Abstract
Atherosclerosis is a progressive, chronic disease of large arteries in which various stages of vascular remodeling finally lead to significant narrowing of the vessel lumen. In the early phase of atherosclerosis, cholesterol particles are incorporated into the vascular wall (i.e., foam cell formation, development of fatty streaks). Later, plaques occur that are prone to rupture with consecutive thrombosis and complete vessel occlusion. In this case, acute clinical syndromes such as myocardial infarction may result. Atherosclerosis is viewed as an inflammatory process in which circulating leukocytes are attached to the endothelium, penetrate into the subendothelial space, and release a wide spectrum of cytokines. Known risk factors for atherosclerosis are, for instance, smoking, diabetes mellitus, and hyperlipidemia.
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References
Shahar E, Whitney CW, Redline S et al (2001) Sleep-disordered breathing and cardiovascular disease. Cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med 163:19–25
Arzt M, Young T, Finn L et al (2005) Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med 172:1447–1451
Ip MS, Tse HF, Lam B et al (2004) Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 169:348–353
Schulz R, Seeger W, Fegbeutel C et al (2005) Changes in extracranial arteries in obstructive sleep apnoea. Eur Respir J 25:69–74
Savransky V, Nanayakkara A, Li J et al (2007) Chronic intermittent hypoxia induces atherosclerosis. Am J Respir Crit Care Med 175:1290–1297
Drager LF, Bortolotto LA, Figueiredo AC et al (2007) Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 176:706–712
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Schulz, R., Reichenberger, F., Mayer, K. (2010). Obstructive Sleep Apnea and Atherosclerosis. In: Esquinas, A. (eds) Noninvasive Mechanical Ventilation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11365-9_19
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DOI: https://doi.org/10.1007/978-3-642-11365-9_19
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