Skip to main content
SpringerLink
Log in

Neurophysiologische Grundlagen psychischer Erkrankungen

  • Chapter
Psychiatrie, Psychosomatik, Psychotherapie

Zusammenfassung

Neurophysiologische Verfahren haben eine große Bedeutung für das Verständnis pathogenetischer Prozesse bei psychischen Erkrankungen, und werden darüber hinaus zu differenzialdiagnostischen Zwecken sowie zur objektiven Erfassung von Effekten pharmakologischer Behandlungen verwendet. In diesem Kapitel wird zunächst ein Charakterisierungsschema für biologische Merkmale bei psychischen Störungen vorgestellt, anhand dessen gefundene neurophysiologische Auffälligkeiten auf ihren Zusammenhang mit der Störung und ihre pathogenetische und klinische Bedeutung hinterfragt werden können. Auf dieses Schema wird bei den dargestellten Befunden Bezug genommen, wobei der Schwerpunkt auf der Elektroenzephalografie und ihrer Bedeutung für pathogenetische Konzepte, Diagnostik und Therapie schizophrener und affektiver Störungen liegt. Ferner werden psychische Störungen bei epileptischer Aktivität sowie die daraus resultierende differenzialdiagnostische Bedeutung des EEG thematisiert

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Ambrosius U, Lietzenmaier S, Wehrle R et al. (2008) Heritability of sleep electroencephalogram. Biol Psychiatry 64: 344–348.

    Article  PubMed  Google Scholar 

  • Barta PE, Powers RE, Aylward EH et al. (1997) Quantitative MRI volume changes in late onset schizophrenia and Alzheimer's disease compared to normal controls. Psychiatry Res: Neuroimaging 68: 65–75

    Article  PubMed  CAS  Google Scholar 

  • Bente D (1964) Die Insuffizienz des Vigilitätstonus. Habilitation, Univ Erlangen

    Google Scholar 

  • Boylan LS (2002) Peri-ictal behavioral and cognitive changes. Epilepsy Behav 3: 16–26

    Article  PubMed  Google Scholar 

  • Bruneau N, Barthelemy C, Roux S et al. (1989) Auditory evoked potential modifications according to clinical and biochemical responsiveness to fenfluramine treatment in children with autistic behavior. Neuropsychobiology 21: 48–52

    Article  PubMed  CAS  Google Scholar 

  • Bschor T, Müller-Oerlinghausen B, Ulrich G (2001) Decreased level of EEG-vigilance in acute mania as a possible predictor for a rapid effect of methylphenidate: a case study. Clin Electroencephalogr 32: 36–39

    PubMed  CAS  Google Scholar 

  • Cendes F, Andermann F, Gloor P et al. (1994) Relationship between atrophy of the amygdala and ictal fear in temporal lobe epilepsy. Brain 117: 739–746

    Article  PubMed  Google Scholar 

  • Daumann J, Till B, Fischermann T et al. (2006) Intensity dependence of auditory evoked dipole source activity in polydrug ecstasy users: evidence from an 18 months longitudinal study. J Psychopharmacol 20: 236–244

    Article  PubMed  Google Scholar 

  • Duncan CC, Barry RJ, Connolly JF et al. (2009) Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400. Clin Neurophysiol 120: 1883–1908

    Article  PubMed  Google Scholar 

  • Edlund MJ, Swann AC, Clothier J (1987) Patients with panic attacks and abnormal EEG results. Am J Psychiatry 144: 508–509

    PubMed  CAS  Google Scholar 

  • Engel AK, Singer W (2001) Temporal binding and the neural correlates of sensory awareness. Trends Cogn Sci. 5: 16–25

    Article  PubMed  Google Scholar 

  • Eysenck HJ (1990) Biological dimensions of personality. In: Pervin L (ed). Handbook of personality: Theory and research. Guilford Press, New York, pp 244–276

