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Transgenic Crop Plants pp 269–299Cite as

Plant-Produced Biopharmaceuticals

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The term “biopharmaceutical” is commonly used to denote a therapeutic protein produced by recombinant (genetic) engineering. In this process, genes encoding proteins or peptides of interest from humans or other organisms are identified, cloned, inserted into an expression vector and the protein or enzyme produced within a prokaryotic or eukaryotic expression host “production platform” organism. Such production platforms may typically be bacteria, yeasts, insects, mammals or plants. Batch cultures of cell suspensions are also commonly used for large-scale production of recombinant therapeutic proteins, a method often referred to as “fermentation culture.” Bacteria and yeast can be grown in closed-loop bioreactors, as can insect, mammal and plant cell-lines, which are generated from whole organisms. This ensures several generations of stable cell line propagation, allowing production of the protein or enzyme of interest.

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Authors and Affiliations

  1. Glycoscience and Glycotechnology Group and the Martin Ryan Institute, National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland

    Jared Q. Gerlach, Michelle Kilcoyne & Lokesh Joshi

  2. Genetics and Biotechnology Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland

    Peter McKeown & Charles Spillane

Authors
  1. Jared Q. Gerlach
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  2. Michelle Kilcoyne
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  3. Peter McKeown
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  4. Charles Spillane
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  5. Lokesh Joshi
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Correspondence to Lokesh Joshi .

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Editors and Affiliations

  1. Department of Genetics & Biochemistry, Clemson University, Clemson, SC, 29634, USA

    Chittaranjan Kole  & Albert G. Abbott  & 

  2. NSF I/UCRC Center for Tree Genetics, Hardwood Tree Improvement and Regeneration Center at Purdue University, West Lafayette, IN, USA

    Charles H. Michler

  3. Institute of Developmental & Molecular Biology Department of Biology, Texas A&M University, College Station, TX, USA

    Timothy C. Hall

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Gerlach, J.Q., Kilcoyne, M., McKeown, P., Spillane, C., Joshi, L. (2010). Plant-Produced Biopharmaceuticals. In: Kole, C., Michler, C.H., Abbott, A.G., Hall, T.C. (eds) Transgenic Crop Plants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04812-8_7

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