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Cervix uteri und Vagina

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Pathologie

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Zusammenfassung

In allen westlichen Ländern sind Inzidenz und Mortalität des Zervixkarzinoms im Wesentlichen dank regelmäßiger zytologischer Krebsfrüherkennungsuntersuchungen massiv zurückgegangen. Doch selbst in Schweden mit seinem seit 40 Jahren funktionierenden flächendeckenden Früherkennungsprogramm ist es bislang nicht gelungen, das Zervixkarzinom völlig auszurotten. Auch wenn Nichtteilnahme an Früherkennungsuntersuchungen der Hauptgrund sein dürfte, ist ein weiterer möglicher Grund die unbefriedigende Sensitivität von bestenfalls 80% des zytologischen Portioabstrichs. Tatsächlich konnte in mehreren Studien gezeigt werden, dass die Früherkennungsuntersuchungen in bis zu 30% der Frauen mit invasivem Zervixkarzinom unauffällig oder falsch-negativ beurteilt oder unterdiagnostiziert worden waren [17, 136]. Selbst durch wiederholte Untersuchungen in regelmäßigen Zeitabständen lassen sich offenbar nicht sämtliche neoplastische Frühveränderungen erfassen [135]. Das spricht für die Notwendigkeit, die Früherkennungsmaßnahmen zu verbessern.

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Literatur

  1. ACOG (2008) Practice Bulletin No 99: management of abnormal cervical cytology and histology. Obstet Gynecol 112: 1419–1444

    Google Scholar 

  2. AG-CPC AfZuK (2008) Empfehlungen der AG-CPC zur Koposkopie bei Erkrankungen des unteren Genitaltraktes der Frau <http://www.ag-cpc.de/>

    Google Scholar 

  3. Algeciras-Schimnich A, Policht F, Sitailo S et al. (2007) Evaluation of quantity and staining pattern of human papillomavirus (HPV)-infected epithelial cells in thin-layer cervical specimens using optimized HPV-CARD assay. Cancer 111: 330–338

    Article  CAS  PubMed  Google Scholar 

  4. Alsharif M, Martin AU, Shelton JB Jr et al. (2008) Paracoccidioides brasiliensis in a liquid-based Papanicolaou test from a pregnant woman: report of a case. Diagn Cytopathol 36: 557–560

    Article  PubMed  Google Scholar 

  5. Anderson GH, Boyes DA, Benedet JL et al. (1988) Organisation and results of the cervical cytology screening programme in British Columbia, 1955–85. Br Med J (Clin Res Ed) 296: 975–978

    Article  CAS  Google Scholar 

  6. Anestad G, Lunde O, Moen M et al. (1987) Infertility and chlamydial infection. Fertil Steril 48: 787–790

    CAS  PubMed  Google Scholar 

  7. Arbyn M, Herbert A, Schenck U et al. (2007) European guidelines for quality assurance in cervical cancer screening: recommendations for collecting samples for conventional and liquid-based cytology. Cytopathology 18: 133–139

    Article  CAS  PubMed  Google Scholar 

  8. Arends MJ, Buckley CH, Wells M (1998) Aetiology, pathogenesis, pathology of cervical neoplasia J Clin Pathol 51: 96–103

    Article  CAS  PubMed  Google Scholar 

  9. Aslan DL, Pambuccian SE, Prekker FL et al. (2008) Accuracy of herpes simplex virus detection in liquid-based (SurePath) Papanicolaou tests: a comparison with polymerase chain reaction. Diagn Cytopathol 36: 94–103

    Article  PubMed  Google Scholar 

  10. Baggish MS, Karran MM (2007) Atlas of pelvic anatomy and gynecologic surgery. Elsvier LTD, Oxford, p 1184

    Google Scholar 

  11. Bean SM, Connolly K, Roberson J et al. (2006) Incidence and clinical significance of morphologically benignappearing endometrial cells in patients age 40 years or older: the impact of the 2001 Bethesda System Cancer 108: 39–44

    Article  PubMed  Google Scholar 

  12. Bedrossian CW (2007) Cytopathology: a global perspective. Diagn Cytopathol 35: 745–748

    Article  PubMed  Google Scholar 

  13. Bennington JL (1969) Cellular kinetics of invasive squamous carcinoma of the human cervix. Cancer Res 29: 1082–1088

    CAS  PubMed  Google Scholar 

  14. Benoit JL, Kini SR (1996) „Arias-Stella reaction“-like changes in endocervical glandular epithelium in cervical smears during pregnancy and postpartum states – a potential diagnostic pitfall. Diagn Cytopathol 14: 349–355

    Article  CAS  PubMed  Google Scholar 

  15. Bidus MA, Maxwell GL, Kulasingam S et al. (2006) Costeffectiveness analysis of liquid-based cytology and human papillomavirus testing in cervical cancer screening. Obstet Gynecol 107: 997–1005

    Article  PubMed  Google Scholar 

  16. Böcking A, Hilgarth M, Auffermann W et al. (1986) DNA-cytometric diagnosis of prospective malignancy in borderline lesions of the uterine cervix. Acta Cytol 30: 608–615

    PubMed  Google Scholar 

  17. Bofin AM, Nygard JF, Skare GB et al. (2007) Papanicolaou smear history in women with low-grade cytology before cervical cancer diagnosis. Cancer 111: 210–216

    Article  PubMed  Google Scholar 

  18. Burghardt E, Pickel H, Girardi F (2001) Atlas der Kolposkopie. Thieme, Stuttgart, 226 S

    Google Scholar 

  19. Burja IT, Thompson SK, Sawyer WL Jr et al. (1999) Atypical glandular cells of undetermined significance on cervical smears. A study with cytohistologic correlation. Acta Cytol 43: 351–356

    CAS  PubMed  Google Scholar 

  20. Campion MJ, McCance DJ, Cuzick J et al. (1986) Progressive potential of mild cervical atypia: prospective cytological, colposcopic, virological study. Lancet 2: 237–240

    Article  CAS  PubMed  Google Scholar 

  21. Castadot MJ, Robinowitz M, Chervenak FA et al. (1980) Recognizing malignancy in intrauterine contraceptive device users. Am J Obstet Gynecol 136: 966–967

    CAS  PubMed  Google Scholar 

  22. Cheung AN, Szeto EF, Leung BS et al. (2003) Liquid-based cytology and conventional cervical smears: a comparison study in an Asian screening population. Cancer 99: 331–335

    Article  PubMed  Google Scholar 

  23. Chhieng DC, Elgert P, Cangiarella JF et al. (2001) Significance of AGUS Pap smears in pregnant and postpartum women. Acta Cytol 45: 294–299

    CAS  PubMed  Google Scholar 

  24. Chhieng DC, Elgert P, Cangiarella JF et al. (2001) Variation in the incidence of AGUS between different patient populations. Acta Cytol 45: 287–293

    CAS  PubMed  Google Scholar 

  25. Chhieng DC, Elgert PA, Cangiarella JF et al. (2000) Clinical significance of atypical glandular cells of undetermined significance. A follow-up study from an academic medical center. Acta Cytol 44: 557–566

    CAS  PubMed  Google Scholar 

  26. Coppleson LW, Brown B (1974) Estimation of the screening error rate from the observed detection rates in repeated cercival cytology. Am J Obstet Gynecol 119: 953–958

    CAS  PubMed  Google Scholar 

  27. Crum CP, Genest DR, Krane JF et al. (1999) Subclassifying atypical squamous cells in Thin-Prep cervical cytology correlates with detection of high-risk human papillomavirus DNA. Am J Clin Pathol 112: 384–390

    CAS  PubMed  Google Scholar 

  28. Davey E, Barratt A, Irwig L et al. (2006) Effect of study design and quality on unsatisfactory rates, cytology classifications, accuracy in liquid-based versus conventional cervical cytology: a systematic review. Lancet 367: 122–132

    Article  PubMed  Google Scholar 

  29. de Somer ML, Willocx F, Van Roy J (1987) Standardized model for diagnosing cervical carcinoma in situ based on the cytologic signs. Acta Cytol 31: 878–882

    PubMed  Google Scholar 

  30. DGGG (2008) Deutsche Gesellschaft für Gynäkologie und Geburtshilfe: Interdisziplinäre S2k-Leitlinie: Prävention, Diagnostik und Therapie der HPV-Infektion und präinvasiver Läsionen des weiblichen Genitale www.dggg.de

    Google Scholar 

  31. Diakomanolis E, Stefanidis K, Rodolakis A et al. (2002) Vaginal intraepithelial neoplasia: report of 102 cases. Eur J Gynaecol Oncol 23: 457–459

    CAS  PubMed  Google Scholar 

  32. Duong TH, Flowers LC (2007) Vulvo-vaginal cancers: risks, evaluation, prevention and early detection. Obstet Gynecol Clin North Am 34: 783–802

    Article  PubMed  Google Scholar 

  33. Eckert LO, Hawes SE, Stevens CE et al. (1998) Vulvovaginal candidiasis: clinical manifestations, risk factors, management algorithm. Obstet Gynecol 92: 757–765

    Article  CAS  PubMed  Google Scholar 

  34. Eltoum IA, Roberson J (2007) Impact of HPV testing, HPV vaccine development, changing screening frequency on national Pap test volume: projections from the National Health Interview Survey (NHIS) Cancer 111: 34–40

    Article  PubMed  Google Scholar 

  35. Engberts MK, Verbruggen BS, Boon ME et al. (2007) Candida and dysbacteriosis: a cytologic, population-based study of 100,605 asymptomatic women concerning cervical carcinogenesis. Cancer 111: 269–274

    Article  PubMed  Google Scholar 

  36. Farghaly H, Bourgeois D, Houser PM et al. (2006) Routine vaginal Pap test is not useful in women status-post hysterectomy for benign disease. Diagn Cytopathol 34: 640–643

    Article  PubMed  Google Scholar 

  37. Feichter G, Curschellas E, Gobat S et al. (1995) Malignant melanoma of the uterine cervix; case report including cytology, histology and immunocytochemistry. Cytopathology 6: 196–200

    CAS  PubMed  Google Scholar 

  38. Feichter GE, Tauber PF, Rosenthal E et al. (1978) Zur bakteriellen Besiedelung kupferhaltiger Intrauterinpessare. Geburtshilfe Frauenheilkd 38: 904–914

    CAS  PubMed  Google Scholar 

  39. Feratovic R, Lewin SN, Sonoda Y et al. (2008) Cytologic findings after fertility-sparing radical trachelectomy. Cancer 114: 1–6

    Article  PubMed  Google Scholar 

  40. Figueiredo PG, Sarian LO, Tambascia JK et al. (2008) Increased detection of clue cells in smears from cervical intraepithelial lesions with reduced expression of COX-2 Diagn Cytopathol 36: 705–709

    Article  PubMed  Google Scholar 

  41. Frega A, Stentella P, De Ioris A et al. (2003) Young women, cervical intraepithelial neoplasia and human papillomavirus: risk factors for persistence and recurrence. Cancer Lett 196: 127–134

    Article  CAS  PubMed  Google Scholar 

  42. Friedlander MA, Rudomina D, Lin O (2008) Effectiveness of the Thin Prep Imaging System in the detection of adenocarcinoma of the gynecologic system. Cancer 114: 7–12

    Article  PubMed  Google Scholar 

  43. Fu YS, Reagan JW, Hsiu JG et al. (1982) Adenocarcinoma and mixed carcinoma of the uterine cervix. I. A clinicopathologic study. Cancer 49: 2560–2570

    Article  CAS  PubMed  Google Scholar 

  44. Fu YS, Reagan JW, Richart RM (1981) Definition of precursors. Gynecol Oncol 12: S220–231

    Article  CAS  PubMed  Google Scholar 

  45. Fu YS, Reagan JW, Townsend DE et al. (1981) Nuclear DNA study of vulvar intraepithelial and invasive squamous neoplasms. Obstet Gynecol 57: 643–652

    CAS  PubMed  Google Scholar 

  46. Garcia MT, Acar BC, Jorda M et al. (2007) Use of p63 for distinction of glandular versus squamous lesions in cervicovaginal specimens. Cancer 111: 54–57

    Article  PubMed  Google Scholar 

  47. Gay JD, Donaldson LD, Goellner JR (1985) False-negative results in cervical cytologic studies. Acta Cytol 29: 1043–1046

    CAS  PubMed  Google Scholar 

  48. Gersell DJ, Mazoujian G, Mutch DG et al. (1988) Smallcell undifferentiated carcinoma of the cervix. A clinicopathologic, ultrastructural, immunocytochemical study of 15 cases. Am J Surg Pathol 12: 684–698

    Article  CAS  PubMed  Google Scholar 

  49. Girianelli VR, Santos Thuler LC (2007) Evaluation of agreement between conventional and liquid-based cytology in cervical cancer early detection based on analysis of 2,091 smears: experience at the Brazilian National Cancer Institute. Diagn Cytopathol 35: 545–549

    Article  PubMed  Google Scholar 

  50. Gloor E, Ruzicka J (1982) Morphology of adenocarcinoma in situ of the uterine cervix: a study of 14 cases. Cancer 49: 294–302

    Article  CAS  PubMed  Google Scholar 

  51. Goodman A, Zukerberg LR, Nikrui N et al. (1991) Vaginal adenosis and clear cell carcinoma after 5-fluorouracil treatment for condylomas. Cancer 68: 1628–1632

    Article  CAS  PubMed  Google Scholar 

  52. Gupta PK, Burroughs F, Luff RD et al. (1978) Epithelial atypias associated with intrauterine contraceptive devices (IUD) Acta Cytol 22: 286–291

    CAS  PubMed  Google Scholar 

  53. Gusberg SB (1988) Detection and prevention of uterine cancer. Cancer 62: 1784–1786

    Article  CAS  PubMed  Google Scholar 

  54. Hall TL, Castleman KR, Rosenthal DL (1988) Canonical analysis of cells in normal and abnormal cervical smears. Anal Quant Cytol Histol 10: 161–165

    CAS  PubMed  Google Scholar 

  55. Heinzl S, Almendral A, Hagmann PD et al. Guideline zum Vorgehen bei suspektem und positivem zytologischem Abstrich der Cervix uteri. www.sggg.ch

    Google Scholar 

  56. Herbert A, Bergeron C, Wiener H et al. (2007) European guidelines for quality assurance in cervical cancer screening: recommendations for cervical cytology terminology. Cytopathology 18: 213–219

    Article  CAS  PubMed  Google Scholar 

  57. Herrington CS (1994) Human papillomaviruses and cervical neoplasia. I. Classification, virology, pathology, epidemiology. J Clin Pathol 47: 1066–1072

    Article  CAS  PubMed  Google Scholar 

  58. Heselmeyer K, Macville M, Schrock E et al. (1997) Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q Genes Chromosomes Cancer 19: 233–240

    CAS  Google Scholar 

  59. Heselmeyer K, Schrock E, du Manoir S et al. (1996) Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc Natl Acad Sci USA 93: 479–484

    Article  CAS  PubMed  Google Scholar 

  60. Hilgarth M (1998) Münchner Nomenklatur II für die gynäkologische Zytodiagnostik. Frauenarzt 39: 392–393

    Google Scholar 

  61. Hilgarth M, Hillemanns HG (1984) Zervixkarzinom: Was leistet die kombinierte Krebsvorsorge? Dtsch Ärztebl 81: 2017–2018

    Google Scholar 

  62. Holladay EB, Logan S, Arnold J et al. (2006) A comparison of the clinical utility of p16(INK4a) immunolocalization with the presence of human papillomavirus by hybrid capture 2 for the detection of cervical dysplasia/neoplasia. Cancer 108: 451–461

    Article  PubMed  Google Scholar 

  63. Hollander DH, Gupta PK (1974) Hematoidin cockleburrs in cervico-vaginal smears. Acta Cytol 18: 268–269

    CAS  PubMed  Google Scholar 

  64. Hong SR, Park JS, Kim HS (2001) Atypical glandular cells of undetermined significance in cervical smears after conization. Cytologic features differentiating them from adenocarcinoma in situ. Acta Cytol 45: 163–168

    CAS  PubMed  Google Scholar 

  65. Hughes RG, Neill WA, Norval M (1989) Papillomavirus and c-myc antigen expression in normal and neoplastic cervical epithelium. J Clin Pathol 42: 46–51

    Article  CAS  PubMed  Google Scholar 

  66. Hunt JL, Baloch Z, Judkins A et al. (1998) Unique cytomegalovirus intracytoplasmic inclusions in ectocervical cells on a cervical/endocervical smear. Diagn Cytopathol 18: 110–112

    Article  CAS  PubMed  Google Scholar 

  67. Hutchinson ML, Isenstein LM, Goodman A et al. (1994) Homogeneous sampling accounts for the increased diagnostic accuracy using the ThinPrep Processor. Am J Clin Pathol 101: 215–219

    CAS  PubMed  Google Scholar 

  68. Johannisson E (1990) Effects on the endometrium, endoand exocervix following the use of local progestogen-releasing delivery systems. Contraception 42: 403–421

    Article  CAS  PubMed  Google Scholar 

  69. Kapali M, Agaram NP, Dabbs D et al. (2007) Routine endometrial sampling of asymptomatic premenopausal women shedding normal endometrial cells in Papanicolaou tests is not cost effective. Cancer 111: 26–33

    Article  PubMed  Google Scholar 

  70. Kapila K, Al-Juwaiser A, Haji BE (2007) Crystalline bodies in Pap smear: a forgotten entity. Diagn Cytopathol 35: 423

    Article  PubMed  Google Scholar 

  71. King LA, Tase T, Twiggs LB et al. (1989) Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix. Cancer 63: 897–900

    Article  CAS  PubMed  Google Scholar 

  72. Klomp JM, Verbruggen BS, Korporaal H et al. (2008) Gardnerella vaginalis and Lactobacillus sp in liquid-based cervical samples in healthy and disturbed vaginal flora using cultivation-independent methods. Diagn Cytopathol 36: 277–284

    Article  PubMed  Google Scholar 

  73. Kohli M, Ferko N, Martin A et al. (2007) Estimating the long-term impact of a prophylactic human papillomavirus 16/18 vaccine on the burden of cervical cancer in the UK. Br J Cancer 96: 143–150

    Article  CAS  PubMed  Google Scholar 

  74. Koss LG, Durfee GR (1956) Unusual patterns of squamous epithelium of the uterine cervix: cytologic and pathologic study of koilocytotic atypia. Ann N Y Acad Sci 63: 1245–1261

    Article  CAS  PubMed  Google Scholar 

  75. Koutsky LA, Holmes KK, Critchlow CW et al. (1992) A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection. N Engl J Med 327: 1272–1278

    Article  CAS  PubMed  Google Scholar 

  76. Krane JF, Granter SR, Trask CE et al. (2001) Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix: a study of 49 cases. Cancer 93: 8–15

    Article  CAS  PubMed  Google Scholar 

  77. Kuebler DL, Illingworth A, Blenc AM et al. (2007) A peer comparison program for the quality assurance of human papillomavirus DNA detection using the Digene Hybrid Capture II/SurePath method shows excellent analytic interlaboratory correlation. Cancer 111: 339–343

    Article  PubMed  Google Scholar 

  78. Kwikkel HJ, Timmers T, Boon ME et al. (1987) Relation of quantitative features of visually normal intermediate cells in cervical intraepithelial neoplasia I and II smears to progression or nonprogression of the lesion. Anal Quant Cytol Histol 9: 405–410