    Google Scholar 

  • Fontaine R, Breton G, Dery R et al. (1990) Temporal lobe abnormalities in panic disorder: an MRI study. Biol Psychiatry 27: 304–310

    Article  PubMed  CAS  Google Scholar 

  • Frodl-Bauch T, Gallinat J, Meisenzahl EM et al. (1999) Subcomponents of the auditory P300 reflect different aspects of psychopathology in schizophrenia. Biol Psychiatry 46: 116–126

    Article  Google Scholar 

  • Gallinat J, Hegerl U (1999) Gesteigerte limbische Erregungsbildung bei Angstattacken. Nervenarzt 70: 206–215

    Article  PubMed  CAS  Google Scholar 

  • Gallinat J, Bottlender R, Juckel G et al. (2000) The loudness dependency of the auditory evoked N1/P2-component as a predictor of the acute SSRI response in depression. Psychopharmacology 148: 404–411

    Article  PubMed  CAS  Google Scholar 

  • Gallinat J, Senkowski D, Wernicke C et al. (2003) Allelic variants of the functional promoter polymorphism of the human serotonin transpoter gene is associated with auditory cortical stimulus processing. Neuropsychopharmacology 28: 530–532

    Article  PubMed  CAS  Google Scholar 

  • Gallinat J, Winterer G, Herrmann CS, Senkowski D (2004) Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing. Clin Neurophysiol. 115: 1863–1874

    Article  PubMed  Google Scholar 

  • Genton P, Bartolomei F, Guerrini R (1995) Panic attacks mistaken for relapse of epilepsy. Epilepsia 36: 48–51

    Article  PubMed  CAS  Google Scholar 

  • Golob EJ, Ringman JM, Irimajiri R et al.(2009) Cortical event-related potentials in preclinical familial Alzheimer disease. Neurology 73: 1649–1655

    Article  PubMed  CAS  Google Scholar 

  • Gould TD, Gottesman II (2006) Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav 5: 113– 119

    Article  PubMed  CAS  Google Scholar 

  • Hall MH, Taylor G, Sham P et al. (2009) The early auditory gammaband response is heritable and a putative endophenotype of schizophrenia. Schizophr Bull. doi:10.1093/schbul/sbp134

    Google Scholar 

  • Hegerl U, Frodl-Bauch T (1997) Dipole source analysis of auditory evoked P300: a methodological advance ? Psychiatry Res: Neuroimaging 74: 109–118

    Article  PubMed  CAS  Google Scholar 

  • Hegerl U, Juckel G (1993) Intensity dependence of auditory evoked potentials as indicator of central serotonergic neurotransmission – A new hypothesis. Biol Psychiatry 33: 173–187

    Article  PubMed  CAS  Google Scholar 

  • Hegerl U, Ulrich G, Müller-Oerlinghausen B (1987) Auditory evoked potentials and response to lithium prophylaxis. Pharmacopsychiatry 20: 213–216

    Article  PubMed  CAS  Google Scholar 

  • Hegerl U, Wulff H, Müller-Oerlinghausen B (1992) Intensity dependence of auditory evoked potentials and clinical response to prophylactic lithium medication: a replication study. Psychiatry Res 44: 181–190

    Article  PubMed  CAS  Google Scholar 

  • Hegerl U, Gallinat J, Mrowinski D (1994) Intensity dependence of auditory evoked dipole source activity. Int J Psychophysiol 17: 1–13

    Article  PubMed  CAS  Google Scholar 

  • Hegerl U, Juckel G, Müller-Schubert A et al. (1995) Schizophrenics with small P300: a subgroup with neurodevelopmental disturbance and high risk for tardive dyskinesia? Acta Psychiatr Scand 91: 120–125

    Article  PubMed  CAS  Google Scholar 

  • Hegerl U, Juckel G, Schmidt LG, Rommelspacher H (1996) Serotonergic ethanol effects and auditory evoked dipole activity in alcoholics and healthy subjects. Psychiatry Res 63: 47–55

