bandshaped corneal opacity in juvenile rheumatoid arthritis. Acta Ophthalmol. (Copenh) 28(3), 321–335 (1950)

    Article  CAS  Google Scholar 

  12. Sullivan, D.B., Cassidy, J.T., Petty, R.E.: Pathogenic implications of age of onset in juvenile rheumatoid arthritis. Arthritis Rheum. 18(3), 251–255 (1975)

    Article  PubMed  CAS  Google Scholar 

  13. Towner, S.R., Michet Jr., C.J., O’Fallon, W.M., Nelson, A.M.: The epidemiology of juvenile arthritis in Rochester, Minnesota 1960-1979. Arthritis Rheum. 26(10), 1208–1213 (1983)

    Article  PubMed  CAS  Google Scholar 

  14. Basic and Clinical Science Course. In: Moorthy, R.S. (ed) Intraocular Inflammation and Uveitis: Noninfectious (Autoimmune) Uveitis, vol. 9. American Academy of Ophthalmology, San Francisco, CA (2007)

    Google Scholar 

  15. Kanski, J.J.: Juvenile arthritis and uveitis. Surv. Ophthalmol. 34(4), 253–267 (1990)

    Article  PubMed  CAS  Google Scholar 

  16. Basic and Clinical Science Course. In: Simon, J.W. (ed) Pediatric Ophthalmology and Strabismus: Uveitis in the Pediatric Age Group, vol. 6. American Academy of Ophthalmology, San Francisco, CA (2007)

    Google Scholar 

  17. Kanski, J.J.: Anterior uveitis in juvenile rheumatoid arthritis. Arch. Ophthalmol. 95(10), 1794–1797 (1977)

    Article  PubMed  CAS  Google Scholar 

  18. Anonymous: American Academy of Pediatrics Section on Rheumatology and Section on Ophthalmology: Guidelines for ophthalmologic examinations in children with juvenile rheumatoid arthritis. Pediatrics 92(2), 295–296 (1993)

    Google Scholar 

  19. Ohno, S., Char, D.H., Kimura, S.J., O’Connor, G.R.: HLA antigens and antinuclear antibody titres in juvenile chronic iridocyclitis. Br. J. Ophthalmol. 61(1), 59–61 (1977)

    Article  PubMed  CAS  Google Scholar 

  20. Monestier, M., Losman, J.A., Fasy, T.M., et al.: Antihistone antibodies in antinuclear antibody-positive juvenile arthritis. Arthritis Rheum. 33(12), 1836–1841 (1990)

    Article  PubMed  CAS  Google Scholar 

  21. Bloom, J.N., Ni, M., Moore, T.L., et al.: Serum antiocular antibodies in patients with juvenile rheumatoid arthritis. J. Pediatr. Ophthalmol. Strabismus 30(4), 243–248 (1993)

    PubMed  CAS  Google Scholar 

  22. Hunt, D.W., Petty, R.E., Millar, F.: Iris protein antibodies in serum of patients with juvenile rheumatoid arthritis and uveitis. Int. Arch. Allergy Immunol. 100(4), 314–318 (1993)

    Article  PubMed  CAS  Google Scholar 

  23. Sabates, R., Smith, T., Apple, D.: Ocular histopathology in juvenile rheumatoid arthritis. Ann. Ophthalmol. 11(5), 733–737 (1979)

    PubMed  CAS  Google Scholar 

  24. Merriam, J.C., Chylack Jr., L.T., Albert, D.M.: Early-onset pauciarticular juvenile rheumatoid arthritis. A histopathologic study. Arch. Ophthalmol. 101(7), 1085–1092 (1983)

    Article  PubMed  CAS  Google Scholar 

  25. Weiss, A.H., Wallace, C.A., Sherry, D.D.: Methotrexate for resistant chronic uveitis in children with juvenile rheumatoid arthritis [see comment]. J. Pediatr. 133(2), 266–268 (1998)

    Article  PubMed  CAS  Google Scholar 

  26. Malagon, C., Van Kerckhove, C., Giannini, E.H., et al.: The iridocyclitis of early onset pauciarticular juvenile rheumatoid arthritis: outcome in immunogenetically characterized patients. J. Rheumatol. 19(1), 160–163 (1992)

    PubMed  CAS  Google Scholar 

  27. Dana, M.R., Merayo-Lloves, J., Schaumberg, D.A., Foster, C.S.: Visual outcomes prognosticators in juvenile rheumatoid arthritis-associated uveitis. Ophthalmology 104(2), 236–244 (1997)

    PubMed  CAS  Google Scholar 

  28. Sachs, J.A., Brewerton, D.A.: HLA, ankylosing spondylitis and rheumatoid arthritis. Br. Med. Bull. 34(3), 275–278 (1978)

    PubMed  CAS  Google Scholar 

  29. Petty, R.E., Malleson, P.: Spondyloarthropathies of childhood. Pediatr. Clin. North Am. 33(5), 1079–1096 (1986)

    PubMed  CAS  Google Scholar 

  30. Power, W.J., Rodriguez, A., Pedroza-Seres, M., Foster, C.S.: Outcomes in anterior uveitis associated with the HLA-B27 haplotype. Ophthalmology 105(9), 1646–1651 (1998)

    Article  PubMed  CAS  Google Scholar 

  31. Hofley, P., Roarty, J., McGinnity, G., et al.: Asymptomatic uveitis in children with chronic inflammatory bowel diseases. J. Pediatr. Gastroenterol. Nutr. 17(4), 397–400 (1993)

    Article  PubMed  CAS  Google Scholar 

  32. Petty, R.E., Smith, J.R., Rosenbaum, J.T.: Arthritis and uveitis in children. A pediatric rheumatology perspective. Am. J. Ophthalmol. 135(6), 879–884 (2003)

    Article  PubMed  Google Scholar 

  33. Rodriguez, A., Akova, Y.A., Pedroza-Seres, M., Foster, C.S.: Posterior segment ocular manifestations in patients with HLA-B27-associated uveitis. Ophthalmology 101(7), 1267–1274 (1994)

    PubMed  CAS  Google Scholar 

  34. Taurog, J.D., el-Zaatari, F.A.: In vitro mutagenesis of HLA-B27. Substitution of an unpaired cysteine residue in the alpha 1 domain causes loss of antibody-defined epitopes. J. Clin. Invest. 82(3), 987–992 (1988)

    Article  PubMed  CAS  Google Scholar 

  35. Ebringer, A.: The cross-tolerance hypothesis, HLA-B27 and ankylosing spondylitis. Br. J. Rheumatol. 22(4 Suppl 2), 53–66 (1983)

    Article  PubMed  CAS  Google Scholar 

  36. Ringrose, J.H.: HLA-B27 associated spondyloarthropathy, an autoimmune disease based on crossreactivity between bacteria and HLA-B27? Ann. Rheum. Dis. 58(10), 598–610 (1999)

    Article  PubMed  CAS  Google Scholar 

  37. Reveille, J.D.: HLA-B27 and the seronegative spondyloarthropathies. Am. J. Med. Sci. 316(4), 239–249 (1998)

    Article  PubMed  CAS  Google Scholar 

  38. Dodds, E.M., Lowder, C.Y., Meisler, D.M.: Posterior segment inflammation in HLA-B27+ acute anterior uveitis: clinical characteristics [see comment]. Ocul. Immunol. Inflamm. 7(2), 85–92 (1999)

    Article  PubMed  CAS  Google Scholar 

  39. Dobrin, R.S., Vernier, R.L., Fish, A.L.: Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome. Am. J. Med. 59(3), 325–333 (1975)

    Article  PubMed  CAS  Google Scholar 

  40. Mandeville, J.T., Levinson, R.D., Holland, G.N.: The tubulointerstitial nephritis and uveitis syndrome [see comment]. Surv. Ophthalmol. 46(3), 195–208 (2001)

    Article  PubMed  CAS  Google Scholar 

  41. Goda, C., Kotake, S., Ichiishi, A., et al.: Clinical features in tubulointerstitial nephritis and uveitis (TINU) syndrome. Am. J. Ophthalmol. 140(4), 637–641 (2005)

    Article  PubMed  Google Scholar 

  42. Gafter, U., Kalechman, Y., Zevin, D., et al.: Tubulointerstitial nephritis and uveitis: association with suppressed cellular immunity. Nephrol. Dial. Transplant. 8(9), 821–826 (1993)

    PubMed  CAS  Google Scholar 

  43. Iitsuka, T., Yamaguchi, N., Kobayashi, M., et al.: HLA tissue types in patients with acute tubulointerstitial nephritis accompanying uveitis. Nippon Jinzo Gakkai Shi. Jpn. J. Nephrol. 35(6), 723–731 (1993)

    CAS  Google Scholar 

  44. Sanchez Roman, J., Gonzalez Reina, I., Castillo Palma, M.J., Rocha Castilla, J.L.: Uveitis posterior asociada a nefritis tubulointersticial aguda con respuesta favorable a ciclosporina. Implicaciones patogenicas. Med. Clin. (Barc) 104(3), 118 (1995)

    CAS  Google Scholar 

  45. Gorrono-Echebarria, M.B., Calvo-Arrabal, M.A., Albarran, F., Alvarez-Mon, M.: The tuberculointerstitial nephritis and uveitis (TINU) syndrome is associated with HLA-DR14 in Spanish patients. Br. J. Ophthalmol. 85(8), 1010–1011 (2001)

    Article  PubMed  CAS  Google Scholar 

  46. Hirano, K., Tomino, Y., Mikami, H., et al.: A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy. Am. J. Nephrol. 9(6), 499–503 (1989)

    Article  PubMed  CAS  Google Scholar 

  47. Radig, H., Bialasiewicz, A.A., Gerding, H., Helmchen, U.: Tubulointerstitielle Nephritis und Uveitis (TINU-Syndrom). Ophthalmologe 89(5), 441–443 (1992)

    PubMed  CAS  Google Scholar 

  48. Ellis, D., Fried, W.A., Yunis, E.J., Blau, E.B.: Acute interstitial nephritis in children: a report of 13 cases and review of the literature. Pediatrics 67(6), 862–870 (1981)

    PubMed  CAS  Google Scholar 

  49. Sharma, O.P.: Sarcoidosis. Dis. Mon. 36(9), 469–535 (1990)

    Article  PubMed  CAS  Google Scholar 

  50. Siltzbach, L.E., James, D.G., Neville, E., et al.: Course and prognosis of sarcoidosis around the world. Am. J. Med. 57(6), 847–852 (1974)

    Article  PubMed  CAS  Google Scholar 

  51. Bresnitz, E.A., Strom, B.L.: Epidemiology of sarcoidosis. Epidemiol. Rev. 5, 124–156 (1983)

    PubMed  CAS  Google Scholar 

  52. Rosenberg, A.M., Yee, E.H., MacKenzie, J.W.: Arthritis in childhood sarcoidosis. J. Rheumatol. 10(6), 987–990 (1983)

    PubMed  CAS  Google Scholar 

  53. Shetty, A.K., Gedalia, A.: Sarcoidosis: a pediatric perspective. Clin. Pediatr. 37(12), 707–717 (1998)

    Article  CAS  Google Scholar 

  54. Sahn, E.E., Hampton, M.T., Garen, P.D., et al.: Preschool sarcoidosis masquerading as juvenile rheumatoid arthritis: two case reports and a review of the literature. Pediatr. Dermatol. 7(3), 208–213 (1990)

    Article  PubMed  CAS  Google Scholar 

  55. Obenauf, C.D., Shaw, H.E., Sydnor, C.F., Klintworth, G.K.: Sarcoidosis and its ophthalmic manifestations. Am. J. Ophthalmol. 86(5), 648–655 (1978)

    PubMed  CAS  Google Scholar 

  56. Hunter, D.G., Foster, C.S.: Ocular manifestations of sarcoidosis. In: Albert, D.M., Jakobiec, F.A. (eds.) Principles and Practice of Ophthalmology. Saunders, Philadelphia, PA (1994)

    Google Scholar 

  57. Johns, C.J., Scott, P.P., Schonfeld, S.A.: Sarcoidosis. Annu. Rev. Med. 40, 353–371 (1989)

    Article  PubMed  CAS  Google Scholar 

  58. Chan, C.C., Wetzig, R.P., Palestine, A.G., et al.: Immunohistopathology of ocular sarcoidosis.Report of a case and discussion of immunopathogenesis. Arch. Ophthalmol. 105(10), 1398–1402 (1987)

    Article  PubMed  CAS  Google Scholar 

  59. Rossman, M.D., Thompson, B., Frederick, M., et al.: HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. Am. J. Hum. Genet. 73(4), 720–735 (2003)

    Article  PubMed  CAS  Google Scholar 

  60. Smith, M.J., Turton, C.W., Mitchell, D.N., et al.: Association of HLA B8 with spontaneous resolution in sarcoidosis. Thorax 36(4), 296–298 (1981)

    Article  PubMed  CAS  Google Scholar 

  61. Welch, R.B., Maumenee, A.E., Wahlen, H.E.: Peripheral posterior segment inflammation, vitreous opacities, and edema of the posterior pole. Arch. Ophthalmol. 64, 540–549 (1960)

    Article  PubMed  CAS  Google Scholar 

  62. Bonfioli, A.A., Damico, F.M., Curi, A.L., Orefice, F.: Intermediate uveitis. Semin. Ophthalmol. 20(3), 147–154 (2005)

    Article  PubMed  Google Scholar 

  63. Guest, S., Funkhouser, E., Lightman, S.: Pars planitis: a comparison of childhood onset and adult onset disease. Clin. Experiment. Ophthalmol. 29(2), 81–84 (2001)

    Article  PubMed  CAS  Google Scholar 

  64. Malinowski, S.M., Pulido, J.S., Folk, J.C.: Long-term visual outcome and complications associated with pars planitis. Ophthalmology 100(6), 818–824 (1993). discussion 25

    PubMed  CAS  Google Scholar 

  65. Pederson, J.E., Kenyon, K.R., Green, W.R., Maumenee, A.E.: Pathology of pars planitis. Am. J. Ophthalmol. 86(6), 762–774 (1978)

    PubMed  CAS  Google Scholar 

  66. Oruc, S., Duffy, B.F., Mohanakumar, T., Kaplan, H.J.: The association of HLA class II with pars planitis. Am. J. Ophthalmol. 131(5), 657–659 (2001)

    Article  PubMed  CAS  Google Scholar 

  67. Raja, S.C., Jabs, D.A., Dunn, J.P., et al.: Pars planitis: clinical features and class II HLA associations. Ophthalmology 106(3), 594–599 (1999)

    Article  PubMed  CAS  Google Scholar 

  68. Davis, J.L., Mittal, K.K., Nussenblatt, R.B.: HLA in intermediate uveitis. Dev. Ophthalmol. 23, 35–37 (1992)

    PubMed  CAS  Google Scholar 

  69. Malinowski, S.M., Pulido, J.S., Goeken, N.E., et al.: The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis. Ophthalmology 100(8), 1199–1205 (1993)

    PubMed  CAS  Google Scholar 

  70. Eichenbaum, J.W., Friedman, A.H., Mamelok, A.E.: A clinical and histopathological review of intermediate uveitis (“pars planitis”). Bull. N. Y. Acad. Med. 64(2), 164–174 (1988)

    PubMed  CAS  Google Scholar 

  71. Green, W.R., Kincaid, M.C., Michels, R.G., et al.: Pars planitis. Trans. Ophthalmol. Soc. U. K. 101(pt 3)(3), 361–367 (1981)

    Google Scholar 

  72. Yoser, S.L., Forster, D.J., Rao, N.A.: Pathology of intermediate uveitis. Dev. Ophthalmol. 23, 60–70 (1992)

    PubMed  CAS  Google Scholar 

  73. Kaplan, H.J.: Intermediate Uveitis (pars planitis, chronic cyclitis) – a four step approach to treatment. In: Saari, K.M. (ed.) Uveitis update. Excerpta medica, Amsterdam (1984)

    Google Scholar 

  74. Lynfield, R., Guerina, N.G.: Toxoplasmosis. Pediatr. Rev. 18(3), 75–83 (1997)

    Article  PubMed  CAS  Google Scholar 

  75. Frenkel, J.F.: Toxoplamosis: parasite life cycle, pathology, and immunology. In: Hammond, D.M., Long, P.L. (eds.) The Coccidia: eimeria, isospora, toxoplasma, and related genera. University Park Press, Baltimore, MD (1973)

    Google Scholar 

  76. Desmonts, G., Couvreur, J.: Congenital toxoplasmosis. A prospective study of 378 pregnancies. N. Engl. J. Med. 290(20), 1110–1116 (1974)

    Article  PubMed  CAS  Google Scholar 

  77. Desmonts, G., Couvreur, J.: Toxoplasmosis in pregnancy and its transmission to the fetus. Bull. N. Y. Acad. Med. 50(2), 146–159 (1974)

    PubMed  CAS  Google Scholar 

  78. McMenamin, P.G., Dutton, G.N., Hay, J., Cameron, S.: The ultrastructural pathology of congenital murine toxoplasmic retinochoroiditis. Part I: The localization and morphology of Toxoplasma cysts in the retina. Exp. Eye Res. 43(4), 529–543 (1986)

    Article  PubMed  CAS  Google Scholar 

  79. Rao, N.A., Font, R.L.: Toxoplasmic retinochoroiditis: electron-microscopic and immunofluorescence studies of formalin-fixed tissue. Arch. Ophthalmol. 95(2), 273–277 (1977)

    Article  PubMed  CAS  Google Scholar 

  80. Bosch-Driessen, L.E., Berendschot, T.T., Ongkosuwito, J.V., Rothova, A.: Ocular toxoplasmosis: clinical features and prognosis of 154 patients. Ophthalmology 109(5), 869–878 (2002)

    Article  PubMed  Google Scholar 

  81. Mets, M.B., Holfels, E., Boyer, K.M., et al.: Eye manifestations of congenital toxoplasmosis. Am. J. Ophthalmol. 122(3), 309–324 (1996)

    PubMed  CAS  Google Scholar 

  82. Holland, G.N.: Ocular toxoplasmosis: a global reassessment. Part I: epidemiology and course of disease. Am. J. Ophthalmol. 136(6), 973–988 (2003)

    Article  PubMed  Google Scholar 

  83. Dodds, E.M.: Module 10: Ocular toxoplasmosis: clinical presentations, diagnosis, and therapy. Focal points: clinical modules for ophthalmologists. American Academy of Ophthalmology, San Francisco, CA (1999)

    Google Scholar 

  84. Rothova, A.: Ocular manifestations of toxoplasmosis. Curr. Opin. Ophthalmol. 14(6), 384–388 (2003)

    Article  PubMed  Google Scholar 

  85. Pinon, J.M., Dumon, H., Chemla, C., et al.: Strategy for diagnosis of congenital toxoplasmosis: evaluation of methods comparing mothers and newborns and standard methods for postnatal detection of immunoglobulin G, M, and A antibodies. J. Clin. Microbiol. 39(6), 2267–2271 (2001)

    Article  PubMed  CAS  Google Scholar 

  86. Stepick-Biek, P., Thulliez, P., Araujo, F.G., Remington, J.S.: IgA antibodies for diagnosis of acute congenital and acquired toxoplasmosis. J. Infect. Dis. 162(1), 270–273 (1990)

    Article  PubMed  CAS  Google Scholar 

  87. Aouizerate, F., Cazenave, J., Poirier, L., et al.: Detection of Toxoplasma gondii in aqueous humour by the polymerase chain reaction. Br. J. Ophthalmol. 77(2), 107–109 (1993)

    Article  PubMed  CAS  Google Scholar 

  88. Bou, G., Figueroa, M.S., Marti-Belda, P., et al.: Value of PCR for detection of Toxoplasma gondii in aqueous humor and blood samples from immunocompetent patients with ocular toxoplasmosis. J. Clin. Microbiol. 37(11), 3465–3468 (1999)

    PubMed  CAS  Google Scholar 

  89. Engstrom Jr., R.E., Holland, G.N., Nussenblatt, R.B., Jabs, D.A.: Current practices in the management of ocular toxoplasmosis. Am. J. Ophthalmol. 111(5), 601–610(1991)

    PubMed  Google Scholar 

  90. Holland, G.N., Lewis, K.G.: An update on current practices in the management of ocular toxoplasmosis [erratum appears in Am J Ophthalmol 2002 Dec;134(6):944]. Am. J. Ophthalmol. 134(1), 102–114 (2002)

    Article  PubMed  Google Scholar 

  91. Stanford, M.R., See, S.E., Jones, L.V., Gilbert, R.E.: Antibiotics for toxoplasmic retinochoroiditis: an evidence-based systematic review [see comment]. Ophthalmology 110(5), 926–931 (2003). quiz 31–2

    Article  PubMed  Google Scholar 

  92. Pearson, P.A., Piracha, A.R., Sen, H.A., Jaffe, G.J.: Atovaquone for the treatment of toxoplasma retinochoroiditis in immunocompetent patients. Ophthalmology 106(1), 148–153 (1999)

    Article  PubMed  CAS  Google Scholar 

  93. McAuley, J., Boyer, K.M., Patel, D., et al.: Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial [erratum appears in Clin Infect Dis 1994 Oct;19(4):820]. Clin. Infect. Dis. 18(1), 38–72 (1994)

    Article  PubMed  CAS  Google Scholar 

  94. Loewer-Sieger, D.H., Rothova, A., Koppe, J.G., Kylstra, A.: Congenital toxoplasmosis, a prospective study based on 1821 pregnant women. In: Saari, K.M. (ed.) Uveitis update. Elsevier Science Publishers, Amsterdam (1984)

    Google Scholar 

  95. Wilder, H.C.: Nematode endophthalmitis. Trans. Am. Acad. Ophthalmol. Otolaryngol. 55, 99–109 (1950)

    PubMed  CAS  Google Scholar 

  96. Shields, J.A.: Ocular toxocariasis. A review. Surv. Ophthalmol. 28(5), 361–381 (1984)

    Article  PubMed  CAS  Google Scholar 

  97. Glickman, L.T., Schantz, P.M.: Epidemiology and pathogenesis of zoonotic toxocariasis. Epidemiol. Rev. 3, 230–250 (1981)

    PubMed  CAS  Google Scholar 

  98. Despommier, D.: Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clin. Microbiol. Rev. 16(2), 265–272 (2003)

    Article  PubMed  Google Scholar 

  99. Molk, R.: Ocular toxocariasis: a review of the literature. Ann. Ophthalmol. 15(3), 216–219 (1983)

    PubMed  CAS  Google Scholar 

  100. Stewart, J.M., Cubillan, L.D., Cunningham Jr., E.T.: Prevalence, clinical features, and causes of vision loss among patients with ocular toxocariasis. Retina 25(8), 1005–1013 (2005)

    Article  PubMed  Google Scholar 

  101. Pollard, Z.F., Jarrett, W.H., Hagler, W.S., et al.: ELISA for diagnosis of ocular toxocariasis. Ophthalmology 86(5), 743–752 (1979)

    PubMed  CAS  Google Scholar 

  102. Gillespie, S.H.: Human toxocariasis. J. Appl. Bacteriol. 63(6), 473–479 (1987)

    Article  PubMed  CAS  Google Scholar 

  103. Siam, A.L.: Toxocaral chorio-retinitis. Treatment of early cases with photocoagulation. Br. J. Ophthalmol. 57(9), 700–703 (1973)

    Article  PubMed  CAS  Google Scholar 

  104. Grand, M.G., Roper-Hall, G.: Pars plana vitrectomy for ocular toxocariasis. Retina 1(3), 258–261 (1981)

    Article  PubMed  CAS  Google Scholar 

  105. Hagler, W.S., Pollard, Z.F., Jarrett, W.H., Donnelly, E.H.: Results of surgery for ocular Toxocara canis. Ophthalmology 88(10), 1081–1086 (1981)

    PubMed  CAS  Google Scholar 

  106. Maguire, A.M., Green, W.R., Michels, R.G., Erozan, Y.S.: Recovery of intraocular Toxocara canis by pars plana vitrectomy. Ophthalmology 97(5), 675–680 (1990)

    PubMed  CAS  Google Scholar 

  107. Small, K.W., McCuen 2nd, B.W., de Juan Jr., E., Machemer, R.: Surgical management of retinal traction caused by toxocariasis. Am. J. Ophthalmol. 108(1), 10–14 (1989)

    PubMed  CAS  Google Scholar 

  108. Adal, K.A., Cockerell, C.J., Petri Jr., W.A.: Cat scratch disease, bacillary angiomatosis, and other infections due to Rochalimaea. N. Engl. J. Med. 330(21), 1509–1515 (1994)

    Article  PubMed  CAS  Google Scholar 

  109. Jones, D.B.: Cat-scratch disease. In: Pepose, J.S., Holland, G.N., Wilhelmus, K.R. (eds.) Ocular infection and immunity. Mosby, St. Louis, MO (1996)

    Google Scholar 

  110. Margileth, A.M.: Antibiotic therapy for cat-scratch disease: clinical study of therapeutic outcome in 268 patients and a review of the literature. Pediatr. Infect. Dis. J. 11(6), 474–478 (1992)

    Article  PubMed  CAS  Google Scholar 

  111. Sweeney, V.P., Drance, S.M.: Optic neuritis and compressive neuropathy associated with cat scratch disease. Can. Med. Assoc. J. 103(13), 1380–1381 (1970)

    PubMed  CAS  Google Scholar 

  112. Regnery, R.L., Anderson, B.E., Clarridge 3rd, J.E., et al.: Characterization of a novel Rochalimaea species, R. henselae sp. nov., isolated from blood of a febrile, human immunodeficiency virus-positive patient. J. Clin. Microbiol. 30(2), 265–274 (1992)

    PubMed  CAS  Google Scholar 

  113. Cunningham, E.T., Koehler, J.E.: Ocular bartonellosis. Am. J. Ophthalmol. 130(3), 340–349 (2000)

    Article  PubMed  CAS  Google Scholar 

  114. Jackson, L.A., Perkins, B.A., Wenger, J.D.: Cat scratch disease in the United States: an analysis of three national databases. Am. J. Public Health 83(12), 1707–1711 (1993)

    Article  PubMed  CAS  Google Scholar 

  115. Koehler, J.E., Glaser, C.A., Tappero, J.W.: Rochalimaea henselae infection. A new zoonosis with the domestic cat as reservoir [see comment]. JAMA 271(7), 531–535 (1994)

    Article  PubMed  CAS  Google Scholar 

  116. Zangwill, K.M., Hamilton, D.H., Perkins, B.A., et al.: Cat scratch disease in Connecticut. Epidemiology, risk factors, and evaluation of a new diagnostic test [see comment]. N. Engl. J. Med. 329(1), 8–13 (1993)

    Article  PubMed  CAS  Google Scholar 

  117. Margileth, A.W., Wear, D.J., Hadfield, T.L., et al.: Cat-scratch disease. Bacteria in skin at the primary inoculation site. JAMA 252(7), 928–931 (1984)

    Article  PubMed  CAS  Google Scholar 

  118. Dreyer, R.F., Hopen, G., Gass, J.D., Smith, J.L.: Leber’s idiopathic stellate neuroretinitis. Arch. Ophthalmol. 102(8), 1140–1145 (1984)

    Article  PubMed  CAS  Google Scholar 

  119. Ormerod, L.D., Skolnick, K.A., Menosky, M.M., et al.: Retinal and choroidal manifestations of cat-scratch disease [see comment]. Ophthalmology 105(6), 1024–1031 (1998)

    Article  PubMed  CAS  Google Scholar 

  120. Reed, J.B., Scales, D.K., Wong, M.T., et al.: Bartonella henselae neuroretinitis in cat scratch disease. Diagnosis, management, and sequelae [see comment]. Ophthalmology 105(3), 459–466 (1998)

    Article  PubMed  CAS  Google Scholar 

  121. Wade, N.K., Levi, L., Jones, M.R., et al.: Optic disk edema associated with peripapillary serous retinal detachment: an early sign of systemic Bartonella henselae infection. Am. J. Ophthalmol. 130(3), 327–334 (2000)

    Article  PubMed  CAS  Google Scholar 

  122. Solley, W.A., Martin, D.F., Newman, N.J., et al.: Cat scratch disease: posterior segment manifestations [see comment]. Ophthalmology 106(8), 1546–1553 (1999)

    Article  PubMed  CAS  Google Scholar 

  123. Suhler, E.B., Lauer, A.K., Rosenbaum, J.T.: Prevalence of serologic evidence of cat scratch disease in patients with neuroretinitis. Ophthalmology 107(5), 871–876 (2000)

    Article  PubMed  CAS  Google Scholar 

  124. Margileth, A.M.: Cat scratch disease. Adv. Pediatr. Infect. Dis. 8, 1–21 (1993)

    PubMed  CAS  Google Scholar 

  125. Sander, A., Posselt, M., Bohm, N., et al.: Detection of Bartonella henselae DNA by two different PCR assays and determination of the genotypes of strains involved in histologically defined cat scratch disease. J. Clin. Microbiol. 37(4), 993–997 (1999)

    PubMed  CAS  Google Scholar 

  126. Gass, J.D., Scelfo, R.: Diffuse unilateral subacute neuroretinitis. J. R. Soc. Med. 71(2), 95–111 (1978)

    PubMed  CAS  Google Scholar 

  127. Gass, J.D., Braunstein, R.A.: Further observations concerning the diffuse unilateral subacute neuroretinitis syndrome. Arch. Ophthalmol. 101(11), 1689–1697 (1983)

    Article  PubMed  CAS  Google Scholar 

  128. Gass, J.D., Gilbert Jr., W.R., Guerry, R.K., Scelfo, R.: Diffuse unilateral subacute neuroretinitis. Ophthalmology 85(5), 521–545 (1978)

    PubMed  CAS  Google Scholar 

  129. Cortez, R., Denny, J.P., Muci-Mendoza, R., et al.: Diffuse unilateral subacute neuroretinitis in Venezuela. Ophthalmology 112(12), 2110–2114 (2005)

    Article  PubMed  Google Scholar 

  130. Carney, M.D., Combs, J.L.: Diffuse unilateral subacute neuroretinitis. Br. J. Ophthalmol. 75(10), 633–635 (1991)

    Article  PubMed  CAS  Google Scholar 

  131. Gass, J.D., Callanan, D.G., Bowman, C.B.: Successful oral therapy for diffuse unilateral subacute neuroretinitis. Trans. Am. Ophthalmol. Soc. 89, 97–112 (1991). discussion 3–6

    PubMed  CAS  Google Scholar 

  132. Wilhelmus, K.R.: The history of ocular syphilis. In: Bialasiwicz, A.A., Schall, K.P. (eds.) Infectious diseases of the eye. Eolus Press, Buren, The Netherlands (1994)

    Google Scholar 

  133. Wilhelmus, K.R., Lukehart, S.A.: Syphilis. In: Pepose, J.S., Holland, G.N., Wilhelmus, K.R. (eds.) Ocular infection and immunity. Mosby, St. Louis, MO (1996)

    Google Scholar 

  134. Deschenes, J., Seamone, C., Baines, M.: The ocular manifestations of sexually transmitted diseases. Can. J. Ophthalmol. 25(4), 177–185 (1990)

    PubMed  CAS  Google Scholar 

  135. Sexually Transmitted Diseases Surveillance 2003. Centers for Disease Control and Prevention. Atlanta, GA: U.S. Department of Health and Human Services, September 2004.

    Google Scholar 

  136. Ingall, D., Sanchez, P., Baker, C.J.: Syphilis. In: Remington, J.S., Llein, J.O. (eds.) Infectious diseases of the fetus and newborn infant, 6th edn. Elsevier Saunders, Philadelphia, PA (2006)

    Google Scholar 

  137. Aldave, A.J., King, J.A., Cunningham Jr., E.T.: Ocular syphilis. Curr. Opin. Ophthalmol. 12(6), 433–441 (2001)

    Article  PubMed  CAS  Google Scholar 

  138. Browning, D.J.: Posterior segment manifestations of active ocular syphilis, their response to a neurosyphilis regimen of penicillin therapy, and the influence of human immunodeficiency virus status on response [see comment]. Ophthalmology 107(11), 2015–2023 (2000)

    Article  PubMed  CAS  Google Scholar 

  139. Tamesis, R.R., Foster, C.S.: Ocular syphilis. Ophthalmology 97(10), 1281–1287 (1990)

    PubMed  CAS  Google Scholar 

  140. Contreras, F., Pereda, J.: Congenital syphilis of the eye with lens involvement. Arch. Ophthalmol. 96(6), 1052–1053 (1978)

    Article  PubMed  CAS  Google Scholar 

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  1. Cleveland Clinic Cole Eye Institute, Cleveland, OH, USA

    Christopher Hood & Careen Y. Lowder

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    James Reynolds

  2. Children's Mercy Hospital, Gillham St. 2401, Kansas City, 64108, Missouri, USA

    Scott Olitsky

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Hood, C., Lowder, C.Y. (2011). Pediatric Uveitis. In: Reynolds, J., Olitsky, S. (eds) Pediatric Retina. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12041-1_19

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