    CAS  PubMed  Google Scholar 

  79. Lee KR, Darragh TM, Joste NE et al. (2002) Atypical glandular cells of undetermined significance (AGUS): Interobserver reproducibility in cervical smears and corresponding thin-layer preparations. Am J Clin Pathol 117: 96–102

    Article  PubMed  Google Scholar 

  80. Liu H, Shi J, Wilkerson M et al. (2007) Immunohistochemical detection of p16INK4a in liquid-based cytology specimens on cell block sections. Cancer 111: 74–82

    Article  CAS  PubMed  Google Scholar 

  81. Lundeen SJ, Horwitz CA, Larson CJ et al. (2002) Abnormal cervicovaginal smears due to endometriosis: a continuing problem. Diagn Cytopathol 26: 35–40

    Article  PubMed  Google Scholar 

  82. Maccallini V, Angeloni C, Caraceni D et al. (2008) Comparison of the conventional cervical smear and liquid-based cytology: results of a controlled, prospective study in the Abruzzo Region of Italy. Acta Cytol 52: 568–574

    PubMed  Google Scholar 

  83. Mattosinho de Castro Ferraz Mda G, Focchi J, Stavale JN et al. (2003) Atypical glandular cells of undetermined significance. Cytologic predictive value for glandular involvement in high grade squamous intraepithelial lesions. Acta Cytol 47: 154–158

    PubMed  Google Scholar 

  84. McGalie CE, McBride HA, McCluggage WG (2004) Cytomegalovirus infection of the cervix: morphological observations in five cases of a possibly under-recognised condition J Clin Pathol 57: 691–694

    Article  CAS  Google Scholar 

  85. McLachlin CM, Crum CP (1997) Papillomavirus and cervical neoplasia. In: Holland JF, Bast RC, Morton DL (eds) Cancer Medicine. William & Wilkins, Baltimore, pp 365–373

    Google Scholar 

  86. Mikami Y, Hata S, Fujiwara K et al. (1999) Florid endocervical glandular hyperplasia with intestinal and pyloric gland metaplasia: worrisome benign mimic of „adenoma malignum“. Gynecol Oncol 74: 504–511

    Article  CAS  PubMed  Google Scholar 

  87. Minassian H, Schinella R, Reilly JC (1993) Crystalline bodies in cervical smears. Clinicocytologic correlation. Acta Cytol 37: 149–152

    CAS  PubMed  Google Scholar 

  88. Modem RR, Otis CN, Florence RR et al. (2007) Intestinal type adenocarcinoma in situ of the cervix. Diagn Cytopathol 35: 584–585

    Article  PubMed  Google Scholar 

  89. Montironi R, Scarpelli M, De Nictolis M et al. (1988) Comparison of computerized analysis of nuclear DNA changes in uterine cervix dysplasia and in urothelial non-invasive papillary carcinoma. Pathol Res Pract 183: 489–496

    CAS  PubMed  Google Scholar 

  90. Moreira MA, Longatto Filho A, Castelo A et al. (2008) How accurate is cytological diagnosis of cervical glandular lesions?. Diagn Cytopathol 36: 270–274

    Article  PubMed  Google Scholar 

  91. Moscicki AB, Hills N, Shiboski S et al. (2001) Risks for incident human papillomavirus infection and low-grade squamous intraepithelial lesion development in young females. Jama 285: 2995–3002

    Article  CAS  PubMed  Google Scholar 

  92. Moscicki AB, Shiboski S, Broering J et al. (1998) The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women J Pediatr 132: 277–284

    Article  CAS  PubMed  Google Scholar 

  93. Mullokandov MR, Kholodilov NG, Atkin NB et al. (1996) Genomic alterations in cervical carcinoma: losses of chromosome heterozygosity and human papilloma virus tumor status. Cancer Res 56: 197–205

    CAS  PubMed  Google Scholar 

  94. Nanbu Y, Fujii S, Konishi I et al. (1988) Immunohistochemical localizations of CA 125, carcinoembryonic antigen, CA 19-9 in normal and neoplastic glandular cells of the uterine cervix. Cancer 62: 2580–2588

    Article  CAS  PubMed  Google Scholar 

  95. Nasiell K, Nasiell M, Vaclavinkova V (1983) Behavior of moderate cervical dysplasia during long-term follow-up. Obstet Gynecol 61: 609–914

    CAS  PubMed  Google Scholar 

  96. Nasuti JF, Fleisher SR, Gupta PK (2002) Atypical glandular cells of undetermined significance (AGUS): clinical considerations and cytohistologic correlation. Diagn Cytopathol 26: 186–190

    Article  PubMed  Google Scholar 

  97. NCI (1989) The 1988 Bethesda System for reporting cervical/vaginal cytologic diagnoses Developed and approved at the National Cancer Institute Workshop, Bethesda, Maryland, USA, December 12–13, 1988 Acta Cytol 33: 567–574

    Google Scholar 

  98. Negri G, Rigo B, Vittadello F et al. (2007) Abnormal cervicovaginal cytology with negative human papillomavirus testing. Cancer 111: 280–284

    Article  PubMed  Google Scholar 

  99. Obenson K, Abreo F, Grafton WD (2000) Cytohistologic correlation between AGUS and biopsy-detected lesions in postmenopausal women. Acta Cytol 44: 41–45

    CAS  PubMed  Google Scholar 

  100. Oliveira ER, Derchain SF, Rabelo-Santos SH et al. (2004) Detection of high-risk human papillomavirus (HPV) DNA by Hybrid Capture II in women referred due to atypical glandular cells in the primary screening. Diagn Cytopathol 31: 19–22

    Article  PubMed  Google Scholar 

  101. Pacheco MC, Conley RC, Pennington DW et al. (2008) Concordance between original screening and final diagnosis using imager vs manual screen of cervical liquidbased cytology slides. Acta Cytol 52: 575–578

    PubMed  Google Scholar 

  102. Pang Y, Smola B, Pu RT et al. (2008) Restoring satisfactory status in ThinPrep Pap test specimens with too few squamous cells and containing microscopic red blood cells. Diagn Cytopathol 36: 696–700

    Article  PubMed  Google Scholar 

  103. Papanicolaou GN, Traut HF (1943) Diagnosis of uterine cancer by the vaginal smear. Harward Univ Press, Cambridge Mass

    Google Scholar 

  104. Raab SS, Geisinger KR, Silverman JF et al. (1998) Interobserver variability of a Papanicolaou smear diagnosis of atypical glandular cells of undetermined significance. Am J Clin Pathol 110: 653–659

    CAS  PubMed  Google Scholar 

  105. Raab SS, Isacson C, Layfield LJ et al. (1995) Atypical glandular cells of undetermined significance. Cytologic criteria to separate clinically significant from benign lesions. Am J Clin Pathol 104: 574–582

    CAS  PubMed  Google Scholar 

  106. Reid-Nicholson M, Gatscha RM, Riedel ER et al. (2007) Atypical squamous cells, cannot exclude high grade intraepithelial lesion (ASC-H): does HPV matter?. Diagn Cytopathol 35: 1–5

    Article  PubMed  Google Scholar 

  107. Reimers LL, Anderson WF, Rosenberg PS et al. (2009) Etiologic heterogeneity for cervical carcinoma by histopathologic type, using comparative age-period-cohort models. Cancer Epidemiol Biomarkers Prev 18: 792–800

    Article  PubMed  Google Scholar 

  108. Renshaw AA, Mody DR, Lozano RL et al. (2004) Detection of adenocarcinoma in situ of the cervix in Papanicolaou tests: comparison of diagnostic accuracy with other high-grade lesions. Arch Pathol Lab Med 128: 153–157

    PubMed  Google Scholar 

  109. Renshaw AA, Young NA, Birdsong GG et al. (2004) Comparison of performance of conventional and ThinPrep gynecologic preparations in the College of American Pathologists Gynecologic Cytology Program. Arch Pathol Lab Med 128: 17–22

    PubMed  Google Scholar 

  110. Ribeiro AA, Santos Sdo C, de Souza e Silva SR et al. (2007) Endocervical component in conventional cervical smears: influence on detection of squamous cytologic abnormalities. Diagn Cytopathol 35: 209–212

    Article  PubMed  Google Scholar 

  111. Richart RM, Barron BA (1969) A follow-up study of patients with cervical dysplasia. Am J Obstet Gynecol 105: 386–393

    CAS  PubMed  Google Scholar 

  112. Robboy SJ, Young RH, Welch WR et al. (1984) Atypical vaginal adenosis and cervical ectropion. Association with clear cell adenocarcinoma in diethylstilbestrol-exposed offspring. Cancer 54: 869–875

    Article  CAS  PubMed  Google Scholar 

  113. Ronnett BM, Manos MM, Ransley JE et al. (1999) Atypical glandular cells of undetermined significance (AGUS): cytopathologic features, histopathologic results, human papillomavirus DNA detection. Hum Pathol 30: 816–825

    Article  CAS  PubMed  Google Scholar 

  114. Rosario D, Zahn CM, Bush AC et al. (2007) The significance of high-risk human papillomavirus detection in women aged > or = 50 years with atypical squamous cells of undetermined significance cytologic preparations. Cancer 111: 487–490

    Article  PubMed  Google Scholar 

  115. Rosenthal DL, Philippe A, Hall TL et al. (1987) Prognosis of moderate dysplasia. Predictive value of selected markers in routinely prepared cervical smears. Anal Quant Cytol Histol 9: 165–168

    CAS  PubMed  Google Scholar 

  116. Rowe LR, Bentz JS (2004) A simple method to determine the need for glacial acetic acid treatment of bloody Thin-Prep Pap tests before slide processing. Diagn Cytopathol 31: 321–325

    Article  PubMed  Google Scholar 

  117. Sadeghi SB, Sadeghi A, Robboy SJ (1988) Prevalence of dysplasia and cancer of the cervix in a nationwide, planned parenthood population. Cancer 61: 2359–2361

    Article  CAS  PubMed  Google Scholar 

  118. Salomao DR, Hughes JH, Raab SS (2002) Atypical glandular cells of undetermined significance favor endometrial origin. Criteria for separating low grade endometrial adenocarcinoma from benign endometrial lesions. Acta Cytol 46: 458–464

    PubMed  Google Scholar 

  119. Schiffman MH (1992) Recent progress in defining the epidemiology of human papillomavirus infection and cervical neoplasia. J Natl Cancer Inst 84: 394–398

    Article  CAS  PubMed  Google Scholar 

  120. Schledermann D, Ersen BT, Bisgaard K et al. (2008) Are adjunctive markers useful in routine cervical cancer screening? Application of p16(INK4a) and HPV-PCR on Thin-Prep samples with histological follow-up. Diagn Cytopathol 36: 453–459

    Article  CAS  PubMed  Google Scholar 

  121. Schmitt A (1953) Eine Gradeinteilung für die funktionelle Zytodiagnostik in der Gynäkologie. Geburtshilfe Frauenheilkd 13: 593–603

    CAS  PubMed  Google Scholar 

  122. Schneider A (1990) Stellenwert morphologischer Verfahren für die HPV-Diagnostik Gynakologe 23: 341–348

    CAS  PubMed  Google Scholar 

  123. Scully RE, Aguirre P, DeLellis RA (1984) Argyrophilia, serotonin, peptide hormones in the female genital tract and its tumors. Int J Gynecol Pathol 3: 51–70

    Article  CAS  PubMed  Google Scholar 

  124. Selvaggi SM and Haefner HK (1997) Microglandular endocervical hyperplasia and tubal metaplasia: pitfalls in the diagnosis of adenocarcinoma on cervical smears. Diagn Cytopathol 16: 168–173

    Article  CAS  PubMed  Google Scholar 

  125. Sevin BU, Nadji M, Averette HE et al. (1992) Microinvasive carcinoma of the cervix. Cancer 70: 2121–2128

    Article  CAS  PubMed  Google Scholar 

  126. Sheppard BL (1987) Endometrial morphological changes in IUD users: a review. Contraception 36: 1–10

    Article  CAS  PubMed  Google Scholar 

  127. Sherman ME, Castle PE, Solomon D (2006) Cervical cytology of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): characteristics and histologic outcomes. Cancer 108: 298–305

    Article  PubMed  Google Scholar 

  128. Sherman ME, Kahler J, Gustafson KS et al. (2006) „Sip volume“ as a quality indicator in liquid-based cervical cytology. Cancer 108: 462–467

    Article  PubMed  Google Scholar 

  129. Sincock AM, Evans-Jones J, Partington CK et al. (1987) Quantitative assessment of cervical neoplasia by hydrolysed DNA assay. Lancet 2: 942–943

    Article  CAS  PubMed  Google Scholar 

  130. Smith HO, Padilla LA (2002) Adenocarcinoma in situ of the cervix: sensitivity of detection by cervical smear: will cytologic screening for adenocarcinoma in situ reduce incidence rates for adenocarcinoma. Cancer 96: 319–322

    Article  PubMed  Google Scholar 

  131. Smith JJ, Cowan L, Hemstreet G 3rd et al. (1987) Automated quantitative fluorescent image analysis of cervical cytology. Gynecol Oncol 28: 241–254

    Article  PubMed  Google Scholar 

  132. Smith JS, Backes DM, Hoots BE et al. (2009) Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors. Obstet Gynecol 113: 917–924

    PubMed  Google Scholar 

  133. Solomon D, Davey D, Kurman R et al. (2002) The 2001 Bethesda System: terminology for reporting results of cervical cytology. Jama 287: 2114–2119

    Article  PubMed  Google Scholar 

  134. Sreekantaiah C, Bhargava MK, Shetty NJ (1988) Chromosome 1 abnormalities in cervical carcinoma. Cancer 62: 1317–1324

    Article  CAS  PubMed  Google Scholar 

  135. Strander B, Ersson-Ellstrom A, Milsom I et al. (2007) Liquid-based cytology versus conventional Papanicolaou smear in an organized screening program: a prospective randomized study. Cancer 111: 285–291

    Article  PubMed  Google Scholar 

  136. Sung HY, Kearney KA, Miller M et al. (2000) Papanicolaou smear history and diagnosis of invasive cervical carcinoma among members of a large prepaid health plan. Cancer 88: 2283–2289

    Article  CAS  PubMed  Google Scholar 

  137. Sweeney BJ, Haq Z, Happel JF et al. (2006) Comparison of the effectiveness of two liquid-based Papanicolaou systems in the handling of adverse limiting factors, such as excessive blood. Cancer 108: 27–31

    Article  PubMed  Google Scholar 

  138. Szyfelbein WM, Baker PM, Bell DA (2004) Superficial endometriosis of the cervix: A source of abnormal glandular cells on cervicovaginal smears. Diagn Cytopathol 30: 88–91

    Article  PubMed  Google Scholar 

  139. Tavassoli FA and Devilee P (2003) Pathology and Genetics of tumours of the breast and female genital organs. IARC Press, Lyon. WHO Classification of tumours, ed. WHO

    Google Scholar 

  140. Tenjin Y, Yamamoto K, Sugishita T et al. (1979) Basic studies on repair, especially histology, cytology and microspectrophotometry of DNA contents. Acta Cytol 23: 245–251

    CAS  PubMed  Google Scholar 

  141. Thomas PA, Zaleski MS, Ohlhausen WW et al. (1996) Cytomorphologic characteristics of thermal injury related to endocervical brushing following loop electrosurgical excision procedure (LEEP) Diagn Cytopathol 14: 212–215

    Article  CAS  PubMed  Google Scholar 

  142. van Aspert-van Erp AJ, van’t Hof-Grootenboer AB, Brugal G et al. (1995) Endocervical columnar cell intraepithelial neoplasia. I. Discriminating cytomorphologic criteria. Acta Cytol 39: 1199–1215

    PubMed  Google Scholar 

  143. van Aspert-van Erp AJ, van’t Hof-Grootenboer AB, Brugal G et al. (1995) Endocervical columnar cell intraepithelial neoplasia. II. Grades of expression of cytomorphologic criteria. Acta Cytol 39: 1216–1232

    PubMed  Google Scholar 

  144. van Nagell JR, Jr , Hudson S, Gay EC et al. (1982) Carcinoembryonic antigen in carcinoma of the uterine cervix: antigen distribution in primary and metastatic tumors. Cancer 49: 379–383

    Article  PubMed  Google Scholar 

  145. van Nagell JR, Jr , Powell DE, Gallion HH et al. (1988) Small cell carcinoma of the uterine cervix. Cancer 62: 1586–1593

    Article  PubMed  Google Scholar 

  146. Vasquez JB, Smith SV, Thomas R et al. (2008) Volvox species in the Pap test of a 24-year-old female. Diagn Cytopathol 36: 574–575

    Article  PubMed  Google Scholar 

  147. Venkataraman G, Kouria G, Mehrotra S et al. (2007) Cytomegalovirus inclusions on a cervical pap test: report of a well-known organism at an uncommon site. Diagn Cytopathol 35: 618–620

    Article  PubMed  Google Scholar 

  148. Verbruggen BS, Boon ME, Boon LM (2006) Dysbacteriosis and squamous (pre)neoplasia of immigrants and Dutch women as established in population-based cervical screening. Diagn Cytopathol 34: 377–381

    Article  PubMed  Google Scholar 

  149. Wald A, Zeh J, Selke S et al. (2000) Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N Engl J Med 342: 844–850

    Article  CAS  PubMed  Google Scholar 

  150. Wells M, Brown LJ (1986) Glandular lesions of the uterine cervix: the present state of our knowledge. Histopathology 10: 777–792

    Article  CAS  PubMed  Google Scholar 

  151. Wood MD, Horst JA, Bibbo M (2007) Weeding atypical glandular cell look-alikes from the true atypical lesions in liquid-based Pap tests: a review. Diagn Cytopathol 35: 12–17

    Article  PubMed  Google Scholar 

  152. Wright TC Jr, Cox JT, Massad LS et al. (2003) 2001 Consensus Guidelines for the Management of Women with Cervical Intraepithelial Neoplasia. J Low Genit Tract Dis 7: 154–167

    Article  PubMed  Google Scholar 

  153. Young RH, Scully RE (1990) Invasive adenocarcinoma and related tumors of the uterine cervix. Semin Diagn Pathol 7: 205–227

    CAS  PubMed  Google Scholar 

  154. zur Hausen H (2009) Papillomaviruses in the causation of human cancers – a brief historical account. Virology 384: 260–265

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institut für Pathologie, Universitätsspital Basel, Schönbeinstrasse 40, 4031, Basel, Schweiz

    Lukas Bubendorf, Georg E. Feichter, Ellen C. Obermann & Peter Dalquen

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  1. Lukas Bubendorf
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  2. Georg E. Feichter
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  3. Ellen C. Obermann
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  4. Peter Dalquen
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  1. Institut für Pathologie, Konsultationszentrum für Pankreas- und Endokrine Tumore, TU München, Ismaninger Straße 22, 81675, München, Deutschland

    Günter Klöppel

  2. Zentrum Pathologie und Rechtsmedizin, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    Hans H. Kreipe

  3. Institut für Pathologie, Kliniken der Landeshauptstadt, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland

    Wolfgang Remmele

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Bubendorf, L., Feichter, G., Obermann, E., Dalquen, P. (2011). Cervix uteri und Vagina. In: Klöppel, G., Kreipe, H., Remmele, W. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04562-2_7

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