Advertisement

Noninvasive Positive Pressure Ventilation in Acute Hypoxemic Respiratory Failure and in Cancer Patients

  • S. Egbert PravinkumarEmail author
Chapter

Abstract

Acute respiratory failure (ARF) is a common occurrence in cancer patients and is associated with a high mortality rate. The role of NPPV in immunosuppressed, hematological malignancies, and solid tumor is an area that interests researchers and clinicians alike. Several randomized controlled trials and systematic reviews have confirmed the benefits of noninvasive positive pressure ventilation (NPPV) in patients with exacerbation of chronic obstructive pulmonary disease (COPD). Benefits achieved from NPPV in COPD patients are largely due to avoidance of invasive mechanical ventilation (IMV) and its complications including worsening of preexisting infections, morbidity and mortality, ventilator associated pneumonia (VAP), ventilator associated lung injury, increased need for sedation resulting in prolonged ventilation, ventilator dependence, and upper airway complications related to endotracheal tube [1]. The use of NPPV in COPD with hypercapneic ARF is no longer debated and is now considered as first-line intervention before considering endotracheal intubation (ETI) and IMV.

Keywords

Chronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Acute Respiratory Failure Ventilator Associate Pneumonia Intensive Care Unit Mortality 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Keenan SP, Sinuff T, Cook DJ, Hill NS (2004) Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? A systematic review. Crit Care Med 32:2516–2523PubMedCrossRefGoogle Scholar
  2. 2.
    Brochard L (2002) Noninvasive ventilation for acute respiratory failure. JAMA 288:932–935PubMedCrossRefGoogle Scholar
  3. 3.
    American Thoracic Society/Infectious Diseases Society of America (2005) Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171:388–416CrossRefGoogle Scholar
  4. 4.
    Carlucci A, Richard JC, Wysocki M, Lepage E, Brochard L (2001) SRLF Collaborative Group on Mechanical Ventilation. Noninvasive versus conventional mechanical ventilation: an epidemiologic survey. Am J Respir Crit Care Med 163:874–880PubMedGoogle Scholar
  5. 5.
    Keenan SP, Sinuff T, Cook DJ, Hill NS (2003) Which patients with acute exacerbation of chronic obstructive pulmonary disease benefit from noninvasive positive pressure ventilation? A systematic review of the literature. Ann Intern Med 138:861–870PubMedGoogle Scholar
  6. 6.
    Nava S, Cuomo AM (2004) Acute respiratory failure in the cancer patient: the role of non-invasive mechanical ventilation. Crit Rev Oncol Hematol 51:91–103PubMedCrossRefGoogle Scholar
  7. 7.
    Azoulay E, Alberti C, Bornstain C, Leleu G, Moreau D, Recher C, Chevret S et al (2001) Improved survival in cancer patients requiring mechanical ventilatory support: impact of noninvasive ventilatory support. Crit Care Med 29:519–525PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of Critical Care, Unit 112UT-M.D. Anderson Cancer CenterHoustonUSA

Personalised recommendations