Abstract
Iraq occupies the northeastern corner of the Arab world; Iran lies to the East and Turkey lies to the North (Fig. 10.1). Its total land surface is 438,000 km2. The northern part is mountainous; the central region is occupied by the Tigris–Euphrates Plain; the south is characterized by marshes; and deserts predominate in the west.
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References
Abboud M (1993) Aminoacidopathies among Iraqi children suspected with inborn errors of metabolism. J Fac Med Baghdad 35(2):57–60
Abdullah NF (1976) Human blood groups in Basrah. Man (NS) 11:239–242
Abdullah NF (1981) Distribution of blood groups among the Iraqi Arabs. J Fac Med Baghdad 23(4):453–472
Ahmad RA, Taha IA (1983) Acetylation in Iraqi population. Iraqi Med J 31:53–57
Al-Agidi SK, Papiha SS, Roberts DF (1977) Immunoglobulin levels in Iraq. Clin Exp Immunol 29(2):247–255
Al-Alami JR, Tayeh MK, Najib DA, Abu-Rubaiha ZA, Majeed HA, Al-Khateeb MS, El-Shanti HI (2003) Familial Mediterranean fever mutation frequencies and carrier rates among a mixed Arabic population. Saudi Med J 24(10):1055–1059
Al-Allaf A, Ali A, Muneer M (2003) Deafness in chilren and the need for cochlear implants. J Bahrain Med Soc 15(4):219–222
Al-Allawi N, Al-Dousky A. Frequency of Hemoglobinopathies and Service Indicators for their Preventive Program in the Dohuk Governerate-Iraq. Accepted for publication in East Mediterr Health J
Al-Allawi N, Badi A, Imanian H, Nikzat N, Jubrael J, Najmabadi H (2009) Molecular characterization of α-thalassemia in the Dohuk region of Iraq. Haemoglobin 33(1):37–44
Al-Allawi N, Jubrael J, Baban N, Gedeon G. Thrombophilic Mutations in Blood Donors in Dohuk- Iraq. Personal communication
Al-Allawi N, Jubrael J, Hilmi F (2004) Factor V Leiden in Blood Donors in Baghdad (Iraq). Clin Chem 50(3):677–678
Al-Allawi NA, Jubrael JM, Hughson M (2006) Molecular characterization of beta-thalassemia in the Dohuk region of Iraq. Hemoglobin 30(4):479–486
Al-Azzawi HT, Al-Salihi AR, Saleem IH, Fadhli AA, Zaidan ZA (1987) alpha Naphthyl acetate esterase activity in monocytes and lymphocytes of normal and muscular dystrophic individuals. Iraqi Med J 35(1):19–24
Al-Ani S, El Sebai HF (1994) Gross congenital malformations in neonates in Ramadi city during the year 1990: types, incidence, and possible teratogens J. Fac Med Baghdad 36(4):609–614
Al-Gazali L, Hamamy H, Al-Arrayad S (2006) Genetic disorders in the Arab world. BMJ 333(7573):831–834
Al-Hadithi F, Al Saleem T (1991) Ocular manifestations of xeroderma pigmentosa in Iraq. Saudi J Ophthalmol 5(1):6–8
Al-Hakeem S, Hamamy H (1992) Genetic studies on institutionalized mentally retarded males with special reference to the FragileX syndrome. Extracted from MSc Thesis, Al-Mustansiriya Medical College, Baghdad
Al-Hassani M (1977) Cystic fibrosis in Iraqi children. J Trop Paed 23:36–137
Al-Helo S, Taghi AS, Mahboba S (2008) Unusual case of accessory nose associated with unilateral complete congenital choanal atresia. Saudi Med J 29(9):1342–1343
Al-Huwaizi F (1987) Waardenburg’s syndrome in an Iraqi family. J Fac Med Baghdad 29(1):81–85
Al-Huwaizi F (1990) Pendred’s syndrome in eleven Iraqi patients. Pendred’s syndrome in eleven Iraqi patients. J Community Med 3(2):123–126
Al-Jadiry A, Rustam H, Al-Saleem T, Ismail MA (1987) Xeroderma pigmentosum. Saudi med J 8:468–475
Ali MM, Shah IH (2000) Sanctions and childhood mortality in Iraq. Lancet 355(9218):1851–1857
Al-Kasab F (1980) Sickle cell disease in southern Iraq. Med J Basrah Univ 3(2):25–38
Al-Kasab F, Al-Kafajei A, Kutty P, Al-Windawi S, Antony R, Zuabie A, Al-Septi S (1987) Hematological profile of women in the reproductive age in southern Iraq. Iraqi Med J 35(1):33–38
Al-Kasab FM, Alkafajei AM, Medbigh SH (1979) The prevalence of diabetes mellitus in a rural community in Iraq. Int J Epidemiol 8(1):69–71
Al-Khafaji SD, Al-Rubeai MA (1976) The frequencies of the ABO and Rh(D) blood groups in the Kurdish population of Iraq. Ann Hum Biol 3(2):189–191
Al-Khaidhaire S (1994) A new concept in diagnosis of osteogenesis imperfecta. J Fac Med Baghdad 36(2):225–229
Al-Khatib A, Abdul Hadi T (1995) Squamous cell carcinoma of the skin of face in patients with xeroderma pigmentosum. J Fac Med Baghdad 37(3):397–400
Al-Kanani S (1990) Childhood blindness in Iraq J Fac Med Baghdad 32(1):103–108
Al-Mefraji SH (2008) May-Jun. Alkaptonuria in a 5-year-old boy in Iraq. East Mediterr Health J 14(3):745–746
Al-Mefraji SH, Al-Tawil NG, Karim LA (2006) Anthropometric measurements of a group of newborns in a teaching hospital in Baghdad. Saudi Med J 27(6):870–873
Al-Mosawi AJ (2006) Genetic drift. Letter from Baghdad: Coffin–Siris syndrome in a girl with absent kidney. Am J Med Genet 140(16):1789–1790
Al-Mosawi AJ (2002) The etiology of chronic renal failure in 54 Iraqi children. Pediatr Nephrol 17(6):463–464
Al-Naama MM, al-Naama LM, al-Sadoon TA (1994) Glucose-6-phosphate dehydrogenase, hexokinase and pyruvate kinase activities in erythrocytes of neonates and adults in Basrah. Ann Trop Paediatr 14(3):195–200
Al-Naama L, Al-Gailany K, Al-Kaysi G (1984) Human erythrocytes glucose 6-phosphate dehydrogenase and 6-phosphogluconate in Basrah area. J Fac Med Baghdad 26(1):101–109
Al-Nadawi M, Atra A (1984) Congenital nephrotic syndrome. J Fac Med Baghdad 26(3):97–102
Al-Rawi F, Al Naddawi M, Al Musawi Z (1986) Mental retardation in Iraqi children. J Fac Med Baghdad 28(4):29–36
Al-Samarrai AH, Adaay MH, Al-Tikriti KA, Al-Anzy MM (2008) Evaluation of some essential element levels in thalassemia major patients in Mosul district, Iraq. Saudi Med J 29(1):94–97
Al-Shawi TS (1988) A study of Sickle Cell Disease in young adult males in Iraq. MSc thesis. College of Medicine, University of Baghdad, Iraq
Al-Shawk S, Mathur S, Al Nasiri N (1983) Peutz-Jeghers syndrome presenting with hypoproteinemia: a case report and review of the literature. Iraqi Med J 31:121–128
Al-Saleem T, Abulkiel A, Sabri Z, Alash N. (1984) Skin cancer in Iraq. J Fac Med Baghdad 28:29–36
Al-Sharbati MM, Al-Chalabi TS, Rummani SF (1993) School screening for scoliosis in Baghdad. Saudi Med J 14:298–302
Al-Taha S (1996) A survey of a genetic clinic patients for chromosomal, genetic syndromes and congenital malformations as detected by clinical and chromosomal studies1989–90vs 1992–93. J Fac Med Baghdad 38(2):137–140
Al-Talabani N, Gataa IS, Latteef SA (2008) Bilateral agenesis of parotid salivary glands, an extremely rare condition: report of a case and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105(3):e73–e75
Al-Thamery D (1999) Frequency of mental retardation in a private paediatric clinic in Baghdad. Ann Coll Med Mosul 25(1–2):35–40
Alwan A, King H (1992) Diabetes in the eastern Mediterranean region. World Health Stat Q 45(4):355–359
