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Tissue Engineering of Organs: Eye/Retina

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Tissue Engineering

Abstract

The loss of retinal neurons due to degenerative diseases such as retinitis pigmentosa and age-related macular degeneration affects millions of people and remains a daunting and untreatable medical problem.

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References

  1. Altshuler D, Lo Turco JJ, Rush J, Cepko C. Taurine promotes the differentiation of a vertebrate retinal cell type in vitro. Development. 1993;119(4)):1317–28.

    CAS  PubMed  Google Scholar 

  2. Bartsch U, Oriyakhel W, Kenna PF, Linke S, Richard G, Petrowitz B, Humphries P, Farrar GJ, Ader M. Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice. Exp Eye Res. 2008;86(4):691–700. Epub 2008 Feb 3.

    Google Scholar 

  3. Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, et al. Genomic analysis of mouse retinal development. PLoS Biol. 2004;2(9):E247.

    Article  PubMed  Google Scholar 

  4. Cepko CL, Austin CP, Yang X, Alexiades M, Ezzeddine D. Cell fate determination in the vertebrate retina. Proc Natl Acad Sci USA. 1996;93(2):589–95.

    Article  CAS  PubMed  Google Scholar 

  5. Colthurst MJ, Williams RL, Hiscott PS, Grierson I. Biomaterials used in the posterior segment of the eye. Biomaterials. 2000;21(7):649–65.

    Article  CAS  PubMed  Google Scholar 

  6. Cook AD, Pajvani UB, Hrkach JS, Cannizzaro SM, Langer R. Colorimetric analysis of surface reactive amino groups on poly(lactic acid-co-lysine):poly(lactic acid) blends. Biomaterials. 1997;18(21):1417–24.

    Article  CAS  PubMed  Google Scholar 

  7. del Cerro M, Notter MF, Grover DA, Olchowka J, Jiang LQ, Wiegand SJ, et al. Retinal transplants for cell replacement in phototoxic retinal degeneration. Prog Clin Biol Res. 1989;314:673–86.

    PubMed  Google Scholar 

  8. Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 2006;126(4):677–89.

    Article  CAS  PubMed  Google Scholar 

  9. Freed LE, Vunjak-Novakovic G, Biron RJ, Eagles DB, Lesnoy DC, Barlow SK, et al. Biodegradable polymer scaffolds for tissue engineering. Biotechnology (N Y). 1994;12(7):689–93.

    Article  CAS  Google Scholar 

  10. Gelain F, Bottai D, Vescovi A, Zhang S. Designer self-assembling Peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. PLoS ONE. 2006;1:e119.

    Article  PubMed  Google Scholar 

  11. Georges PC, Miller WJ, Meaney DF, Sawyer ES, Janmey PA. Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures. Biophys J. 2006;90(8):3012–8.

    Article  CAS  PubMed  Google Scholar 

  12. Gouras P, Du J, Gelanze M, Lopez R, Kwun R, Kjeldbye H, et al. Survival and synapse formation of transplanted rat rods. J Neural Transplant Plast. 1991;2(2):91–100.

    Article  CAS  PubMed  Google Scholar 

  13. Hu Y, Arulpragasam A, Plant GW, Hendriks WT, Cui Q, Harvey AR. The importance of transgene and cell type on the regeneration of adult retinal ganglion cell axons within reconstituted bridging grafts. Exp Neurol. 2007;207(2):314–28.

    Article  CAS  PubMed  Google Scholar 

  14. Ikeda H, Osakada F, Watanabe K, Mizuseki K, Haraguchi T, Miyoshi H, et al. Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc Natl Acad Sci USA. 2005;102(32):11331–6.

    Article  CAS  PubMed  Google Scholar 

  15. Ikegami T, Nakamura M, Yamane J, Katoh H, Okada S, Iwanami A, et al. Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury. Eur J Neurosci. 2005;22(12):3036–46.

    Article  PubMed  Google Scholar 

  16. Jiang C, Moore MJ, Zhang X, Klassen H, Langer R, Young M. Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma. Mol Vis. 2007;13:1783–92.

