Abstract
Irreversible electroporation (IRE) and electrochemotherapy are two electroporation-based antitumor treatments, both relying on the delivery of short electric pulses of a typical duration of 100 microseconds. Constant current, radiofrequency electromagnetic fields and other types of pulses are also used in the clinics or are tested in preclinical trials. In electrochemotherapy, cell reversible electropermeabilization allows the uptake of non-permeant or low-permeant anticancer drugs and the tumor cells killer is the drug. In IRE, the killer is the electric field which irreversibly perturbs membranes structure and cells homeostasis. The characteristics of IRE and electrochemotherapy are compared, showing the differences and the complementarities of these two antitumor approaches.
Abbreviations: IRE: Irreversible electroporation, ECT: electrochemotherapy, SOP: Standard Operating Procedures.
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Mir, L.M. (2010). The Place of the Electroporation-Based Antitumor Therapies in the Electrical Armamentarium against Cancer. In: Rubinsky, B. (eds) Irreversible Electroporation. Series in Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05420-4_9
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DOI: https://doi.org/10.1007/978-3-642-05420-4_9
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