Abstract
Bacterial biofilms are three-dimensional aggregates of bacteria encased in secreted exopolysaccharides (slime) and lack vulnerability to antibiotics that planktonic bacteria demonstrate. Biofilm-forming bacteria are common. Bacterial biofilms may contribute to medically recalcitrant chronic rhinosinusitis (CRS). Tactics developed to treat planktonic bacteria are ineffective against bacteria in a biofilm – this helps explain a portion of the persistent and recurrent infections observed in CRS. Understanding how biofilm infections form is fundamental to developing rational strategies for the prevention and treatment of biofilm-associated CRS. New investigations into therapeutic remedies aimed at eradicating biofilm infections are ongoing and hold promise for alleviating individuals’ suffering from recurrent infections associated with CRS.
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Woodworth, B.A., Palmer, J.N. (2010). Biofilms. In: Önerci, T., Ferguson, B. (eds) Nasal Polyposis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11412-0_9
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DOI: https://doi.org/10.1007/978-3-642-11412-0_9
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