Skip to main content

Epidemiology of Mesothelioma and Historical Background

  • Chapter
  • First Online:
Malignant Mesothelioma

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 189))

Abstract

Mesothelioma is a “new” malignant disease strongly associated with exposure to amphibole asbestos exposure (amosite and crocidolite) environmentally and in the work place. Nonetheless, in recent years, we have learned that many cases of mesothelioma are idiopathic, while some are caused by therapeutic irradiation or chronic inflammation in body cavities. This paper reviews the key epidemiological features of the malignancy in the context of the biological and mineralogical factors that influence mesothelioma development. These tumors challenge the diagnostic pathologist’s acumen, the epidemiologist’s skill in devising meaningful and definitive studies, the industrial hygienist’s knowledge of environmental hazards in diverse occupational settings, and the clinician’s skill in managing an intrepid and uniformly fatal malignancy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Anderson KA et al (1985) Malignant pleural mesothelioma following radiotherapy in a 16-year-old boy. Cancer 56:273

    Article  PubMed  CAS  Google Scholar 

  2. Armstrong BK et al (1984) Epidemiology of malignant mesothelioma in Western Australia. Med J Aust 141:86

    PubMed  CAS  Google Scholar 

  3. Armstrong BK et al (1988) Mortality in miners and millers of crocidolite in Western Australia. Br J Ind Med 45:5–13

    PubMed  CAS  Google Scholar 

  4. Artvinli M, Baris YI (1979) Malignant mesotheliomas in a small village in the Anatolian region of Turkey: an epidemiologic study. J Natl Cancer Inst 63:17

    PubMed  CAS  Google Scholar 

  5. Berman DW, Crump KS (2008) Technical support document for a protocol to assess asbestos-related risk. US Environmental Protection Agency publication. US Environmental Protection Agency, Washington, DC

    Google Scholar 

  6. Berman DW et al (1995) The sizes, shapes, and mineralogy of asbestos structures that induce lung tumors or mesothelioma in AF/HAN rats following inhalation. Risk Anal 15:181–195

    Article  PubMed  CAS  Google Scholar 

  7. Bianchi C et al (1993) Asbestos-related famililal mesothelioma. Eur J Cancer Prevent 2:247–250

    Article  CAS  Google Scholar 

  8. Bischoff F, Bryson G (1964) Carcinogenesis through solid state surfaces. Prog Exp Tumor Res 5:65

    Google Scholar 

  9. Bohlig H et al (1970) Epidemiology of malignant mesothelioma in Hamburg. Environ Res 3:365

    Article  Google Scholar 

  10. Bolen JW, Thorning D (1980) Mesotheliomas: a light and electronmicroscopical study concerning histogenetic relationships between the epithelial and the mesenchymal variants. Am J Surg Pathol 4:451

    Article  PubMed  CAS  Google Scholar 

  11. Brain JD (1989) The susceptible individual: an overview. In: Utell M (ed) Susceptibility to inhaled pollutants, ASTM Special Technical Publication. ASTM, Philadelphia

    Google Scholar 

  12. Brody AR, Overby LH (1989) Incorporation of tritiated thymidine by epithelial and interstitial cells in bronchiolar-alveolar regions of asbestos-exposed rats. Am J Pathol 134:133–140

    PubMed  CAS  Google Scholar 

  13. Buoen LC et al (1975) Foreign body tumorigenesis: in vitro isolation and expansion of preneoplastaic clonal cell populations. J Natl Cancer Inst 55:721

    PubMed  CAS  Google Scholar 

  14. Burdorf A et al (2007) Asbestos exposure and differences in occurrences of peritoneal mesothelioma between men and women across countries. Occup Environ Med 64:839–842

    Article  PubMed  CAS  Google Scholar 

  15. Chanhinian AP, Pass HI (2000) Malignant mesothelioma. In: Holland JC, Frei E (eds) Cancer medicine, 5th edn. BC Decker, Hamilton

    Google Scholar 

  16. Coggon D et al (1995) Differences in occupational mortality from pleural cancer, peritoneal cancer and asbestosis. Occup Environ Med 52:775–777

