Noninvasive Ventilation Pressure Adjustments in Patients with Amyotrophic Lateral Sclerosis

  • Kirsten L. GruisEmail author


Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of motor neurons. Patients with ALS develop diffuse skeletal muscle weakness in addition to respiratory muscle weakness, and respiratory failure is the most common cause of death. Tolerance to intermittent use of noninvasive ventilation (NIV) for 4 h or more a day is associated with improved survival and quality of life in patients with ALS [1, 5].


  1. 1.
    Kleopa KA, Sherman M, Neal B, Romano GJ (1999) Heiman–Patterson T Bipap improves survival and rate of pulmonary function decline in patients with ALS. J Neurol Sci 164:82–88PubMedCrossRefGoogle Scholar
  2. 2.
    Aboussouan LS, Khan SU, Banerjee M, Arroliga AC, Mitsumoto H (2001) Objective measures of the efficacy of noninvasive positive-pressure ventilation in amyotrophic lateral sclerosis. Muscle Nerve 24:403–409PubMedCrossRefGoogle Scholar
  3. 3.
    Melo J, Homma A, Iturriaga E et al (1999) Pulmonary evaluation and prevalence of non-invasive ventilation in patients with amyotrophic lateral sclerosis: a multicenter survey and proposal of a pulmonary protocol. J Neurol Sci 169:114–117PubMedCrossRefGoogle Scholar
  4. 4.
    Gruis KL, Brown DL, Lisabeth LD, Zebarah VA, Chervin RD, Feldman EL (2006) Longitudinal assessment of noninvasive positive pressure ventilation adjustments in ALS patients. J Neurol Sci 247(1):59–63PubMedCrossRefGoogle Scholar
  5. 5.
    Bourke SC, Tomlinson M, Williams TL, Bullock RE, Shaw PJ, Gibson GJ (2006) Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial. Lancet Neurol 5:140–147PubMedCrossRefGoogle Scholar
  6. 6.
    Butz M, Wollinsky KH, Wiedemuth-Catrinescu U et al (2003) Longitudinal effects of noninvasive positive-pressure ventilation in patients with amyotrophic lateral sclerosis. Am J Phys Med Rehabil 82:597–604PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of Neurology, 1914/0316 Taubman CenterMotor Neuron Disease Center, University of Michigan Health SystemAnn ArborUSA

Personalised recommendations