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Comparative and Veterinary Pharmacogenomics

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Book cover Comparative and Veterinary Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 199))

Abstract

Pharmacogenomics is the study of the impact of genetic variation on drug effects, with the ultimate goal of achieving “personalised medicine”. Since the completion of the Human Genome Project, great strides have been made towards the goal of personalised dosing of drugs in people, as exemplified by the development of gene-guided dosing of the anticoagulant drug, warfarin. Although the pharmacogenomics of domestic animals is still at an early stage of development, there is great potential for advances in the coming years as the direct result of complete genome sequences currently being derived for many of the species of significance to veterinary and comparative medicine. This sequence information is being used to discover sequence variants in candidate genes associated with altered drug response, as well as to develop whole genome high density single nucleotide polymorphism arrays for genotype–phenotype linkage analysis. This review summarises the current state of veterinary pharmacogenomics research, including drug response variability phenotypes with either known genetic aetiology or strong circumstantial evidence for genetic involvement. Polymorphisms and rarer gene variants affecting drug disposition (pharmacokinetics) and drug effect (pharmacodynamics) are discussed. In addition to providing the veterinary clinician with useful information for the practise of therapeutics, it is envisaged that the increasing knowledge base will also provide a resource for individuals involved in veterinary and comparative biomedical research.

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  1. Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA

    Carrie M. Mosher & Michael H. Court

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  1. Carrie M. Mosher
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  2. Michael H. Court
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Correspondence to Michael H. Court .

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  1. Dept. Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom

    Fiona Cunningham

  2. Dept. Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom

    Jonathan Elliott

  3. Dept. Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom

    Peter Lees

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Mosher, C.M., Court, M.H. (2010). Comparative and Veterinary Pharmacogenomics. In: Cunningham, F., Elliott, J., Lees, P. (eds) Comparative and Veterinary Pharmacology. Handbook of Experimental Pharmacology, vol 199. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-10324-7_3

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