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Asymmetric Organocatalysis pp 145–200Cite as

Enamine Catalysis

Part of the Topics in Current Chemistry book series (TOPCURRCHEM,volume 291)

Abstract

The reversible reaction of primary or secondary amines with enolizable aldehydes or ketones affords nucleophilic intermediates, enamines. With chiral amines, catalytic enantioselective reactions via enamine intermediates become possible. In this review, structure-activity relationships and the scope as well as current limitations of enamine catalysis are discussed.

Keywords

  • Aldehydes and ketones
  • Alpha-functionalization
  • Amines
  • Enamine catalysis
  • Organocatalysis

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Authors and Affiliations

  1. Department of Chemistry, University of Jyväskylä, 35, FI-40014 JYU, Jyväskylä, Finland

    Petri M. Pihko

  2. Department of Chemistry, Helsinki University of Technology, 6100, FI-02015 TKK, Espoo, Finland

    Inkeri Majander & Anniina Erkkilä

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  1. Petri M. Pihko
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Correspondence to Petri M. Pihko .

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  1. MPI für Kohleforschung, Kaiser-Wilhelm-Platz 1, Mülheim, 45470, Germany

    Benjamin List

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Pihko, P.M., Majander, I., Erkkilä, A. (2010). Enamine Catalysis. In: List, B. (eds) Asymmetric Organocatalysis. Topics in Current Chemistry, vol 291. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02815-1_21

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