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Leberzirrhose und deren Komplikationen

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Pathologie

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Dieses Kapitel beschreibt das Endstadium einer Fibrosierung der Leber mit Umbau des Gewebes zu diffusen Regeneratknoten mit fibrösen Septen, die sich als Reaktion auf eine chronische, meist inflammatorische Schädigung des Parenchyms entwickeln. Es wird ein aktueller Überblick über die mit der Progression der Erkrankungen einhergehenden hämodynamischen Veränderungen und deren Folgen sowie über die Fortschritte auf dem Gebiet der nichtinvasiven Fibrosediagnostik gegeben. Ein besonderer Schwerpunkt liegt dabei auf der Beschreibung der Zirrhose-assoziierten Komplikationen und deren pathophysiologischen Grundlagen. Die Leberzirrhose als komplexe Multisystemerkrankung mit weitreichenden Auswirkungen auf verschiedene Organsysteme zu verstehen, ist Voraussetzung für die Entwicklung neuer und dringend benötigter therapeutischer Interventionen.

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Authors and Affiliations

  1. Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Sektion Hepatologie, Universitätsmedizin Leipzig, Leipzig, Deutschland

    Dr. Cornelius Engelmann

  2. Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Sektion Hepatologie, Universitätsmedizin Leipzig, Leipzig, Deutschland

    Dr. Albrecht Böhlig

  3. Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Sektion Hepatologie, Universitätsmedizin Leipzig, Leipzig, Deutschland

    Prof. Dr. Thomas Berg

Authors
  1. Dr. Cornelius Engelmann
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  2. Dr. Albrecht Böhlig
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  3. Prof. Dr. Thomas Berg
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Correspondence to Cornelius Engelmann .

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Editors and Affiliations

  1. Institut für Pathologie, Ruhr-Universität Bochem, Bochum, Nordrhein-Westfalen, Germany

    Andrea Tannapfel

  2. Konsultationszentrum für Pankreas- und Endokrine Tumore, Technische Universität München, München, Germany

    Günter Klöppel

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Engelmann, C., Böhlig, A., Berg, T. (2020). Leberzirrhose und deren Komplikationen. In: Tannapfel, A., Klöppel, G. (eds) Pathologie. Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04557-8_10

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  • DOI: https://doi.org/10.1007/978-3-642-04557-8_10

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