Zusammenfassung
Neben den klassischen Zytostatika haben sich sog. biologisch zielgerichtete Wirkstoffe in der Systemtherapie viszeraler Tumorerkrankungen etabliert. Entsprechend des typischen Entwicklungszyklus pharmazeutischer Produkte ist deren Wirksamkeit bislang vor allem für die Therapie fortgeschrittener Tumorstadien belegt. Der Stellenwert biologisch zielgerichteter Therapien in der adjuvanten Indikation ist noch ganz überwiegend in klinischer Überprüfung.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Abbrederis K, Kremer M, Schuhmacher C (2008) Bevacizuman (Avastin) bedingte ischämische Anastomosenperforation 10 Monate postoperativ: Ein Fallbericht. Chirurg 79: 354–355
Amado RG, Wolf M, Peeters M, et al. (2008) Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 26: 1626–1634
Bach F, Uddin FJ, Burke D (2007) Angiopoietins in malignancy. Eur J Surg Oncol 33: 7–15
Baselga J, Tripathy D, Mendelsohn J, et al. (1996) Phase II study of weekly intravenous recombinant humanized antip185 monoclonal antibody in patients with HER-2/neu-overexpressing metastatic breast cancer. J Clin Oncol 14: 737–744
Beekman KW, Colevas AD, Cooney K, et al. (2006) Phase II evaluations of cilengitide in asymptomatic patients with androgen-independent prostate cancer: scientific rationale and study design. Clin Genitourin Cancer 4: 299–302
Blazer DG, Kishi Y, Maru DM, et al. (2008) Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. J Clin Oncol 26: 5344–5351
Bokemeyer C, Bondarenko I, Makhson A, et al. (2009) Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the firstline treatment of metastatic colorectal cancer. J Clin Oncol 27: 663–667
Bonner JA, Harari PM, Giralt J et al. (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354: 567–578
Brooks PC, Clark RAF, Cheresh DA (1994) Requirement of vascular integrin avb3 for angiogenesis. Science 2674: 569–571
Bunn PA, Thatcher N (2008) Conclusion. The Oncologist 13(suppl 1): 37–46
Cannistra SA, Matulonis U, Penson R, et al. (2006) Bevacizumab in patients with platinum-resistant ovarian cancer. J Clin Oncol 24(suppl 18): 5006 (abstr)
Ciardiello F, Tortora G (2008) EGFR antagonists in cancer treatment. N Eng J Med 358: 1160–1174
Cunningham D, Humblet Y, Siena S, et al. (2004) Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351: 337–345
Demetri GD, van Oosterom AT, Garrett CR, et al. (2006) Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial. Lancet 368:1329–1338
Di Nicolantio F, Martini M, Molinari F, et al. (2008) Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 26: 5705–5712
Duda DG (2006) Antiangiogenesis and drug delivery to tumors: bench to bedside and back. Cancer Research 66: 3967–3970
Ellis LM, Curley SA, Grothey A (2005) Surgical resection after downsizing of colorectal liver metastasis in the era of bevacizumab. J Clin Oncol 23: 4853–4854
Escudier B, Eisen T, Stadler WM, et al. (2007) Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356: 125–134
Escudier B, et al. (2007) Sunitinib in advanced renal cell carcinoma. Lancet 370: 2103–2111
Ferrara N, Hillan KJ, Gerber HP, Novotny W (2004) Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 3: 391–399
Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182–1186
Folkman J (1990) What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4–6
Geyer CE, Forster J, Lindquist D, et al. (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355: 2733–2743
Giantonio BJ, Catalano PJ, Meropol NJ, et al. (2007) Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 25:1539–1544
Gordon MS, Margolin K, Talpaz M, et al. (2001) Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 19: 843–849
Graff JR, McNulty AM, Hanna KR, et al. (2005) The protein kinase CB-selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT Pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 65: 7462–7469
Han SW, Kim TY, Hwang PG et al. (2005) Predictive and prognostic impact of epidermal growth factor receptor mutation in nonsmall-cell lung cancer patients treated with gefitinib. J Clin Oncol 23: 2493–2501
Heger U, Weitz J, Lordick F (2008) Indications for pre-and postoperative treatment with imatinib for GIST. Chirurg 79: 630–637
Hicklin DJ, Ellis LM (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23: 1011–1027
Howdieshell TR, Callaway D, Webb WL, et al. (2001) Antibody neutralization of vascular endothelial growth factor inhibits wound granulation tissue formation. J Surg Res 96: 173–180
Hurwitz H, Fehrenbacher L, Novotny W, et al. (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350: 2335–2341
Jain RK (2005) Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307: 58–62
Jonker DJ, O’Callaghan CJ, Karapetis CS, et al. (2007) Cetuximab for the treatment of colorectal cancer. N Engl J Med 357: 2040–2048
Kang SP, Saif MW (2007) Infusion-related and hypersensitivity reactions of monoclonal antibodies used to treat colorectal cancer identification, prevention, and management. J Support Onco1 5: 451–457
Kang X, Patel D, Ng S, et al. (2007) High affinity Fc receptor binding and potent induction of antibody-dependent cellular cytotoxicity (ADCC) in vitro by anti-epidermal growth factor receptor antibody cetuximab. J Clin Oncol 25:Suppl: 128s (abstract)
Karapetis CS, Khambata-Ford S, Jonker DJ, et al. (2008) K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 359: 1757–1765
Lacouture ME (2006) Mechanisms of cutaneous toxicities to EGFR inhibitors. Nature Reviews Cancer 6: 803–812
Lièvre A, Bachet JB, Boige V, et al. (2008) KRAS Mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 26: 374–379
Linardou H, Dahabre I, Kanaloupiti D, et al. (2008) Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and metaanalysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol 9: 962–972
Llovet JM, Ricci S, Mazzaferro V, et al. (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359: 378–390
Lordick F, Geinitz H, Theisen J, Sendler A, Sarbia M (2006) Increased risk of ischemic bowel complications during treatment with bevacizumab after pelvic irradiation: report of three cases. In J Radiat Oncol Biol Phys 64: 1295–1297
Lordick F, Leon-Chong J, Kang Y, et al. (2007) Her2 status of advanced gastric cancer is similar in Europe and Asia. Ann Oncol 18(suppl 7): abstr. 253
Lordick F, Siewert JR (2008) Bevacizumab (Avastin®) related surgical complications. Chirurg 79: 356–360
Maitra A, Hruban RH (2008) Pancreatic cancer. Annu Rev Pathol Mech Dis 3: 157–188
Makinde T, Agrawal DK (2008) Intra and extravascular transmembrane signalling of angiopoietin-1-Tie2 receptor in health and disease. J Cell Mol Med 12: 810–828
Manegold C, Lurje G, Pohl A, et al. Can we predict the response to epidermal growth factor receptor targeted therapy? Target Oncol 3: 87–99
Miller KD, Wang M, Gralow J et al. (2005) A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer: A trial coordinated by the Eastern Cooperative Oncology Group (E2100). Breast Cancer Res Treat 94: S279
Moore MJ, Goldstein D, Hamm J, et al. (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25: 1960–1966
Moroni M, Sartore-Bianchi A, Veronese S, Siena S (2008) EGFR FISH in colorectal cancer: what is the current reality? Lancet Oncol 9: 402–403
Motzer RJ, Hutson TE, Tomczak P, et al. (2007) Sunitinib versus interferon alfa in metastatic renal cell carcinoma. N Engl J Med 356:115–124
Motzer RJ, Michaelson MD, Redman BG, et al. (2006) Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24:16–24
Oliner J, Min H, Yu D, et al. (2004) Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 5: 507–516
Pérez-Soler R, Chachoua A, Hammond LA et al. Determinants of tumor response and survival with erlotinib in patients with non-smallcell lung cancer. J Clin Oncol 22: 3238–3247
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. (2005) Trastuzumab after adjuvant chemotherapy in HER-2-positive breast cancer. N Engl J Med 353: 1659–1672
Riely GJ, Pao W, Pham D et al.(2006) Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 12: 839–844
Roman CD, Choy H, Nanney L, et al. (2002) Vascular endothelial growth factor-mediated angiogenesis inhibition and postoperative wound healing in rats. J Surg Res 105: 43–50
Romond EH, Perez EA, Bryant J, et al. (2005) Trastuzumab plus adjuvant chemotherapy for operable HER-2-positive breast cancer. N Engl J Med 353: 1673–1684
Salomon DS, Brandt R, Ciardiello F, Normanno N (1995) Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19:183–232
Sandler A, Gray R, Perry MC et al. (2006) Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355: 2542–2550
Scappaticci FA, Fehrenbacher L, Cartwright T, et al. (2005) Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab. J Surg Oncol 91: 173–179
Shepherd FA, Rodrigues Pereira J, et al. (2005) Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353:123–132
Slamon DJ, Leyland-Jones B, Shak S, et al. (2001) Use of chemotherapy plus a monoclonal antibody against HER-2 for metastatic breast cancer that overexpresses HER-2. N Engl J Med 344: 783–792
Sleijfer S, Wiemer E, Verweij J (2008) Drug Insight: gastrointestinal stromal tumors (GIST) — the solid tumor model for cancer-specific treatment. Nature Clinical Practice Oncology 5: 102–111
Sugrue M, Kozloff M, Hainsworth J, et al. (2006) Risk factors for gastrointestinal perforations in patients with metastatic colorectal cancer receiving bevacizumab plus chemotherapy. J Clin Oncol 24(suppl 18): 3535 (abstr)
Teicher BA (2006) Protein kinase C as a therapeutic target. Clin Cance Res 12: 5336–5345
Van Cutsem E, Kang YK, Chung HC, et al. (2009) Efficacy results from the ToGA trial: a Phase III study of trastuzumab added to standard chemotherapy (CT) in first-line human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (GC). J Clin Oncol (18S): abstract LBA4509
Van Cutsem E, Köhne CH, Hitre E, et al. (2009) Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360: 1408–1417
Van Cutsem E, Peeters M, Siena S, et al. (2007) Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 25: 1658–1664
Vermorken JB, Mesia R, Rivera F, et al. (2008) Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 359: 1116–1127
Yang XD (2001) Development of ABX-EGFR, a fully human anti EGFR monoclonal antibody for cancer therapy. Crit Rev Hematol Oncol 38: 17–23
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Lordick, F. (2010). Biologisch zielgerichtete medikamentöse Therapie. In: Siewert, J.R., Rothmund, M., Schumpelick, V. (eds) Praxis der Viszeralchirurgie Onkologische Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03808-2_24
Download citation
DOI: https://doi.org/10.1007/978-3-642-03808-2_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-03807-5
Online ISBN: 978-3-642-03808-2
eBook Packages: Medicine (German Language)