Improving Outcomes in Sepsis and Septic Shock: Getting it Right the First Time

  • Duane Funk
  • Shravan Kethireddy
  • Anand KumarEmail author


Infections among critically ill patients have convincingly been shown to directly increase mortality, prolong hospital length of stays, and increase healthcare costs (Chastre and Fagon 2002; Rello et al. 2002). In the past the general approach to antimicrobial therapy of infection involved an escalation strategy wherein patients were started on the narrowest reasonable antimicrobial regimen expected to cover a majority of common pathogens. In addition to mild and moderately ill patients, this strategy was also applied to the critically ill at high risk of death.


Septic Shock Antimicrobial Therapy Minimum Inhibitory Concentration Inappropriate Therapy Baseline Mortality 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Section of Critical Care MedicineUniversity of ManitobaWinnipegCanada
  2. 2.Section of Critical Care Medicine, Section of Infectious DiseasesUniversity of ManitobaWinnipegCanada
  3. 3.Section of Critical Care Medicine, JJ399dHealth Sciences CentreWinnipegCanada
  4. 4.Robert Wood Johnson Medical SchoolUniversity of Medicine and DentistryPiscatawayUSA

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