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Genetics of Inflammation in the Gastrointestinal Tract and How it Can Cause Cancer

  • Mairi H. McLean
  • Emad M. El-OmarEmail author
Chapter
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 185)

Abstract

Genetic epidemiology is an important discipline that is helping to unravel the aetiology and pathogenesis of complex human diseases. In the context of gastrointestinal malignancy, the paradigm model of host genetic influence on disease outcome is H. pylori-associated gastric adenocarcinoma. This cancer represents a classic example of an inflammation-induced malignancy and highlights the importance of host genetics in disease development. This chapter gives an insight into how genetic epidemiology can play an important role in the development of gastric cancer. Increasing our understanding of host genetics in cancer development may allow particularly susceptible individuals to be targeted for screening or treatment to reduce risk of future malignant transformation.

Keywords

Gastric Cancer Pylorus Infection Gastric Cancer Risk Gastric Atrophy Prostate Stem Cell Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Velag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Gastrointestinal Research Group, Division of Applied MedicineSchool of Medicine and Dentistry, Institute of Medical Sciences, Aberdeen UniversityScotlandUK

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