Skip to main content

Hair, Skin, and Nails in Patients with Laron Syndrome

  • Chapter
  • First Online:
Book cover Laron Syndrome - From Man to Mouse
  • 589 Accesses

Core Message

The hair of patients with Laron syndrome grows slowly and shows pathological features on electron microscopy. Young adults have sparse hair to alopecia.

The skin is thin and on histological examination shows changes in the elastin fibers. The appearance of acne is dependent on the sex hormone concentrations and the latter on the IGF-I dose during treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abramovici A, Josefsberg Z, Mimouni M, Liban E, Laron Z (1983) Histopathological features of the skin in hypopituitarism in Laron type dwarfism. Isr J Med Sci 19:515–519

    PubMed  CAS  Google Scholar 

  • Bean WB (1980) Nail growth. Thirty-five years of observation. Arch Intern Med 140:73–76

    Article  PubMed  CAS  Google Scholar 

  • Ben-Amitai D, Laron Z (2010) Effect of insulin-like growth ­factor-1 (IGF-1) deficiency or administration on the occurrence of acne. J Eur Acad Dermatol Venerol (in press)

    Google Scholar 

  • Blume-Peytavi U, Orfanos CE (1995) Microscopy of the hair. In: Seruo J, Jemec GBE (eds) Handbook of non-invasive methods and the skin. CRC Press, Boca Raton, pp 549–555

    Google Scholar 

  • Hogan PA (2006) Cutaneous manifestations of endocrine disease. In: Harper J, Orange A, Prose N (eds) Textbook of pediatric dermatology, vol 2. Blackwell, Malden, MA, pp 1–2013

    Google Scholar 

  • Itami S, Kurata S, Sonoda T, Takayasu S (1995) Interaction between dermal papilla cells and follicular epithelial cells in vitro: effect of androgen. Br J Dermatol 132:527–532

    PubMed  CAS  Google Scholar 

  • Klinger B, Jensen LT, Silbergeld A, Laron Z (1996) Insulin-like growth factor-I raises serum procollagen levels in children and adults with Laron syndrome. Clin Endocrinol 46:423–429

    Article  Google Scholar 

  • Laron Z (1969) The hypothalamus and the pituitary gland (hypophysis). In: Hubble D (ed) Paediatric endocrinology. Blackwell Scientific Publications, Oxford, p 76

    Google Scholar 

  • Laron Z (2004) Laron syndrome (primary growth hormone resistance or insensitivity). The personal experience 1958-2003. J Clin Endocrinol Metab 89:1031–1044

    Article  PubMed  CAS  Google Scholar 

  • Laron Z (2008) Insulin-like growth factor-I treatment of children with Laron syndrome (primary growth hormone insensitivity). Pediatr Endocrinol Rev 5:766–771

    PubMed  Google Scholar 

  • Laron Z, Pertzelan A, Karp M (1968) Pituitary dwarfism with high serum levels of growth hormone. Isr J Med Sci 4:883–894

    PubMed  CAS  Google Scholar 

  • Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-1) and type 1 IGF receptor (IGF-1r). Cell 75:59–72

    PubMed  CAS  Google Scholar 

  • Lurie R, Ben-Amitai D, Laron Z (2004) Laron syndrome (primary growth hormone insensitivity): a unique model to explore the effect of insulin-like growth factor 1 deficiency on human hair. Dermatology 208:314–318

    Article  PubMed  CAS  Google Scholar 

  • Melmed S, Kleinberg D (2003) Anterior pituitary. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS (eds) Williams textbook of endocrinology, 10th edn. Saunders/Elsevier, Philadelphia, p 235

    Google Scholar 

  • Peus D, Pittelkow MR (1996) Growth factors in hair organ development and the hair growth cycle. Dermatol Clin 14:559–572

    Article  PubMed  CAS  Google Scholar 

  • Philpott MP, Sanders DA, Kealey T (1994) Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro. J Invest Dermatol 102:857–861

    Article  PubMed  CAS  Google Scholar 

  • Randall VA (2007) Hormonal regulation of hair follicles exhibits a biological paradox. Semin Cell Dev Biol 18:274–285

    Article  PubMed  CAS  Google Scholar 

  • Randall VA (2008) The endocrine control of the hair follicle. In: Blume-Peytavi U, Tosti A, Whiting DA, Trueb RM (eds) Hair growth and disorders. Springer, Berlin-Heidelberg, pp 23–39

    Google Scholar 

  • Stenn KS, Combates NJ, Eilertsen KJ, Gordon JS, Pardinas JR, Parimoo S, Prouty SM (1996) Hair follicle growth controls. Dermatol Clin 14:543–558

    Article  PubMed  CAS  Google Scholar 

  • Tavakkol A, Elder JT, Griffiths CE, Cooper KD, Talwar H, Fisher GJ, Keane KM, Foltin SK, Voorhees JJ (1992) Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin. J Invest Dermatol 99:343–349

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zvi Laron .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Laron, Z. (2011). Hair, Skin, and Nails in Patients with Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-11183-9_24

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11182-2

  • Online ISBN: 978-3-642-11183-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics