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The Heterocyclic Antiviral Agents

  • Baoan Song
  • Linhong Jin
  • Song Yang
  • Pinaki S. Bhadury

Abstract

In conclusion, a series of novel pyrazole derivatives were synthesized by the treatment of 1-substituted phenyl-3-methyl-5-substituted phenylthio-4-pyrazolaldoximes 4.3 with acyl chloride. Their structures were verified by spectroscopic data. The results of bioassay showed that these title compounds exhibited weak to good anti-TMV bioactivity. Title compounds 4.4l, 4.4m showed better biological activity than their structurally related analogues 4.4a-4.4k and 4.4n Preliminary studies showed that treatment by compound 4.4l can significantly enhance disease resistance of tobacco and also show that the compound 4.4l is structurally related to TMV by exhibiting a higher affinity for TMV CP. So, the action mechanism of curative effect by the compound 4.4l was mainly attributed to the induced disease resistance against tobacco while the action mechanism of inactivation effect was caused by its affinity towards TMV CP. More detailed studies on mechanistic aspects are currently underway.

Keywords

Antiviral Activity Title Compound Tobacco Mosaic Virus Antiviral Agent Tobacco Leaf 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Chemical Industry Press, Beijing and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Baoan Song
    • 1
  • Linhong Jin
    • 1
  • Song Yang
    • 1
  • Pinaki S. Bhadury
    • 1
  1. 1.Center for R&D of Fine ChemicalsGuizhou UniversityGuiyangChina

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