Multiorgan Dysfunction Syndrome (MODS): What is New?

  • Jean-Louis VincentEmail author
  • Marjorie Beumier
  • Antoine Herpain
  • Katia Donadello


Multiorgan dysfunction syndrome (MODS) was defined by the ACCP/SCCM conference almost 20 years ago as the situation in an acutely ill patient whereby organ function is disrupted such that it is unable to maintain homeostasis. Importantly, MODS is a dynamic process, changing over time according to various host-related factors and as the patient responds (or not) to therapeutic interventions. In this chapter, we will discuss some of the current concepts surrounding MODS, and highlight recent advances in our understanding of the pathophysiology and treatment for this condition.


Organ Failure Mean Arterial Pressure Organ Dysfunction Intensive Care Unit Patient Sequential Organ Failure Assessment 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Jean-Louis Vincent
    • 1
    Email author
  • Marjorie Beumier
    • 1
  • Antoine Herpain
    • 1
  • Katia Donadello
    • 1
  1. 1.Department of Intensive Care, Erasme HospitalUniversité Libre de BruxellesBrusselsBelgium

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