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Endothelial Progenitor Cells for Vascular Repair

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Abstract

Endothelial progenitor cells (EPCs), present in the blood and bone marrow, represent a potential source of endothelial cells for repair of injured blood vessels, neovascularization, and tissue engineering. EPCs are present at low levels in peripheral blood, although their numbers increase in response to cytokines, VEGF, and statins. There are at least two types of EPCs characterized following in vitro culture: colony-forming unit ECs (CFU-ECs) and endothelial colony-forming cells (ECFCs). CFU-ECs appear early in culture, have limited ability to proliferate, and share markers for endothelial cells and monocytes. In contrast, ECFCs appear later in culture, grow rapidly, and to large numbers express only endothelial cell markers. This chapter examines the properties of these EPCs, in vitro and in vivo studies using these two cell types, and the potential of these EPCs for therapeutic applications.

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Acknowledgments

This work was supported by NIH Grants RO1 HL57446, RO1 HL 88825, and NIH Biotechnology Training Grant (GM8555) fellowship to C.S.C. and an American Heart Association Fellowship to M.A.B.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Duke University, Durham, NC, USA

    Melissa A. Brown, Cindy S. Cheng & George A. Truskey

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  1. Melissa A. Brown
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  2. Cindy S. Cheng
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  3. George A. Truskey
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Correspondence to George A. Truskey .

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  1. FH Aachen, Standort Jülich, Ginsterweg 1, Jülich, 52428, Germany

    Gerhard M. Artmann

  2. Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, London, SE11UL, United Kingdom

    Stephen Minger

  3. Inst. Neurophysiologie, Universitätsklinikum Köln, Robert-Koch-Str. 39, Köln, 50931, Germany

    Jürgen Hescheler

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Brown, M.A., Cheng, C.S., Truskey, G.A. (2011). Endothelial Progenitor Cells for Vascular Repair. In: Artmann, G., Minger, S., Hescheler, J. (eds) Stem Cell Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11865-4_13

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