Skip to main content

Animal and Human Cancer Therapeutic Studies

  • Chapter
  • 716 Accesses

Shortly after Roentgen discovered X-rays in 1895, scientists learned that low-dose X-ray exposures cured and prevented infections and inflammations, primarily due to immune system stimulation. The stimulatory virtues of radium therapy for health and well-being were promoted until the late 1920s, when the hazards of very high radiation doses from internal radium became apparent. Studies showing that low-dose radiation is beneficial were simply ignored by the federal agencies and their advisory bodies. In 1936, a US National Academy of Sciences study discounted the known stimulatory effects of low-dose radiation [1].

Some of the many benefits of low-dose radiation identified in the early 1900s were cure of diphtheria, relief from arthritis and rheumatism pain and swelling, relief from symptoms of bronchitis, cure of gas gangrene and tuberculosis infections, and reduction of cancer incidence (in animals). Clostridium is the cause of gas gangrene, which is rapidly fatal if not immediately treated. During 1920s to 1940s, gas gangrene infections were successfully treated by exposure of the infected area to an X-ray dose of about 0.5 Gy. X-ray therapy often stopped the infection without requiring amputation. Mortality was cut to about 5% if patients were treated by radiotherapy prior to severe progression of the infection [2]. A book published by Kelly and Dowell in 1942 on The Roentgen Treatment of Infections contained hundreds of case reports demonstrating the efficacy of low doses roentgen radiation in treating various infections and cancers [3].

Readily available LDRT is needed in the U.S. for the more effective treatment of cancer

(Jerry Cuttler)

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Cuttler JM (2008) Therapeutic applications of radiation hormesis. Cuttler & Associates, Mississauga, ON

    Google Scholar 

  2. Cuttler JM (2004) Low-dose irradiation therapy to cure gas gangrene infections. Int J Low Radiat 1:318–28

    Google Scholar 

  3. Cuttler JM (2008) Book review: Roentgen treatment of infections by JF Kelly and DA Dowell. Can Nucl Soc Bull 29:43–4

    Google Scholar 

  4. http://www.cnn.com/2009/HEALTH/04/16/longevity/index.html

  5. Erickson BE (2007) The therapeutic use of radon: a biomedical treatment in Europe; an “alternative” remedy in the United States. Dose Response 5:48–62

    Article  CAS  Google Scholar 

  6. Becker K (2004) One century of radon therapy. Int J Low Radiat 1:333–57

    Google Scholar 

  7. Scott BR, Belinsky SA, Leng S et al (2009) Radiation-simulated epigenetic reprogramming of adaptive-response genes in the lung-an evolutionary gift for mounting adaptive protection against lung cancer. Dose Response 7:104 –131

    Article  CAS  PubMed  Google Scholar 

  8. Cheda A, Wrembel-Wargocka J, Lisiak E et al (2004) Single low doses of X rays inhibit the development of experimental tumor metastases and trigger the activities of NK cells in mice. Radiat Res 161:335–40

    Article  CAS  PubMed  Google Scholar 

  9. Hayase H, Ohshima Y, Mareyuki M, Kojima S (2008) The enhancement of Th-1 immunity and the suppression of tumour growth by low dose g-radiation. Int J Low Radiat 5:275–89

    Article  CAS  Google Scholar 

  10. Murphy JB (1920) The effect of physical agents on the resistance of mice to cancer. Proc Natl Acad Sci USA 6:35–8

    Article  CAS  PubMed  Google Scholar 

  11. Yu H-S, Song A-Q, Lu Y-D et al (2004) Effects of low-dose radiation on tumor growth, eryth-rocyte immune function and SOD activity in tumor-bearing mice. Chin Med J 117:1036–9

    CAS  PubMed  Google Scholar 

  12. Qutob SS, Asha AS, Pathak S et al (2006) Fractionated X-radiation treatment can elicit an inducible-like radioprotective response that is not dependent on the intrinsic cellular X-radiation resistance/sensitivity. Radiat Res 166:590–9

    Article  CAS  PubMed  Google Scholar 

  13. Demaria S, Bruce NG, Devitt ML et al (2004) Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys 58:862–70

    PubMed  Google Scholar 

  14. Jin GH, Jin SZ, Liu Y et al (2005) Therapeutic effect of gene therapy in combination with local x-irradiation in a mouse malignant melanoma model. Biochem Biophys Res Commun 330:975–81

    Article  CAS  PubMed  Google Scholar 

  15. Wu N, Jin S-Z, Pan X-N, Liu S-Z (2008) Increase in efficacy of cancer radiotherapy by combination with whole-body low dose irradiation. Int J Radiat Biol 84:201–10

    Article  CAS  PubMed  Google Scholar 

  16. Sakamoto K, Myogin M, Hosoi Y et al (1997) Fundamental and clinical studies on cancer control with total or upper half body irradiation. J Jpn Soc Ther Radiol Oncol 9:161–75

    Google Scholar 

  17. Hashimoto S, Shirato H, Hosokawa M et al (1999) The suppression of metastases and the change in host immune response after low-dose total-body irradiation in tumor-bearing rats. Radiat Res 151:717–24

    Article  CAS  PubMed  Google Scholar 

  18. Lumniczky K, Szatmari T, Bogdandi N, Safrany G (2007) Effects of low dose irradiation on the main immune parameters and on the antitumor immune surveillance in mice. In: Sixth LOWRAD Conference, Budapest, Hungary, Abstract; p 78

    Google Scholar 

  19. Takahashi M, Kojima S (2006) Suppression of atopic dermatitis and tumor metastasis in mice by small amounts of radon. Radiat Res 165:337–42

    Article  CAS  PubMed  Google Scholar 

  20. Ohshima Y, Tukimoto M, Kojima S (2007) Inhibitory mechanism of low-dose, whole-body irradiation with gamma-rays against tumor metastasis. In: Sixth LOWRAD Conference, Budapest, Hungary, Abstract; p 103

    Google Scholar 

  21. Ohsma Y, Tsukimoto M, Kojima S (2008) The novel mechanism of metastasis inhibition by low-dose whole-body irradiation with gamma-rays. Int J Low Radiat 5:156–67

    Article  Google Scholar 

  22. Ina Y, Tanooka H, Yamada T et al (2005) Suppression of thymic lymphoma induction by lifelong low-dose-rate irradiation accompanied by immune activation in C57BL/6 mice. Radiat Res 163:153–8

    Article  CAS  PubMed  Google Scholar 

  23. Liu S-Z (2007) Cancer control related to stimulation of immunity by low-dose radiation. Dose Response 5:39–47

    Article  CAS  Google Scholar 

  24. http://www.researchandmarkets.com/products/a3992c/analytical_tool_apoptosis_in_ oncology

  25. Safwat A (2000) The role of low-dose total body irradiation in treatment of non-Hodgkin's lymphoma: a new look at an old method. Radiother Oncol 56:1–8

    Article  CAS  PubMed  Google Scholar 

  26. Cuttler JM, Pollycove M, Welsh JS (2000) Application of low doses of radiation for curing cancer. Can Nucl Soc Bull 21:45–6

    Google Scholar 

  27. Cuttler JM (2006) Low-dose irradiation for controlling prostate cancer. Int J Low Radiat 2:45–59

    Article  Google Scholar 

  28. Satti J (2009) The emerging low-dose therapy for advanced cancers. Dose Response (in press)

    Google Scholar 

  29. Mattson MP, Cheng A (2006) Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses. Trends Neurosci 29:632–9

    Article  CAS  PubMed  Google Scholar 

  30. Wojcik M, Zabek M, Rzeznik D et al (2002) Half body irradiation (HBI) in palliative treatment of multiple cancer metastases – contemporary evaluation. Wspolczesna Onkologia 8:395–9

    Google Scholar 

  31. Personal communication from Jerry M. Cuttler MD, Cuttler & Associates Inc., 1781 Medallion Court, Mississauga, Ontario, L5J 2L6, Canada. Contact information is: Liu Shu-Zheng MD, Professor Emeritus, Radiation Biology, Jilin University Health Sciences Center, 828 Xinmin street, Changchun 130021, P.R. China, Email: drliusz@yahoo.com

    Google Scholar 

  32. Jaworowski Z (2009) Radiation hormesis — a remedy for fear. BELLE Newsletter 15:14–20

    Google Scholar 

  33. Chaffey JT, Rosenthal DS, Moloney WD, Hellman S (1976) Total body irradiation as treatment for lymphosarcoma. Int J Radiat Oncol Biol Phys 1:399–405

    CAS  PubMed  Google Scholar 

  34. Choi NC, Timothy AR, Kaufman SD et al (1979) Low dose fractionated whole body irradiation in the treatment of advanced non-Hodgkin's lymphoma. Cancer 43:1636–42

    Article  CAS  PubMed  Google Scholar 

  35. Richaud PM, Soubeyran P, Eghbali H et al (1998) Place of low-dose total body irradiation in the treatment of localized follicular non-Hodgkin's lymphoma: results of a pilot study. Int J Radiat Oncol Biol Phys 40:387–90

    CAS  PubMed  Google Scholar 

  36. Safwat A (2000) The role of low-dose total body irradiation in treatment of non-Hodgkin's lymphoma: a new look at an old method. Radiother Oncol 56:1–8

    Article  CAS  PubMed  Google Scholar 

  37. Holder DL (1965) Total body irradiation in multiple myeloma. Radiology 84:83–6

    Google Scholar 

  38. Mishra KP, Ahmed M, Hill RP (2008) Low-dose radiation effects on human health with implications to radioprotection and cancer radiotherapy. Int J Radiat Biol 84:441–4

    Article  CAS  PubMed  Google Scholar 

Download references

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

(2010). Animal and Human Cancer Therapeutic Studies. In: Sanders, C.L. (eds) Radiation Hormesis and the Linear-No-Threshold Assumption. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03720-7_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-03720-7_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-03719-1

  • Online ISBN: 978-3-642-03720-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics