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Evidence-Based Practice: Toward Optimizing Clinical Outcomes pp 17–33Cite as

Overview, Strengths, and Limitations of Systematic Reviews and Meta-Analyses

Abstract

While the main focus of this chapter will be meta-analysis, it cannot be completely isolated from several prerequisites assessed in the systematic review. For example, the studies must address a common question. The eligibility criteria of the underlying studies must be well established. Evaluation techniques for endpoints must be reasonably consistent across the studies. In the clinical setting, when making comparisons between a treatment and control, the underlying studies must be properly randomized. Exploratory meta-analyses and meta-regressions may examine associations between interventions, covariates, and secondary events.

Keywords

  • Publication Bias
  • Random Effect Model
  • Fixed Effect Model
  • Random Model
  • Prior Belief

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  1. Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL, 35294-0022, USA

    Alfred A. Bartolucci & William B. Hillegass

Authors
  1. Alfred A. Bartolucci
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  2. William B. Hillegass
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Correspondence to Alfred A. Bartolucci .

Editor information

Editors and Affiliations

  1. School of Dentistry, Div. Oral Biology & Medicine, University of California, Los Angeles, Los Angeles, 90095-1668, USA

    Francesco Chiappelli

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Bartolucci, A.A., Hillegass, W.B. (2010). Overview, Strengths, and Limitations of Systematic Reviews and Meta-Analyses. In: Chiappelli, F. (eds) Evidence-Based Practice: Toward Optimizing Clinical Outcomes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05025-1_2

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  • DOI: https://doi.org/10.1007/978-3-642-05025-1_2

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  • Print ISBN: 978-3-642-05024-4

  • Online ISBN: 978-3-642-05025-1

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