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Resonant Waveguide Grating Biosensor for Microarrays

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Optical Guided-wave Chemical and Biosensors II

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 8))

Abstract

A microarray consists of an indexed series of micron-sized spots of biological specimens for biomolecular interaction analysis. Microarray technologies present miniaturized and multiplexed approaches for sensitive and selective profiling of genes, proteins, and/or small molecules. Concurrent with the increasing applications of microarrays is the continuous efforts in developing novel detection systems for improving sensitivity and reliability in signal detection. This chapter describes the concept and applications of microarray technologies, and the principle of detection with an emphasis of resonant waveguide grating biosensor for microarray-based assays.

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Abbreviations

DMR:

Dynamic mass redistribution

DNA:

Deoxyribonucleic acid

GPCR:

G protein-coupled receptor

mRNA:

Messenger RNA

RNA:

Ribonucleic acid

RWG:

Resonant waveguide grating

SPR:

Surface plasmon resonance

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Author information

Authors and Affiliations

  1. Biochemical Technologies, Science and Technology Division, Corning Incorporated, Sullivan Park, Corning, NY, 14831, USA

    Ye Fang

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  1. Ye Fang
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Correspondence to Ye Fang .

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Editors and Affiliations

  1. GDG Environnement Ltée, 430, rue St-Laurent, Trois-Rivières, Quebec, G8T 6H3, Canada

    Mohammed Zourob

  2. INRS Énergie, Matériaux et Télécommunications, 1650, boul. Lionel-Boulet, Varennes, Québec, J3X 1S2, Canada

    Mohammed Zourob

  3. Dept. Engineering Science & Mechanics, Pennsylvania State University, University Park, SA, 16802, USA

    Akhlesh Lakhtakia

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Fang, Y. (2010). Resonant Waveguide Grating Biosensor for Microarrays. In: Zourob, M., Lakhtakia, A. (eds) Optical Guided-wave Chemical and Biosensors II. Springer Series on Chemical Sensors and Biosensors, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02827-4_2

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