    CAS  PubMed  Google Scholar 

  17. Johnston Jr RJ, Desplan C. Stochastic neuronal cell fate choices. Curr Opin Neurobiol. 2008;18(1):20–7.

    Article  CAS  PubMed  Google Scholar 

  18. Joussen AM, Heussen FM, Joeres S, Llacer H, Prinz B, Rohrschneider K, et al. Autologous translocation of the choroid and retinal pigment epithelium in age-related macular degeneration. Am J Ophthalmol. 2006;142(1):17–30.

    Article  PubMed  Google Scholar 

  19. Kelley MW, Turner JK, Reh TA. Retinoic acid promotes differentiation of photoreceptors in vitro. Development. 1994;120(8):2091–102.

    CAS  PubMed  Google Scholar 

  20. Kinouchi R, Takeda M, Yang L, Wilhelmsson U, Lundkvist A, Pekny M, et al. Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin. Nat Neurosci. 2003;6(8):863–8.

    Article  CAS  PubMed  Google Scholar 

  21. Klassen HJ, Ng TF, Kurimoto Y, Kirov I, Shatos M, Coffey P, et al. Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. Invest Ophthalmol Vis Sci. 2004;45(11):4167–73.

    Article  PubMed  Google Scholar 

  22. Koike-Kiriyama N, Adachi Y, Minamino K, Iwasaki M, Nakano K, Koike Y, et al. Human cord blood cells can differentiate into retinal nerve cells. Acta Neurobiol Exp. 2007;67(4):359–65.

    Google Scholar 

  23. Langer R. Biomaterials in drug delivery and tissue engineering: one laboratory’s experience. Acc Chem Res. 2000;33(2):94–101.

    Article  CAS  PubMed  Google Scholar 

  24. Lavik EB, Klassen H, Warfvinge K, Langer R, Young MJ. Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitors. Biomaterials. 2005;26(16):3187–96.

    Article  CAS  PubMed  Google Scholar 

  25. Layer PG, Robitzki A, Rothermel A, Willbold E. Of layers and spheres: the reaggregate approach in tissue engineering. Trends Neurosci. 2002;25(3):131–4.

    Article  CAS  PubMed  Google Scholar 

  26. Little L, Healy KE, Schaffer D. Engineering biomaterials for synthetic neural stem cell microenvironments. Chem Rev. 2008;108(5):1787–96.

    Article  CAS  PubMed  Google Scholar 

  27. Lu L, Yaszemski MJ, Mikos AG. Retinal pigment epithelium engineering using synthetic biodegradable polymers. Biomaterials. 2001;22(24):3345–55.

    Article  CAS  PubMed  Google Scholar 

  28. MacLaren RE, Pearson RA, MacNeil A, Douglas RH, Salt TE, Akimoto M, et al. Retinal repair by transplantation of photoreceptor precursors. Nature. 2006;444(7116):203–7.

    Article  CAS  PubMed  Google Scholar 

  29. Miller C, Jeftinija S, Mallapragada S. Synergistic effects of physical and chemical guidance cues on neurite alignment and outgrowth on biodegradable polymer substrates. Tissue Eng. 2002;8(3):367–78.

    Google Scholar 

  30. Neeley WL, Redenti S, Klassen H, Tao S, Desai T, Young MJ, et al. A microfabricated scaffold for retinal progenitor cell grafting. Biomaterials. 2008;29(4):418–26.

    Article  CAS  PubMed  Google Scholar 

  31. Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N, et al. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol. 2008;26(2):215–24.

    Article  CAS  PubMed  Google Scholar 

  32. Plant GW, Harvey AR. A new type of biocompatible bridging structure supports axon regrowth after implantation into the lesioned rat optic tract. Cell Transplant. 2000;9(6):759–72.

    Google Scholar 

  33. Radtke ND, Aramant RB, Petry HM, Green PT, Pidwell DJ, Seiler MJ. Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium. Am J Ophthalmol. 2008;146(2):172–82.

    Article  PubMed  Google Scholar 

  34. Redenti S, Tao S, Yang J, Gu P, Klassen H, Saigal S, Desai T, Young M. Retinal tissue engineering using mouse retinal progenitor cells and a novel biodegradable, thin-film poly(e-caprolactone) nanowire scaffold. J Occul Biol Dis Inform. 2008;1:19–29.

    Google Scholar 

  35. Recknor JB, Sakaguchi DS, Mallapragada SK. Growth and differentiation of astrocytes and neural progenitor cells on micropatterned polymer films. Ann N Y Acad Sci. 2005;1049:24–7.

    Google Scholar 

  36. Recknor JB, Sakaguchi DS, Mallapragada SK. Directed growth and selective differentiation of neural progenitor cells on micropatterned polymer substrates. Biomaterials. 2006;27(22):4098–108.

    Google Scholar 

  37. Reh TA, Fischer AJ. Retinal stem cells. Methods Enzymol. 2006;419:52–73.

    Article  CAS  PubMed  Google Scholar 

  38. Rich KA, Figueroa SL, Zhan Y, Blanks JC. Effects of Müller cell disruption on mouse photoreceptor cell development. Exp Eye Res. 1995;61(2):235–48.

    Article  CAS  PubMed  Google Scholar 

  39. Rieke M, Gottwald E, Weibezahn KF, Layer PG. Tissue reconstruction in 3D-spheroids from rodent retina in a motion-free, bioreactor-based microstructure. Lab Chip. 2008;8(12):2206–13.

    Article  CAS  PubMed  Google Scholar 

  40. Roberts MR, Srinivas M, Forrest D, Morreale de Escobar G, Reh TA. Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retina. Proc Natl Acad Sci USA. 2006;103(16):6218–23.

    Google Scholar 

  41. Royo PE, Quay WB. Retinal transplantation from fetal to maternal mammalian eye. Growth. 1959;23:313–36.

    CAS  PubMed  Google Scholar 

  42. Sakaguchi DS, Van Hoffelen SJ, Theusch E, Parker E, Orasky J, Harper MM, et al. Transplantation of neural progenitor cells into the developing retina of the Brazilian opossum: an in vivo system for studying stem/progenitor cell plasticity. Dev Neurosci. 2004;26(5–6):336–45.

    Article  CAS  PubMed  Google Scholar 

  43. Saha K, Keung AJ, Irwin EF, Li Y, Little L, Schaffer DV, et al. Substrate modulus directs neural stem cell behavior. Biophys J. 2008;95(9):4426–38.

    Article  CAS  PubMed  Google Scholar 

  44. Seiler MJ, Thomas BB, Chen Z, Wu R, Sadda SR, Aramant RB. Retinal transplants restore visual responses: trans-synaptic tracing from visually responsive sites labels transplant neurons. Eur J Neurosci. 2008;28(1):208–20.

    Article  PubMed  Google Scholar 

  45. Sharma RK, O’Leary TE, Fields CM, Johnson DA. Development of the outer retina in the mouse. Brain Res Dev Brain Res. 2003;145(1):93–105.

    Article  CAS  PubMed  Google Scholar 

  46. Sieving PA, Caruso RC, Tao W, Coleman HR, Thompson DJ, Fullmer KR, Bush RA.Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proc Natl Acad Sci USA. 2006;103(10):3896–901.

    Google Scholar 

  47. Silva GA, Czeisler C, Niece KL, Beniash E, Harrington DA, Kessler JA, et al. Selective differentiation of neural progenitor cells by high-epitope density nanofibers. Science. 2004;303(5662):1352–5.

    Article  CAS  PubMed  Google Scholar 

  48. Singhal S, Lawrence JM, Bhatia B, Ellis JS, Kwan AS, Macneil A, et al. Chondroitin sulfate proteoglycans and microglia prevent migration and integration of grafted Müller stem cells into degenerating retina. Stem Cells. 2008;26(4):1074–82.

    Article  PubMed  Google Scholar 

  49. Suzuki T, Mandai M, Akimoto M, Yoshimura N, Takahashi M. The simultaneous treatment of MMP-2 stimulants in retinal transplantation enhances grafted cell migration into the host retina. Stem Cells. 2006;24(11):2406–11.

    Article  CAS  PubMed  Google Scholar 

  50. Takahashi K, Okita K, Nakagawa M, Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc. 2007;2(12):3081–9.

    Article  CAS  PubMed  Google Scholar 

  51. Tao S, Young C, Redenti S, Zhang Y, Klassen H, Desai T, et al. Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space. Lab Chip. 2007;7(6):695–701.

    Article  CAS  PubMed  Google Scholar 

  52. Tao SL, Desai TA. Aligned arrays of biodegradable poly(epsilon-caprolactone) nanowires and nanofibers by template synthesis. Nano Lett. 2007;7(6):1463–8.

    Article  CAS  PubMed  Google Scholar 

  53. Temenoff JS, Mikos AG. Review: tissue engineering for regeneration of articular cartilage. Biomaterials. 2000;21(5):431–40.

    Article  CAS  PubMed  Google Scholar 

  54. Tezcaner A, Hicks D, Boulmedais F, Sahel J, Schaaf P, Voegel JC, et al. Polyelectrolyte multilayer films as substrates for photoreceptor cells. Biomacromolecules. 2006;7(1):86–94.

    Article  CAS  PubMed  Google Scholar 

  55. Thanos C, Emerich D. Delivery of neurotrophic factors and therapeutic proteins for retinal diseases. Expert Opin Biol Ther. 2005;5(11):1443–52.

    Article  CAS  PubMed  Google Scholar 

  56. Tomita M, Lavik E, Klassen H, Zahir T, Langer R, Young MJ. Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells. Stem Cells. 2005;23(10):1579–88.

    Google Scholar 

  57. Tomita M, Adachi Y, Yamada H, Takahashi K, Kiuchi K, Oyaizu H, et al. Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina. Stem Cells. 2002;20(4):279–83.

    Article  CAS  PubMed  Google Scholar 

  58. Tropepe V, Coles BL, Chiasson BJ, Horsford DJ, Elia AJ, McInnes RR, et al. Retinal stem cells in the adult mammalian eye. Science. 2000;287(5460):2032–6.

    Article  CAS  PubMed  Google Scholar 

  59. Uga S, Smelser GK. Comparative study of the fine structure of retinal Müller cells in various vertebrates. Invest Ophthalmol. 1973;12(6):434–48.

    CAS  PubMed  Google Scholar 

  60. Van Hoffelen SJ, Young MJ, Shatos MA, Sakaguchi DS. Incorporation of murine brain progenitor cells into the developing mammalian retina. Invest Ophthalmol Vis Sci. 2003;44(1):426–34.

    Article  PubMed  Google Scholar 

  61. Ward MS, Khoobehi A, Lavik EB, Langer R, Young MJ. Neuroprotection of retinal ganglion cells in DBA/2J mice with GDNF-loaded biodegradable microspheres. J Pharm Sci. 2007;96(3):558–68.

    Article  CAS  PubMed  Google Scholar 

  62. West EL, Pearson RA, Tschernutter M, Sowden JC, Maclaren RE, Ali RR. Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors. Exp Eye Res. 2008;86(4):601–11.

    Article  CAS  PubMed  Google Scholar 

  63. Woodford BJ, Blanks JC. Uptake of tritiated thymidine in mitochondria of the retina. Invest Ophthalmol Vis Sci. 1989;30(12):2528–32.

    CAS  PubMed  Google Scholar 

  64. Zhang Y, Klassen HJ, Tucker BA, Perez MT, Young MJ. CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism. J Neurosci. 2007;27(17):4499–506.

    Article  CAS  PubMed  Google Scholar 

  65. Zuo J, Ferguson TA, Hernandez YJ, Stetler-Stevenson WG, Muir D. Neuronal matrix metalloproteinase-2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan. J Neurosci. 1998;18(14):5203–11.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA

    Stephen Redenti & Michael Young

  2. Department of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA, USA

    Henry Klassen

Authors
  1. Stephen Redenti
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  2. Henry Klassen
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  3. Michael Young
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Corresponding author

Correspondence to Michael Young .

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Editors and Affiliations

  1. Klinik für Plastische Chirurgie,, Hand- und Verbrennungschirurgie, Universitätsklinikum Aachen, Pauwelsstr. 30, Aachen, 52057, Germany

    Norbert Pallua

  2. Klinik für Plastische Chirurgie,, Hand- und Verbrennungschirurgie, Universitätsklinikum Aachen, Pauwelsstr. 30, Aachen, 52057, Germany

    Christoph V. Suscheck

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Redenti, S., Klassen, H., Young, M. (2011). Tissue Engineering of Organs: Eye/Retina. In: Pallua, N., Suscheck, C. (eds) Tissue Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02824-3_17

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