Alwan AA, Al-Tahafi NA, Saleh AM (1982) Studies on the prevalence of hypertension in Iraqi rural and urban communities. Iraqi Med J 29–30:61–70
Alwan A, Shamdeen L (1989) Clinical Presentation of Iraqi diabetes in Iraq. Proceedings of the second Scientific Research exhibition, Ministry of higher education and Scientific Research, Baghdad
Alwan AA (1993) Cardiovascular diseases in the eastern Mediterranean region. World Health Stat Q 46(2):97–100
Alwan A, Modell B (2003) Recommendations for introducing genetics services in developing countries. Nat Rev Genet 4:61–68
Al-Wattar KM (2003) Congenital prepubic sinus: an epispadiac variant of urethral duplication: case report and review of literature. J Pediatr Surg 38(4):E18
Al-Windawi S, Al Naama L (1984) Acute intermittent porphyria: 2 cases from Southern Iraq. J Fac Med Baghdad 26(4):85–91
Al-Yazachi MB (1986) Gorlin syndrome, Naevoid basal cell carcinoma. J Fac Med baghdad 28:69–76
Amin-Zaki L, el-Din ST, Kubba K (1972) Glucose-6-phosphate dehydrogenase deficiency among ethnic groups in Iraq. Bull World Health Organ 47(1):1–5
Al-Zubaidee A, Hammash M (1997) Cleft lip and palate in children of Baghdad’s Al-Resafa schools. J Fac Med Baghdad 39(1):53–60
Bakir F, Murtadha M (1975) Periodic peritonitis. Report of 41 cases without amyloidosis. Trans R Soc Trop Med Hyg 69(1):111–117
Bakir F, Murtadha M, Issa N (1979) Amyloidosis and Periodic Peritonitis (Familial Mediterranean Fever). West J Med 131(3):193–195
Balow JE Jr, Shelton DA, Orsborn A, Mangelsdorf M, Aksentijevich I, Blake T, Sood R, Gardner D, Liu R, Pras E, Levy EN, Centola M, Deng Z, Zaks N, Wood G, Chen X, Richards N, Shohat M, Livneh A, Pras M, Doggett NA, Collins FS, Liu PP, Rotter JI, Kastner DL et al (1997) High-resolution genetic map of the familial Mediterranean fever candidate region allows identification of haplotype-sharing among ethnic groups. Genomics 44(3):280–291
Baraitser M, Burn J (1983) Recessively inherited brachydactyly type C. J Med Genet 20:128–129
Barakat MH, Karnik AM, Majeed HW, el-Sobki NI, Fenech FF (1986) Familial Mediterranean fever (recurrent hereditary polyserositis) in Arabs—a study of 175 patients and review of the literature. Q J Med 60(233):837–847
Bashir F, Al Taee M (1988) Congenital methemoglobinemia due to haemoglobinopathy-M. Jordan Med J 21(1):61–68
Beales PL, Katsanis N, Lewis RA, Ansley SJ, Elcioglu N, Raza J, Woods MO, Green JS, Parfrey PS, Davidson WS, Lupski JR (2001) Genetic and mutational analyses of a large multiethnic Bardet-Biedl cohort reveal a minor involvement of BBS6 and delineate the critical intervals of other loci. Am J Hum Genet 68:606–616
Bittles AH, Mason WM, Greene J, Rao NA (1991) Reproductive behavior and health in consanguineous marriages. Science 252(5007):789–794
Bittles AH, Grant JC, Shami SA (1993) Consanguinity as a determinant of reproductive behaviour and mortality in Pakistan. Int J Epidemiol 22(3):463–467
Børglum AD, Balslev T, Haagerup A, Birkebaek N, Binderup H, Kruse TA, Hertz JM (2001) A new locus for Seckel syndrome on chromosome 18p11.31–q11.2. Eur J Hum Genet 9(10):753–757
Christianson A, Howson C, Modell B (2006) Global Report on Birth Defects. The Hidden Toll of Dying and Disabled Children. White Plains, N.Y, March of Dimes Birth Defects Foundation
