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Dermatology and the Oesophagus

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Esophageal and Gastric Disorders in Infancy and Childhood
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Abstract

Diseases of the oesophagus can occur in association with skin diseases. Even though these conditions are rare, identification of this association is important. Skin manifestation of gastrointestinal disease is easy to recognise and facilitates the diagnosis of these conditions. An awareness of oesophageal disease in association with dermatological disease helps in early recognition and management of gastrointestinal disease. The involvement of the oesophagus is usually immune mediated as a result of infection. Immune-mediated disease mainly involves the mucosa followed by muscular layer and rarely causes vasculitis. Diagnosis of mucosal disease is confirmed principally with oesophagoscopy and that of muscular involvement with manometry. The characteristic features seen in various conditions are described further. Management of the primary condition is the mainstay of treatment, and specific management of various conditions is outlined.

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References

  1. Al-Amri SM. The pattern of esophageal manometry in progressive systemic sclerosis. Saudi Med J. 2003;24(1):68–71.

    PubMed  Google Scholar 

  2. Al Robaee A, Hamadah IR, Khuroo S, Alfadley A. Extensive Darier’s disease with esophageal involvement. Int J Dermatol. 2004;43:835–9.

    Article  PubMed  Google Scholar 

  3. Al-Shihabi BMS, Jackson JMG. Dysphagia due to pharyngeal and esophageal lichen planus. J Laryngol Otol. 1982;96:567–71.

    Article  CAS  PubMed  Google Scholar 

  4. Anderson SR, Sinacori JT. Plummer-Vinson syndrome heralded by postcricoid carcinoma. Am J Otolaryngol. 2007;28(1):22–4.

    Article  PubMed  Google Scholar 

  5. Appeleton AL, Sviland L, Pearson ADJ, et al. The need for endoscopic biopsy in the diagnosis of upper gastrointestinal graft-versus-host disease. J Pediatr Gastroenterol Nutr. 1993;16:183–5.

    Article  Google Scholar 

  6. Aractingi S, Chosidow O. Cutaneous graft-versus-host disease. Arch Dermatol. 1998;134:602–12.

    Article  CAS  PubMed  Google Scholar 

  7. Baehr P, McDonald G. Esophageal infections: risk factors, presentation, diagnosis, and treatment. Gastroenterology. 1994;106:509–32.

    Article  CAS  PubMed  Google Scholar 

  8. Bobadilla J, van der Hulst RWM, ten Kate FJW, Tytgat GNJ. Esophageal lichen planus. Gastrointest Endosc. 1999;50:268–71.

    Article  CAS  PubMed  Google Scholar 

  9. Burge S. Darier’s disease clinical features and pathogenesis. Clin Exp Dermatol. 1994;19:193–205.

    Article  CAS  PubMed  Google Scholar 

  10. Castillo RO, Davies YK, Lin YC, et al. Management of esophageal strictures in children with recessive dystrophic epidermolysis bullosa. J Pediatr Gastroenterol Nutr. 2002;34:535–41.

    Article  PubMed  Google Scholar 

  11. Castrucci G, Alimandi L, Fichera A, Altomonte L, Zoli A. Changes in esophageal motility in patients with systemic lupus erythematosus: an esophago-manometric study. Minerva Dietol Gastroenterol. 1990;36(1):3–7.

    CAS  PubMed  Google Scholar 

  12. Chabás E, Salazar F, Rovira I, Nalda MA. Stevens-Johnson syndrome associated with esophageal stenosis. Rev Esp Anestesiol Reanim. 1990;37(6):364–5.

    PubMed  Google Scholar 

  13. Chen TS, Chen PS. Rise and fall of the Plummer-Vinson syndrome. J Gastroenterol Hepatol. 1994;9(6):654–8.

    Article  CAS  PubMed  Google Scholar 

  14. De Castro Parga ML, Alonso P, García Porrua C, Prada JI. Esophageal mucosal lesions and scleroderma: prevalence, symptoms and risk factors. Rev Esp Enferm Dig. 1996;88(2):93–8.

    PubMed  Google Scholar 

  15. De D, Kanwar AJ. Childhood pemphigus. Indian J Dermatol. 2006;51:89–95.

    Article  Google Scholar 

  16. Dougenis D, Papathanasopoulos PG, Paschalis C, Papapetropoulos T. Spontaneous esophageal rupture in adult dermatomyositis. Eur J Cardiothorac Surg. 1996;10:1021–3.

    Article  CAS  PubMed  Google Scholar 

  17. Ebert EC. Esophageal disease in scleroderma. J Clin Gastroenterol. 2006;40:769–75.

    Article  PubMed  Google Scholar 

  18. James L, Ferrara M. Advances in the clinical management of GVHD. Best practice & research. Clin Haematol. 2008;21(4):677–82.

    Google Scholar 

  19. Fine JD, Bauer EA, McGuire J, Moshell A, editors. Epidermolysis bullosa: clinical, epidemiologic, and laboratory advances and the findings of the national epidermolysis bullosa registry. Baltimore: Johns Hopkins University Press; 1999.

    Google Scholar 

  20. Holder PD, Wong WL, Pemberton J, Thompson RPH, Parker SC. Diagnosis and treatment of an esophageal stricture due to lichen planus. Br J Radiol. 1992;65:451–2.

    Article  CAS  PubMed  Google Scholar 

  21. Horowitz M, McNeil JD, Maddern GJ, Collins PJ, Shearman DJ. Abnormalities of gastric and esophageal emptying in polymyositis and dermatomyositis. Gastroenterology. 1986;90(2):434–9.

    Article  CAS  PubMed  Google Scholar 

  22. Glesby MJ, Moore RD, Chaisson RE. Clinical spectrum of herpes zoster in adults infected with human immunodeficiency virus. Clin Infect Dis. 1995;21(2):370–5.

    Article  CAS  PubMed  Google Scholar 

  23. Gregory B, Ho VC. Cutaneous manifestations of gastrointestinal disorders. J Am Acad Dermatol. 1992;26:371–83.

    Article  CAS  PubMed  Google Scholar 

  24. Guariso G, Conte S, Galeazzi F, et al. Oesophageal involvement in localized scleroderma: a pilot study. Clin Exp Rheumatol. 2007;25(5):786–9.

    CAS  PubMed  Google Scholar 

  25. Gutierrez F, Valenzuela JE, Ehresmann GR, Quismorio FP, Kitridou RC. Esophageal dysfunction in patients with mixed connective tissue diseases and systemic lupus erythematosus. Dig Dis Sci. 1982;27:592–7.

    Article  CAS  PubMed  Google Scholar 

  26. Jacob H, Berkowitz D, McDonald E. The esophageal motility disorder of polymyositis. A prospective study. Arch Intern Med. 1983;143(12):2262–4.

    Article  CAS  PubMed  Google Scholar 

  27. Jimenez-Alonso J, Esteva D, Vera C, Sabio JM. Dysphagia in patients with systemic lupus erythematosus. Lupus. 2003;12:49313.

    Google Scholar 

  28. Johnston GA, Graham-Brown RAC. The skin and disorders of the alimentary tract and the hepatobiliary system. In: Fitzpatrick TB, Freedberg IM, editors. Fitzpatrick’s dermatology in general medicine. 6th ed. New York: McGraw-Hill, Medical Pub. Division; 2003. p. 1609.

    Google Scholar 

  29. Jordan RE, Ihrig JJ, Perry HO. Childhood pemphigus vulgaris. Arch Dermatol. 1969;99:176–9.

    Article  Google Scholar 

  30. Kirsch M. Esophageal lichen planus: a forgotten diagnosis. J Clin Gastroenterol. 1995;20:145–6.

    Article  CAS  PubMed  Google Scholar 

  31. Kurahara K, Aoyagi K, Nakamura S, et al. Treatment of herpes simplex esophagitis in an immunocompetent patient with intravenous acyclovir: a case report and review of the literature. Am J Gastroenterol. 1998;93:2239–40.

    CAS  PubMed  Google Scholar 

  32. Levine JB, Lukawski-Trubish D. Extraintestinal considerations in inflammatory bowel disease. Gastroenterology. 1995;24:633–46.

    CAS  Google Scholar 

  33. Marinkovich MP, Khavari PA, Herron GS, et al. Inherited epidermolysis bullosa. In: Fitzpatrick TB, Freedberg IM, editors. Fitzpatrick’s dermatology in general medicine. 6th ed. New York: McGraw-Hill, Medical Pub. Division; 2003. p. 596–609.

    Google Scholar 

  34. Marshall JB, Kretschmar JM, Gerhardt DC, Winship DH, Winn D, Treadwell EL, et al. Gastrointestinal manifestations of mixed connective tissue disease. Gastroenterology. 1990;98:1232–8.

    Article  CAS  PubMed  Google Scholar 

  35. Martínez Salmerón JF, Gutiérrez-Rave Pecero V, Uariachi M, Ogea García JL, Franco Cebrián J, Castillo Higueras P. Esophageal involvement in Behcet’s disease. Rev Esp Enferm Dig. 1992;82(3):187–8.

    PubMed  Google Scholar 

  36. Martin P, Carpenter P, Sanders J, Flowers M. Diagnosis and clinical management of chronic graft-versus-host disease. Int J Hematol. 2004;79:221–8.

    Article  PubMed  Google Scholar 

  37. Mavilio F, Pellegrini G, Ferrari S, et al. Correction of junctional epidermolysis bullosa by transplantation of genetically modified stem cells. Nat Med. 2006;12:1397–402.

    Article  CAS  PubMed  Google Scholar 

  38. McBane RD, Gross JB. Herpes oesophagitis: clinical syndrome, endoscopic appearance, and diagnosis in 23 patients. Gastrointest Endosc. 1991;37(6):600–3.

    Article  CAS  PubMed  Google Scholar 

  39. McDonald GB, Sullivan KM, Plumley TF. Radiographic features of oesophageal involvement in chronic graft-vs.-host disease. Am J Roentgenol. 1984;142:501–6.

    Article  CAS  Google Scholar 

  40. Mignon FC, Laroche L, Revuz J, Chatel A, Cattan D, Bader JP. Acanthosis nigricans associated with diffuse esophageal papillomatosis. Nouv Presse Med. 1975;4(35):2507–10.

    CAS  PubMed  Google Scholar 

  41. Mori S, Yoshihira A, Kawamura H, Takeuchi A, Hashimoto T, Inaba G. Oesophageal involvement in Behcet’s disease. Am J Gastroenterol. 1983;78(9):548–53.

    CAS  PubMed  Google Scholar 

  42. Murphy PJ, Harrell ER, Arbor A. Pemphigus vulgaris in childhood. Am J Dis Child. 1972;123:70–1.

    CAS  PubMed  Google Scholar 

  43. Novacek G. Plummer-Vinson syndrome. Orphanet J Rare Dis. 2006;1:36.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Ntoumazios SK, Voulgari PV, Potsis K, Koutis E, Tsifetaki N, Assimakopoulos DA. Esophageal involvement in scleroderma: gastroesophageal reflux, the common problem. Semin Arthritis Rheum. 2006;36(3):173–81.

    Article  PubMed  Google Scholar 

  45. Ozen S. The spectrum of vasculitis in children. Best Pract Res Clin Rheumatol. 2002;16:411–25.

    Article  CAS  PubMed  Google Scholar 

  46. Pace FA, Antinori SB, Repici AC. What is new in oesophageal injury (infection, drug-induced, caustic, stricture, perforation)? Curr Opin Gastroenterol. 2009;25(4):372–9.

    Article  Google Scholar 

  47. Pachman LM. Juvenile dermatomyositis: pathophysiology and disease expression. Pediatr Clin North Am. 1995;42:1071–97.

    Article  CAS  PubMed  Google Scholar 

  48. Ponec RJ, Hackman RC, McDonald GB. Endoscopic and histologic diagnosis of intestinal graft-versus-host disease after marrow transplantation. Gastrointest Endosc. 1999;49:612–21.

    Article  CAS  PubMed  Google Scholar 

  49. Rajaratnam R, Mann C, Balasubramaniam P, Marsden JR, Taibjee SM, Shah F, Lim R, Papini R, Moiemen N, Lewis H. Toxic epidermal necrolysis: retrospective analysis of 21 consecutive cases managed at a tertiary centre. Clin Exp Dermatol. 2010;35(8):853–62.

