Noninvasive Positive Pressure Ventilation in Amyotrophic Lateral Sclerosis

  • Daniele Lo CocoEmail author
  • Santino Marchese
  • Albino Lo Coco


Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of unknown origin that affects approximately 1.5 individuals per 100,000 every year; usually, these individuals are between 55 and 75 years of age [1]. ALS causes progressive weakness of voluntary muscle groups, including respiratory ones, and respiratory failure or pneumonia related to respiratory muscle weakness is the most frequent cause of death.


Amyotrophic Lateral Sclerosis Force Vital Capacity Amyotrophic Lateral Sclerosis Patient Noninvasive Positive Pressure Ventilation Percutaneous Endoscopic Gastrostomy Tube 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Radunović A, Mitsumoto H, Leigh PN (2007) Clinical care of patients with amyotrophic lateral sclerosis. Lancet Neurol 6:913–925PubMedCrossRefGoogle Scholar
  2. 2.
    Beneditt JO, Boitano L (2008) Respiratory treatment of amyotrophic lateral sclerosis. Phys Med Rehabil Clin N Am 19:559–572CrossRefGoogle Scholar
  3. 3.
    Heffernan C, Jenkinson C, Holmes T et al (2006) Mangement of respiration in MND/ALS patients: an evidence based review. Amyotroph Lateral Scler 7:5–15PubMedCrossRefGoogle Scholar
  4. 4.
    Heiman-Patterson TD, Miller RG (2006) NIPPV: a treatment for ALS whose time has come. Neurology 67:736–737PubMedCrossRefGoogle Scholar
  5. 5.
    Lo Coco D, Marchese S, Pesco MC, La Bella V, Piccoli F, Lo Coco A (2006) Noninvasive positive-pressure ventilation in ALS. Predictors of tolerance and survival. Neurology 67:761–765PubMedCrossRefGoogle Scholar
  6. 6.
    Miller RG, Anderson F, Brooks BR, Mitsumoto H, Bradley WG, Ringel SP, ALS CARE Study Group (2009). Outcomes research in amyotrophic lateral sclerosis: lessons learned from the amyotrophic lateral sclerosis clinical assessment, research, and education database. Ann Neurol 65(Suppl 1):S24–S28Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Daniele Lo Coco
    • 1
    Email author
  • Santino Marchese
    • 2
  • Albino Lo Coco
    • 3
  1. 1.ALS Clinical Research Center, Dipartimento Universitario di Neuroscienze Cliniche (DiNeC)University of PalermoPalermoItaly
  2. 2.Respiratory Intensive Care Unit, Ospedale Civico e BenfratelliARNASPalermoItaly
  3. 3.Pulmonary Department and Respiratory Intensive Care Unit, Ospedale Civico e BenfratelliARNASPalermoItaly

Personalised recommendations