    Article  PubMed  CAS  Google Scholar 

  17. Craighead JE (1987) Current pathogenetic concepts of diffuse malignant mesothelioma. Hum Pathol 18:544–557

    Article  PubMed  CAS  Google Scholar 

  18. Craighead JE, Gibbs AR (2008) Asbestos and its diseases. Oxford University Press, New York

    Book  Google Scholar 

  19. Craighead J et al (1987) Biologic characteristics of asbestos-induced malignant mesothelioma in rats. Chest 91S:12–13

    Article  Google Scholar 

  20. Craighead JE et al (1993) Genetic factors influence malignant mesothelioma development in mice. Eur Respir Rev 3:118–120

    Google Scholar 

  21. Craighead JE et al (1993) The pathogenetic role of growth factors in human and rat malignant mesotheliomas. Eur Respir Rev 3(11):159–160

    Google Scholar 

  22. Dionne GP, Wang NS (1977) A scanning electron microscopic study of diffuse mesothelioma and some lung carcinomas. Cancer 40:707

    Article  PubMed  CAS  Google Scholar 

  23. Dodson RF et al (2005) Asbestos burden in cases of mesothelioma from individuals from various regions of the United States. Ultrastruct Pathol 29:415–433

    Article  PubMed  Google Scholar 

  24. Dogan AU et al (2006) Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey. Cancer Res 66:5063–5068

    Article  PubMed  CAS  Google Scholar 

  25. Dreessen WC et al. (1938) A study of asbestosis in the asbestos textile industry. Public Health Bulletin 241. US Treasury Department, Public Health Service

    Google Scholar 

  26. Edge JR (1976) Asbestos related disease in Barrow-in-Furness. Environ Res 11:244–247

    Article  PubMed  CAS  Google Scholar 

  27. Enterline PE (1983) Cancer produced by nonoccupational asbestos exposure in the United States. J Air Pollut Control Assoc 33:318–322

    Article  PubMed  CAS  Google Scholar 

  28. Ferrante D et al (2007) Cancer mortality and incidence of mesothelioma in a cohort of wives of asbestos workers in Casale Monferranto, Italy. Environ Health Perspect 115:1401–1405

    PubMed  Google Scholar 

  29. Fischbein A, Rohl AN (1985) Pleural mesothelioma and neighborhood asbestos exposure. JAMA 252:86

    Article  Google Scholar 

  30. Fleischer WE et al (1946) A health survey of pipe covering operations in constructing naval vessels. J Ind Hyg Toxicol 28:9

    PubMed  CAS  Google Scholar 

  31. Goldberg S, Rey G, Luce D et al (2010) Possible effect of environmental exposure to asbestos on geographical variation in mesothelioma rates. Occup Environ Med 67(6):417–421

    Article  PubMed  Google Scholar 

  32. Greenberg M, Davies TA (1974) Mesothelioma register 1967–1968. Br J Ind Med 31:91

    PubMed  CAS  Google Scholar 

  33. Grundy GW, Miller RW (1972) Malignant mesothelioma in childhood. Cancer 30:1216

    Article  PubMed  CAS  Google Scholar 

  34. Haries PG (1976) Experience with asbestos disease and its control in Great Britain’s naval dockyards. Environ Res 11:261–267

    Article  Google Scholar 

  35. Heintz NH et al (2010) Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. Am J Respir Cell Mol Biol 42:133–139

    Article  PubMed  CAS  Google Scholar 

  36. Hillerdal G (1999) Mesothelioma: cases associated with non-occupational and low dose exposures. Occup Environ Med 56:505–513

    Article  PubMed  CAS  Google Scholar 

  37. Hodgson JT, Darnton A (2000) The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure. Ann Occup Hyg 44:565–601

    PubMed  CAS  Google Scholar 

  38. Hodgson JT, Darnton A (2010) Mesothelioma risk from chrysotile. Occup Environ Med 67:432

    Article  PubMed  CAS  Google Scholar 

  39. Kannerstein M, Churg J (1979) Functions of mesothelioma panels. Ann NY Acad Sci 330:433

    Article  PubMed  CAS  Google Scholar 

  40. Karn CM et al (1994) Cardiac synovial sarcoma with translocation (X; 18) associated with asbestos exposure. Cancer 73:74–78

