Skip to main content

Botanicals in Pediatric Oncology and the Issue of Botanical/Drug Interactions

  • 1120 Accesses

Part of the Pediatric Oncology book series (PEDIATRICO)

Abstract

Cancer patients frequently explore complementary and alternative medicine (CAM) modalities to alleviate symptoms related to disease and treatment. Patients are increasingly turning to botanical and herbal medicines to replace or supplement conventional treatments in order to provide relief.

Keywords

  • Chinese Herbal Medicine
  • Vinca Alkaloid
  • Pediatric Cancer
  • Milk Thistle
  • Herbal Medicinal Product

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-04201-0_10
  • Chapter length: 10 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   109.00
Price excludes VAT (USA)
  • ISBN: 978-3-642-04201-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   149.00
Price excludes VAT (USA)
Hardcover Book
USD   149.99
Price excludes VAT (USA)

References

  • Abe Y, Hashimoto S et al (1999) Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res 39(1):41–47

    PubMed  CrossRef  CAS  Google Scholar 

  • Aggarwal BB, Kumar A (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23(1A):363–398

    PubMed  CAS  Google Scholar 

  • Bharti AC, Donato N et al (2003) Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 101(3):1053–1062

    PubMed  CrossRef  CAS  Google Scholar 

  • Bharti AC, Shishodia S et al (2004a) Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood 103(8):3175–3184

    PubMed  CrossRef  CAS  Google Scholar 

  • Bharti AC, Takada Y et al (2004b) Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J Immunol 172(10):5940–5947

    PubMed  CAS  Google Scholar 

  • Bishop FL, Prescott P (2010) Prevalence of complementary medicine use in pediatric cancer: a systematic review. Pediatrics 125(4):768–776

    PubMed  CrossRef  Google Scholar 

  • Block KI, Gyllenhaal C et al (2004) Safety and efficacy of herbal sedatives in cancer care. Integr Cancer Ther 3(2):128–148

    PubMed  CrossRef  CAS  Google Scholar 

  • Cheng AL, Hsu CH (2001) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21(4B):2895–2900

    PubMed  CAS  Google Scholar 

  • Dhillon N, Aggarwal BB et al (2008) Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 14(14):4491–4499

    PubMed  CrossRef  CAS  Google Scholar 

  • Dorai T, Cao YC et al (2001) Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 47(4):293–303

    PubMed  CrossRef  CAS  Google Scholar 

  • Elam JL, Carpenter JS et al (2006) Methodological issues in the investigation of ginseng as an intervention for fatigue. Clin Nurse Spec 20(4):183–189

    PubMed  CrossRef  Google Scholar 

  • Ernst E, Pittler MH (2000) Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anaesth 84(3):367–371

    PubMed  CrossRef  CAS  Google Scholar 

  • Forester SC, Lambert JD (2011) The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention. Mol Nutr Food Res 55(6):844–854

    PubMed  CrossRef  CAS  Google Scholar 

  • Garami M, Schuler D et al (2004) Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients. J Pediatr Hematol Oncol 26(10):631–635

    PubMed  CrossRef  Google Scholar 

  • Goel A, Kunnumakkara AB et al (2008) Curcumin as “Curecumin”: from kitchen to clinic. Biochem Pharmacol 75(4):787–809

    PubMed  CrossRef  CAS  Google Scholar 

  • Karmakar S, Choudhury SR (2011) Molecular mechanisms of anti-cancer action of garlic compounds in neuroblastoma. Anticancer Agents Med Chem 11(4):398–407

    PubMed  CrossRef  CAS  Google Scholar 

  • Kim JY, Kwon O (2009) Garlic intake and cancer risk: an analysis using the Food and Drug Administration’s evidence-based review system for the scientific evaluation of health claims. Am J Clin Nutr 89(1):257–264

    PubMed  CrossRef  CAS  Google Scholar 

  • Korutla L, Kumar R (1994) Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochim Biophys Acta 1224(3):597–600

    PubMed  CrossRef  Google Scholar 

  • Korutla L, Cheung JY et al (1995) Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin. Carcinogenesis 16(8):1741–1745

    PubMed  CrossRef  CAS  Google Scholar 

  • Ladas EJ, Kroll DJ (2010) A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer 116(2):506–513

    PubMed  CrossRef  CAS  Google Scholar 

  • Mansky PJ, Straus SE (2002) St. John’s Wort: more implications for cancer patients. J Natl Cancer Inst 94(16):1187–1188

    PubMed  CrossRef  CAS  Google Scholar 

  • Mansky PJ, Wallerstedt DB (2006) Complementary medicine in palliative care and cancer symptom management. Cancer J 12(5):425–431

    PubMed  CrossRef  Google Scholar 

  • Mathijssen RH, Verweij J et al (2002) Effects of St. John’s Wort on irinotecan metabolism. J Natl Cancer Inst 94(16):1247–1249

    PubMed  CrossRef  CAS  Google Scholar 

  • Mizutani Y, Nio Y, Yoshida O (1992) Effect of PSK and its subfractions on peripheral blood lymphocytes mediated cytotoxicity against urinary bladder tumor cells. J Urol 148(5):1571–1576