    Article  PubMed  CAS  Google Scholar 

  • Hegerl U, Bottlender R, Gallinat J et al. (1998) The serotonin syndrome scale: first results on validity. Eur Arch Psychiatry Neurol Sci 248: 96–103

    Article  CAS  Google Scholar 

  • Hegerl U, Stein M, Mulert C et al. (2008) EEG-vigilance differences between patients with borderline personality disorder, patients with obsessive-compulsive disorder and healthy controls. Eur Arch Psychiatry Clin Neurosci 258: 137–143

    Article  PubMed  Google Scholar 

  • Hegerl U, Sander C, Olbrich S, Schoenknecht P (2009) Are psychostimulants a treatment option in mania? Pharmacopsychiatry 42: 169–174

    Article  PubMed  CAS  Google Scholar 

  • Hegerl U, Himmerich H, Engmann B, Hensch T (2010) Mania and attention- deficit/hyperactivity disorder: common symptomatology, common pathophysiology and common treatment? Curr Opin Psychiatry 23: 1–7

    Article  PubMed  Google Scholar 

  • Hensch T, Strobel A (2010) Differenziellpsychologische Aspekte und ihr Nutzen für die Klinische Psychologie. In: Wittchen U, Hoyer J (Hrsg) Klinische Psychologie und Psychotherapie, 2. Aufl. Springer, Berlin Heidelberg New York Tokio (im Druck)

    Google Scholar 

  • Hensch T, Wargelius HL, Herold U et al. (2006) Further evidence for an association of 5-HTTLPR with intensity dependence of auditoryevoked potentials. Neuropsychopharmacology 31: 2047–2054

    Article  PubMed  CAS  Google Scholar 

  • Hensch T, Herold U, Brocke B (2007) An electrophysiological endophenotype of hypomanic and hyperthymic personality. J Affect Disord 101: 13–26

    Article  PubMed  Google Scholar 

  • Hensch T, Herold U, Diers K et al. (2008) Reliability of intensity dependence of auditory-evoked potentials. Clin Neurophysiol 119: 224–236

    Article  PubMed  CAS  Google Scholar 

  • Hensch T, Himmerich H, Hegerl U (2010) Stimulants in bipolar disorder: beyond common beliefs. CNS Spectrums 15: 469–472

    PubMed  Google Scholar 

  • Herrmann CS, Munk MH, Engel AK (2004) Cognitive functions of gamma- band activity: memory match and utilization. Trends Cogn Sci 8: 347–355

    Article  PubMed  Google Scholar 

  • Hurtig T, Ebeling H, Taanila A et al. (2007) ADHD symptoms and subtypes: relationship between childhood and adolescent symptoms. J Am Acad Child Adolesc Psychiatry 46:1605–1613

    Article  PubMed  Google Scholar 

  • Jabourian AP, Erlich M, Desvignes C et al. (1992) Attaques de panique et EEG ambulatoire de 24 heures. Ann Med Psychol 150: 240– 245

    CAS  Google Scholar 

  • Juckel G, Müller-Schubert A, Gaebel W, Hegerl U (1996) Residual symptoms and P300 in schizophrenic outpatients. Psychiatry Res 65: 23–32

    Article  PubMed  CAS  Google Scholar 

  • Juckel G, Hegerl U, Molnár M et al. (1999) Auditory evoked potentials reflect serotonergic neural activity – a study in behaving cats administered drugs acting on 5-HT1a autoreceptors in the dorsal raphe nucleus. Neuropsychopharmacology 21: 710–716

    Article  PubMed  CAS  Google Scholar 

  • Juckel G, Mavrogiorgou P, Bredemeier S et al. (2004) Loudness dependence of primary auditory-cortex-evoked activity as predictor of therapeutic outcome to prophylactic lithium treatment in affective disorders--a retrospective study. Pharmacopsychiatry 37: 46–51

    PubMed  CAS  Google Scholar 

  • Juckel G, Pogarell O, Augustin H et al. (2007) Differential prediction of first clinical response to serotonergic and noradrenergic antidepressants using the loudness dependence of auditory evoked potentials in patients with major depressive disorder. J Clin Psychiatry 68: 1206–1212

    Article  PubMed  Google Scholar 

  • Juckel G, Clotz F, Frodl T et al. (2008 a) Diagnostic usefulness of cognitive auditory event-related p300 subcomponents in patients with Alzheimers disease? J Clin Neurophysiol 25:147–152

    Article  Google Scholar 

  • Juckel G, Hegerl U, Giegling I et al. (2008 b) Association of 5-HT1B receptor polymorphisms with the loudness dependence of auditory evoked potentials in a community-based sample of healthy volunteers. Am J Med Genet B Neuropsychiatr Genet 147B: 454– 458

    Article  Google Scholar 

  • Juckel G, Schumacher C, Giegling I et al. (2010) Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene. J Psychiatr Res 44(8):541–546

    Article  PubMed  Google Scholar 

  • Lai CL, Lin RT, Liou LM et al. (2010 a) The effects of metabolic syndrome and apolipoprotein E4 on cognitive event-related potentials. Biol Psychol 83: 56–61

    Article  Google Scholar 

  • Lai CL, Lin RT, Liou LM, Liu CK (2010 b) The role of event-related potentials in cognitive decline in Alzheimer's disease. Clin Neurophysiol 121: 194–199

    Article  Google Scholar 

  • Landolt H (1955) Über Verstimmungen, Dämmerzustände und schizophrene Zustandsbilder bei Epilepsie. Schweiz Arch Neurol Psychiatr 76: 313–321

    PubMed  CAS  Google Scholar 

  • Lee TW, Yu YW, Chen TJ, Tsai SJ (2005) Loudness dependence of the auditory evoked potential and response to antidepressants in Chinese patients with major depression. J Psychiatry Neurosci 30: 202–205

    PubMed  Google Scholar 

  • Leicht G, Kirsch V, Giegling I et al. (2010) Reduced early auditory evoked gamma-band response in patients with schizophrenia. Biol Psychiatry. 67: 224–231

    Article  PubMed  Google Scholar 

  • Leonhard K (1986) Aufteilung der endogenen Psychosen und ihre differenzierte Ätiologie. Akademie, Berlin

    Google Scholar 

  • Linka T, Müller BW, Bender S et al. (2005) The intensity dependence of auditory evoked ERP components predicts responsiveness to reboxetine treatment in major depression. Pharmacopsychiatry 38: 139–143

    Article  PubMed  CAS  Google Scholar 

  • Linka T, Müller BW, Bender S, Sartory G (2004) The intensity dependence of the auditory evoked N1 component as a predictor of response to Citalopram treatment in patients with major depression. Neurosci Lett 367: 375–378

    Article  PubMed  CAS  Google Scholar 

  • Marsh L, Rao V (2002) Psychiatric complications in patients with epilepsy: a review. Epilepsy Res 49: 11⊠33

    Article  PubMed  Google Scholar 

  • Mulert C, Juckel G, Augustin H, Hegerl U (2002) Comparison between the analysis of the loudness dependency of the auditory N1/P2 component with LORETA and dipole source analysis in the prediction of treatment response to the selective serotonin reuptake inhibitor citalopram in major depression. Clin Neurophysiol 113: 1566–1572

    Article  PubMed  CAS  Google Scholar 

  • Mulert C, Jager L, Schmitt R et al. (2004 a) Integration of fMRI and simultaneous EEG: toward a comprehensive understanding of the localisation and time-course of brain activity in target detection. Neuroimage 22: 83–94

    Article  Google Scholar 

  • Mulert C, Pogarell O, Juckel G et al. (2004 b) The neural basis of the P300 potential. Focus on the time-course of the underlying cortical generators. Eur Arch Psychiatry Clin Neurosci 254: 190–198

    CAS  Google Scholar 

  • Mulert C, Jager L, Propp S et al. (2005) Sound level dependence of the primary auditory cortex: Simultaneous measurement with 61-channel EEG and fMRI. Neuroimage 28: 49–58

    Article  PubMed  Google Scholar 

  • Mulert C, Leicht G, Hepp P et al. (2010) Single-trial coupling of the gamma-band response and the corresponding BOLD signal. Neuroimage 49: 2238–2247

    Article  PubMed  CAS  Google Scholar 

  • Nathan PJ, Segrave R, Phan KL et al. (2006) Direct evidence that acutely enhancing serotonin with the selective serotonin reuptake inhibitor citalopram modulates the loudness dependence of the auditory evoked potential (LDAEP) marker of central serotonin function. Hum Psychopharmacol 21: 47–52

    Article  PubMed  CAS  Google Scholar 

  • Nordahl TE, Semple WE, Gross M et al. (1990) Cerebral glucose metabolic differences in patients with panic disorder. Neuropsychopharmacology 3: 261–272

    PubMed  CAS  Google Scholar 

  • Olbrich S, Mulert C, Karch S et al. (2009) EEG-vigilance and BOLD effect during simultaneous EEG/fMRI measurement. Neuroimage 45: 319–332

    Article  PubMed  Google Scholar 

  • Pae JS, Kwon JS, Youn T et al. (2003) LORETA imaging of P300 in schizophrenia with individual MRI and 128-channel EEG. Neuroimage 20: 1552–1560

    Article  PubMed  Google Scholar 

  • Paige SR, Fitzpatrick DF, Kline JP et al. (1994) Event-related potential amplitude/intensity slopes predict response to antidepressants. Neuropsychobiology 30: 197–201

    Article  PubMed  CAS  Google Scholar 

  • Paige SR, Hendricks SE, Fitzpatrick DF et al. (1995) Amplitude/intensity functions of auditory event-related potentials predict responsiveness to bupropion in major depressive disorder. Psychopharmacol Bull 31: 243–248

    PubMed  CAS  Google Scholar 

  • Papaliagkas V, Kimiskidis V, Tsolaki M, Anogianakis G (2008) Usefulness of event-related potentials in the assessment of mild cognitive impairment. BMC Neurosci 9: 107

    Article  PubMed  Google Scholar 

  • Pariente PD, Lepine JP, Lellouch J (1991) Lifetime history of panic attacks and epilepsy: an association from a general population survey [letter]. J Clin Psychiatry 52: 88–89

    PubMed  CAS  Google Scholar 

  • Pascual-Marqui RD (2002) Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. Methods Find Exp Clin Pharmacol 24 Suppl D: 5–12

    PubMed  Google Scholar 

  • Pascual-Marqui RD, Michel CM, Lehmann D (1994) Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. Int J Psychophysiol 18: 49–65

    Article  PubMed  CAS  Google Scholar 

  • Pascual-Marqui RD, Lehmann D, Koenig T et al. (1999) Low resolution brain electromagnetic tomography (LORETA) functional imaging in acute, neuroleptic-naïve, first-episode, productive schizophrenia. Psychiatry Res 90: 169–179

    Article  PubMed  CAS  Google Scholar 

  • Pineda JA, Holmes TC, Foote SL (1991) Intensity-amplitude relationships in monkey event-related potentials: parallels to human augmenting-reducing responses. Electroencephalogr Clin Neurophysiol 78: 456–465

    Article  PubMed  CAS  Google Scholar 

  • Polich J (2007) Updating P300: an integrative theory of P3a and P3b. Clin Neurophysiol 118: 2128–2148

    Article  PubMed  Google Scholar 

  • Polich J, Ehlers CL, Otis S et al. (1986) P300 latency reflects the degree of cognitive decline in dementing illness. Electroencephalogr Clin Neurophysiol 63: 138–144

    Article  PubMed  CAS  Google Scholar 

  • Price GW, Michie PT, Johnston J et al. (2006) A multivariate electrophysiological endophenotype, from a unitary cohort, shows greater research utility than any single feature in the Western Australian family study of schizophrenia. Biol Psychiatry 60: 1–10

    Article  PubMed  Google Scholar 

  • Reiman EM, Raichle ME, Robins E et al. (1986) The application of positron emission tomography to the study of panic disorder. Am J Psychiatry 143: 469–477

    PubMed  CAS  Google Scholar 

  • Rodriguez E, George N, Lachaux JP et al. (1999) Perception's shadow: long-distance synchronization of human brain activity. Nature. 397: 430–433

    Article  PubMed  CAS  Google Scholar 

  • Sazgar M, Carlen PL, Wennberg R (2003) Panic attack semiology in right temporal lobe epilepsy. Epileptic Disord 5: 93–100

    PubMed  Google Scholar 

  • Schmitz B (1992) Psychosis and epilepsy: the link to the temporal lobe. In: Trimble MR, Bolwig TG (eds) The temporal lobes and the limbic system. Wrightson Biomedical Publishing, pp 149–167

    Google Scholar 

  • Schoenknecht P, Olbrich S, Sander C et al. (2010) Treatment of acute mania with modafinil monotherapy. Biol Psychiatry 67(11): e55– e57

    Article  PubMed  Google Scholar 

  • Schreiber H, Stolz-Born G, Kornhuber HH, Born J (1996) Event-related brain potentials and psychometric performance in adolescents at genetic risk for schizophrenia. In: Ogura C, Koga Y, Shimokochi M (eds) Recent advances in event-related brain potential research. Elsevier Science, Amsterdam, pp 550–557

    Google Scholar 

  • Siniatchkin M, Kropp P, Neumann M et al. (2000) Intensity dependence of auditory evoked cortical potentials in migraine families. Pain 85: 247–254

    Article  PubMed  CAS  Google Scholar 

  • Sohal VS, Zhang F, Yizhar O, Deisseroth K (2009) Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature. 459: 698–702

    Article  PubMed  CAS  Google Scholar 

  • Soufflet L, Boeijinga PH (2005) Linear inverse solutions: simulations from a realistic head model in MEG. Brain Topogr 18: 87–99

    Article  PubMed  Google Scholar 

  • Spencer KM (2008) Visual gamma oscillations in schizophrenia: implications for understanding neural circuitry abnormalities. Clin EEG Neurosci 39: 65–68

    PubMed  Google Scholar 

  • Stein MB, Uhde TW (1989) Infrequent occurrence of EEG abnormalities in panic disorder. Am J Psychiatry 146: 517–520

    PubMed  CAS  Google Scholar 

  • Strik WK, Dierks T, Maurer K (1993 a) Amplitudes of auditory P300 in remitted and residual schizophrenics: Correlations with clinical features. Neuropsychobiology 27: 54–60

    Article  CAS  Google Scholar 

  • Strik WK, Dierks T, Franzek E et al. (1993 b) Differences in P300 amplitudes and topography between cycloid psychosis and schizophrenia in Leonhard's classification. Acta Psychiatr Scand 87: 179–183

    Article  CAS  Google Scholar 

  • Strik WK, Dierks T, Kulke H et al. (1996) The predictive value of P300-amplitudes in the course of schizophrenic disorders. J Neural Transm 103: 1351–1359

    Article  PubMed  CAS  Google Scholar 

  • Swanwick GR, Rowan MJ, Coen RF et al (1997) Measuring cognitive deterioration in Alzheimer's disease. Br J Psychiatry 170: 580

    Article  PubMed  CAS  Google Scholar 

  • Trimble MR (1988) Personality disorders and epilepsy. Acta Neurochir 44 (Suppl): 98–101

    CAS  Google Scholar 

  • Uhlhaas PJ, Singer W (2010) Abnormal neural oscillations and synchrony in schizophrenia. Nat Rev Neurosci 11: 100–113

    Article  PubMed  CAS  Google Scholar 

  • Ulrich G (1994) Psychiatrische Elektroenzephalographie. Gustav Fischer, Jena

    Google Scholar 

  • van der Stelt O, Belger A (2007) Application of electroencephalography to the study of cognitive and brain functions in schizophrenia. Schizophr Bull 33: 955–970

    Article  PubMed  Google Scholar 

  • Wagner M, Fuchs M, Kastner J (2004) Evaluation of sLORETA in the presence of noise and multiple sources. Brain Topogr 16: 277– 280

    Article  PubMed  Google Scholar 

  • Weilburg JB, Schachter S, Worth J et al. (1995) EEG abnormalities in patients with atypical panic attacks. J Clin Psychiatry 56: 358– 362

    PubMed  CAS  Google Scholar 

  • Werber EA, Gandelman-Marton R, Klein C, Rabey JM (2003) The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients. J Neural Transm 110: 659–669

    Article  PubMed  CAS  Google Scholar 

  • Wieser HB (1980) Temporal lobe or psychomotor status epilepticus. A case report. Electroencephalogr Clin Neurophysiol 48: 558– 572

    Article  PubMed  CAS  Google Scholar 

  • Wutzler A, Winter C, Kitzrow W et al. (2008) Loudness dependence of auditory evoked potentials as indicator of central serotonergic neurotransmission: simultaneous electrophysiological recordings and in vivo microdialysis in the rat primary auditory cortex. Neuropsychopharmacology 33: 3176–3181

    Article  PubMed  CAS  Google Scholar 

  • Young GB, Chandarana PC, Blume WT et al. (1995) Mesial temporal lobe seizures presenting as anxiety disorders. J Neuropsychiatry Clin Neurosci 7: 352–357

    PubMed  CAS  Google Scholar 

  • Zuckerman M (1994) Behavioral expressions and biosocial bases of sensation seeking. Cambridge University Press, Cambridge

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Zentrum für Psychische Gesundheit, Universitätsklinikum Leipzig, Semmelweisstraße 10, 04103, Leipzig

    Prof. Dr. U. Hegerl

  2. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Leipzig AöR, Semmelweisstr. 10, 04103, Leipzig

    Dr. T. Hensch

  3. Klinik für Psychiatrie und Psychotherapie Forschungsbereich Bildgebung, Universitätsklinikum Hamburg- Eppendorf, Martinistr. 52, 20246, Hamburg

    Prof. Dr. C. Mulert

Authors
  1. Prof. Dr. U. Hegerl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dr. T. Hensch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Prof. Dr. C. Mulert
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Ludwig-Maximilians-Universität München, Nußbaumstr. 7, 80336, München

    H.-J. Möller

  2. Kliniken des Bezirks Oberbayern Inn-Salzach-Klinikum Wasserburg a. Inn · Rosenheim · Freilassing Psychiatrie, Psychotherapie, Psychosomatische Medizin und Neurologie, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universität München, Gabersee 7, 83512, Wasserburg am Inn

    G. Laux

  3. Klinik für Psychiatrie, Medizinische Universität Graz, Auenbruggerplatz 31, 8036, Graz, Österreich

    H.-P. Kapfhammer

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hegerl, U., Hensch, T., Mulert, C. (2011). Neurophysiologische Grundlagen psychischer Erkrankungen. In: Möller, HJ., Laux, G., Kapfhammer, HP. (eds) Psychiatrie, Psychosomatik, Psychotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03637-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-03637-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-03636-1

  • Online ISBN: 978-3-642-03637-8

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation