Streptomycete Heavy Metal Resistance: Extracellular and Intracellular Mechanisms

  • Erika Kothe
  • Christian Dimkpa
  • Götz Haferburg
  • André Schmidt
  • Astrid Schmidt
  • Eileen Schütze
Part of the Soil Biology book series (SOILBIOL, volume 19)


The responses of microorganisms to heavy metal stress involve both extracellular and intracellular mechanisms. In contaminated soils, streptomycetes are an important group with a particularly versatile secondary metabolism. The roles of extracellular and intracellular mechanisms for heavy metal retention in growth at contaminated sites were investigated, with emphasis placed on chelator and siderophore excretion, biomineralization, cell wall adsorption, and intracellular storage. The combined result of all of these processes is heavy metal resistance, which was specifically addressed for nickel. Strains withstanding up to 130 mM nickel in minimal media were isolated from a former uranium mining site near Ronneburg in Eastern Thuringia, Germany.



This work was supported by IMPRS (Max-Planck Society), HIGRADE (Helmholtz Association), Gk1257 and JSMC (DFG).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Erika Kothe
    • 1
  • Christian Dimkpa
    • 1
  • Götz Haferburg
    • 1
  • André Schmidt
    • 1
  • Astrid Schmidt
    • 1
  • Eileen Schütze
    • 1
  1. 1.Institute for MicrobiologyFriedrich-Schiller- University JenaJenaGermany

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