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Oesophagus Tissue Engineering: Future Options in Oesophageal Replacement Through Regenerative Medicine

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Esophageal and Gastric Disorders in Infancy and Childhood

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Abstract

Tissue engineering is a multidisciplinary science in which the principles of engineering are applied to biological sciences with the aim of providing solutions for current clinical problems. Tissue engineering of the oesophagus is a promising alternative to transposition procedures in oesophageal replacement; however, the proposition is challenging due to the anatomical complexity of this tubular organ. In this chapter, the principles and concepts of tissue engineering are discussed with an overview of issues relating to the sourcing of cells, design and selection of scaffolds and polymers, hybrid construct and coculture approaches of tissue engineering and the use of bioreactors. Finally, current research in the field of oesophageal tissue engineering, from in vitro studies of cell biology to in vivo large animal studies, are reviewed.

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Author information

Authors and Affiliations

  1. Department of Pediatric Surgery, Chelsea Children’s Hospital, Chelsea and Westminster NHS Fdn Trust, Imperial College London, 369 Fulham Road, London, SW10 9NH, UK

    Amulya K. Saxena MD,PhD,DSc(hc),FRCS(Paed.Surg.)

Authors
  1. Amulya K. Saxena MD,PhD,DSc(hc),FRCS(Paed.Surg.)
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Correspondence to Amulya K. Saxena MD,PhD,DSc(hc),FRCS(Paed.Surg.) .

Editor information

Editors and Affiliations

  1. Medical University of Graz, Graz, Austria

    Holger Till

  2. Sheffield Children’s Hospital, Paediatric Gastroenterology Centre, Sheffield, United Kingdom

    Mike Thomson

  3. Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota, USA

    John E. Foker

  4. Department Surgery, University of Missouri, Kansas City Children’s Mercy Hospital, Kansas City, Missouri, USA

    George W. Holcomb III

  5. University of Arizona, Tucson, Arizona, USA

    Khalid M. Khan

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Saxena, A.K. (2017). Oesophagus Tissue Engineering: Future Options in Oesophageal Replacement Through Regenerative Medicine. In: Till, H., Thomson, M., Foker, J., Holcomb III, G., Khan, K. (eds) Esophageal and Gastric Disorders in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11202-7_32

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  • DOI: https://doi.org/10.1007/978-3-642-11202-7_32

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  • Online ISBN: 978-3-642-11202-7

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