    PubMed  CAS  Google Scholar 

  • Mukhopadhyay A, Banerjee S et al (2002) Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 21(57):8852–8861

    PubMed  CrossRef  CAS  Google Scholar 

  • Ng TB (1998) A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae). Gen Pharmacol 30(1):1–4

    PubMed  CrossRef  CAS  Google Scholar 

  • Oba K, Teramukai S et al (2007) Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer. Cancer Immunol Immunother 56(6):905–911

    PubMed  CrossRef  CAS  Google Scholar 

  • Oberbaum M, Yaniv I et al (2001) A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation. Cancer 92(3):684–690

    PubMed  CrossRef  CAS  Google Scholar 

  • Piscitelli SC, Burstein AH et al (2000) Indinavir concentrations and St John’s wort. Lancet 355(9203):547–548

    PubMed  CrossRef  CAS  Google Scholar 

  • Plummer SM, Holloway KA et al (1999) Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene 18(44):6013–6020

    PubMed  CrossRef  CAS  Google Scholar 

  • Rao CV, Simi B et al (1993) Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis 14(11):2219–2225

    PubMed  CrossRef  CAS  Google Scholar 

  • Richardson MA, Sanders T et al (2000) Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol 18(13):2505–2514

    PubMed  CAS  Google Scholar 

  • Sandur SK, Pandey MK et al (2007) Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 28(8):1765–1773

    PubMed  CrossRef  CAS  Google Scholar 

  • Sharma RA, Euden SA et al (2004) Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res 10(20):6847–6854

    PubMed  CrossRef  CAS  Google Scholar 

  • Sharma RA, Steward WP et al (2007) Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol 595:453–470

    PubMed  CrossRef  Google Scholar 

  • Shishodia S, Chaturvedi MM et al (2007) Role of curcumin in cancer therapy. Curr Probl Cancer 31(4):243–305

    PubMed  CrossRef  Google Scholar 

  • Singh BN, Shankar S (2011) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem Pharmacol 82(12):1807–1821

    PubMed  CrossRef  CAS  Google Scholar 

  • Singh AK, Sidhu GS et al (1996) Curcumin inhibits the proliferation and cell cycle progression of human umbilical vein endothelial cell. Cancer Lett 107(1):109–115

    PubMed  CrossRef  CAS  Google Scholar 

  • Smith JE, Rowan NJ, Sullivan R (2002) Medicinal mushrooms: their therapeutic properties and current medical usage with special emphasis on cancer treatments. University of Strathclyde, Strathclyde, pp 1–256

    Google Scholar 

  • Sontakke S, Thawani V et al (2003) Ginger as an antiemetic in nausea and vomiting induced by chemotherapy: a randomized, cross-over, double blind study. Indian J Pharmacol 35(1):32–36

    Google Scholar 

  • Sparreboom A, Baker SD (2009) CAM: chemo interactions – what is known? In: Abrams D, Weil A (eds) Integrative oncology. Oxford University Press, New York

    Google Scholar 

  • Sullivan R, Smith JE et al (2006) Medicinal mushrooms and cancer therapy: translating a traditional practice into western medicine. Perspect Biol Med 49(2):159–170

    PubMed  CrossRef  CAS  Google Scholar 

  • Taixiang W, Munro AJ et al (2005) Chinese medical herbs for chemotherapy side effects in colorectal cancer patients. Cochrane Database Syst Rev (1):CD004540

    Google Scholar 

  • Tamayo C, Diamond S (2007) Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.). Integr Cancer Ther 6(2):146–157

    PubMed  CrossRef  CAS  Google Scholar 

  • Thaloor D, Singh AK et al (1998) Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin. Cell Growth Differ 9(4):305–312

    PubMed  CAS  Google Scholar 

  • van Erp NP, Baker SD et al (2005) Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan. Clin Cancer Res 11(21):7800–7806

    PubMed  CrossRef  Google Scholar 

  • Xu L, Lao LX et al (2007) Chinese herbal medicine for cancer pain. Integr Cancer Ther 6(3):208–234

    PubMed  CrossRef  Google Scholar 

  • Ying JZ et al (1987) Icons of medicinal fungi from China (trans: Xu YH). Science Press, Beijing

    Google Scholar 

  • Yodkeeree S, Chaiwangyen W (2008) Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J Nutr Biochem 20(2):87–95

    PubMed  CrossRef  Google Scholar 

  • Yuan JM, Sun C (2011) Tea and cancer prevention: epidemiological studies. Pharmacol Res 64(2):123–135

    PubMed  CrossRef  CAS  Google Scholar 

  • Zhang M, Liu X et al (2007) Chinese medicinal herbs to treat the side-effects of chemotherapy in breast cancer patients. Cochrane Database Syst Rev (2):CD004921

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Patrick J. Mansky M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mansky, P.J. (2012). Botanicals in Pediatric Oncology and the Issue of Botanical/Drug Interactions. In: Längler, A., Mansky, P., Seifert, G. (eds) Integrative Pediatric Oncology. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04201-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-04201-0_10

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-04200-3

  • Online ISBN: 978-3-642-04201-0

  • eBook Packages: MedicineMedicine (R0)