Abstract
Hyperpolarized xenon is an exquisite NMR probe for sensing molecular environments of the noble gas in solution. By trapping it in molecular cages like cryptophane-A, 129Xe can report information about molecular-specific binding events or resolve multiple signals simultaneously from different micro-environments in a lipid emulsion-a macroscopically-homogeneous phase that mimics properties of biological relevance. The Hyper-CEST detection scheme can be used in this context to pair significant signal enhancement with high specificity of xenon NMR resonances. Hyper-CEST can reduce the measurement time by a factor of up to 16 million and is currently able to detect biosensor concentrations as low as 1.4 nM. When combined with highly frequency-selective pulses, it also allows for demonstration of multiplexing potential using a single cage type as contrast agent for different environments in NMR imaging. This molecular imaging approach enables a switchable contrast that includes also temperature-sensitive imaging with molecular sensors that can be functionalized with various targeting molecules to bind, e.g., specifically to receptors of cancer cells.
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© 2009 International Federation for Medical and Biological Engineering
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Schröder, L. et al. (2009). Xenon Biosensors for Multi-Purpose Molecular Imaging. In: Dössel, O., Schlegel, W.C. (eds) World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany. IFMBE Proceedings, vol 25/13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03895-2_51
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DOI: https://doi.org/10.1007/978-3-642-03895-2_51
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-03894-5
Online ISBN: 978-3-642-03895-2
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