Skip to main content
SpringerLink
Log in
Book cover

Laron Syndrome - From Man to Mouse pp 201–208Cite as

Ocular Findings in Laron Syndrome

  • Chapter
  • First Online:

  • 584 Accesses

Core Message

Ophthalmological investigations of untreated Laron syndrome patients revealed retarded growth of the ocular globe. The shorter anterior length of the anterior chamber was normalized by IGF-I treatment. The retinal vascularization was reduced as were the number of tortuosities of the arteries. Two patients with diabetes mellitus developed retinal neovascularization.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Alemany J, Borras T, de Pablo F (1990) Transcriptional stimulation of the delta 1-crystallin gene by insulin-like growth factor I and insulin requires DNA cis elements in chicken. Proc Natl Acad Sci U S A 87:3353–3357

    Article  PubMed  CAS  Google Scholar 

  • Benjamin B, Davey JB, Sheridan M, Sorsby A, Tanner JM (1957) Emmetropia and its aberations: a study in the correlation of the optical components of the eye. Spec Rep Ser Med Res Counc (G B) 11:1–69

    CAS  Google Scholar 

  • Bourla DH, Laron Z, Snir M, Lilos P, Weinberger D, Axer-Siegel R (2006) Insulinlike growth factor I affects ocular development: a study of untreated and treated patients with Laron syndrome. Ophthalmology 113(1197):e1–e5

    PubMed  Google Scholar 

  • Bourla DH, Bourla N, Axer-Siegel R (2007) Endocrine effects on the growth, development and function of the eye. Pediatr Endocrinol Rev 4:111–116

    Google Scholar 

  • Garner LF, Kinnear RF, McKellar M, Klinger J, Hovander MS, Grosvenor T (1988) Refraction and its components in Melanesian school-children in Vanuatu. Am J Optom Physiol Opt 65:182–189

    Article  PubMed  CAS  Google Scholar 

  • Garner LF, Meng CK, Grosvenor TP, Mohidin N (1990) Ocular dimensions and refractive power in Malay and Melanesian children. Ophthalmic Physiol Opt 10:234–238

    Article  PubMed  CAS  Google Scholar 

  • Harvey S, Baudet ML, Sanders EJ (2007) Growth hormone and developmental ocular function: clinical and basic studies. Pediatr Endocrinol Rev 5:510–515

    PubMed  Google Scholar 

  • Hellström A, Carlsson B, Niklasson A, Segnestam K, Boguszewski M, de Lacerda L, Savage M, Svensson E, Smith L, Weinberger D, Albertsson Wikland K, Laron Z (2002) IGF-I is critical for normal vascularization of the human retina. J Clin Endocrinol Metab 87:3413–3416

    Article  PubMed  Google Scholar 

  • Kusakari T, Sato T, Tokoro T (2001) Visual deprivation stimulates the exchange of the fibrous sclera into the cartilaginous sclera in chicks. Exp Eye Res 73:533–546

    Article  PubMed  CAS  Google Scholar 

  • Lang RA (1999) Which factors stimulate lens fiber cell differentiation in vivo? Invest Ophthalmol Vis Sci 40:3075–3078

    PubMed  CAS  Google Scholar 

  • Laron Z, Weinberger D (2004) Diabetic retinopathy, nephropathy and cardiovascular disease in a patient with GH gene deletion. Eur J Endocrinol 151:103–106

    Article  PubMed  CAS  Google Scholar 

  • Lin D, Boyle DL, Takemoto DJ (2003) IGF-I-induced phosphorylation of connexin 43 by PKCgamma: regulation of gap junctions in rabbit lens epithelial cells. Invest Ophthalmol Vis Sci 44:1160–1168

    Article  PubMed  Google Scholar 

  • Parentin F, Tonini G, Perissutti P (2004) Refractive evaluation in children with growth defect. Curr Eye Res 28:11–15

    Article  PubMed  Google Scholar 

  • Shirke S, Faber SC, Hallem E, Makarenkova HP, Robinson ML, Overbeek PA, Lang RA (2001) Misexpression of IGF-I in the mouse lens expands the transitional zone and perturbs lens polarization. Mech Dev 101:167–174

    Article  PubMed  CAS  Google Scholar 

  • Sorsby A, Leary GA (1969) A longitudinal study of refraction and its components during growth. Spec Rep Ser Med Res Counc (G B) 309:1–41

    CAS  Google Scholar 

  • Sorsby A, Benjamin B, Sheridan M, Stone J, Leary GA (1961) Refraction and its components during the growth of the eye from the age of three. Memo Med Res Counc 301:1–67

    PubMed  Google Scholar 

  • Stenstrom S (1948) Investigation of the variation and the correlation of the optical elements of human eyes. Am J Optom Arch Am Acad Optom 25:218–286, 340–388, 438–496

    Google Scholar 

  • Wong TY, Foster PJ, Johnson GJ, Klein BE, Seah SK (2002) The relationship between ocular dimensions and refraction with adult stature: the Tanjong Pagar Survey. Invest Ophthalmol Vis Sci 42:1237–1242

    Google Scholar 

  • Zadnik K, Manny RE, Yu JA, Mitchell GL, Cotter SA, Quiralte JC, Shipp M, Friedman NE, Kleinstein RN, Walker TW, Jones LA, Moeschberger ML, Mutti DO; Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group (2003) Ocular component data in school children as a function of age and gender. Optom Vis Sci 80:226–236

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, 49100, Petah Tikva, Israel

    Dan H. Bourla & Dov Weinberger

Authors
  1. Dan H. Bourla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dov Weinberger
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dan H. Bourla .

Editor information

Editors and Affiliations

  1. Endocrinology & Diabetes Research Unit, Schneider Children's Hospital, Kaplan Street 14, Petah Tikva, 49 202, Israel

    Zvi Laron

  2. Edison Biotechnology Institute, Ohio University, Athens, 45701, Ohio, USA

    J. Kopchick

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Berlin Heidelberg

About this chapter

Cite this chapter

Bourla, D.H., Weinberger, D. (2011). Ocular Findings in Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-11183-9_21

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-11182-2

  • Online ISBN: 978-3-642-11183-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation