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Physical Activity and Gynecologic Cancer Prevention

Part of the Recent Results in Cancer Research book series (RECENTCANCER,volume 186)

Abstract

This chapter reviews the findings from epidemiologic studies of the associations of physical activity with gynecologic cancers, including those of the endometrium, ovaries, and cervix, and the biologic mechanisms mediating the associations. The epidemiologic evidence to date suggests that physical activity probably protects against endometrial cancer, with a risk reduction of about 20–30% for those with the highest levels of physical activity compared to those with the lowest levels, and that light to moderate physical activity including housework, gardening, or walking for transportation may reduce risk. The role of physical activity in ovarian cancer development remains uncertain, as findings from these studies have been inconsistent with about half the studies suggesting physical activity modestly decreases risk and about half the studies suggesting no association. A recent meta-analysis of studies examining recreational physical activity with ovarian cancer risk estimated a 20% reduced risk for the most active versus least active women. There is mounting evidence that sedentary behaviors such as sitting time probably increase risk of endometrial and ovarian cancers. Overall, there is insufficient evidence to draw a conclusion on a possible role of physical activity in the development of cervical cancer, although a modest influence on risk is possible through effects on sex steroid hormones and immune function. The biologic evidence provides strong support for a protective role of physical activity on cancer of the endometrium, and moderate support for cancer of the ovaries, as these cancers have a strong hormonal etiology. The more established biologic mechanisms that are supported by epidemiologic and experimental data involve endogenous sex hormone levels, insulin-mediated pathways, and maintenance of energy balance.

In this chapter, we will discuss the evidence for an association of physical activity with gynecologic cancers including those of the endometrium, ovaries, and cervix. Cancers of the endometrium and ovaries have a strong hormonal etiology (Risch 1998; Kaaks et al. 2002; Lukanova and Kaaks 2005), and physical activity has been postulated as a potential modifiable risk factor for prevention of these cancers because it can influence circulating hormone levels, energy balance, and insulin-mediated pathways that are thought to be important mediators underlying the associations. Few studies have evaluated the association of physical activity with cervical cancer because the main causal factor is infection with certain types of human papillomavirus (HPV), although other hormonal and immune factors are also thought to play a role (Smith et al. 2003; Waggoner 2003). We review the findings from epidemiologic studies that have examined the associations of physical activity with gynecologic cancers, and the biologic mechanisms that might mediate the associations.

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References

  • Ainsworth BE (2000) Issues in the assessment of physical activity in women. Res Q Exerc Sport 71:S37–S42

    CAS  PubMed  Google Scholar 

  • Ainsworth BE, Haskell WL, Whitt MC et al (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32:S498–S504

    CAS  PubMed  Google Scholar 

  • Albanes D, Blair A, Taylor PR (1989) Physical activity and risk of cancer in the NHANES I population. Am J Public Health 79:744–750

    CAS  PubMed  Google Scholar 

  • Allen NE, Appleby PN, Kaaks R et al (2003) Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women. Cancer Causes Control 14:65–74

    PubMed  Google Scholar 

  • Amant F, Moerman P, Neven P et al (2005) Endometrial cancer. Lancet 366:491–505

    PubMed  Google Scholar 

  • Anderson JP, Ross JA, Folsom AR (2004) Anthropometric variables, physical activity, and incidence of ovarian cancer: The Iowa women’s health study. Cancer 100:1515–1521

    PubMed  Google Scholar 

  • Armstrong BK, White E, Saracci R (1992) Principles of exposure measurement in epidemiology. Oxford University Press, Oxford, NY

    Google Scholar 

  • Atkinson C, Lampe JW, Tworoger SS et al (2004) Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomark Prev 13:868–874

    CAS  Google Scholar 

  • Australian Government Department of Health and Ageing (2005) National physical activity guidelines for adults. Australian Government Department of Health and Ageing, Canberra

    Google Scholar 

  • Bentz AT, Schneider CM, Westerlind KC (2005) The relationship between physical activity and 2-hydroxyestrone, 16alpha-hydroxyestrone, and the 2/16 ratio in premenopausal women (United States). Cancer Causes Control 16:455–461

    PubMed  Google Scholar 

  • Beral V, Doll R, Hermon C et al (2008) Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls. Lancet 371:303–314

    CAS  PubMed  Google Scholar 

  • Bernstein L, Ross RK, Lobo RA et al (1987) The effects of moderate physical activity on menstrual cycle patterns in adolescence: implications for breast cancer prevention. Br J Cancer 55: 681–685

    CAS  PubMed  Google Scholar 

  • Bertone-Johnson ER, Tworoger SS, Hankinson SE (2009) Recreational physical activity and steroid hormone levels in postmenopausal women. Am J Epidemiol 170:1095–1104

    PubMed  Google Scholar 

  • Bertone ER, Willett WC, Rosner BA et al (2001) Prospective study of recreational physical activity and ovarian cancer. J Natl Cancer Inst 93: 942–948

    CAS  PubMed  Google Scholar 

  • Bertone ER, Newcomb PA, Willett WC et al (2002) Recreational physical activity and ovarian cancer in a population-based case-control study. Int J Cancer 99:431–436

    CAS  PubMed  Google Scholar 

  • Biesma RG, Schouten LJ, Dirx MJ et al (2006) Physical activity and risk of ovarian cancer: results from the Netherlands Cohort Study (The Netherlands). Cancer Causes Control 17: 109–115

    PubMed  Google Scholar 

  • Bonen A (1992) Recreational exercise does not impair menstrual cycles: a prospective study. Int J Sports Med 13:110–120

    CAS  PubMed  Google Scholar 

  • Borghouts LB, Keizer HA (2000) Exercise and insulin sensitivity: a review. Int J Sports Med 21: 1–12

    CAS  PubMed  Google Scholar 

  • Boule NG, Haddad E, Kenny GP et al (2001) Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 286:1218–1227

    CAS  PubMed  Google Scholar 

  • Broocks A, Pirke KM, Schweiger U et al (1990) Cyclic ovarian function in recreational athletes. J Appl Physiol 68:2083–2086

    CAS  PubMed  Google Scholar 

  • Bullen BA, Skrinar GS, Beitins IZ et al (1985) Induction of menstrual disorders by strenuous exercise in untrained women. N Engl J Med 312: 1349–1353

    CAS  PubMed  Google Scholar 

  • Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4:579–591

    CAS  PubMed  Google Scholar 

  • Campbell KL, Westerlind KC, Harber VJ et al (2005) Associations between aerobic fitness and estrogen metabolites in premenopausal women. Med Sci Sports Exerc 37:585–592

    CAS  PubMed  Google Scholar 

  • Campbell KL, McTiernan A (2007) Exercise and biomarkers for cancer prevention studies. J Nutr 137:161S–169S

    CAS  PubMed  Google Scholar 

  • Campbell PT, Wener MH, Sorensen B et al (2008) Effect of exercise on in vitro immune function: a 12-month randomized, controlled trial among postmenopausal women. J Appl Physiol 104: 1648–1655

    PubMed  Google Scholar 

  • Cannistra SA (2004) Cancer of the ovary. N Engl J Med 351:2519–2529

    CAS  PubMed  Google Scholar 

  • Carnide N, Kreiger N, Cotterchio M (2009) Association between frequency and intensity of recreational physical activity and epithelial ovarian cancer risk by age period. Eur J Cancer Prev 18:322–330

    PubMed  Google Scholar 

  • Cauley JA, Gutai JP, Kuller LH et al (1989) The epidemiology of serum sex hormones in postmenopausal women. Am J Epidemiol 129:1120–1131

    CAS  PubMed  Google Scholar 

  • Chen VW, Ruiz B, Killeen JL et al (2003) Pathology and classification of ovarian tumors. Cancer 97:2631–2642

    PubMed  Google Scholar 

  • Clark BK, Sugiyama T, Healy GN et al (2008) Validity and reliability of measures of television viewing time and other non-occupational sedentary behaviour of adults: a review. Obes Rev Jul 8

    Google Scholar 

  • Colbert LH, Lacey JV Jr, Schairer C et al (2003) Physical activity and risk of endometrial cancer in a prospective cohort study (United States). Cancer Causes Control 14:559–567

    PubMed  Google Scholar 

  • Conroy MB, Sattelmair JR, Cook NR et al (2009) Physical activity, adiposity, and risk of endometrial cancer. Cancer Causes Control 20: 1107–1115

    PubMed  Google Scholar 

  • Cottreau CM, Ness RB, Kriska AM (2000) Physical activity and reduced risk of ovarian cancer. Obstet Gynecol 96:609–614

    CAS  PubMed  Google Scholar 

  • Cust AE, Allen NE, Rinaldi S et al (2007a) Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; Results from the European prospective investigation into cancer and nutrition. Int J Cancer 120:2656–2664

    CAS  PubMed  Google Scholar 

  • Cust AE, Armstrong BK, Friedenreich CM et al (2007b) Physical activity and endometrial cancer risk: a review of the current evidence, biologic mechanisms and the quality of physical activity assessment methods. Cancer Causes Control 18:243–258

    PubMed  Google Scholar 

  • Cust AE, Kaaks R, Friedenreich C et al (2007c) Plasma adiponectin levels and endometrial cancer risk in pre- and postmenopausal women. J Clin Endocrinol Metab 92:255–263

    CAS  PubMed  Google Scholar 

  • Cust AE, Kaaks R, Friedenreich C et al (2007d) Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Endocr Relat Cancer 14:755–767

    CAS  PubMed  Google Scholar 

  • Dale E, Gerlach DH, Wilhite AL (1979) Menstrual dysfunction in distance runners. Obstet Gynecol 54:47–53

    CAS  PubMed  Google Scholar 

  • De Souza MJ, Miller BE, Loucks AB et al (1998) High frequency of luteal phase deficiency and anovulation in recreational women runners: blunted elevation in follicle-stimulating hormone observed during luteal-follicular transition. J Clin Endocrinol Metab 83:4220–4232

    PubMed  Google Scholar 

  • De Souza MJ (2003) Menstrual disturbances in athletes: a focus on luteal phase defects. Med Sci Sports Exerc 35:1553–1563

    PubMed  Google Scholar 

  • Delvenne P, Herman L, Kholod N et al (2007) Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix. Mol Cell Endocrinol 264:1–5

    CAS  PubMed  Google Scholar 

  • Dosemeci M, Hayes RB, Vetter R et al (1993) Occupational physical activity, socioeconomic status, and risks of 15 cancer sites in Turkey. Cancer Causes Control 4:313–321

    CAS  PubMed  Google Scholar 

  • Dreher D, Junod AF (1996) Role of oxygen free radicals in cancer development. Eur J Cancer 32A:30–38

    CAS  PubMed  Google Scholar 

  • Duncan GE, Perri MG, Theriaque DW et al (2003) Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diab Care 26:557–562

    CAS  Google Scholar 

  • Ferlay J, Bray F, Pisani P et al (2004). GLOBOCAN 2002: Cancer incidence, mortality and prevalence worldwide. IARC CancerBase No. 5. version 2.0. IARC Press, Lyon. http://www-dep.iarc.fr/

  • Feskens EJ, Loeber JG, Kromhout D (1994) Diet and physical activity as determinants of hyperinsulinemia: the Zutphen Elderly Study. Am J Epidemiol 140:350–360

    CAS  PubMed  Google Scholar 

  • Forney JP, Milewich L, Chen GT et al (1981) Aromatization of androstenedione to estrone by human adipose tissue in vitro. Correlation with adipose tissue mass, age, and endometrial neoplasia. J Clin Endocrinol Metab 53:192–199

    CAS  PubMed  Google Scholar 

  • Frank LL, Sorensen BE, Yasui Y et al (2005) Effects of exercise on metabolic risk variables in overweight postmenopausal women: a randomized clinical trial. Obes Res 13:615–625

    PubMed  Google Scholar 

  • Friberg E, Mantzoros CS, Wolk A (2006) Physical activity and risk of endometrial cancer: a population-based prospective cohort study. Cancer Epidemiol Biomark Prev 15:2136–2140

    Google Scholar 

  • Friedenreich CM (2001) Physical activity and cancer prevention: from observational to intervention research. Cancer Epidemiol Biomark Prev 10:287–301

    CAS  Google Scholar 

  • Friedenreich CM, Cust A, Lahmann PH et al (2007) Physical activity and risk of endometrial cancer: The European prospective investigation into cancer and nutrition. Int J Cancer 121: 347–355

    CAS  PubMed  Google Scholar 

  • Friedenreich CM, Cook LS, Magliocco AM et al (2010) Case-control study of lifetime total physical activity and endometrial cancer risk. Cancer Causes Control Mar 25; epub ahead of print

    Google Scholar 

  • Frisch RE, Wyshak G, Vincent L (1980) Delayed menarche and amenorrhea in ballet dancers. N Engl J Med 303:17–19

    CAS  PubMed  Google Scholar 

  • Frisch RE, Gotz-Welbergen AV, McArthur JW et al (1981) Delayed menarche and amenorrhea of college athletes in relation to age of onset of training. JAMA 246:1559–1563

    CAS  PubMed  Google Scholar 

  • Frisch RE, Wyshak G, Albright NL et al (1987) Lower lifetime occurrence of breast cancer and cancers of the reproductive system among former college athletes. Am J Clin Nutr 45: 328–335

    CAS  PubMed  Google Scholar 

  • Furberg AS, Thune I (2003) Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort. Int J Cancer 104: 669–676

    CAS  PubMed  Google Scholar 

  • Gertig D, Hunter D (2002) Ovarian Cancer. In: Adami HO, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology. Oxford University Press, Oxford, pp 378–399

    Google Scholar 

  • Gierach GL, Chang SC, Brinton LA et al (2009) Physical activity, sedentary behavior, and endometrial cancer risk in the NIH-AARP diet and health study. Int J Cancer 124:2139–2147

    CAS  PubMed  Google Scholar 

  • Giuliano A (2003) Cervical carcinogenesis: the role of co-factors and generation of reactive oxygen species. Salud Pública Méx 45(Suppl 3): S354–S360

    PubMed  Google Scholar 

  • Goodman MT, Hankin JH, Wilkens LR et al (1997) Diet, body size, physical activity, and the risk of endometrial cancer. Cancer Res 57:5077–5085

    CAS  PubMed  Google Scholar 

  • Hamalainen E, Tikkanen H, Harkonen M et al (1987) Serum lipoproteins, sex hormones and sex hormone binding globulin in middle-aged men of different physical fitness and risk of coronary heart disease. Atherosclerosis 67: 155–162

    CAS  PubMed  Google Scholar 

  • Hannan LM, Leitzmann MF, Lacey JV Jr et al (2004) Physical activity and risk of ovarian cancer: a prospective cohort study in the United States. Cancer Epidemiol Biomark Prev 13: 765–770

    Google Scholar 

  • Haskell WL, Lee IM, Pate RR et al (2007) Physical activity and public health: updated recommendation for adults from the American college of sports medicine and the American heart association. Circulation 116:1081–1093

    PubMed  Google Scholar 

  • Healy GN, Dunstan DW, Salmon J et al (2007) Objectively measured light-intensity physical activity is independently associated with 2-hr plasma glucose. Diab Care 30:1384–1389

    CAS  Google Scholar 

  • Hecht JL, Kotsopoulos J, Hankinson SE et al (2009) Relationship between epidemiologic risk factors and hormone receptor expression in ovarian cancer: results from the nurses’ health study. Cancer Epidemiol Biomark Prev 18:1624–1630

    CAS  Google Scholar 

  • Henderson BE, Casagrande JT, Pike MC et al (1983) The epidemiology of endometrial cancer in young women. Br J Cancer 47:749–756

    CAS  PubMed  Google Scholar 

  • Hirose K, Tajima K, Hamajima N et al (1996) Subsite (cervix/endometrium)-specific risk and protective factors in uterus cancer. Jpn J Cancer Res 87:1001–1009

    CAS  PubMed  Google Scholar 

  • Il’yasova D, Colbert LH, Harris TB et al (2005) Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. Cancer Epidemiol Biomark Prev 14:2413–2418

    Google Scholar 

  • International Agency for Research on Cancer (IARC), World Health Organization (WHO) (2002) Weight control and physical activity. IARC Handbook for cancer prevention, vol 6. IARC Press, Lyon, France

    Google Scholar 

  • Irwin ML, Mayer-Davis EJ, Addy CL et al (2000) Moderate-intensity physical activity and fasting insulin levels in women: the cross-cultural activity participation study. Diab Care 23:449–454

    CAS  Google Scholar 

  • Irwin ML, Ainsworth BE, Mayer-Davis EJ et al (2002) Physical activity and the metabolic syndrome in a tri-ethnic sample of women. Obes Res 10:1030–1037

    PubMed  Google Scholar 

  • Jakobisiak M, Lasek W, Golab J (2003) Natural mechanisms protecting against cancer. Immunol Lett 90:103–122

    CAS  PubMed  Google Scholar 

  • Kaaks R, Lukanova A (2001) Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc 60:91–106

    CAS  PubMed  Google Scholar 

  • Kaaks R, Lukanova A (2002) Effects of weight control and physical activity in cancer prevention: role of endogenous hormone metabolism. Ann NY Acad Sci 963:268–281

    CAS  PubMed  Google Scholar 

  • Kaaks R, Lukanova A, Kurzer MS (2002) Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomark Prev 11:1531–1543

    CAS  Google Scholar 

  • Kaaks R, Berrino F, Key T et al (2005) Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 97:755–765

    CAS  PubMed  Google Scholar 

  • Kalandidi A, Tzonou A, Lipworth L et al (1996) A case-control study of endometrial cancer in relation to reproductive, somatometric, and life-style variables. Oncology 53:354–359

    CAS  PubMed  Google Scholar 

  • Kasapis C, Thompson PD (2005) The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol 45:1563–1569

    CAS  PubMed  Google Scholar 

  • Kelesidis I, Kelesidis T, Mantzoros CS (2006) Adiponectin and cancer: a systematic review. Br J Cancer 94:1221–1225

    CAS  PubMed  Google Scholar 

  • Key TJ, Pike MC (1988) The dose-effect relationship between ‘unopposed’ oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk. Br J Cancer 57:205–212

    CAS  PubMed  Google Scholar 

  • Key TJ, Allen NE, Verkasalo PK et al (2001) Energy balance and cancer: the role of sex hormones. Proc Nutr Soc 60:81–89

    CAS  PubMed  Google Scholar 

  • King AC, Tribble DL (1991) The role of exercise in weight regulation in nonathletes. Sports Med 11:331–349

    CAS  PubMed  Google Scholar 

  • Kristensen GB, Trope C (1997) Epithelial ovarian carcinoma. Lancet 349:113–117

    CAS  PubMed  Google Scholar 

  • Kurian AW, Balise RR, McGuire V et al (2005) Histologic types of epithelial ovarian cancer: have they different risk factors? Gynecol Oncol 96:520–530

    PubMed  Google Scholar 

  • Lahmann PH, Cust AE, Friedenreich CM et al (2009a) Anthropometric measures and epithelial ovarian cancer risk in the Europeaneuropean prospective investigation into cancer and nutrition. Int J Cancer 126: 2404–2415

    Google Scholar 

  • Lahmann PH, Friedenreich C, Schulz M et al (2009b) Physical activity and ovarian cancer risk: the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomark Prev 18:351–354

    Google Scholar 

  • Lee IM (1995) Exercise and physical health: cancer and immune function. Res Q Exerc Sport 66:286–291

    CAS  PubMed  Google Scholar 

  • Leitzmann MF, Koebnick C, Moore SC et al (2009) Prospective study of physical activity and the risk of ovarian cancer. Cancer Causes Control 20:765–773

    PubMed  Google Scholar 

  • Levi F, La Vecchia C, Negri E et al (1993) Selected physical activities and the risk of endometrial cancer. Br J Cancer 67:846–851

    CAS  PubMed  Google Scholar 

  • Levine JA (2004) Non-exercise activity thermogenesis (NEAT). Nutr Rev 62:S82–S97

    PubMed  Google Scholar 

  • Levine JA, Lanningham-Foster LM, McCrady SK et al (2005) Interindividual variation in posture allocation: possible role in human obesity. Science 307:584–586

    CAS  PubMed  Google Scholar 

  • Levine JA, Vander Weg MW, Hill JO et al (2006) Non-exercise activity thermogenesis: the crouching tiger hidden dragon of societal weight gain. Arterioscler Thromb Vasc Biol 26:729–736

    CAS  PubMed  Google Scholar 

  • Littman AJ, Voigt LF, Beresford SA et al (2001) Recreational physical activity and endometrial cancer risk. Am J Epidemiol 154:924–933

    CAS  PubMed  Google Scholar 

  • Loucks AB (2003) Energy availability, not body fatness, regulates reproductive function in women. Exerc Sport Sci Rev 31:144–148

    PubMed  Google Scholar 

  • Lukanova A, Lundin E, Toniolo P et al (2002) Circulating levels of insulin-like growth factor-I and risk of ovarian cancer. Int J Cancer 101: 549–554

    CAS  PubMed  Google Scholar 

  • Lukanova A, Lundin E, Akhmedkhanov A et al (2003) Circulating levels of sex steroid hormones and risk of ovarian cancer. Int J Cancer 104:636–642

    CAS  PubMed  Google Scholar 

  • Lukanova A, Zeleniuch-Jacquotte A, Lundin E et al (2004) Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer. Int J Cancer 108:262–268

    CAS  PubMed  Google Scholar 

  • Lukanova A, Kaaks R (2005) Endogenous hormones and ovarian cancer: epidemiology and current hypotheses. Cancer Epidemiol Biomark Prev 14:98–107

    CAS  Google Scholar 

  • Luo Z, Saha AK, Xiang X et al (2005) AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci 26:69–76

    CAS  PubMed  Google Scholar 

  • Marti A, Marcos A, Martinez JA (2001) Obesity and immune function relationships. Obes Rev 2:131–140

    CAS  PubMed  Google Scholar 

  • Mathew A, George PS (2009) Trends in incidence and mortality rates of squamous cell carcinoma and adenocarcinoma of cervix – worldwide. Asian Pac J Cancer Prev 10:645–650

    PubMed  Google Scholar 

  • Matthews CE, Fowke JH, Dai Q et al (2004) Physical activity, body size, and estrogen metabolism in women. Cancer Causes Control 15:473–481

    PubMed  Google Scholar 

  • Matthews CE, Xu WH, Zheng W et al (2005) Physical activity and risk of endometrial cancer: a report from the Shanghai endometrial cancer study. Cancer Epidemiol Biomark Prev 14: 779–785

    Google Scholar 

  • Mayer-Davis EJ, D’Agostino R Jr, Karter AJ et al (1998) Intensity and amount of physical activity in relation to insulin sensitivity: the insulin resistance atherosclerosis study. JAMA 279: 669–674

    CAS  PubMed  Google Scholar 

  • McTiernan A, Tworoger SS, Rajan KB et al (2004a) Effect of exercise on serum androgens in postmenopausal women: a 12-month randomized clinical trial. Cancer Epidemiol Biomark Prev 13:1099–1105

    CAS  Google Scholar 

  • McTiernan A, Tworoger SS, Ulrich CM et al (2004b) Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial. Cancer Res 64:2923–2928

    CAS  PubMed  Google Scholar 

  • McTiernan A, Sorensen B, Yasui Y et al (2005) No effect of exercise on insulin-like growth factor 1 and insulin-like growth factor binding protein 3 in postmenopausal women: a 12-month randomized clinical trial. Cancer Epidemiol Biomark Prev 14:1020–1021

    CAS  Google Scholar 

  • McTiernan A (2008) Mechanisms linking physical activity with cancer. Nat Rev Cancer 8:205–211

    CAS  PubMed  Google Scholar 

  • Miyazaki H, Oh-ishi S, Ookawara T et al (2001) Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur J Appl Physiol 84:1–6

    CAS  PubMed  Google Scholar 

  • Modugno F, Ness RB, Chen C et al (2005) Inflammation and endometrial cancer: a hypothesis. Cancer Epidemiol Biomark Prev 14: 2840–2847

    CAS  Google Scholar 

  • Moldoveanu AI, Shephard RJ, Shek PN (2001) The cytokine response to physical activity and training. Sports Med 31:115–144

    CAS  PubMed  Google Scholar 

  • Moodley M, Moodley J, Chetty R et al (2003) The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: a review. Int J Gynecol Cancer 13:103–110

    CAS  PubMed  Google Scholar 

  • Moradi T, Nyren O, Bergstrom R et al (1998) Risk for endometrial cancer in relation to occupational physical activity: a nationwide cohort study in Sweden. Int J Cancer 76:665–670

    CAS  PubMed  Google Scholar 

  • Moradi T, Weiderpass E, Signorello LB et al (2000) Physical activity and postmenopausal endometrial cancer risk (Sweden). Cancer Causes Control 11:829–837

    CAS  PubMed  Google Scholar 

  • Mota F, De Oliveira C (2003) Symptoms, signs and clinico-pathological prognostic factors. In: Bösze Mayenne P (ed) Endometrial cancer. Elsevier, France, pp 55–65

    Google Scholar 

  • National Center for Chronic Disease Prevention and Health Promotion; Centers for Disease Control and Prevention (1996). Physical activity and health: a report of the Surgeon General, Atlanta, GA

    Google Scholar 

  • Nehlsen-Cannarella SL (1998) Cellular responses to moderate and heavy exercise. Can J Physiol Pharmacol 76:485–489

    CAS  PubMed  Google Scholar 

  • Nelson ME, Meredith CN, Dawson-Hughes B et al (1988) Hormone and bone mineral status in endurance-trained and sedentary postmenopausal women. J Clin Endocrinol Metab 66: 927–933

    CAS  PubMed  Google Scholar 

  • Ness RB, Cottreau C (1999) Possible role of ovarian epithelial inflammation in ovarian cancer. J Natl Cancer Inst 91:1459–1467

    CAS  PubMed  Google Scholar 

  • Nieman DC (1997) Exercise immunology: practical applications. Int J Sports Med 18(Suppl 1): S91–S100

    CAS  PubMed  Google Scholar 

  • Olsen CM, Bain CJ, Jordan SJ et al (2007a) Recreational physical activity and epithelial ovarian cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomark Prev 16:2321–2330

    Google Scholar 

  • Olsen CM, Green AC, Whiteman DC et al (2007b) Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis. Eur J Cancer 43:690–709

    PubMed  Google Scholar 

  • Olsen CM, Green AC, Nagle CM et al (2008) Epithelial ovarian cancer: testing the ‘andro-gens hypothesis’. Endocr Relat Cancer 15: 1061–1068

    CAS  PubMed  Google Scholar 

  • Olson SH, Vena JE, Dorn JP et al (1997) Exercise, occupational activity, and risk of endometrial cancer. Ann Epidemiol 7:46–53

    CAS  PubMed  Google Scholar 

  • Pan SY, Ugnat AM, Mao Y (2005) Physical activity and the risk of ovarian cancer: a case-control study in Canada. Int J Cancer 117:300–307

    CAS  PubMed  Google Scholar 

  • Parkin DM, Bray F, Ferlay J et al (2005) Global cancer statistics, 2002. CA Cancer J Clin 55: 74–108

    PubMed  Google Scholar 

  • Pate RR, Pratt M, Blair SN et al (1995) Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 273:402–407

    CAS  PubMed  Google Scholar 

  • Patel AV, Rodriguez C, Pavluck AL et al (2006) Recreational physical activity and sedentary behavior in relation to ovarian cancer risk in a large cohort of US women. Am J Epidemiol 163:709–716

    PubMed  Google Scholar 

  • Patel AV, Feigelson HS, Talbot JT et al (2008) The role of body weight in the relationship between physical activity and endometrial cancer: results from a large cohort of US women. Int J Cancer 123:1877–1882

    CAS  PubMed  Google Scholar 

  • Pecorelli S, Benedet JL, Creasman WT et al (1999) FIGO staging of gynecologic cancer. 1994–1997 FIGO Committee on Gynecologic Oncology. International Federation of Gynecology and Obstetrics. Int J Gynaecol Obstet 64:5–10

    CAS  PubMed  Google Scholar 

  • Pedersen BK, Ostrowski K, Rohde T et al (1998) The cytokine response to strenuous exercise. Can J Physiol Pharmacol 76:505–511

    CAS  PubMed  Google Scholar 

  • Peeters PH, Lukanova A, Allen N et al (2007) Serum IGF-I, its major binding protein (IGFBP-3) and epithelial ovarian cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC). Endocr Relat Cancer 14: 81–90

    CAS  PubMed  Google Scholar 

  • Pischon T, Hankinson SE, Hotamisligil GS et al (2003) Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 11:1055–1064

    CAS  PubMed  Google Scholar 

  • Pukkala E, Poskiparta M, Apter D et al (1993) Life-long physical activity and cancer risk among Finnish female teachers. Eur J Cancer Prev 2: 369–376

    CAS  PubMed  Google Scholar 

  • Purdie DM, Bain CJ, Siskind V et al (2003) Ovulation and risk of epithelial ovarian cancer. Int J Cancer 104:228–232

    CAS  PubMed  Google Scholar 

  • Purohit A, Newman SP, Reed MJ (2002) The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer. Breast Cancer Res 4:65–69

    CAS  PubMed  Google Scholar 

  • Rajaram S, Baylink DJ, Mohan S (1997) Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocr Rev 18:801–831

    CAS  PubMed  Google Scholar 

  • Ravussin E (2005) Physiology. A NEAT way to control weight? Science 307:530–531

    CAS  PubMed  Google Scholar 

  • Riman T, Dickman PW, Nilsson S et al (2004) Some life-style factors and the risk of invasive epithelial ovarian cancer in Swedish women. Eur J Epidemiol 19:1011–1019

    PubMed  Google Scholar 

  • Rinaldi S, Key TJ, Peeters PH et al (2006) Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study within the EPIC cohort. Int J Cancer 118:2832–2839

    CAS  PubMed  Google Scholar 

  • Rinaldi S, Dossus L, Lukanova A et al (2007) Endogenous androgens and risk of epithelial ovarian cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiol Biomark Prev 16:23–29

    CAS  Google Scholar 

  • Risch HA (1998) Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst 90:1774–1786

    CAS  PubMed  Google Scholar 

  • Robertson JD, Maughan RJ, Duthie GG et al (1991) Increased blood antioxidant systems of runners in response to training load. Clin Sci (Lond) 80:611–618

    CAS  Google Scholar 

  • Rogol AD, Weltman A, Weltman JY et al (1992) Durability of the reproductive axis in eumenorrheic women during 1 yr of endurance training. J Appl Physiol 72:1571–1580

    CAS  PubMed  Google Scholar 

  • Rose PG (1996) Endometrial carcinoma. N Engl J Med 335:640–649

    CAS  PubMed  Google Scholar 

  • Ross R, Dagnone D, Jones PJ et al (2000) Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med 133:92–103

    CAS  PubMed  Google Scholar 

  • Ross R, Janssen I, Dawson J et al (2004) Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res 12:789–798

    PubMed  Google Scholar 

  • Rossing MA, Cushing-Haugen KL, Wicklund KG et al (2010) Recreational physical activity and risk of epithelial ovarian cancer. Cancer Causes Control 21:485–491

    PubMed  Google Scholar 

  • Salazar-Martinez E, Lazcano-Ponce EC, Lira-Lira GG et al (2000) Case-control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women. Cancer Causes Control 11:707–711

    CAS  PubMed  Google Scholar 

  • Schnohr P, Gronbaek M, Petersen L et al (2005) Physical activity in leisure-time and risk of cancer: 14-year follow-up of 28,000 Danish men and women. Scand J Public Health 33: 244–249

    PubMed  Google Scholar 

  • Schouten LJ, Goldbohm RA, van den Brandt PA (2004) Anthropometry, physical activity, and endometrial cancer risk: results from the Netherlands cohort study. J Natl Cancer Inst 96: 1635–1638

    PubMed  Google Scholar 

  • Schouten LJ, Rivera C, Hunter DJ et al (2008) Height, body mass index, and ovarian cancer: a pooled analysis of 12 cohort studies. Cancer Epidemiol Biomark Prev 17:902–912

    Google Scholar 

  • Shephard RJ, Shek PN (1998) Associations between physical activity and susceptibility to cancer: possible mechanisms. Sports Med 26: 293–315

    CAS  PubMed  Google Scholar 

  • Sherman B, Wallace R, Bean J et al (1981) Relationship of body weight to menarcheal and menopausal age: implications for breast cancer risk. J Clin Endocrinol Metab 52:488–493

    CAS  PubMed  Google Scholar 

  • Shu XO, Hatch MC, Zheng W et al (1993) Physical activity and risk of endometrial cancer. Epidemiology 4:342–349

    CAS  PubMed  Google Scholar 

  • Smith JS, Green J, Berrington de Gonzalez A et al (2003) Cervical cancer and use of hormonal contraceptives: a systematic review. Lancet 361: 1159–1167

    PubMed  Google Scholar 

  • Steben M, Duarte-Franco E (2007) Human papillomavirus infection: epidemiology and pathophysiology. Gynecol Oncol 107:S2–S5

    CAS  PubMed  Google Scholar 

  • Sturgeon SR, Brinton LA, Berman ML et al (1993) Past and present physical activity and endometrial cancer risk. Br J Cancer 68:584–589

    CAS  PubMed  Google Scholar 

  • Stuver S, Adami H (2002) Cervical cancer. In: Adami HO, Hunter D, Trichopoulos D (eds) Textbook of cancer epidemiology. Oxford University Press, Oxford, pp 340–354

    Google Scholar 

  • Tavani A, Gallus S, La Vecchia C et al (2001) Physical activity and risk of ovarian cancer: an Italian case-control study. Int J Cancer 91: 407–411

    CAS  PubMed  Google Scholar 

  • Tavani A, Bravi F, Dal Maso L et al (2009) Physical activity and risk of endometrial cancer: an Italian case-control study. Eur J Cancer Prev 18:303–306

    PubMed  Google Scholar 

  • Terry P, Baron JA, Weiderpass E et al (1999) Lifestyle and endometrial cancer risk: a cohort study from the Swedish Twin Registry. Int J Cancer 82:38–42

    CAS  PubMed  Google Scholar 

  • Thune I, Furberg AS (2001) Physical activity and cancer risk: dose-response and cancer, all sites and site-specific. Med Sci Sports Exerc 33:S530–S550, discussion S609–510

    CAS  PubMed  Google Scholar 

  • Tworoger SS, Eliassen AH, Missmer SA et al (2006) Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal women. Cancer Epidemiol Biomark Prev 15:2494–2501

    CAS  Google Scholar 

  • van Gils CH, Peeters PH, Schoenmakers MC et al (2009) Physical activity and endogenous sex hormone levels in postmenopausal women: a cross-sectional study in the Prospect-EPIC Cohort. Cancer Epidemiol Biomark Prev 18: 377–383

    Google Scholar 

  • Verkasalo PK, Thomas HV, Appleby PN et al (2001) Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre- and postmenopausal women (United Kingdom). Cancer Causes Control 12:47–59

    CAS  PubMed  Google Scholar 

  • Voskuil DW, Monninkhof EM, Elias SG et al (2007) Physical activity and endometrial cancer risk, a systematic review of current evidence. Cancer Epidemiol Biomark Prev 16:639–648

    Google Scholar 

  • Waggoner SE (2003) Cervical cancer. Lancet 361: 2217–2225

    PubMed  Google Scholar 

  • Warren MP (1980) The effects of exercise on pubertal progression and reproductive function in girls. J Clin Endocrinol Metab 51:1150–1157

    CAS  PubMed  Google Scholar 

  • Weiderpass E, Margolis KL, Sandin S et al (2006) Prospective study of physical activity in different periods of life and the risk of ovarian cancer. Int J Cancer 118:3153–3160

    CAS  PubMed  Google Scholar 

  • Willett W (1989) An overview of issues related to the correction of non-differential exposure measurement error in epidemiologic studies. Stat Med 8:1031–1040, discussion 1071–1033

    CAS  PubMed  Google Scholar 

  • World Cancer Research Fund & American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. American Institute for Cancer Research, Washington, DC

    Google Scholar 

  • Zhang M, Lee AH, Binns CW (2003) Physical activity and epithelial ovarian cancer risk: a case-control study in China. Int J Cancer 105: 838–843

    CAS  PubMed  Google Scholar 

  • Zhang M, Xie X, Lee AH et al (2004) Sedentary behaviours and epithelial ovarian cancer risk. Cancer Causes Control 15:83–89

    PubMed  Google Scholar 

  • Zheng W, Shu XO, McLaughlin JK et al (1993) Occupational physical activity and the incidence of cancer of the breast, corpus uteri, and ovary in Shanghai. Cancer 71:3620–3624

    CAS  PubMed  Google Scholar 

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Acknowledgment

Anne Cust is the recipient of a National Health and Medical Research Council public health postdoctoral fellowship #520018

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Cust, A.E. (2010). Physical Activity and Gynecologic Cancer Prevention. In: Courneya, K., Friedenreich, C. (eds) Physical Activity and Cancer. Recent Results in Cancer Research, vol 186. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04231-7_7

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