CIA World Factbook https://www.cia.gov/library/publications/the-world-factbook/geos/iz.html
Cundy T, Hegde M, Naot D, Chong B, King A, Wallace R, Mulley J, Love DR, Seidel J, Fawkner M, Banovic T, Callon KE, Grey AB, Reid IR, Middleton-Hardie CA, Cornish J (2002) A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Hum Mol Genet 11:2119–2127
Deutsch S, Darbellay R, Offord R, Frutiger A, Kister J, Wajcman H, Beris P (1999) Hb Iraq-Halabja beta10 (A7) Ala–>Val (GCC–>GTC): a new beta-chain silent variant in a family with multiple Hb disorders. Am J Hematol 61(3):187–193
El Hassani N, Al Ani H, Al Naaman Y (1981) Kartagener’s syndrome [a report of six cases]. J Fac Med Baghdad 23(3):313–322
Emery A, Mueller R (1992) Elements of medical genetics. Churchill Livingstone, Edinburgh
Farman N, Shakir A (1976) Karyotypic analysis of 150 cases of Down’s syndrome in Iraq. J Ment Def Res 20:83–87
Fensom AH, El Kalla S, Bizzari R, Fahmy NA, Semrin A, Benson PF, Shubbar AI (1990) Clinical Presentation and Diagnosis of Niemann- Pick Disease Type C. Emirates Med J 8:215–219
Habeeb S, Al-Sadoon I (1995) The incidence of congenital malformation and associated risk factors in Basrah city. J Fac Med Baghdad 37(4):520–526
Hamamy H, Al-Bayati N, Al-Kubaisy W (1986) Consanguineous marriages in Iraqi urban population and the effect on pregnancy outcome and infant mortality. Iraqi Med J 34:76–80
Hamamy H, Alwan A (1994) Hereditary disorders in the Eastern Mediterranean Region. Bull World Health Organ 72(1):145–154
Hamamy H, Bittles A (2008) Genetic Clinics in Arab Communities: Meeting Individual, Family and Community Needs. Public Health Genomics 12(1):10.1159/000153428
Hamamy H, Shubber EK, al-Allak BM (1992) Sister chromatid exchange frequencies in a group of individuals with unfavorable reproductive health. Eur J Obstet Gynecol Reprod Biol 43(1):45–49
Hamamy H, Al-Taha S (1989a) Cytogenetic Investigations in a Referred Population of Azoospermic Males. J Fac Med Baghdad 31(3):311–315
Hamamy H, Al-Taha S (1989b) Cytogenetic Investigations in 201 Females with Primary Amenorrhea. J Fac Med Baghdad 31(3):317–322
Hamamy H (1984) Chromosome Studies and Genetic Counseling in Iraq: One Year’s Experience. Saudi Med 5:46–52
Hamamy H (1989) Genetic factors and congenital malformations. Proceedings of the Fifth Conference of the Scientific Research Council, Baghdad 5(2):1–8
Hamamy HA, al-Hakkak ZS, al-Taha S (1990) Consanguinity and the genetic control of Down syndrome. Clin Genet 37(1):24–29
Hamamy HA, al-Hakkak ZS (1989) Consanguinity and reproductive health in Iraq. Hum Hered 39(5):271–275
Hamamy HA, Saeed TK (1981) Glucose-6-phosphate dehydrogenase deficiency in Iraq. Hum Genet 58(4):434–435
Harbord MG, Harden A, Harding B, Brett EM, Baraitser M (1990) Megalencephaly with dysmyelination, spasticity, ataxia, seizures and distinctive neurophysiological findings in two siblings. Neuropediatrics 21:164–168
Harith A (1990) The aetiological contribute to severe sensorineural hearing impairment in children. J Community Med 3(2):111–121
Hassan MK, Taha JY, Al-Naama LM, Widad NM, Jasim SN (2003) Frequency of haemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in Basra. East Mediterr Health J 9(1–2):45–54
Hilmi FA, Al-Allawi NA, Rassam M, Al-Shamma G, Al-Hashimi A (2002) Red cell glucose-6-phosphate dehydrogenase phenotypes in Iraq. East Mediterr Health J 8(1):42–48
Hussien H, Jamil H (1993) The prevalence rate of hypertension among a group of industrial population-Iraq. J Community Med 6(1):51–55
Ikin EW, Mourant AE, Lehman H (1965) The blood groups and hemoglobin of the Assyrians of Iraq. Man 65:110–111
Jalal S, Al-Allawi N, Faraj A, Ahmed N (2008) Prevalence of hemoglobinopathies in Sulaimani-Iraq. Dohuk Med J 2(1):17–79
Jamil L, Yaldo M, Jamil H (1994) A study of the prevalence rate of obvious eye diseases in Baghdad city-Iraq. J Fac Med Baghdad 36(4):671–676
Kheder HH, Bashir FZ (1990) Beta thalassemia trait in Mosul. Saudi Med J 11(6):460–462
Kramer SN (1967) Editors of time-life books. Time-Life Books, New York, Cradle of Civilizations
Mahdi A (1992) Consanguinity and its effect on major congenital malformations. Iraqi Med J 40–42:170–176
Mansour AA (2008) Patients’ opinion on the barriers to diabetes control in areas of conflicts: The Iraqi example. Confl Health 2:7
Mansour AA, Wanoose HL, Hani I, Abed-Alzahrea A, Wanoose HL (2008) Diabetes screening in Basrah, Iraq: a population-based cross-sectional study. Diabetes Res Clin Pract 79(1):147–150
Mansour AA (2003) Influence of sickle hemoglobinopathy on growth and development of young adult males in Southern Iraq. Saudi Med J 24(5):544–546
Megarbane A, Ruchoux MM, Loeys B, Ayoub N, Nuytinck L (2001) Short stature, abnormal face, joint laxity, dislocation, hernias, delayed bone age, and severe psychomotor retardation in two brothers: previously undescribed MCA/MR syndrome. Am J Med Genet 104(3):221–224
Mourant AE, Kopec AC, Domaniewska-Sobczak K (1976) The distribution of the human blood groups and other polymorphism. Oxford University Press, London
Abed M, Waad Allah S (1992) The prevalence of diabetes mellitus in a rural community in Northern Iraq. Med J Basrah Univ 10(1–2):63–69
Nagi NA (1979) Diabetes insipidus, diabetes mellitus, optic atrophy and deafness. A clinical and genetic study. Postgrad Med J 55(644):377–380
Najim RA, Al-waizt M, Al-Razzuqi RA (2005) Acetylator phenotype in Iraqi patients with allergic contact dermatitis. Ann Saudi Med 25(6):473–476
Nasheit NA (2003) Perinatal and neonatal mortality and morbidity in Iraq. J Matern Fetal Neonatal Med 13(1):64–67
Nasir GA, Rahma S, Kadim AH (2000) Neonatal intestinal obstruction. East Mediterr Health J 6(1):187–193
Rofoo F, Hashim H, Al Jaff H (1995) Disribution of ABO and RH blood group systems among Arbil population. Zanco J Med Sci 2(1):21–25
Roux G (1980) Ancient Iraq. Penguin Books, London
Saeed TK, Hamamy HA, Alwan AA (1985) Association of glucose-6-phosphate dehydrogenase deficiency with diabetes mellitus. Diabet Med 2(2):110–112
Safar S, Sawa T (1992) Gardner’s syndrome: the place of colectomy in the management: a study of two families. J Fac Med Baghdad 34(4):453–460
Saleem M, Mahmoud N (1988) Distribution of A B O and Rh D blood group systems among Mosul population. Ann Coll Med Mosul 14(1):61–65
Sarsam H, Izzat M (1986) Short stature in Iraq. J Fac Med Baghdad 28(4):37–47
Schaffer JV, Bazzi H, Vitebsky A, Witkiewicz A, Kovich OI, Kamino H, Shapiro LS, Amin SP, Orlow SJ, Christiano AM (2006) Mutations in the desmoglein 4 gene underlie localized autosomal recessive hypotrichosis with monilethrix hairs and congenital scalp erosions. J Invest Dermatol 126(6):1286–1291
Schmidt H, Rudolph G, Hergersberg M, Schneider K, Moradi S, Meitinger T (2001) Retinal detachment and cataract, facial dysmorphism, generalized osteoporosis, immobile spine and platyspondyly in a consanguinous kindred–a possible new syndrome. Clin Genet 59(2):99–105
Shah G, Sattar N (1981) The incidence of phenyl thiocarbamide [PTC] taste threshold and sensitivity in Iraqi Arabs. Med J Basrah Univ 4(2):121–131
Shahar E, Brand N, Shapira Y, Barash V, Gutman A (1988) Familial carnitine deficiency: further evidence for autosomal recessive transmission with variable expression. J Neurol Neurosurg Psychiatry 51(2):298–300
Shaikhow S, Al Jawadi A (1989) Incidence of mitral valve prolapse in children. J Fac Med Baghdad 31(2):181–184
Shawky S (2001) Infant mortality in Arab countries: sociodemographic, perinatal and economic factors. East Mediterr Health J 7(6):956–965
Shehab N, Al Hubaitty A, Al Hiyalli Y (1998) Choanal atresia. Ann Coll Med Mosul 24(1–2):50–53
Shiyaa N, Balasim R, Habib O (2006) Pregnancy outcome and fate of neonates: a hospital-based study. J Bahrain Med Soc 18(1):19–22
Shubber EK, Hamami HA, Allak BM, Khaleel AH (1991) Sister-chromatid exchanges in lymphocytes from infants with Down’s syndrome. Mutat Res 248(1):61–72
Stoffman N, Magal N, Shohat T, Lotan R, Koman S, Oron A, Danon Y, Halpern GJ, Lifshitz Y, Shohat M (2000) Higher than expected carrier rates for familial Mediterranean fever in various Jewish ethnic groups. Eur J Hum Genet 8(4):307–310
Subhi MD (2006) Blood pressure profiles and hypertension in Iraqi primary school children. Saudi Med J 27(4):482–486
Teebi A (1994) Autosomal recessive disorders among Arabs: an overview from Kuwait. J Med Genet 31:224–233
UNICEF. http://www.unicef.org/infobycountry/iraq_statistics.html
WHO Index Medicus for the Eastern Mediterranean Region. http://www.who.int/library/databases/emro/en/index.html
WHO Advisory Group Report [1985]: Community approaches to the control of hereditary diseases HDP/WG/85-10
WHO, EMRO country profiles. http://www.emro.who.int/emrinfo/index.asp?Ctry=irq
World Bank. World Development Report (1993) Investing in health. Oxford University Press, New York
World Bank Iraq data sheet http://www.iraqslogger.com/downloads/DATASHEETIraqDec2006.pdf
World Health Report, 2000 http://www.who.int/whr/2000/en/annex02_en.pdf
Yahya H, Khalel K, Al-Allawi N, Helmi F (1996) Thalassaemia genes in Baghdad, Iraq. East Mediterr Health J 2:31–35
Yaseen N (1995) Inheritance pattern of nystagmus in Iraqi families. Med J Tikrit Univ 1(1):25–35
Yasseen A, Aunuiz A, Al-Mosawi M (2001) Chromosome studies in male patients suffering from infertility. Saudi Med J 22(3):223–226
Yasseen A, Aunuiz A (2002) High frequency of satellite association in metaphases of infertile male patients. Saudi Med J 23(4):427–431
Yasseen AA, Al-Musawi TA (2001) Cytogenetics study in severely mentally retarded patients. Saudi Med J 22(5):444–449
Acknowledgment
I am deeply grateful to Professor Nasir Al-Allawi, Professor of Hematology, Scientific supervisor of Hemoglobinopathy preventive program, College of Medicine, University of Dohuk, Iraq, for providing me with valuable data and references on hereditary blood disorders in Iraq.
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Hamamy, H.A. (2010). Genetic Diseases in Iraq. In: Teebi, A. (eds) Genetic Disorders Among Arab Populations. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05080-0_10
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