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Interactions of Cells with Elastic Cholesteryl Liquid Crystals

  • C. F. Soon
  • M. Youseffi
  • N. Blagden
  • S. B. Lobo
  • F. A. Javid
  • M. C. T. Denyer
Part of the IFMBE Proceedings book series (IFMBE, volume 25/10)

Abstract

Exploitation of elastic property of the liquid crystal to sense cells mechanics is a novel application. Both quantitative and qualitative analysis of cholesteryl liquid crystal has shown flexibility and elasticity of the material to sense cell contraction and relaxation over a period of time. Importantly, cells adhesion was precluded with the use of extracellular matrix proteins in this technique. The optimum operating range with linear elasticity of the cholesteryl liquid crystal is ≤ 0.1s− 1 which has a good correlation with the shear rate of the cells originated from the focal adhesions. Localized contraction was observed with a good resolution. In addition, clear definition of deformation lines between two cells has shown their interacting path through active mechano-sensing.

Keywords

Shear Rate Liquid Crystal Complex Viscosity Cholesteric Liquid Crystal Liquid Crystal Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • C. F. Soon
    • 1
    • 2
  • M. Youseffi
    • 3
  • N. Blagden
    • 2
  • S. B. Lobo
    • 2
  • F. A. Javid
    • 4
  • M. C. T. Denyer
    • 2
  1. 1.Faculty of Electrical and Electronic EngineeringUniversiti Tun Hussein Onn MalaysiaJohorMalaysia
  2. 2.School of PharmacyUniversity of BradfordBradfordUnited Kingdom
  3. 3.School of Engineering, Design and Technology-Medical EngineeringUniversity of BradfordBradfordUnited Kingdom
  4. 4.School of Applied Sciences-Division of PharmacyUniversity of HuddersfieldHuddersfieldUnited Kingdom

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