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Influence of Antigenic Mutations in Time Evolution of the Immune Memory – A Dynamic Modeling

  • Alexandre de Castro
  • Carlos Frederico Fronza
  • Poliana Fernanda Giachetto
  • Domingos Alves
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5676)

Abstract

In this paper, we study the behavior of immune memory against antigenic mutation. Using a dynamic model proposed in previous studies, we have performed simulations of several inoculations, where in each virtual sample the viral population undergoes mutations. Our results suggest that the sustainability of the immunizations is dependent on viral variability and that the memory lifetimes are not random, what contradicts what was suggested by recent works. We show that what may cause an apparent random behavior of the immune memory is the antigenic variability.

Keywords

Dynamic model Immune memory Viral mutation B-cell evolution Antibodies 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Alexandre de Castro
    • 1
    • 2
  • Carlos Frederico Fronza
    • 2
  • Poliana Fernanda Giachetto
    • 1
  • Domingos Alves
    • 2
    • 3
  1. 1.Embrapa Informática Agropecuária – EMBRAPACampinasBrazil
  2. 2.Dep. de Informática em SaúdeUniversidade Federal de São Paulo – UNIFESPSão PauloBrazil
  3. 3.Dep. de Medicina SocialUniversidade de São Paulo – USPSão PauloBrazil

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