    Article  PubMed  CAS  Google Scholar 

  41. Klemperer P, Rabin CB (1931) Primary neoplasms of the pleura. A report of five cases. Arch Pathol 11:385

    Google Scholar 

  42. Kurumatani N, Kumagai S (2008) Mapping the risk of mesothelioma due to neighborhood asbestos exposure. Am J Respir Crit Care Med 178:624–629

    Article  PubMed  Google Scholar 

  43. Lidar M et al (2002) Thoracic and lung involvement in familial Mediterranean fever (FMF). Clin Chest Med 23:505–511

    Article  PubMed  Google Scholar 

  44. Loomis D et al (2009) Lung cancer mortality and fibre exposures among North Carolina asbestos textile workers. Occup Environ Med 66:535–542

    Article  PubMed  Google Scholar 

  45. Luo S et al (2003) Asbestos related diseases from environmental exposure to crocidolite in Da-yao, China. I. Review of exposure and epidemiological data. Occup Environ Med 60:35–42

    Article  PubMed  CAS  Google Scholar 

  46. Lynch HT et al (1985) Familial mesothelioma: review and family study. Cancer Genet Cytogenet 15:25

    Article  PubMed  CAS  Google Scholar 

  47. Mack TM (1995) Sarcomas and other malignancies of soft tissue, retroperitoneum, peritoneum, pleura, heart, mediastinum, and spleen. Cancer 75:211–244

    Article  PubMed  CAS  Google Scholar 

  48. Marchand PE (1991) The discovery of mesothelioma in the Northwestern Cape Province in the Republic of South Africa. Am J Ind Med 19:241–246

    Article  PubMed  CAS  Google Scholar 

  49. Martensson G et al (1984) Malignant mesothelioma in two pairs of siblings: is there a hereditary predisposing factor? Eur J Respir Dis 65:179

    PubMed  CAS  Google Scholar 

  50. Maule MM et al (2007) Modeling mesothelioma risk associated with environmental asbestos exposure. Environ Health Perspect 115:1066–1071

    Article  PubMed  CAS  Google Scholar 

  51. Maurer R, Egloff B (1975) Malignant peritoneal mesothelioma after cholangiography with thorotrast. Cancer 36:1381

    Article  PubMed  CAS  Google Scholar 

  52. Maximow A (1927) Morphology of the mesenchymal reactions. Arch Pathol 4:557–606

    Google Scholar 

  53. Maximow A (1927) Uber das mesothel (deckzellen der serosen haute) und die zellen der serosen exsudate. Untersuchungen an entzundetem Gewebe und an Gewebskulturen. Arch Exp Zellforsch 4:1

    Google Scholar 

  54. McDonald JC et al (1999) Editorial: chrysotile, tremolite and fibrogenicity. Ann Occup Hyg 43(7):439–442

    PubMed  CAS  Google Scholar 

  55. McQualter JL et al (2010) Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung. Proc Natl Acad Sci 107(4):1414–1419

    Article  PubMed  CAS  Google Scholar 

  56. Merewether ERA (1934) A memorandum on asbestosis. Tubercle 75:69–81, 109–118, 152–159

    Google Scholar 

  57. Merewether ERA, Price CW (1930) Report on the effects of asbestos dust on the lungs and dust suppression in the asbestos industry. Her Majesty’s Stationery Office, London

    Google Scholar 

  58. Mossman BT et al (1986) Alteration of superoxide dismutase activity in tracheal epithelial cells by asbestos and inhibition of cytotoxicity by antioxidants. Lab Invest 54:204

    PubMed  CAS  Google Scholar 

  59. Murphy RLH et al (1972) Low exposure to asbestos. Gas exchange in ship pipe coverers and controls. Arch Environ Health 25:253

    PubMed  Google Scholar 

  60. Newhouse ML, Thompson H (1965) Epidemiology of mesothelial tumors in the London area. Ann NY Acad Sci 132:579–588

    Article  PubMed  CAS  Google Scholar 

  61. Rees D et al (2001) Asbestos lung fibre concentrations in South African chrysotile mine workers. Ann Occup Hyg 45:473–477

    PubMed  CAS  Google Scholar 

  62. Reid A et al (2007) Age and sex differences in malignant mesothelioma after residential exposure to blue asbestos (crocidolite). Chest 131:376–382

