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Maligne Lungentumoren

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Praxis der Viszeralchirurgie Onkologische Chirurgie

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Zusammenfassung

Mit annähernd 500.000 Sterbefällen pro Jahr in den Industrienationen der Nordhalbkugel ist und bleibt der Lungenkrebs die häufigste Krebstodesursache - zu 90% durch Zigarettenrauchen bedingt. Die Biologie der Tumoren ist äußerst variabel, histologisch sind Mischtypen mit kleinzelligen Anteilen besonders häufig. Nur 30% aller Erkrankten werden mit kurativer Zielsetzung operiert. Trotz enormer chirurgischer Fortschritte (Letalität der Lobektomie 1–4%) konnte die Langzeitprognose aller Operierten mit ca. 35% 5-Jahres-überleben nicht relevant verbessert werden. Auch sog. Frühstadien scheinen bereits zellulär zu streuen, sodass die neoadjuvante/adjuvante Chemotherapiestrategie auch in diesen frühen Stadien eine Bedeutung erlangt hat. Unabhängig davon wird auch in Zukunft in weit fortgeschrittenen Stadien die Operation mit palliativer Zielsetzung ihren festen Stellenwert haben.

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Literatur

  • Adler J (1912) Primary malignant growth of the lungs and bronchi; a morphological and clinical study. Longmanns Green, New York

    Google Scholar 

  • Alam N, et al. (2005) Compliance with post-operative adjuvant chemotherapy in non-small cell lung cancer. An analysis of National Cancer Institute of Canada and intergroup trial JBR.10 and a review of the literature. Lung Cancer 47(3): 385–394

    Article  PubMed  Google Scholar 

  • American Cancer Society (1990) Shopland study. Semin Oncol 17: 402–412

    Google Scholar 

  • American Joint Committee for Cancer Staging and End Results Reporting (1979) Staging of lung cancer 1979. American Joint Committee, Chicago

    Google Scholar 

  • Arriagada R, et al. (2004) Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 350(4): 351–360

    Article  PubMed  Google Scholar 

  • Auperin A, et al. (2006) Concomitant radio-chemotherapy based on platin compounds in patients with locally advanced non-small cell lung cancer (NSCLC): a meta-analysis of individual data from 1764 patients. Ann Oncol 17(3): 473–483

    Article  CAS  PubMed  Google Scholar 

  • Breen D, Barlesi F (2008) The place of excision repair cross complementation 1 (ERCC1) in surgically treated non-small cell lung cancer. Eur J Cardiothorac Surg 33(5): 805–811

    Article  PubMed  Google Scholar 

  • British Medical Research Council (1966) Comparative trial of surgery and radiotherapy for primary treatment of small cell or oat cell carcinoma of the bronchus. Lancet 2: 979–986

    Google Scholar 

  • Doddoli C, et al. (2005) One hundred consecutive pneumonectomies after induction therapy for non-small cell lung cancer: an uncertain balance between risks and benefits. J Thorac Cardiovasc Surg 130(2): 416–425

    Article  PubMed  Google Scholar 

  • Dwanema BA, Sommad SS, Angobaldo JO, Wahl RL (1999) Metastases from non small cell lung cancer: mediastinal staging in the 1990 s-meta analytic comparison of PET and CT. Radiology 213: 530–536

    Google Scholar 

  • Gilbert S, Reid KR, Lau MG, Petsikas D (2000) Who should follow up lung cancer patients after operation? Ann Thorac Surg 69: 1696–1700

    Article  CAS  PubMed  Google Scholar 

  • Goldstraw P, et al. (2007) The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol 2(8): 706–714

    Article  PubMed  Google Scholar 

  • Karp DD, Law A (1997) Lung cancer chemoprevention and management of carcinoma in situ. Prog Resp Res 29: 1–20

    Article  Google Scholar 

  • Karrer K, Shields T (1991) For the JSC. Lung Cancer Study Group: the importance for complete resection in the multi modality treatment of SCLC. Lung Cancer 7[Suppl]: 254–271

    Google Scholar 

  • Komaki R, Milas L, Ro JY et al. (1998) Prognostic biomarker study in pathologically staged N1 non small cell lung cancer. Int J Radiat Oncol Biol Phys 40: 787–796

    Article  CAS  PubMed  Google Scholar 

  • Le Chevalier T, et al. (2005) Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes. Lung Cancer 47(1): 69–80

    Article  PubMed  Google Scholar 

  • Lilenbaum RC (2008) New horizons in chemotherapy: platforms for combinations in first-line advanced non-small cell lung cancer. J Thorac Oncol 3(6 Suppl 2): S171–S174

    Article  PubMed  Google Scholar 

  • Loddenkemper (1983) Criteria of functional operability in patients with bronchial carcinoma: preoperative assessment of risk and prediction of postoperative function. J Thorac Cardiovasc Surg 31: 334–337

    Article  CAS  Google Scholar 

  • Mountain CF (1986) A new international staging system for lung cancer. Chest 89: 2258

    Google Scholar 

  • Mountain CF (2000) The international system for staging lung cancer. Semin Surg Oncol 18: 106–115

    Article  CAS  PubMed  Google Scholar 

  • Müller KM, Fesseler-Eckhoff A (1997) Pathologie der Lungentumoren. In: Drings P, Vogt Moykopf I (Hrsg) Thoraxtumoren, Diagnostik, Staging, Therapiekonzept. Springer, Berlin Heidelberg New York Tokio, S 5–24

    Google Scholar 

  • Müller KM, Wiethrich T, Tolnay E, Junker K (1997) Variable Biologie der Lungentumoren. Atem Lungenkrankh 23: 302–307

    Google Scholar 

  • Naruke T, Suemasu K, Ishikawa S (1998) Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg 96: 440

    Google Scholar 

  • Parkin DM (2001) Global cancer statistics in the year 2000. Lancet Oncol 2(9): 533–543

    Article  CAS  PubMed  Google Scholar 

  • Petersen I, et al. (1997) Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17p. Br J Cancer 75(1): 79–86

    CAS  PubMed  Google Scholar 

  • Pignon JP, et al. (2008) Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group. J Clin Oncol 26(21): 3552–3559

    Article  PubMed  Google Scholar 

  • Pisters KM, et al. (2007) Cancer Care Ontario and American Society of Clinical Oncology adjuvant chemotherapy and adjuvant radiation therapy for stages I–IIIA resectable non small-cell lung cancer guideline. J Clin Oncol 25(34): 5506–5518

    Article  PubMed  Google Scholar 

  • Ramström LM (1997) Prevalence and other dimensions of smoking in the world. Prog Resp Res 28: 64–77

    Article  Google Scholar 

  • Schalhorn A, Sunder-Plassmann L (2000) Bronchialcarcinome. In: Wilmann W, Huhn D, Wilms K (Hrsg) Internistische Onkologie. Thieme, Stuttgart, S 617–637

    Google Scholar 

  • Schirren J, Krysa S, Bülzebruck H, Vogt-Moykopf J (1991) Das kleinzellige Bronchialcarzinom-Eine Operationsindikation? Z Herz Thorax Gefaeßchir 5: 260–266

    Google Scholar 

  • Schmähl D (1997) Ätiologie des Bronchialcarcinoms. In: Drings P, Vogt Moykopf I (Hrsg) Thoraxtumoren, Diagnostik, Staging, Therapiekonzept. Springer, Berlin Heidelberg New York Tokio, S 24–29

    Google Scholar 

  • Shepherd FA, Ginsburg RJ, Evans WK (1983) Reduction in local recurrence and improved survival in surgically treated patients with small cell carcinoma of the lung. J Thorac Cardiovasc Surg 86: 598

    Google Scholar 

  • Shepherd FA, Ginsburg RJ, Patterson GA, Evans WK Feld R (1989) A prospective study of adjuvant surgical resection after chemotherapy for limited small cell lung cancer. J Thorac Cardiovasc Surg 97: 177–186

    CAS  PubMed  Google Scholar 

  • Shields TW, Higgins GA, Matthews NJ, Kiihn RJ (1982) Surgical resection in the management of small cell carcinoma of the lung. J Thorac Cardiovasc Surg 84: 481

    CAS  PubMed  Google Scholar 

  • Shields TW, Robinson PG, Radosevich JA (1994) Lung cancer: etiology, carcinogenesis, molecular biology and pathology. In: Shields TW (ed) General thoracic surgery, 4th edn. Williams & Wilkins, Baltimore, pp 1095–1113

    Google Scholar 

  • Spira A, Ettinger DS (2004) Multidisciplinary management of lung cancer. N Engl J Med 350: 379–392

    Article  CAS  PubMed  Google Scholar 

  • Sunder-Plassmann L (1998) Stellenwert der Operation beim kleinzelligen Bronchialcarcinom. Onkologe 4: 1035–1038

    Article  Google Scholar 

  • Sunder-Plassmann L, Dienemann H, Heberer G (1991a) Primäre maligne Tumoren der Lunge. In: Heberer G, Schildberg FW, Sunder-Plassmann L, Vogt Moykopf I (Hrsg) Lunge und Mediastinum. Springer, Berlin Heidelberg New York Tokio, pp 409–419

    Google Scholar 

  • Sunder-Plassmann L, Dienemann H, Heberer G (1991b) Anatomische Lungenresektionen. In: Heberer G, Schildberg FW, Sunder-Plassmann L, Vogt Moykopf I (Hrsg) Lunge und Mediastinum. Springer, Berlin Heidelberg New York Tokio, S 423–476

    Google Scholar 

  • The International Adjuvant Lung Cancer Trial Collaborative Group (2004) Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 350: 351–360

    Article  Google Scholar 

  • Travis WD, et al. (2004) Pathology and genetics of tumours of the lung, pleura, thymus and heart. WHO Classification of tumours, vol. 10. IARC 344

    Google Scholar 

  • Wada H, Yokonuse H, Tanaka F, Hirata T, Fubuse T (1995) Surgical treatment of small cell carcinoma of the lung; advantage of preoperative chemotherapy. Lung Cancer 13: 45–56

    Article  CAS  PubMed  Google Scholar 

  • Walch AK, et al. (1998) Typical and atypical carcinoid tumors of the lung are characterized by 11q deletions as detected by comparative genomic hybridization. Am J Pathol 153(4): 1089–1098

    CAS  PubMed  Google Scholar 

  • Wiethege T, Voss B, Müller KM (1994) Onkogene und Tumorsuppressorgene bei der Pathogenese von Lungentumoren. Der Pathologe 15(6): 321–330

    Article  CAS  PubMed  Google Scholar 

  • World Health Organization (1982) The World Health Organization histological typing of lung tumors, 2nd edn. Am J Clinic Pathol 77: 123–136

    Google Scholar 

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Authors and Affiliations

  1. Chirurgische Klinik, Klinikum Bogenhausen, Städtisches Klinikum München GmbH, Englschalkinger Straße 77, 81925, München

    Univ.-Prof. em. Dr. med. L. Sunder-Plassmann

  2. Zentrum für Innere Medizin, Klinik für Innere Medizin II, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm

    OA Dr. med. C. Schumann

Authors
  1. Univ.-Prof. em. Dr. med. L. Sunder-Plassmann
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  2. OA Dr. med. C. Schumann
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Editor information

Editors and Affiliations

  1. Universitätsklinikum Heidelberg, Im Neuenheimer Feld 672, 69120, Heidelberg

    J. R. Siewert (Leitender Ärztlicher Direktor und Vorstandsvorsitzender) (Leitender Ärztlicher Direktor und Vorstandsvorsitzender)

  2. Zentrum für Operative Medizin I, Klinikum der Philipps-Universität, Baldinger Straße, 35043, Marburg

    Matthias Rothmund

  3. Universitätsklinik und Poliklinik, Medizinische Fakultät der RWTH, Pauwelsstraße 30, 52057, Aachen

    Volker Schumpelick

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Sunder-Plassmann, L., Schumann, C. (2010). Maligne Lungentumoren. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie Onkologische Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03808-2_36

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  • DOI: https://doi.org/10.1007/978-3-642-03808-2_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-03807-5

  • Online ISBN: 978-3-642-03808-2

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