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Pathologie pp 481–549Cite as

Tumoren

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Zusammenfassung

Im allgemeinen Teil werden Klinik, Epidemiologie, Ätiologie, Pathogenese und diagnostische Verfahren (Stereotaxie, Immunhistochemie, Molekularpathologie) von Tumoren des Nervensystems besprochen. Daran schließt sich eine detaillierte Darstellung der makroskopischen, histologischen und molekularen Pathologie der einzelnen Tumortypen an, wobei der Schwerpunkt auf der Diagnostik liegt. Das Kapitel schließt mit Paraneoplasien und Therapie-induzierten Schäden des Gehirns.

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Literatur

  1. Ahlbom A, Feychting M, Green A, Kheifets L, Savitz DA, Swerdlow AJ (2009) Epidemiologic evidence on mobile phones and tumor risk: a review. Epidemiology 20: 639–652

    PubMed  Google Scholar 

  2. Allen JC, Miller DC, Budzilovich GN, Epstein FJ (1991) Brain and spinal cord hemorrhage in long-term survivors of malignant pediatric brain tumors: a possible late effect of therapy. Neurology 41: 148–150

    PubMed  CAS  Google Scholar 

  3. Arnold PM, Oldershaw JB, McDonald LW, Langer BG (1990) Myxomatous cyst of the brachial plexus. Case report. J Neurosurg 73: 782–784

    PubMed  CAS  Google Scholar 

  4. Awad IA, Robinson JR, Jr., Mohanty S, Estes ML (1993) Mixed vascular malformations of the brain: clinical and pathogenetic considerations. Neurosurgery 33: 179–188; discussion 188

    PubMed  CAS  Google Scholar 

  5. Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A (2008) Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol 116: 597–602

    PubMed  CAS  Google Scholar 

  6. Banerjee AK, Sharma BS, Vashista RK, Kak VK (1992) Intracranial olfactory neuroblastoma: evidence for olfactory epithelial origin. J Clin Pathol 45: 299–302

    PubMed  CAS  Google Scholar 

  7. Batara JF, Grossman SA (2003) Primary central nervous system lymphomas. Curr Opin Neurol 16: 671–675

    PubMed  Google Scholar 

  8. Becher MW, Abel TW, Thompson RC, Weaver KD, Davis LE (2006) Immunohistochemical analysis of metastatic neoplasms of the central nervous system. J Neuropathol Exp Neurol 65: 935–944

    PubMed  CAS  Google Scholar 

  9. Bell JE (1994) Update on central nervous system cytopathology. I. Cerebrospinal fluid. J Clin Pathol 47: 573–578

    PubMed  CAS  Google Scholar 

  10. Bilzer T, Reifenberger G, Wechsler W (1989) Chemical induction of brain tumors in rats by nitrosoureas: molecular biology and neuropathology. Neurotoxicol Teratol 11: 551–556

    PubMed  CAS  Google Scholar 

  11. Brat DJ, Scheithauer BW, Staugaitis SM, Cortez SC, Brecher K, Burger PC (1998) Third ventricular chordoid glioma: a distinct clinicopathologic entity. J Neuropathol Exp Neurol 57: 283–290

    PubMed  CAS  Google Scholar 

  12. Brat DJ, Giannini C, Scheithauer BW, Burger PC (1999) Primary melanocytic neoplasms of the central nervous systems. Am J Surg Pathol 23: 745–754

    PubMed  CAS  Google Scholar 

  13. Brat DJ, James CD, Jedlicka AE et al. (1999) Molecular genetic alterations in radiation-induced astrocytomas. Am J Pathol 154: 1431–1438

    PubMed  CAS  Google Scholar 

  14. Brat DJ, Hirose Y, Cohen KJ, Feuerstein BG, Burger PC (2000) Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. Brain Pathol 10: 342–352

    PubMed  CAS  Google Scholar 

  15. Brat DJ, Scheithauer BW, Staugaitis SM, Holtzman RN, Morgello S, Burger PC (2000) Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am J Surg Pathol 24: 362–368

    PubMed  CAS  Google Scholar 

  16. Bruna J, Brell M, Ferrer I, Gimenez-Bonafe P, Tortosa A (2007) Ki-67 proliferative index predicts clinical outcome in patients with atypical or anaplastic meningioma. Neuropathology 27: 114–120

    PubMed  Google Scholar 

  17. Budka H, Pilz P, Guseo A (1975) Primary leptomeningeal sarcomatosis. Clinicopathological report of six cases. J Neurol 211: 77–93

    PubMed  CAS  Google Scholar 

  18. Caccamo D, Herman MM, Urich H, Rubinstein LJ (1989) Focal neuronal gigantism and cerebral cortical thickening after therapeutic irradiation of the central nervous system. Arch Pathol Lab Med 113: 880–885

    PubMed  CAS  Google Scholar 

  19. Cai DX, Mafra M, Schmidt RE, Scheithauer BW, Park TS, Perry A (2000) Medulloblastomas with extensive posttherapy neuronal maturation. Report of two cases. J Neurosurg 93: 330–334

    PubMed  CAS  Google Scholar 

  20. Capper D, Zentgraf H, Balss J, Hartmann C, von Deimling A (2009) Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol 118: 599–601

    PubMed  CAS  Google Scholar 

  21. Capper D, Sahm F, Hartmann C, Meyermann R, von Deimling A, Schittenhelm J (2010) Application of mutant IDH1 antibody to differentiate diffuse glioma from nonneoplastic central nervous system lesions and therapy-induced changes. Am J Surg Pathol 34: 1199–1204

    PubMed  Google Scholar 

  22. Capper D, Weissert S, Balss J et al. (2010) Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol 20: 245–254

    PubMed  CAS  Google Scholar 

  23. Capper D, Reuss D, Schittenhelm J et al. (2011) Mutationspecific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology. Acta Neuropathol 121: 241–252

    PubMed  Google Scholar 

  24. Carney JA (1990) Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome. Am J Surg Pathol 14: 206–222

    PubMed  CAS  Google Scholar 

  25. Casadei GP, Komori T, Scheithauer BW, Miller GM, Parisi JE, Kelly PJ (1993) Intracranial parenchymal schwannoma. A clinicopathological and neuroimaging study of nine cases. J Neurosurg 79: 217–222

    PubMed  CAS  Google Scholar 

  26. Casadei GP, Scheithauer BW, Hirose T, Manfrini M, Van Houton C, Wood MB (1995) Cellular schwannoma. A clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. Cancer 75: 1109–1119

    PubMed  CAS  Google Scholar 

  27. Casey M, Vaughan CJ, He J et al. (2000) Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex. J Clin Invest 106: R31–38

    PubMed  CAS  Google Scholar 

  28. CBTRUS (2010) Primary brain tumors in the United States statistical report 2004–2006. Central Brain Tumor Registry of the United States, Hinsdale

    Google Scholar 

  29. Cerda-Nicolas M, Kepes JJ (1993) Gliofibromas (including malignant forms), and gliosarcomas: a comparative study and review of the literature. Acta Neuropathol 85: 349–361

    PubMed  CAS  Google Scholar 

  30. Cohen-Gadol AA, Pichelmann MA, Link MJ et al. (2003) Granular cell tumor of the sellar and suprasellar region: clinicopathologic study of 11 cases and literature review. Mayo Clin Proc 78: 567–573

    PubMed  Google Scholar 

  31. Coons SW, Johnson PC (1993) Regional heterogeneity in the proliferative activity of human gliomas as measured by the Ki-67 labeling index. J Neuropathol Exp Neurol 52: 609–618

    PubMed  CAS  Google Scholar 

  32. Couch V, Lindor NM, Karnes PS, Michels VV (2000) von Hippel-Lindau disease. Mayo Clin Proc 75: 265–272

    PubMed  CAS  Google Scholar 

  33. Crawford JR, MacDonald TJ, Packer RJ (2007) Medulloblastoma in childhood: new biological advances. Lancet Neurol 6: 1073–1085

    PubMed  CAS  Google Scholar 

  34. Crotty TB, Scheithauer BW, Young WF, Jr., Davis DH, Shaw EG, Miller GM, Burger PC (1995) Papillary craniopharyngioma: a clinicopathological study of 48 cases. J Neurosurg 83: 206–214

    PubMed  Google Scholar 

  35. Curatolo P, Bombardieri R, Jozwiak S (2008) Tuberous sclerosis. Lancet 372: 657–668

    PubMed  CAS  Google Scholar 

  36. Daumas-Duport C, Scheithauer B, O’Fallon J, Kelly P (1988) Grading of astrocytomas. A simple and reproducible method. Cancer 62: 2152–2165

    PubMed  CAS  Google Scholar 

  37. Daumas-Duport C, Scheithauer BW, Chodkiewicz JP, Laws ER, Jr., Vedrenne C (1988) Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Report of thirty-nine cases. Neurosurgery 23: 545–556

    PubMed  CAS  Google Scholar 

  38. Daumas-Duport C, Varlet P, Bacha S, Beuvon F, Cervera-Pierot P, Chodkiewicz JP (1999) Dysembryoplastic neuroepithelial tumors: nonspecific histological forms – a study of 40 cases. J Neurooncol 41: 267–280

    PubMed  CAS  Google Scholar 

  39. De Vleeschouwer S, Fieuws S, Rutkowski S et al. (2008) Postoperative adjuvant dendritic cell-based immunotherapy in patients with relapsed glioblastoma multiforme. Clin Cancer Res 14: 3098–3104

    PubMed  Google Scholar 

  40. Del Bigio MR, Jay V, Drake JM (1992) Prepontine cyst lined by respiratory epithelium with squamous metaplasia: immunohistochemical and ultrastructural study. Acta Neuropathol 83: 564–568

    PubMed  Google Scholar 

  41. Deonna T, Ziegler AL (2000) Hypothalamic hamartoma, precocious puberty and gelastic seizures: a special model of „epileptic“ developmental disorder. Epileptic Disord 2: 33–37

    PubMed  CAS  Google Scholar 

  42. Deorah S, Lynch CF, Sibenaller ZA, Ryken TC (2006) Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus 20: E1

    PubMed  Google Scholar 

  43. Diepholder HM, Schwechheimer K, Mohadjer M, Knoth R, Volk B (1991) A clinicopathologic and immunomorphologic study of 13 cases of ganglioglioma. Cancer 68: 2192–2201

    PubMed  CAS  Google Scholar 

  44. Dix AR, Brooks WH, Roszman TL, Morford LA (1999) Immune defects observed in patients with primary malignant brain tumors. J Neuroimmunol 100: 216–232

    PubMed  CAS  Google Scholar 

  45. Ducatman BS, Scheithauer BW (1984) Malignant peripheral nerve sheath tumors with divergent differentiation. Cancer 54: 1049–1057

    PubMed  CAS  Google Scholar 

  46. Eaton KW, Tooke LS, Wainwright LM, Judkins AR, Biegel JA (2011) Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors. Pediatr Blood Cancer 56: 7–15

    PubMed  Google Scholar 

  47. Eberhart CG, Brat DJ, Cohen KJ, Burger PC (2000) Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes. Pediatr Dev Pathol 3: 346–352

    PubMed  CAS  Google Scholar 

  48. Emory TS, Scheithauer BW, Hirose T, Wood M, Onofrio BM, Jenkins RB (1995) Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22. Am J Clin Pathol 103: 696–704

    PubMed  CAS  Google Scholar 

  49. Engel U, Gottschalk S, Niehaus L, Lehmann R, May C, Vogel S, Janisch W (2000) Cystic lesions of the pineal region – MRI and pathology. Neuroradiology 42: 399–402

    PubMed  CAS  Google Scholar 

  50. Ferlay J, Bray F, Pisani P, Parkin DM (2010) GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. International Agency for Research on Cancer, Lyon

    Google Scholar 

  51. Fernandez C, Figarella-Branger D, Girard N, Bouvier-Labit C, Gouvernet J, Paz Paredes A, Lena G (2003) Pilocytic astrocytomas in children: prognostic factors--a retrospective study of 80 cases. Neurosurgery 53: 544–553; discussion 554–545

    Google Scholar 

  52. Fevre-Montange M, Hasselblatt M, Figarella-Branger D et al. (2006) Prognosis and histopathologic features in papillary tumors of the pineal region: a retrospective multicenter study of 31 cases. J Neuropathol Exp Neurol 65: 1004–1011

    PubMed  Google Scholar 

  53. Firlik KS, Martinez AJ, Lunsford LD (1999) Use of cytologicalpreparationsfor the intraoperative diagnosis of stereo-tactically obtained brain biopsies: a 19-year experience and survey of neuropathologists. J Neurosurg 91: 454–458

    PubMed  CAS  Google Scholar 

  54. Franke FE, Schachenmayr W, Osborn M, Altmannsberger M (1991) Unexpected immunoreactivities of intermediate filament antibodies in human brain and brain tumors. Am J Pathol 139: 67–79

    PubMed  CAS  Google Scholar 

  55. Friede RL (1989) Meningeal cysts. In: Friede RL (ed) Developmental neuropathology. Springer, Berlin Heidelberg New York, pp 209–230

    Google Scholar 

  56. Gambini C, Rongioletti F, Rebora A (2000) Proliferation of eccrine sweat ducts associated with heterotopic neural tissue (nasal glioma). Am J Dermatopathol 22: 179–182

    PubMed  CAS  Google Scholar 

  57. Geddes JF, Thom M, Robinson SF, Revesz T (1996) Granular cell change in astrocytic tumors. Am J Surg Pathol 20: 55–63

    PubMed  CAS  Google Scholar 

  58. Geddes JF, Jansen GH, Robinson SF, Gomori E, Holton JL, Monson JP, Besser GM, Revesz T (2000) ‘Gangliocytomas’ of the pituitary: a heterogeneous group of lesions with differing histogenesis. Am J Surg Pathol 24: 607–613

    PubMed  CAS  Google Scholar 

  59. Geppert M, Ostertag CB, Seitz G, Kiessling M (1990) Glucocorticoid therapy obscures the diagnosis of cerebral lymphoma. Acta Neuropathol 80: 629–634

    PubMed  CAS  Google Scholar 

  60. Gessi M, Giangaspero F, Lauriola L et al. (2009) Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. Am J Surg Pathol 33: 211–217

    PubMed  Google Scholar 

  61. Giangaspero F, Rigobello L, Badiali M, Loda M, Andreini L, Basso G, Zorzi F, Montaldi A (1992) Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. Am J Surg Pathol 16: 687–693

    PubMed  CAS  Google Scholar 

  62. Giannini C, Scheithauer BW, Jenkins RB, Erlandson RA, Perry A, Borell TJ, Hoda RS, Woodruff JM (1997) Softtissue perineurioma. Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol 21: 164–173

    PubMed  CAS  Google Scholar 

  63. Giannini C, Scheithauer BW, Burger PC, Brat DJ, Wollan PC, Lach B, O’Neill BP (1999) Pleomorphic xanthoastrocytoma: what do we really know about it? Cancer 85: 2033–2045

    PubMed  CAS  Google Scholar 

  64. GKR (2009) Krebsinzidenz 2005-2006 im Erfassungsgebiet des Gemeinsamen Krebsregisters. Broschuere.de Verlag, Berlin

    Google Scholar 

  65. Glantz MJ, Burger PC, Herndon JE, 2nd, Friedman AH, Cairncross JG, Vick NA, Schold SC Jr (1991) Influence of the type of surgery on the histologic diagnosis in patients with anaplastic gliomas. Neurology 41: 1741–1744

    PubMed  CAS  Google Scholar 

  66. Goodwin TL, Sainani K, Fisher PG (2009) Incidence patterns of central nervous system germ cell tumors: a SEER Study. J Pediatr Hematol Oncol 31: 541–544

    PubMed  Google Scholar 

  67. Gottschalk J, Jautzke G, Paulus W, Goebel S, Cervos-Navarro J (1993) The use of immunomorphology to differentiate choroid plexus tumors from metastatic carcinomas. Cancer 72: 1343–1349

    PubMed  CAS  Google Scholar 

  68. Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, Posner JB, Dalmau J (2000) Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain 123: 1481–1494

    PubMed  Google Scholar 

  69. Haas-Kogan DA, Prados MD, Tihan T et al. (2005) Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J Natl Cancer Inst 97: 880–887

    PubMed  CAS  Google Scholar 

  70. Haberler C, Gelpi E, Marosi C, Rossler K, Birner P, Budka H, Hainfellner JA (2006) Immunohistochemical analysis of platelet-derived growth factor receptor-alpha, -beta, ckit, c-abl, and arg proteins in glioblastoma: possible implications for patient selection for imatinib mesylate therapy. J Neurooncol 76: 105–109

    PubMed  CAS  Google Scholar 

  71. Hammer GP, Seidenbusch MC, Schneider K, Regulla DF, Zeeb H, Spix C, Blettner M (2009) A cohort study of childhood cancer incidence after postnatal diagnostic X-ray exposure. Radiat Res 171: 504–512

    PubMed  CAS  Google Scholar 

  72. Hammond RR, Duggal N, Woulfe JM, Girvin JP (2000) Malignant transformation of a dysembryoplastic neuroepithelial tumor. Case report. J Neurosurg 92: 722–725

    PubMed  CAS  Google Scholar 

  73. Hartmann C, Meyer J, Balss J et al. (2009) Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol 118: 469–474

    PubMed  Google Scholar 

  74. Hartmann C, Hentschel B, Wick W et al. (2010) Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. Acta Neuropathol 120: 707–718

    PubMed  Google Scholar 

  75. Hasselblatt M, Paulus W (2003) Sensitivity and specificity of epithelial membrane antigen staining patterns in ependymomas. Acta Neuropathol 106: 385–388

    PubMed  Google Scholar 

  76. Hasselblatt M, Nolte KW, Paulus W (2004) Angiomatous meningioma: a clinicopathologic study of 38 cases. Am J Surg Pathol 28: 390–393

    PubMed  Google Scholar 

  77. Hasselblatt M, Jeibmann A, Gerss J, Behrens C, Rama B, Wassmann H, Paulus W (2005) Cellular and reticular variants of haemangioblastoma revisited: a clinicopathologic study of 88 cases. Neuropathol Appl Neurobiol 31: 618–622

    PubMed  CAS  Google Scholar 

  78. Hasselblatt M, Blumcke I, Jeibmann A et al. (2006a) Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region. Neuropathol Appl Neurobiol 32: 278–283

    CAS  Google Scholar 

  79. Hasselblatt M, Bohm C, Tatenhorst L et al. (2006b) Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. Am J Surg Pathol 30: 66–74

    Google Scholar 

  80. Hasselblatt M (2008) Molekulare Diagnostik von Gliomen. Pathologe 29: 422–427

    PubMed  CAS  Google Scholar 

  81. Hasselblatt M, Oyen F, Gesk S et al. (2009) Cribriform neuroepithelial tumor (CRINET): a nonrhabdoid ventricular tumor with INI1 loss and relatively favorable prognosis. J Neuropathol Exp Neurol 68: 1249–1255

    PubMed  Google Scholar 

  82. Hess KR, Broglio KR, Bondy ML (2004) Adult glioma incidence trends in the United States, 1977–2000. Cancer 101: 2293–2299

    PubMed  Google Scholar 

  83. Ho DM, Liu HC (1992) Primary intracranial germ cell tumor. Pathologic study of 51 patients. Cancer 70: 1577–1584

    PubMed  CAS  Google Scholar 

  84. Hoffman S, Propp JM, McCarthy BJ (2006) Temporal trends in incidence of primary brain tumors in the United States, 1985-1999. Neuro Oncol 8: 27–37

    PubMed  Google Scholar 

  85. Honnorat J, Antoine JC, Derrington E, Aguera M, Belin MF (1996) Antibodies to a subpopulation of glial cells and a 66 kDa developmental protein in patients with paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry 61: 270–278

    PubMed  CAS  Google Scholar 

  86. Horbinski C, Hamilton RL, Nikiforov Y, Pollack IF (2010) Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas. Acta Neuropathol 119: 641–649

    PubMed  CAS  Google Scholar 

  87. Hsu DW, Efird JT, Hedley-Whyte ET (1997) Progesterone and estrogen receptors in meningiomas: prognostic considerations. J Neurosurg 86: 113–120

    PubMed  CAS  Google Scholar 

  88. Huang H, Reis R, Yonekawa Y, Lopes JM, Kleihues P, Ohgaki H (1999) Identification in human brain tumors of DNA sequences specific for SV40 large T antigen. Brain Pathol 9: 33–42

    PubMed  CAS  Google Scholar 

  89. Jackson EM, Sievert AJ, Gai X et al. (2009) Genomic analysis using high-density single nucleotide polymorphismbased oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors. Clin Cancer Res 15: 1923–1930

    PubMed  CAS  Google Scholar 

  90. Jänisch W, Schreiber D, Gerlach H (1980) Tumoren des Zentralnervensystems bei Feten und Säuglingen. Gustav Fischer, Jena

    Google Scholar 

  91. Jänisch W, Lammel H, Staneczek W (1986) Zur Epidemiologie der Geschwülste des Zentralnervensystems in der DDR. Zentralbl Pathol 132: 145

    Google Scholar 

  92. Jänisch W, Schreiber D, Güthert H (1988) Neuropathologie. Tumoren des Nervensystems. Gustav Fischer, Stuttgart

    Google Scholar 

  93. Jeibmann A, Hasselblatt M, Gerss J et al. (2006) Prognostic implications of atypical histologic features in choroid plexus papilloma. J Neuropathol Exp Neurol 65: 1069–1073

    PubMed  Google Scholar 

  94. Jeibmann A, Wrede B, Peters O, Wolff JE, Paulus W, Hasselblatt M (2007) Malignant progression in choroid plexus papillomas. J Neurosurg 107: 199–202

    PubMed  Google Scholar 

  95. Jeibmann A, Egensperger R, Kuchelmeister K et al. (2009) Extent of surgical resection but not myxopapillary versus classical histopathological subtype affects prognosis in lumbo-sacral ependymomas. Histopathology 54: 260–262

    PubMed  Google Scholar 

  96. Jeibmann A, Hasselblatt M, Pfister S et al. (2009) From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior. J Neurosurg Pediatr 4: 475–478

    PubMed  Google Scholar 

  97. Jellinger K, Machacek E (1982) Rare intracranial tumours in infancy and childhood. In: Voth D, Gutjahr P, Langmaid C (eds) Tumours of the central nervous system in infancy and childhood. Springer, Berlin Heidelberg New York, pp 44–52

    Google Scholar 

  98. Jellinger KA, Paulus W (1992) Primary central nervous system lymphomas – an update. J Cancer Res Clin Oncol 119: 7–27

    PubMed  CAS  Google Scholar 

  99. Jeuken J, Cornelissen S, Boots-Sprenger S, Gijsen S, Wesseling P (2006) Multiplex ligation-dependent probe amplification: a diagnostic tool for simultaneous identification of different genetic markers in glial tumors. J Mol Diagn 8: 433–443

    PubMed  CAS  Google Scholar 

  100. Jeuken JW, von Deimling A, Wesseling P (2004) Molecular pathogenesis of oligodendroglial tumors. J Neurooncol 70: 161–181

    PubMed  Google Scholar 

  101. Jeuken JW, Wesseling P (2010) MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential. J Pathol 222: 324–328

    PubMed  CAS  Google Scholar 

  102. Jones DT, Kocialkowski S, Liu L, Pearson DM, Backlund LM, Ichimura K, Collins VP (2008) Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res 68: 8673–8677

    PubMed  CAS  Google Scholar 

  103. Jouvet A, Saint-Pierre G, Fauchon F et al.(2000) Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol 10: 49–60

    PubMed  CAS  Google Scholar 

  104. Jouvet A, Fauchon F, Liberski P et al. (2003) Papillary tumor of the pineal region. Am J Surg Pathol 27: 505–512

    PubMed  Google Scholar 

  105. Judkins AR, Mauger J, Ht A, Rorke LB, Biegel JA (2004) Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms. Am J Surg Pathol 28: 644–650

    PubMed  Google Scholar 

  106. Judkins AR, Burger PC, Hamilton RL et al. (2005) INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma. J Neuropathol Exp Neurol 64: 391–397

    PubMed  CAS  Google Scholar 

  107. Kaatsch P, Rickert CH, Kuhl J, Schuz J, Michaelis J (2001) Population-based epidemiologic data on brain tumors in German children. Cancer 92: 3155–3164

    PubMed  CAS  Google Scholar 

  108. Kaiser R (1999) Parneoplastische Syndrome. Nervenarzt 70: 688–701

    PubMed  CAS  Google Scholar 

  109. Katsetos CD, Herman MM, Frankfurter A et al.(1989) Cerebellar desmoplastic medulloblastomas. A further immunohistochemical characterization of the reticulin-free pale islands. Arch Pathol Lab Med 113: 1019–1029

    PubMed  CAS  Google Scholar 

  110. Kawano N, Ohba Y, Nagashima K (2000) Eosinophilic inclusions in ependymoma represent microlumina: a light and electron microscopic study. Acta Neuropathol 99: 214–218

    PubMed  CAS  Google Scholar 

  111. Kepes JJ, Rubinstein LJ, Eng LF (1979) Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with relatively favorable prognosis. A study of 12 cases. Cancer 44: 1839–1852

    PubMed  CAS  Google Scholar 

  112. Kleihues P, Ohgaki H (2000) Phenotype vs genotype in the evolution of astrocytic brain tumors. Toxicol Pathol 28: 164–170

    PubMed  CAS  Google Scholar 

  113. Klein P, Rubinstein LJ (1989) Benign symptomatic glial cysts of the pineal gland: a report of seven cases and review of the literature. J Neurol Neurosurg Psychiatry 52: 991–995

    PubMed  CAS  Google Scholar 

  114. Klingebiel R, Bohner G (2009) Neuroimaging. Recent Results Cancer Res 171: 175–190

    PubMed  CAS  Google Scholar 

  115. Kluge H, Wieczorek V, Linke E, Zimmermann K, Witte OW (2005) Atlas der praktischen Liquorzytologie. Thieme, Stuttgart

    Google Scholar 

  116. Komori T, Scheithauer BW, Anthony DC et al. (1998) Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm. Am J Surg Pathol 22: 1171–1183

    PubMed  CAS  Google Scholar 

  117. Komori T, Scheithauer BW, Hirose T (2002) A rosette-forming glioneuronal tumor of the fourth ventricle: infratentorial form of dysembryoplastic neuroepithelial tumor? Am J Surg Pathol 26: 582–591

    PubMed  Google Scholar 

  118. Kordes U, Gesk S, Fruhwald MC et al. (2010) Clinical and molecular features in patients with atypical teratoid rhabdoid tumor or malignant rhabdoid tumor. Genes Chromosomes Cancer 49: 176–181

    PubMed  CAS  Google Scholar 

  119. Korshunov A, Meyer J, Capper D et al. (2009) Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma. Acta Neuropathol 118: 401–405

    PubMed  CAS  Google Scholar 

  120. Korshunov A, Remke M, Gessi M et al. (2010) Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. Acta Neuropathol 120: 253–260

    PubMed  Google Scholar 

  121. Koul D (2008) PTEN signaling pathways in glioblastoma. Cancer Biol Ther 7: 1321–1325

    PubMed  CAS  Google Scholar 

  122. Kraus JA, Wenghoefer M, Schmidt MC et al. (2000) Longterm survival of glioblastoma multiforme: importance of histopathological reevaluation. J Neurol 247: 455–460

    PubMed  CAS  Google Scholar 

  123. Krex D, Klink B, Hartmann C et al. (2007) Long-term survival with glioblastoma multiforme. Brain 130: 2596–2606

    PubMed  Google Scholar 

  124. Krouwer HG, Davis RL, Silver P, Prados M (1991) Gemistocytic astrocytomas: a reappraisal. J Neurosurg 74: 399–406

    PubMed  CAS  Google Scholar 

  125. Kuhlmann T, Gutenberg A, Schulten HJ, Paulus W, Rohde V, Bruck W (2008) Nogo-a expression in glial CNS tumors: a tool to differentiate between oligodendrogliomas and other gliomas? Am J Surg Pathol 32: 1444–1453

    PubMed  Google Scholar 

  126. Kurt E, Zheng PP, Hop WC, van der Weiden M, Bol M, van den Bent MJ, Avezaat CJ, Kros JM (2006) Identification of relevant prognostic histopathologic features in 69 intracranial ependymomas, excluding myxopapillary ependymomas and subependymomas. Cancer 106: 388–395

    PubMed  Google Scholar 

  127. Lach B, Scheithauer BW, Gregor A, Wick MR (1993) Colloid cyst of the third ventricle. A comparative immunohistochemical study of neuraxis cysts and choroid plexus epithelium. J Neurosurg 78: 101–111

    PubMed  CAS  Google Scholar 

  128. Langford LA, Barre GM (1997) Tanycytic ependymoma. Ultrastruct Pathol 21: 135–142

    PubMed  CAS  Google Scholar 

  129. Lantos PL, VandenBerg SR, Kleihues P (1997) Tumours of the nervous system. In: Graham DI, Lantos PL (eds) Greenfieldś Neuropathology. Arnold, London, pp 583–879

    Google Scholar 

  130. Lawson AR, Tatevossian RG, Phipps KP, Picker SR, Michalski A, Sheer D, Jacques TS, Forshew T (2010) RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort. Acta Neuropathol 120: 271–273

    PubMed  Google Scholar 

  131. Lombardi D, Scheithauer BW, Meyer FB, Forbes GS, Shaw EG, Gibney DJ, Katzmann JA (1991) Symptomatic subependymoma: a clinicopathological and flow cytometric study. J Neurosurg 75: 583–588

    PubMed  CAS  Google Scholar 

  132. Lopes MB, Altermatt HJ, Scheithauer BW, Shepherd CW, VandenBerg SR (1996) Immunohistochemical characterization of subependymal giant cell astrocytomas. Acta Neuropathol 91: 368–375

    PubMed  CAS  Google Scholar 

  133. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) (2007) WHO Classification of tumours of the central nervous system. IARC Press, Lyon

    Google Scholar 

  134. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114: 97–109

    PubMed  Google Scholar 

  135. Luque FA, Furneaux HM, Ferziger R et al. (1991) Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer. Ann Neurol 29: 241–251

    PubMed  CAS  Google Scholar 

  136. Mackenzie IR, Gilbert JJ (1991) Cysts of the neuraxis of endodermal origin. J Neurol Neurosurg Psychiatry 54: 572–575

    PubMed  CAS  Google Scholar 

  137. Mazloom A, Wolff JE, Paulino AC (2010) The impact of radiotherapy fields in the treatment of patients with choroid plexus carcinoma. Int J Radiat Oncol Biol Phys 78: 79–84

    PubMed  Google Scholar 

  138. McGirt MJ, Villavicencio AT, Bulsara KR, Friedman AH (2003) MRI-guided stereotactic biopsy in the diagnosis of glioma: comparison of biopsy and surgical resection specimen. Surg Neurol 59: 277–281; discussion 281–272

    Google Scholar 

  139. Mehling M, Simon P, Mittelbronn M, Meyermann R, Ferrone S, Weller M, Wiendl H (2007) WHO grade associated downregulation of MHC class I antigen-processing machinery components in human astrocytomas: does it reflect a potential immune escape mechanism? Acta Neuropathol 114: 111–119

    PubMed  CAS  Google Scholar 

  140. Meis JM, Martz KL, Nelson JS (1991) Mixed glioblastoma multiforme and sarcoma. A clinicopathologic study of 26 radiation therapy oncology group cases. Cancer 67: 2342–2349

    PubMed  CAS  Google Scholar 

  141. Mena H, Ribas JL, Pezeshkpour GH, Cowan DN, Parisi JE (1991) Hemangiopericytoma of the central nervous system: a review of 94 cases. Hum Pathol 22: 84–91

    PubMed  CAS  Google Scholar 

  142. Mengel M, von Wasielewski R, Wiese B, Rudiger T, Muller-Hermelink HK, Kreipe H (2002) Inter-laboratory and inter-observer reproducibility of immunohistochemical assessment of the Ki-67 labelling index in a large multicentre trial. J Pathol 198: 292–299

    PubMed  Google Scholar 

  143. Miller DC, Hochberg FH, Harris NL, Gruber ML, Louis DN, Cohen H (1994) Pathology with clinical correlations of primary central nervous system non-Hodgkin’s lymphoma. The Massachusetts General Hospital experience 1958-1989. Cancer 74: 1383–1397

    PubMed  CAS  Google Scholar 

  144. Min KW, Scheithauer BW (1997) Clear cell ependymoma: a mimic of oligodendroglioma: clinicopathologic and ultratructural considerations. Am J Surg Pathol 21: 820–826

    PubMed  CAS  Google Scholar 

  145. Mobley BC, McKenney JK, Bangs CD et al. (2010) Loss of SMARCB1/INI1 expression in poorly differentiated chordomas. Acta Neuropathol 120: 745–753

    PubMed  CAS  Google Scholar 

  146. Molloy PT, Yachnis AT, Rorke LB et al. (1996) Central nervous system medulloepithelioma: a series of eight cases including two arising in the pons. J Neurosurg 84: 430–436

    PubMed  CAS  Google Scholar 

  147. Moss TH, Nicoll JAR, Ironside JW (1997) Intra-operative Diagnosis of CNS Tumours. Arnold, London

    Google Scholar 

  148. Muenchau A, Laas R (1997) Xanthogranuloma and xanthoma of the choroid plexus: evidence for different etiology and pathogenesis. Clin Neuropathol 16: 72–76

    PubMed  CAS  Google Scholar 

  149. Mukherjee JJ, Islam N, Kaltsas G et al. (1997) Clinical, radiological and pathological features of patients with Rathke’s cleft cysts: tumors that may recur. J Clin Endocrinol Metab 82: 2357–2362

    PubMed  CAS  Google Scholar 

  150. Mulhern RK, Merchant TE, Gajjar A, Reddick WE, Kun LE (2004) Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncol 5: 399–408

    PubMed  Google Scholar 

  151. Nelen MR, Kremer H, Konings IB et al. (1999) Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations. Eur J Hum Genet 7: 267–273

    PubMed  CAS  Google Scholar 

  152. Ng HK, Poon WS (1998) Primary leptomeningeal astrocytoma. Case report. J Neurosurg 88: 586–589

    PubMed  CAS  Google Scholar 

  153. Nigro JM, Takahashi MA, Ginzinger DG, Law M, Passe S, Jenkins RB, Aldape K (2001) Detection of 1p and 19q loss in oligodendroglioma by quantitative microsatellite analysis, a real-time quantitative polymerase chain reaction assay. Am J Pathol 158: 1253–1262

    PubMed  CAS  Google Scholar 

  154. Norden AD, Drappatz J, Wen PY (2008) Novel anti-angiogenic therapies for malignant gliomas. Lancet Neurol 7: 1152–1160

    PubMed  CAS  Google Scholar 

  155. Oh D, Prayson RA (1999) Evaluation of epithelial and keratin markers in glioblastoma multiforme: an immunohistochemical study. Arch Pathol Lab Med 123: 917–920

    PubMed  CAS  Google Scholar 

  156. Ohgaki H, Huang H, Haltia M, Vainio H, Kleihues P (2000) More about: cell and molecular biology of simian virus 40: implications for human infections and disease. J Natl Cancer Inst 92: 495–497

    PubMed  CAS  Google Scholar 

  157. Ohgaki H, Kleihues P (2007) Genetic pathways to primary and secondary glioblastoma. Am J Pathol 170: 1445–1453

    PubMed  CAS  Google Scholar 

  158. Ordonez NG, Mackay B (1999) Granular cell tumor: a review of the pathology and histogenesis. Ultrastruct Pathol 23: 207–222

    PubMed  CAS  Google Scholar 

  159. Parney IF, Farr-Jones MA, Chang LJ, Petruk KC (2000) Human glioma immunobiology in vitro: implications for immunogene therapy. Neurosurgery 46: 1169–1177; discussion 1177–1168

    Google Scholar 

  160. Patil S, Perry A, Maccollin M, Dong S, Betensky RA, Yeh TH, Gutmann DH, Stemmer-Rachamimov AO (2008) Immunohistochemical analysis supports a role for INI1/ SMARCB1 in hereditary forms of schwannomas, but not in solitary, sporadic schwannomas. Brain Pathol 18: 517–519

    PubMed  CAS  Google Scholar 

  161. Paulus W, Peiffer J (1989) Intratumoral histologic heterogeneity of gliomas. A quantitative study. Cancer 64: 442–447

    PubMed  CAS  Google Scholar 

  162. Paulus W, Jellinger K, Perneczky G (1991) Intraspinal neurothekeoma (nerve sheath myxoma). A report of two cases. Am J Clin Pathol 95: 511–516

    PubMed  CAS  Google Scholar 

  163. Paulus W, Schlote W, Perentes E, Jacobi G, Warmuth-Metz M, Roggendorf W (1992) Desmoplastic supratentorial neuroepithelial tumours of infancy. Histopathology 21: 43–49

    PubMed  CAS  Google Scholar 

  164. Paulus W, Bayas A, Ott G, Roggendorf W (1994) Interphase cytogenetics of glioblastoma and gliosarcoma. Acta Neuropathol 88: 420–425

    PubMed  CAS  Google Scholar 

  165. Paulus W, Baur I, Dours-Zimmermann MT, Zimmermann DR (1996) Differential expression of versican isoforms in brain tumors. J Neuropathol Exp Neurol 55: 528–533

    PubMed  CAS  Google Scholar 

  166. Paulus W, Honegger J, Keyvani K, Fahlbusch R (1999) Xanthogranuloma of the sellar region: a clinicopathological entity different from adamantinomatous craniopharyngioma. Acta Neuropathol 97: 377–382

    PubMed  CAS  Google Scholar 

  167. Paulus W, Kleihues P (2010) Genetic profiling of CNS tumors extends histological classification. Acta Neuropathol 120: 269–270

    PubMed  Google Scholar 

  168. Peiffer J (1987) Encephalomyelopathies associated with extracerebral malignant tumors. Pathol Res Pract 182: 585–608

    PubMed  CAS  Google Scholar 

  169. Peraud A, Watanabe K, Schwechheimer K, Yonekawa Y, Kleihues P, Ohgaki H (1999) Genetic profile of the giant cell glioblastoma. Lab Invest 79: 123–129

    PubMed  CAS  Google Scholar 

  170. Peris-Bonet R, Martinez-Garcia C, Lacour B, Petrovich S, Giner-Ripoll B, Navajas A, Steliarova-Foucher E (2006) Childhood central nervous system tumours--incidence and survival in Europe (1978–1997): report from Automated Childhood Cancer Information System project. Eur J Cancer 42: 2064–2080

    PubMed  Google Scholar 

  171. Perry A, Parisi JE, Kurtin PJ (1997) Metastatic adenocarcinoma to the brain: an immunohistochemical approach. Hum Pathol 28: 938–943

    PubMed  CAS  Google Scholar 

  172. Perry A, Fuller CE, Judkins AR, Dehner LP, Biegel JA (2005) INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas. Mod Pathol 18: 951–958

    PubMed  CAS  Google Scholar 

  173. Pfister SM, Korshunov A, Kool M, Hasselblatt M, Eberhart C, Taylor MD (2010) Molecular diagnostics of CNS embryonal tumors. Acta Neuropathol 120: 553–566

    PubMed  CAS  Google Scholar 

  174. Pilkington GJ (1997) The paradox of neoplastic glial cell invasion of the brain and apparent metastatic failure. Anticancer Res 17: 4103–4105

    PubMed  CAS  Google Scholar 

  175. Prayson RA, Estes ML (1996) MIB1 and p53 immunoreactivity in protoplasmic astrocytomas. Pathol Int 46: 862–866

    PubMed  CAS  Google Scholar 

  176. Preusser M, Heinzl H, Gelpi E et al. (2008) Ki67 index in intracranial ependymoma: a promising histopathological candidate biomarker. Histopathology 53: 39–47

    PubMed  CAS  Google Scholar 

  177. Quinn B (1998) Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma. Am J Surg Pathol 22: 550–556

    PubMed  CAS  Google Scholar 

  178. Rasmussen SA, Friedman JM (2000) NF1 gene and neurofibromatosis 1. Am J Epidemiol 151: 33–40

    PubMed  CAS  Google Scholar 

  179. Reich P, Walther EU, Liebetrau M et al. (2000) Gliomatosis cerebri. Nervenarzt 71: 481–484

    PubMed  CAS  Google Scholar 

  180. Reifenberger G, Weber T, Weber RG et al. (1999) Chordoid glioma of the third ventricle: immunohistochemical and molecular genetic characterization of a novel tumor entity. Brain Pathol 9: 617–626

    PubMed  CAS  Google Scholar 

  181. Reis RM, Konu-Lebleblicioglu D, Lopes JM, Kleihues P, Ohgaki H (2000) Genetic profile of gliosarcomas. Am J Pathol 156: 425–432

    PubMed  CAS  Google Scholar 

  182. Relling MV, Rubnitz JE, Rivera GK et al. (1999) High incidence of secondary brain tumours after radiotherapy and antimetabolites. Lancet 354: 34–39

    PubMed  CAS  Google Scholar 

  183. Riant F, Bergametti F, Ayrignac X, Boulday G, Tournier-Lasserve E (2010) Recent insights into cerebral cavernous malformations: the molecular genetics of CCM. FEBS J 277: 1070–1075

    PubMed  CAS  Google Scholar 

  184. Rickert CH (1999) Neuropathology and prognosis of foetal brain tumours. Acta Neuropathol 98: 567–576

    PubMed  CAS  Google Scholar 

  185. Rickert CH, Simon R, Bergmann M, Dockhorn-Dworniczak B, Paulus W (2000) Comparative genomic hybridization in pineal germ cell tumors. J Neuropathol Exp Neurol 59: 815–821

    PubMed  CAS  Google Scholar 

  186. Riemenschneider MJ, Jeuken JW, Wesseling P, Reifenberger G (2010) Molecular diagnostics of gliomas: state of the art. Acta Neuropathol 120: 567–584

    PubMed  CAS  Google Scholar 

  187. Rigamonti D, Johnson PC, Spetzler RF, Hadley MN, Drayer BP (1991) Cavernous malformations and capillary telangiectasia: a spectrum within a single pathological entity. Neurosurgery 28: 60–64

    PubMed  CAS  Google Scholar 

  188. Roberts CW, Biegel JA (2009) The role of SMARCB1/INI1 in development of rhabdoid tumor. Cancer Biol Ther 8: 412–416

    PubMed  CAS  Google Scholar 

  189. Robinson S, Cohen AR (2000) Cowden disease and Lhermitte-Duclos disease: characterization of a new phakomatosis. Neurosurgery 46: 371–383

    PubMed  CAS  Google Scholar 

  190. Roncaroli F, Scheithauer BW, Cenacchi G, Horvath E, Kovacs K, Lloyd RV, Abell-Aleff P, Santi M, Yates AJ (2002) „Spindle cell oncocytoma“ of the adenohypophysis: a tumor of folliculostellate cells? Am J Surg Pathol 26: 1048–1055

    PubMed  Google Scholar 

  191. Rorke LB (1983) The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropathol Exp Neurol 42: 1–15

    PubMed  CAS  Google Scholar 

  192. Rosenblum MK, Erlandson RA, Budzilovich GN (1991) The lipid-rich epithelioid glioblastoma. Am J Surg Pathol 15: 925–934

    PubMed  CAS  Google Scholar 

  193. Rubinstein LJ (1985) Embryonal central neuroepithelial tumors and their differentiating potential. A cytogenetic view of a complex neuro-oncological problem. J Neurosurg 62: 795–805

    PubMed  CAS  Google Scholar 

  194. Rubinstein LJ (1986) Inaugural Dorothy S. Russell memorial lecture. Immunohistochemical signposts – not markers – in neural tumour differentiation. Neuropathol Appl Neurobiol 12: 523–537

    PubMed  CAS  Google Scholar 

  195. Rubinstein LJ, Herman MM (1989) The astroblastoma and its possible cytogenic relationship to the tanycyte. An electron microscopic, immunohistochemical, tissue- and organ-culture study. Acta Neuropathol 78: 472–483

    PubMed  CAS  Google Scholar 

  196. Ruggieri M (1999) The different forms of neurofibromatosis. Childs Nerv Syst 15: 295–308

    PubMed  CAS  Google Scholar 

  197. Ruggieri M, Pascual-Castroviejo I, Di Rocco C (eds) (2008) Neurocutaneous disorders. Phakomatoses and hamartoneoplastic syndromes. Springer, Wien

    Google Scholar 

  198. Sarasa JL, Fortes J (1991) Ecchordosis physaliphora: an immunohistochemical study of two cases. Histopathology 18: 273–275

    PubMed  CAS  Google Scholar 

  199. Sathornsumetee S, Cao Y, Marcello JE et al. (2008) Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol 26: 271–278

    PubMed  CAS  Google Scholar 

  200. Schiffer D, Cravioto H, Giordana MT, Migheli A, Pezzulo T, Vigliani MC (1993) Is polar spongioblastoma a tumor entity? J Neurosurg 78: 587–591

    PubMed  CAS  Google Scholar 

  201. Schild SE, Scheithauer BW, Schomberg PJ, Hook CC, Kelly PJ, Frick L, Robinow JS, Buskirk SJ (1993) Pineal parenchymal tumors. Clinical, pathologic, and therapeutic aspects. Cancer 72: 870–880

    PubMed  CAS  Google Scholar 

  202. Schindler G, Capper D, Meyer J et al. (2011) Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 121: 397–405

    PubMed  CAS  Google Scholar 

  203. Schneppenheim R, Fruhwald MC, Gesk S et al. (2010) Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome. Am J Hum Genet 86: 279–284

    PubMed  CAS  Google Scholar 

  204. Senzer N, Nemunaitis J (2009) A review of contusugene ladenovec (Advexin) p53 therapy. Curr Opin Mol Ther 11: 54–61

    PubMed  CAS  Google Scholar 

  205. Shapiro S, Mealey J Jr, Sartorius C (1989) Radiation-induced intracranial malignant gliomas. J Neurosurg 71: 77–82

    PubMed  CAS  Google Scholar 

  206. Shaw EG, Scheithauer BW, O’Fallon JR, Tazelaar HD, Davis DH (1992) Oligodendrogliomas: the Mayo Clinic experience. J Neurosurg 76: 428–434

    PubMed  CAS  Google Scholar 

  207. Silverman TA, Enzinger FM (1985) Fibrolipomatous hamartoma of nerve. A clinicopathologic analysis of 26 cases. Am J Surg Pathol 9: 7–14

    PubMed  CAS  Google Scholar 

  208. Sommer C, Weishaupt A, Brinkhoff J, Biko L, Wessig C, Gold R, Toyka KV (2005) Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin. Lancet 365: 1406–1411

    PubMed  CAS  Google Scholar 

  209. Sonneland PR, Scheithauer BW, Onofrio BM (1985) Myxopapillary ependymoma. A clinicopathologic and immunocytochemical study of 77 cases. Cancer 56: 883–893

    PubMed  CAS  Google Scholar 

  210. Sonoda Y, Kumabe T, Watanabe M, Nakazato Y, Inoue T, Kanamori M, Tominaga T (2009) Long-term survivors of glioblastoma: clinical features and molecular analysis. Acta Neurochir (Wien) 151: 1349–1358

    Google Scholar 

  211. Soylemezoglu F, Soffer D, Onol B, Schwechheimer K, Kleihues P (1996) Lipomatous medulloblastoma in adults. A distinct clinicopathological entity. Am J Surg Pathol 20: 413–418

    PubMed  CAS  Google Scholar 

  212. Stupp R, Mason WP, van den Bent MJ et al. (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352: 987–996

    PubMed  CAS  Google Scholar 

  213. Stupp R, Hegi ME, Mason WP et al. (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10: 459–466

    PubMed  CAS  Google Scholar 

  214. Sujansky E, Conradi S (1995) Outcome of Sturge-Weber syndrome in 52 adults. Am J Med Genet 57: 35–45

    PubMed  CAS  Google Scholar 

  215. Suzuki Y, Yagi K, Kodama T, Shinoura N (2009) Corticospinal tract extraction combining diffusion tensor tractography with FMRI in patients with brain diseases. Magn Reson Med Sci 8: 9–16

    PubMed  Google Scholar 

  216. Tabori U, Baskin B, Shago M et al. (2010) Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations. J Clin Oncol 28: 1345–1350

    PubMed  CAS  Google Scholar 

  217. Taratuto AL, Monges J, Lylyk P, Leiguarda R (1984) Superficial cerebral astrocytoma attached to dura. Report of six cases in infants. Cancer 54: 2505–2512

    PubMed  CAS  Google Scholar 

  218. Tavangar SM, Larijani B, Mahta A, Hosseini SM, Mehrazine M, Bandarian F (2004) Craniopharyngioma: a clinicopathological study of 141 cases. Endocr Pathol 15: 339–344

    PubMed  Google Scholar 

  219. Teo JG, Gultekin SH, Bilsky M, Gutin P, Rosenblum MK (1999) A distinctive glioneuronal tumor of the adult cerebrum with neuropil-like (including „rosetted“) islands: report of 4 cases. Am J Surg Pathol 23: 502–510

    PubMed  CAS  Google Scholar 

  220. Tihan T, Fisher PG, Kepner JL, Godfraind C, McComb RD, Goldthwaite PT, Burger PC (1999) Pediatric astrocytomas with monomorphous pilomyxoid features and a less favorable outcome. J Neuropathol Exp Neurol 58: 1061–1068

    PubMed  CAS  Google Scholar 

  221. Tomokane N, Iwaki T, Tateishi J, Iwaki A, Goldman JE (1991) Rosenthal fibers share epitopes with alpha B-crystallin, glial fibrillary acidic protein, and ubiquitin, but not with vimentin. Immunoelectron microscopy with colloidal gold. Am J Pathol 138: 875–885

    PubMed  CAS  Google Scholar 

  222. van Breemen MS, Wilms EB, Vecht CJ (2007) Epilepsy in patients with brain tumours: epidemiology, mechanisms, and management. Lancet Neurol 6: 421–430

    PubMed  Google Scholar 

  223. van den Bent MJ, Brandes AA, Rampling R et al. (2009) Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J Clin Oncol 27: 1268–1274

    PubMed  Google Scholar 

  224. Van Dorpe J, Sciot R, De Vos R, Uyttebroeck A, Stas M, Van Damme B (1997) Neuromuscular choristoma (hamartoma) with smooth and striated muscle component: case report with immunohistochemical and ultrastructural analysis. Am J Surg Pathol 21: 1090–1095

    PubMed  Google Scholar 

  225. Van Gool S, Maes W, Ardon H, Verschuere T, Van Cauter S, De Vleeschouwer S (2009) Dendritic cell therapy of high-grade gliomas. Brain Pathol 19: 694–712

    PubMed  Google Scholar 

  226. VandenBerg SR (1993) Desmoplastic infantile ganglioglioma and desmoplastic cerebral astrocytoma of infancy. Brain Pathol 3: 275–281

    PubMed  CAS  Google Scholar 

  227. Varley JM (2003) Germline TP53 mutations and Li-Fraumeni syndrome. Hum Mutat 21: 313–320

    PubMed  CAS  Google Scholar 

  228. von Hoff K, Hartmann W, von Bueren AO, Gerber NU, Grotzer MA, Pietsch T, Rutkowski S (2010) Large cell/anaplastic medulloblastoma: outcome according to myc status, histopathological, and clinical risk factors. Pediatr Blood Cancer 54:369–376

    Google Scholar 

  229. Wang M, Tihan T, Rojiani AM et al. (2005) Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. J Neuropathol Exp Neurol 64: 875–881

    PubMed  Google Scholar 

  230. Watanabe K, Peraud A, Gratas C, Wakai S, Kleihues P, Ohgaki H (1998) p53 and PTEN gene mutations in gemistocytic astrocytomas. Acta Neuropathol 95: 559–564

    PubMed  CAS  Google Scholar 

  231. Waziri A (2010) Glioblastoma-derived mechanisms of systemic immunosuppression. Neurosurg Clin N Am 21: 31–42

    PubMed  Google Scholar 

  232. Wessig C, Klein R, Schneider MF, Toyka KV, Naumann M, Sommer C (2003) Neuropathology and binding studies in anti-amphiphysin-associated stiff-person syndrome. Neurology 61: 195–198

    PubMed  CAS  Google Scholar 

  233. Wharton SB, Chan KK, Hamilton FA, Anderson JR (1998) Expression of neuronal markers in oligodendrogliomas: an immunohistochemical study. Neuropathol Appl Neurobiol 24: 302–308

    PubMed  CAS  Google Scholar 

  234. Wheeler CJ, Black KL, Liu G et al. (2008) Vaccination elicits correlated immune and clinical responses in glioblastoma multiforme patients. Cancer Res 68: 5955–5964

    PubMed  CAS  Google Scholar 

  235. Williams VC, Lucas J, Babcock MA, Gutmann DH, Korf B, Maria BL (2009) Neurofibromatosis type 1 revisited. Pediatrics 123: 124–133

    PubMed  Google Scholar 

  236. Wong TT, Ho DM, Chang KP et al. (2005) Primary pediatric brain tumors: statistics of Taipei VGH, Taiwan (1975-2004). Cancer 104: 2156–2167

    PubMed  Google Scholar 

  237. Wrede B, Hasselblatt M, Peters O et al. (2009) Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neurooncol 95: 383–392

    PubMed  CAS  Google Scholar 

  238. Yasargil MG, von Ammon K, von Deimling A, Valavanis A, Wichmann W, Wiestler OD (1992) Central neurocytoma: histopathological variants and therapeutic approaches. J Neurosurg 76: 32–37

    PubMed  CAS  Google Scholar 

  239. Yonehara S, Brenner AV, Kishikawa M, Inskip PD, Preston DL, Ron E, Mabuchi K, Tokuoka S (2004) Clinical and epidemiologic characteristics of first primary tumors of the central nervous system and related organs among atomic bomb survivors in Hiroshima and Nagasaki, 1958-1995. Cancer 101: 1644–1654

    PubMed  Google Scholar 

  240. Zhou J, Tryggestad E, Wen Z et al. (2011) Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med 17: 130–134

    PubMed  CAS  Google Scholar 

  241. Zülch KJ (1986) Brain tumors. Their biology and pathology. 3rd edn. Springer, Berlin Heidelberg New York

    Google Scholar 

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  1. Institut für Neuropathologie, Universitätsklinikum Münster, Domagkstraße 19, 48149, Münster, Deutschland

    Werner Paulus & Martin Hasselblatt

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  1. Institut für Pathologie Konsultationszentrum für Pankreas- und Endokrine Tumore, TU München, Ismaninger Straße 22, 81675, München, Deutschland

    Günter Klöppel (Werkherausgeber) (Werkherausgeber)

  2. Zentrum Pathologie und Rechtsmedizin, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    Hans H. Kreipe (Werkherausgeber) (Werkherausgeber)

  3. Institut für Pathologie, Kliniken der Landeshauptstadt, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland

    Wolfgang Remmele (Werkherausgeber) (Werkherausgeber)

  4. Institut für Neuropathologie, Universitätsklinikum Münster, Domagkstraße 19, 48149, Münster, Deutschland

    Werner Paulus (Bandherausgeber) (Bandherausgeber)

  5. Institut für Neuropathologie, Universitätsklinikum der Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    J. Michael Schröder (Bandherausgeber) (Bandherausgeber)

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© 2012 Springer-Verlag Berlin Heidelberg

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Paulus, W., Hasselblatt, M. (2012). Tumoren. In: Klöppel, G., Kreipe, H., Remmele, W., Paulus, W., Schröder, J. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02324-8_18

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  • DOI: https://doi.org/10.1007/978-3-642-02324-8_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02323-1

  • Online ISBN: 978-3-642-02324-8

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