    Article  CAS  PubMed  Google Scholar 

  50. Revuz J, Penso D, Roujeau JC, Guillaume JC, Payne CR, Wechsler J, Touraine R. Toxic epidermal necrolysis. Clinical findings and prognosis factors in 87 patients. Arch Dermatol. 1987;123:1160–5.

    Article  CAS  PubMed  Google Scholar 

  51. Rodrigues F, Brand + úo N, Duque V, Ribeiro C, Ant + ¦nio AM. Herpes simplex virus esophagitis in immunocompetent children. J Pediatr Gastroenterol Nutr. 2004;39:560–3.

    Article  PubMed  Google Scholar 

  52. Sakuntabhai A, Ruiz-Perez V, Carter S, et al. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet. 1999;21(3):271–7.

    Article  CAS  PubMed  Google Scholar 

  53. Sawant P, Chopda N, et al. Oesophageal involvement in pemphigus vulgaris. Indian J Gastroenterol. 1994;13:133–4.

    CAS  PubMed  Google Scholar 

  54. Sawczenko A, Sandhu BK. Presenting features of inflammatory bowel disease in Great Britain and Ireland. Arch Dis Child. 2003;88:995–1000.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Scalapino K, Arkachaisri T, Lucas M, et al. Childhood onset systemic sclerosis: classification, clinical and serologic features, and survival in comparison with adult onset disease. J Rheumatol. 2006;33:1004–13.

    PubMed  Google Scholar 

  56. Serota FT, Rosenberg HK, Rosen J, et al. Delayed onset of gastrointestinal disease in the recipients of bone marrow transplants. A variant graft-versus-host reaction. Transplantation. 1982;34:60–4.

    Article  CAS  PubMed  Google Scholar 

  57. Shashidhar H, Integlia M, Grand RJ. Clinical manifestations of pediatric inflammatory bowel disease. In: Kirsner JB, editor. Inflammatory bowel disease. Philadelphia: WB Saunders; 2000. p. 326–41.

    Google Scholar 

  58. Sinha S, Schwartz RA. Juvenile acanthosis nigricans. J Am Acad Dermatol. 2007;57(3):502–8.

    Article  PubMed  Google Scholar 

  59. Sobol UA, Sherman KL, Smith J, et al. J Dermatol. 2009;48(10):1062–5.

    Google Scholar 

  60. Sonta T, Araki Y, Koubokawa M, Tamura Y, Ochiai T, Harada N, Chijiiwa Y, Nawata H. The beneficial effect of mesalazine on oesophageal ulcers in intestinal Behcet’s disease. J Clin Gastroenterol. 2000;30(2):195–9.

    Article  CAS  PubMed  Google Scholar 

  61. Takatoku M, Muroi K, Kawano-Yamamoto C, et al. Involvement of the esophagus and stomach as a first manifestation of varicella zoster virus infection after allogeneic bone marrow transplantation. Intern Med. 2004;43:861–4.

    Article  PubMed  Google Scholar 

  62. Terdiman JP, Linker CA, Ries CA, et al. The role of endoscopic evaluation in patients with suspected intestinal graft-versus-host disease after allogenic bone marrow transplantation. Endoscopy. 1996;28:680–5.

    Article  CAS  PubMed  Google Scholar 

  63. Terry HO, Brumfiled KA, Hoskin TL, et al. Dysphagia in inflammatory myopathy: clinical characteristics, treatment strategies and outcome in 62 patients. Mayo Clin Proc. 2007;82(4):441–7.

    Article  Google Scholar 

  64. Williams RB, Grehan MJ, Hersch M, Andree J, Cook IJ. Biomechanics, diagnosis, and treatment outcome in inflammatory myopathy presenting as oropharyngeal dysphagia. Gut. 2003;52:471–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Zimmer V, Buecker A, Lammert F. Gastroenterology. 2009;137(6):e1–2.

    Article  PubMed  Google Scholar 

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Protheroe, S. (2017). Dermatology and the Oesophagus. In: Till, H., Thomson, M., Foker, J., Holcomb III, G., Khan, K. (eds) Esophageal and Gastric Disorders in Infancy and Childhood. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11202-7_130

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  • DOI: https://doi.org/10.1007/978-3-642-11202-7_130

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