Abstract
The medial and lateral perforant pathways (MPP and LPP) conveying spatial and non-spatial information terminate within the middle and the outer 1/3 of the dentate molecular layer, respectively. MPP projection neurons generate subthreshold oscillations, whereas LPP projection neurons do not, implying that the MPP signal is regular and the LPP signal is rather random. In this paper, we investigated synaptic modification caused by uncorrelated signals through MPP and LPP synapses using a multi-compartmental model of the dentate granule cell. MPP and LPP synapses were subject to an asymmetric spike-timing-dependent plasticity (STDP) rule. As a result, the MPP synaptic weight was enhanced and the LPP synaptic weight was rather depressed. This suggests that LPP signal conveying non-spatial information promotes enhancement of MPP synaptic weight where spatial information passes through.
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Nonaka, Y., Hayashi, H. (2010). Spike-Timing-Dependent LTP/LTD Caused by Uncorrelated Signals through Medial and Lateral Perforant Pathways in the Dentate Granule Cell. In: Hanazawa, A., Miki, T., Horio, K. (eds) Brain-Inspired Information Technology. Studies in Computational Intelligence, vol 266. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04025-2_19
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DOI: https://doi.org/10.1007/978-3-642-04025-2_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-04024-5
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