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The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells

Abstract

The altered metabolism of cancer cells was recognized and pioneered by the elegant works of Otto Warburg in the 1920s and popularized in the 1950s. Presently, it is well recognized that over sixty percent of all cancers are glycolytic. The Warburg effect or phenomenon is discussed, and the molecular understanding of some of Warburg’s statements is provided with regard to modern knowledge of carcinogenesis. In addition, molecular explanation of aerobic glycolysis of the cancer cell is detailed. Other metabolic alterations of the cancer cell including glutaminolysis and lipogenesis are discussed. The altered citrate metabolism specifically associated with malignant transformation of peripheral zone prostate epithelial cells, and the potential clinical applications of such metabolic alterations conclude this chapter.

Keywords

  • Aerobic Glycolysis
  • Fumarate Hydratase
  • Glutamine Metabolism
  • Citrate Transport Protein
  • Citrate Oxidation

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Fig. 2.1
Fig. 2.2
Fig. 2.3

Notes

  1. 1.

    Grana refers to mitochondria.

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Correspondence to Gabriel D. Dakubo .

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Dakubo, G.D. (2010). The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells. In: Mitochondrial Genetics and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11416-8_2

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