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Interactions Between NK Cells and Dendritic Cells

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Abstract

Dendritic cells (DC) represent the most powerful antigen-presenting cells (APC). Located in peripheral tissues in an immature form, DC are efficient in capturing antigens such as pathogens and dying cells. In general, microbial stimulation causes DC to convert from the immature state, in which they induce abortive or tolerogenic T cell responses, to a mature state, in which they elicit a productive response.

The functional links between natural killer (NK) cells and DC have been widely investigated in the last years and different studies have demonstrated that reciprocal activations ensue upon NK/DC interactions. More recently, the anatomical sites where these interactions take place have been identified together with the related cell subsets involved. Remarkably, there is now “in vivo” evidence that this cellular cross-talk occurring during the innate phase of the immune response can deeply affect the magnitude and the quality of the subsequent adaptive response. Thus, NK cells are not merely cytotoxic lymphocytes competent in containing the spreading of viruses and tumors but can now rather be considered as crucial fine-tuning effector cells.

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  1. Laboratory of Immunology and Biotherapy, University of Messina, Messina, Italy

    Guido Ferlazzo

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  1. Guido Ferlazzo
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Correspondence to Guido Ferlazzo .

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  1. Lab. Immuno-Allergologie, Centre de Recherche Public, Val Fleuri 84, Luxembourg, 1526, Luxembourg

    Jacques Zimmer

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Ferlazzo, G. (2010). Interactions Between NK Cells and Dendritic Cells. In: Zimmer, J. (eds) Natural Killer Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02309-5_16

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