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The Role of NK Cells in Bacterial Infections

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Natural Killer Cells

Abstract

Natural killer (NK) cells are best known for their ability to kill virally infected and transformed cells. Evidence of the contributions they make to other immune functions is, however, growing. This review will focus on the important role that NK cells play in the immune response to bacterial pathogens. We will present the experimental evidence defining recent advances in our understanding of NK cell receptor recognition of bacteria. In particular, we now appreciate the fact that NK cells can recognize and respond to bacteria directly through pattern recognition receptors including Toll-like receptors and Nod-2. They can also be activated indirectly by accessory cells that have responded to pathogen infection. Stimulated accessory cells produce cytokines including IL-12 and IL-18 which activate NK cell functions. They also upregulate NK cell ligands leading to NK cell activation through engagement of receptors on their surface. In addition to their antiviral defences, we will describe the impressive arsenal of antimicrobial defences that NK cells employ, including cytokine production, cytotoxicity, production of antimicrobial peptides, and immuno-regulation.

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Authors and Affiliations

  1. Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland

    Brian P. McSharry

  2. NK cell group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland

    Clair M. Gardiner

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  1. Brian P. McSharry
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  2. Clair M. Gardiner
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Editors and Affiliations

  1. Lab. Immuno-Allergologie, Centre de Recherche Public, Val Fleuri 84, Luxembourg, 1526, Luxembourg

    Jacques Zimmer

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McSharry, B.P., Gardiner, C.M. (2010). The Role of NK Cells in Bacterial Infections. In: Zimmer, J. (eds) Natural Killer Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02309-5_7

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