    Article  PubMed  Google Scholar 

  63. Riddell RH et al (1981) Peritoneal malignant mesothelioma in a patient with recurrent peritonitis. Cancer 48:134

    Article  PubMed  CAS  Google Scholar 

  64. Risberg B et al (1980) Familial clustering of malignant mesothelioma. Cancer 45:2422

    Article  PubMed  CAS  Google Scholar 

  65. Roggli VL et al (1997) Malignant mesothelioma in women. Anat Pathol 2:147–163

    PubMed  CAS  Google Scholar 

  66. Rovario GC et al (1982) The association of pleural mesothelioma and tuberculosis. Am Rev Respir Dis 126:569

    Google Scholar 

  67. Sebastien P, McDonald JC (1997) Mesothelioma in Quebec chrysotile miners and millers: epidemiology and aetiology. Ann Occup Hyg 41(6):707–719

    PubMed  Google Scholar 

  68. Sheers G (1980) Mesothelioma risks in a naval dockyard. Arch Environ Health 35:276–282

    Article  PubMed  CAS  Google Scholar 

  69. Sheers G, Templeton AR (1968) Effects of asbestos in dockyard workers. Br Med J 11:574

    Article  Google Scholar 

  70. Spirtas R et al (1994) Malignant mesothelioma: attributable risk of asbestos exposure. Occup Environ Med 51:804–811

    Article  PubMed  CAS  Google Scholar 

  71. Stanton MF, Wrench C (1978) Mechanisms of mesothelioma induction with asbestos and fibrous glass. J Natl Cancer Inst 48:797

    Google Scholar 

  72. Stock RJ et al (1979) Malignant peritoneal mesothelioma following radiotherapy for seminoma of the testis. Cancer 44:914

    Article  PubMed  CAS  Google Scholar 

  73. Stout AP, Murray MR (1942) Localized pleural mesothelioma: investigation of its characteristics and histogenesis by the method of tissue culture. Arch Pathol 34:951

    Google Scholar 

  74. Stumphius J (1971) Epidemiology of mesothelioma on Waicheren Island. Br J Ind Med 28:59

    PubMed  CAS  Google Scholar 

  75. Suzuki Y et al (1976) Ultrastructure of human malignant diffuse mesothelioma. Am J Pathol 85:241

    PubMed  CAS  Google Scholar 

  76. Tagnon I et al (1980) Mesothelioma associated with the shipbuilding industry in coastal Virginia. Cancer Res 40:3875

    PubMed  CAS  Google Scholar 

  77. Timbrell V (1965) The inhalation of fibrous dusts. Ann NY Acad Sci 132:255

    Article  PubMed  CAS  Google Scholar 

  78. Tossavainen A (2004) Global use of asbestos and the incidence of mesothelioma. Int J Occup Environ Health 10:22–25

    PubMed  Google Scholar 

  79. Wagner E (1870) Das tuberkelahnliche lymphadenom (der cytogene oder reticulierte Tuberkel). Arch Heilk 11:497

    Google Scholar 

  80. Wagner JC (1991) The discovery of the association between blue asbestos and mesotheliomas and the aftermath. Br J Ind Med 48:399–403

    PubMed  CAS  Google Scholar 

  81. Wagner JC, Sleggs CA, Marchand P (1960) Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province. Br J Ind Med 17:260

    PubMed  CAS  Google Scholar 

  82. Webster I (1973) Asbestos and malignancy. S Afr Med J 47:165

    PubMed  CAS  Google Scholar 

  83. Wedler HW (1943) Asbetsose und lungenkrebs bei asbestoste. Dtsch Arch Klin Med 191:189

    Google Scholar 

  84. Wedler HW (1943) Asbetsose und lungenkrebs. Dtsch Med Wochenschr 69:575

    Article  Google Scholar 

  85. Whitwell F, Rawcliffe RM (1971) Diffuse malignant pleural mesothelioma and asbestos exposure. Thorax 26:6–22

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J. E. Craighead .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Craighead, J.E. (2011). Epidemiology of Mesothelioma and Historical Background. In: Tannapfel, A. (eds) Malignant Mesothelioma. Recent Results in Cancer Research, vol 189. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-10862-4_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-10862-4_2

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-10861-7

  • Online ISBN: 978-3-642-10862-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics