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Bio-synthetic Encapsulation Systems for Organ Engineering: Focus on Diabetes

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Abstract

The development of a safe and effective bio-synthetic encapsulation system will potentially improve the treatment of diseases known to benefit from cell implantation therapies. This is of particular importance in the progression towards a permanent treatment for type 1 diabetes. Cell-based therapies for insulin-dependent diabetics ultimately aim to eliminate the need for exogenous insulin through the implantation of donor islet cells or, alternately, stem cells differentiated into glucose-sensitive islet-like cells. Encapsulation devices are required to protect implanted cells from destructive host immune factors. A successful design will be bio-synthetic, having well-defined permeability and providing appropriate biomolecules for physiological functionality and survival of the encapsulated cells.

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Authors and Affiliations

  1. Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, Australia

    Rylie A. Green, Penny J. Martens, Robert Nordon & Laura A. Poole-Warren

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  1. Rylie A. Green
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  2. Penny J. Martens
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  3. Robert Nordon
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  4. Laura A. Poole-Warren
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Editors and Affiliations

  1. FH Aachen, Standort Jülich, Ginsterweg 1, Jülich, 52428, Germany

    Gerhard M. Artmann

  2. Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, London, SE11UL, United Kingdom

    Stephen Minger

  3. Inst. Neurophysiologie, Universitätsklinikum Köln, Robert-Koch-Str. 39, Köln, 50931, Germany

    Jürgen Hescheler

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Green, R.A., Martens, P.J., Nordon, R., Poole-Warren, L.A. (2011). Bio-synthetic Encapsulation Systems for Organ Engineering: Focus on Diabetes. In: Artmann, G., Minger, S., Hescheler, J. (eds) Stem Cell Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11865-4_16

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  • DOI: https://doi.org/10.1007/978-3-642-11865-4_16

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