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PIRO Concept and Clinical Failure

  • Thiago LisboaEmail author
  • Jordi Rello
Chapter
  • 2k Downloads

Abstract

In 2001, a consensus conference on sepsis definitions was convened, sponsored by several major medical societies (Levy et al. 2003). The participants at this meeting agreed that the SIRS concept was not helpful and should no longer be used per se, but rather that the systemic inflammatory response syndrome (SIRS) criteria should be incorporated into a longer list of signs of sepsis. This list includes biological signs of inflammation (e.g., increased concentrations of C-reactive protein [CRP] or procalcitonin), hemodynamic parameters [e.g., increased cardiac output, low systemic vascular resistance (SVR), low oxygen extraction ratio], signs of altered tissue perfusion (e.g., altered skin perfusion, reduced urine output), and signs of organ dysfunction (e.g., increased urea and creatinine, low platelet count or other coagulation abnormalities, and hyperbilirubinemia).

Keywords

Severe Sepsis Organ Dysfunction Systemic Inflammatory Response Syndrome Sequential Organ Failure Assessment Clinical Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Critical Care Department and Infection Control CommitteeHospital de Clinicas de Porto AlegrePorto AlegreBrazil
  2. 2.Intensive Care Unit, Hospital Santa RitaRede Institucional de Pesquisa e Inovação em Medicina Intensiva (RIPIMI)Porto AlegreBrazil
  3. 3.Critical Care DepartmentVall d’Hebron University HospitalBarcelonaSpain

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